'Crescendo' transient ischemic attacks: clinical and angiographic correlations.


:Forty-seven consecutive patients presenting acutely with repetitive symptoms indicative of anterior circulation ischemia ("crescendo" transient ischemic attacks) were evaluated to identify clinical features that might reliably predict the presence of significant stenosis, ulceration, or both in the presumably symptomatic internal carotid artery. Angiographic or intraoperative correlation was obtained in all patients, and 26 (55%) were found to have anatomically significant disease. Of 20 patients with signs or symptoms suggestive of cortical ischemia, amaurosis fugax, or both, 17 (85%) had "positive" angiograms; of 18 with numbness/weakness only, 9 (50%) had positive angiograms; of 9 whose symptoms suggested lacunar ischemia, none had positive angiograms.






Rothrock JF,Lyden PD,Yee J,Wiederholt WC




Has Abstract


1988-02-01 00:00:00












  • Incidence of migraine relative to menstrual cycle phases of rising and falling estrogen.

    abstract:OBJECTIVE:To investigate the association between urinary hormone levels and migraine, with particular reference to rising and falling levels of estrogen across the menstrual cycle in women with menstrual and menstrually related migraine. METHODS:Women with regular menstrual cycles, who were not using hormonal contrace...


    pub_type: 杂志文章


    authors: MacGregor EA,Frith A,Ellis J,Aspinall L,Hackshaw A

    更新日期:2006-12-26 00:00:00

  • Intravenous t-PA for acute ischemic stroke: therapeutic yield of a stroke code system.

    abstract::Subsequent to publication of the NINDS t-PA Stroke Study results, we sought to determine the proportion of patients eligible for and receiving intravenous tissue plasminogen activator (t-PA) at an active acute stroke treatment center. Over a 12-month period there were 185 stroke code activations. Of these, 134 involve...


    pub_type: 杂志文章


    authors: Zweifler RM,Brody ML,Graves GC,U TT,Drinkard R,Cunningham S,Rothrock JF

    更新日期:1998-02-01 00:00:00

  • Physical activity, but not body mass index, predicts less disability before and after stroke.

    abstract:OBJECTIVE:To determine whether physical activity and body mass index (BMI) predict instrumental or basic activities of daily living (I/ADL) trajectories before or after stroke compared to individuals who remained stroke-free. METHODS:Using a prospective cohort, the Health and Retirement Study, we followed adults witho...


    pub_type: 杂志文章


    authors: Rist PM,Capistrant BD,Mayeda ER,Liu SY,Glymour MM

    更新日期:2017-05-02 00:00:00

  • Delivery of epilepsy care to adults with intellectual and developmental disabilities.

    abstract::Epilepsy is common in people with intellectual and developmental disabilities (IDD). In adulthood, patients with IDD and epilepsy (IDD-E) have neurologic, psychiatric, medical, and social challenges compounded by fragmented and limited care. With increasing neurologic disability, there is a higher frequency of epileps...


    pub_type: 杂志文章,评审


    authors: Devinsky O,Asato M,Camfield P,Geller E,Kanner AM,Keller S,Kerr M,Kossoff EH,Lau H,Kothare S,Singh BK,Wirrell E

    更新日期:2015-10-27 00:00:00

  • Evidence report: Genetic and metabolic testing on children with global developmental delay: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.

    abstract:OBJECTIVE:To systematically review the evidence concerning the diagnostic yield of genetic and metabolic evaluation of children with global developmental delay or intellectual disability (GDD/ID). METHODS:Relevant literature was reviewed, abstracted, and classified according to the 4-tiered American Academy of Neurolo...


    pub_type: 杂志文章,评审


    authors: Michelson DJ,Shevell MI,Sherr EH,Moeschler JB,Gropman AL,Ashwal S

    更新日期:2011-10-25 00:00:00

  • Hemorrhagic infarction in white matter following acute carbon monoxide poisoning.

    abstract::Hemorrhage complicating acute carbon monoxide poisoning is usually confined to the basal ganglia. The authors report three people with acute carbon monoxide poisoning manifesting selective or prominent white matter involvement complicated by hemorrhagic infarction on CT and MRI in one and by subcortical T2*-weighted M...


    pub_type: 杂志文章


    authors: Finelli PF,DiMario FJ Jr

    更新日期:2004-09-28 00:00:00

  • Migraine association and linkage studies of an endothelial nitric oxide synthase (NOS3) gene polymorphism.

    abstract::Migraine shows strong familial aggregation. However, the number of genes involved in the disorder is unknown and not identified. Nitric oxide is involved in the central processing of pain stimuli and plays an important role in the regulation of basal or stimulated vasodilation. Nitric oxide synthase, which controls th...


    pub_type: 杂志文章


    authors: Griffiths LR,Nyholt DR,Curtain RP,Goadsby PJ,Brimage PJ

    更新日期:1997-08-01 00:00:00

  • Microdysgenesis in resected temporal neocortex: incidence and clinical significance in focal epilepsy.

    abstract::Fifty patients underwent superficial temporal lobectomy for intractable temporal lobe epilepsy. Total cure rate was 52%, and significant improvement was achieved in 88%. Cytoarchitectural changes in gray and white tissue were analyzed under light microscopy. Neuronal dysgenesis was correlated with the duration of seiz...


    pub_type: 杂志文章


    authors: Hardiman O,Burke T,Phillips J,Murphy S,O'Moore B,Staunton H,Farrell MA

    更新日期:1988-07-01 00:00:00

  • Recanalization after thrombolysis in stroke patients: predictors and prognostic implications.

    abstract:OBJECTIVE:To estimate rates, predictors, and prognostic importance of recanalization in an unselected series of patients with stroke treated with IV thrombolysis. METHODS:We performed a CT angiography or transcranial Doppler (TCD) follow-up examination 24 hours after IV thrombolysis in 64 patients with documented occl...


    pub_type: 杂志文章


    authors: Zangerle A,Kiechl S,Spiegel M,Furtner M,Knoflach M,Werner P,Mair A,Wille G,Schmidauer C,Gautsch K,Gotwald T,Felber S,Poewe W,Willeit J

    更新日期:2007-01-02 00:00:00

  • Extending neurologic services to rural children.

    abstract::The University of Kentucky provides neurologic services to rural children by a traveling clinic. In 1978, 438 children (including 231 new patients) made 646 clinic visits. The primary diagnoses were appropriate for a neurology clinic; epilepsy was the most common (74 of 231) among new patients. A community survey of s...


    pub_type: 杂志文章


    authors: Baumann RJ,Leonidakis MG

    更新日期:1979-09-01 00:00:00

  • Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD.

    abstract:BACKGROUND:Abeta42-immunization reduces plaque burden and improves cognition in transgenic mouse models of Alzheimer disease (AD). This phase 1 study evaluated the safety, tolerability, and immunogenicity of AN1792 (human aggregated Abeta42) in patients with mild to moderate AD. METHODS:Twenty patients were enrolled i...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Bayer AJ,Bullock R,Jones RW,Wilkinson D,Paterson KR,Jenkins L,Millais SB,Donoghue S

    更新日期:2005-01-11 00:00:00

  • Clinical and laboratory assessment of distal peripheral nerves in Gulf War veterans and spouses.

    abstract:BACKGROUND:The prevalence of symptoms suggesting distal symmetric polyneuropathy (DSP) was reported to be higher among deployed veterans (DV) to the Persian Gulf in 1990-1991 than to control non-deployed veterans (NDV). The authors therefore compared the prevalence of DSP by direct examination of DV and their spouses t...


    pub_type: 历史文章,杂志文章,多中心研究


    authors: Davis LE,Eisen SA,Murphy FM,Alpern R,Parks BJ,Blanchard M,Reda DJ,King MK,Mithen FA,Kang HK

    更新日期:2004-09-28 00:00:00

  • New-onset afebrile seizures in infants: role of neuroimaging.

    abstract:OBJECTIVE:To investigate the presenting characteristics of new-onset afebrile seizures in infants (age 1-24 months) and the yield of neuroimaging. METHODS:Prospective data were obtained from a standardized evaluation and management plan mandated by a critical care pathway. A total of 317 infants presented with new-ons...


    pub_type: 杂志文章


    authors: Hsieh DT,Chang T,Tsuchida TN,Vezina LG,Vanderver A,Siedel J,Brown K,Berl MM,Stephens S,Zeitchick A,Gaillard WD

    更新日期:2010-01-12 00:00:00

  • Initial experiences of US neurologists in practice during the COVID-19 pandemic via survey.

    abstract:OBJECTIVE:To test the hypothesis that US neurologists were experiencing significant challenges with lack of personal protective equipment (PPE), rapid changes in practice, and varying institutional protocols, we conducted this survey study. The current coronavirus disease of 2019 (COVID-19) pandemic has caused widespre...


    pub_type: 杂志文章


    authors: Sharma A,Maxwell CR,Farmer J,Greene-Chandos D,LaFaver K,Benameur K

    更新日期:2020-08-04 00:00:00

  • Neurotransmitters in basal ganglia and cortex of Alzheimer's disease with and without Lewy bodies.

    abstract::We measured the concentrations of the monoamines, their precursors, and their metabolites, and the activity of choline acetyltransferase (ChAT) in basal ganglia and cortical regions of postmortem brains from cases with histologically verified pure Alzheimer's disease (AD), AD with diffusely distributed Lewy bodies (Le...


    pub_type: 杂志文章


    authors: Langlais PJ,Thal L,Hansen L,Galasko D,Alford M,Masliah E

    更新日期:1993-10-01 00:00:00

  • Phenotypic variability of aprataxin gene mutations.

    abstract::The clinical and genetic features of three non-Portuguese and non-Japanese patients with aprataxin gene mutations are reported. Patient 1 came from Italy and presented with typical ataxia with ocular motor apraxia (OMA). She was homozygous for the W279X nonsense mutation, which is associated with the Portuguese foundi...


    pub_type: 杂志文章


    authors: Tranchant C,Fleury M,Moreira MC,Koenig M,Warter JM

    更新日期:2003-03-11 00:00:00

  • The effects of myasthenic immunoglobulins on neuromuscular transmission and thymus histology in mice.

    abstract::An autoimmune reaction to the endplate acetylcholine receptor (AChR) is thought to be responsible for the muscular weakness of myasthenia gravis (MG). However, the significance of antithymic antibodies and the thymic AChR-like protein is still uncertain. We transferred immunoglobulins (Igs) from patients with MG to mi...


    pub_type: 杂志文章


    authors: Dalkara T,Onur R,Ruacan SA,Topaktaş S

    更新日期:1983-10-01 00:00:00

  • Effect of insurance status on postacute care among working age stroke survivors.

    abstract:OBJECTIVE:Utilization of postacute care is associated with improved poststroke outcomes. However, more than 20% of American adults under age 65 are uninsured. We sought to determine whether insurance status is associated with utilization and intensity of institutional postacute care among working age stroke survivors. ...


    pub_type: 杂志文章


    authors: Skolarus LE,Meurer WJ,Burke JF,Prvu Bettger J,Lisabeth LD

    更新日期:2012-05-15 00:00:00

  • CSF analysis differentiates multiple-system atrophy from idiopathic late-onset cerebellar ataxia.

    abstract:BACKGROUND:Differentiating idiopathic late-onset cerebellar ataxia (ILOCA) from ataxia due to the cerebellar subtype of multiple-system atrophy (MSA-C) can be difficult in the early stages of the disease METHODS:The authors analyzed the levels of various CSF biomarkers in 27 patients with MSA-C and 18 patients with IL...


    pub_type: 杂志文章


    authors: Abdo WF,van de Warrenburg BP,Munneke M,van Geel WJ,Bloem BR,Kremer HP,Verbeek MM

    更新日期:2006-08-08 00:00:00

  • Tourette's syndrome and 'PANDAS': will the relation bear out? Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection.

    abstract::Despite strong evidence of the importance of hereditary factors in the etiology of Tourette's syndrome (TS), research findings have consistently pointed to a role of environmental influences. A recent line of research has suggested that tic disorders and associated behavioral disturbances, such as obsessive-compulsive...


    pub_type: 评论,杂志文章,评审


    authors: Kurlan R

    更新日期:1998-06-01 00:00:00

  • MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study.

    abstract:BACKGROUND:Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins, are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine whether patterns of gray matter atrophy from antemortem MRI correlate with Braak staging of NFT pathology. METHODS:Eighty-three subjects with Bra...


    pub_type: 杂志文章


    authors: Whitwell JL,Josephs KA,Murray ME,Kantarci K,Przybelski SA,Weigand SD,Vemuri P,Senjem ML,Parisi JE,Knopman DS,Boeve BF,Petersen RC,Dickson DW,Jack CR Jr

    更新日期:2008-09-02 00:00:00

  • Loss of catecholaminergic neurons in the medullary reticular formation in myotonic dystrophy.

    abstract:OBJECTIVE:To clarify the possible relation between the extent of involvement of catecholaminergic neurons and the presence of alveolar hypoventilation in patients with myotonic dystrophy (MyD). BACKGROUND:Respiratory insufficiency has been reported frequently in MyD patients. Recent data support the hypothesis that th...


    pub_type: 杂志文章


    authors: Ono S,Takahashi K,Jinnai K,Kanda F,Fukuoka Y,Kurisaki H,Mitake S,Inagaki T,Yamano T,Shimizu N,Nagao K

    更新日期:1998-10-01 00:00:00

  • Does platelet antiaggregant therapy lessen the severity of stroke?

    abstract::Data from the Aspirin in Transient Ischemic Attack (AITIA) study, an ongoing study of two platelet antiaggregant drugs, and other published therapeutic trials were reviewed to determine whether the severity of stroke is reduced in patients taking platelet antiaggregants. Data from three of four studies suggest that st...


    pub_type: 临床试验,杂志文章,随机对照试验,评审


    authors: Grotta JC,Lemak NA,Gary H,Fields WS,Vital D

    更新日期:1985-05-01 00:00:00

  • Psychological stress as risk factor for exacerbations in multiple sclerosis.

    abstract::We prospectively evaluated the relationship between a common psychological stressor and relapses in multiple sclerosis (MS) in a group of 32 MS patients exposed to the threat of missile attacks during the Persian Gulf War of 1991. The number of relapses during the war and the following 2 months was significantly lower...


    pub_type: 杂志文章


    authors: Nisipeanu P,Korczyn AD

    更新日期:1993-07-01 00:00:00

  • Biologic impact of interferon antibodies, and complexities in assessing their clinical significance.

    abstract::The relevance of neutralizing antibodies (NAb) to interferon-beta (IFNbeta) for patients with MS treated with IFNbeta injections has been controversial. Published data from several double-blind, randomized clinical trials demonstrate that disease activity in IFNbeta-treated patients with MS is similar to placebo-treat...


    pub_type: 杂志文章,评审


    authors: Rudick RA

    更新日期:2003-11-11 00:00:00

  • Effect of L-dopa on visual evoked potential in patients with Parkinson's disease.

    abstract::In 47 patients with Parkinson's disease, we studied the visual evoked potential (VEP) using the pattern-reversal checkerboard (CBVEP) and the grating (GVEP) stimuli before and after 3 months of L-dopa therapy. The P100 latency in both CBVEP and GVEP was prolonged before L-dopa therapy, usually commensurate with the de...


    pub_type: 杂志文章


    authors: Bhaskar PA,Vanchilingam S,Bhaskar EA,Devaprabhu A,Ganesan RA

    更新日期:1986-08-01 00:00:00

  • Magnesium, hemostasis, and outcomes in patients with intracerebral hemorrhage.

    abstract:OBJECTIVE:We tested the hypothesis that admission serum magnesium levels are associated with hematoma volume, hematoma growth, and functional outcomes in patients with intracerebral hemorrhage (ICH). METHODS:Patients presenting with spontaneous ICH were enrolled in an observational cohort study that prospectively coll...


    pub_type: 杂志文章


    authors: Liotta EM,Prabhakaran S,Sangha RS,Bush RA,Long AE,Trevick SA,Potts MB,Jahromi BS,Kim M,Manno EM,Sorond FA,Naidech AM,Maas MB

    更新日期:2017-08-22 00:00:00

  • Long-term experience with selegiline and levodopa in Parkinson's disease.

    abstract::Between 1982 and 1989, 197 patients with Parkinson's disease were treated with selegiline and levodopa for at least 0.3 years. Two groups of patients were included: a group of 65 patients (stage 2 or 3 on the Hoehn and Yahr Scale) who recently had been started on levodopa and were not experiencing response fluctuation...


    pub_type: 杂志文章


    authors: Lieberman A

    更新日期:1992-04-01 00:00:00

  • Lesch-Nyhan syndrome: CSF neurotransmitter abnormalities.

    abstract::Serial determinations of spinal fluid homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were made in four patients with the Lesch-Nyhan syndrome over a 5-year period. Control spinal fluids for age-matched comparison were obtained from 194 neurologic and nonneurologic pediatric patients. A rapid decline i...


    pub_type: 杂志文章


    authors: Silverstein FS,Johnston MV,Hutchinson RJ,Edwards NL

    更新日期:1985-06-01 00:00:00

  • Time trends in incidence, comorbidity, and mortality of ischemic stroke in Denmark (1996-2016).

    abstract:OBJECTIVE:To examine whether the incidence, comorbidity, and mortality of first-time ischemic stroke changed in Denmark between 1996 and 2016 overall and according to age and sex using a nationwide cohort design. METHODS:In this cohort study, 224,617 individuals ≥18 years of age admitted with first-time ischemic strok...


    pub_type: 杂志文章


    authors: Yafasova A,Fosbøl EL,Christiansen MN,Vinding NE,Andersson C,Kruuse C,Johnsen SP,Gislason GH,Torp-Pedersen C,Køber L,Butt JH

    更新日期:2020-10-27 00:00:00