Increased florbetapir binding in the temporal neocortex from age 20 to 60 years.

abstract：:The authors identified a novel mtDNA mutation (T9176G) in the ATPase 6 gene in a family in which a 10-year-old girl had a severe neurodegenerative disorder, her elder sister had died of Leigh syndrome (LS), and a maternal uncle had a spinocerebellar disorder. Biochemical studies disclosed a reduced rate of ATP synthes...

journal_title：Neurology

authors： Carrozzo R,Tessa A,Vázquez-Memije ME,Piemonte F,Patrono C,Malandrini A,Dionisi-Vici C,Vilarinho L,Villanova M,Schägger H,Federico A,Bertini E,Santorelli FM

更新日期：2001-03-13 00:00:00

abstract：:In a previously unreported family with olivopontocerebellar atrophy, the kindred contained over 600 individuals in five generations. Of 83 offsping of affected individuals who over over 38.8 years of age (the mean age of the onset of disease in this family), 47 had ataxia; there was autosomal dominant transmission. Cl...

journal_title：Neurology

authors： Nino HE,Noreen HJ,Dubey DP,Resch JA,Namboodiri K,Elston RC,Yunis EJ

更新日期：1980-01-01 00:00:00

abstract：:Four patients with presumed Tolosa-Hunt syndrome ultimately proved to have a parasellar tumor. All four had manifestations of a cavernous sinus syndrome, normal radiologic and medical investigations, and response to steroid therapy. The Tolosa-Hunt syndrome is a diagnosis of exclusion; many other lesions can simulate ...

journal_title：Neurology

authors： Spector RH,Fiandaca MS

更新日期：1986-02-01 00:00:00

abstract：:Essential tremor (ET) is a common movement disorder that often causes functional disability, potentially leading to physical and emotional difficulties. The paucity of data available regarding the underlying pathophysiologic mechanism of ET hinders the development of innovative approaches to pharmacotherapeutic treatm...

journal_title：Neurology

authors： Koller WC,Hristova A,Brin M

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To examine the role of mutations in GABRB3 encoding the β3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. METHODS:We performed massive parallel sequencing of GABRB3 in 416 patient...

journal_title：Neurology

authors： Møller RS,Wuttke TV,Helbig I,Marini C,Johannesen KM,Brilstra EH,Vaher U,Borggraefe I,Talvik I,Talvik T,Kluger G,Francois LL,Lesca G,de Bellescize J,Blichfeldt S,Chatron N,Holert N,Jacobs J,Swinkels M,Betzler C,Syr

更新日期：2017-01-31 00:00:00

abstract：BACKGROUND:Cerebral infarctions are common in older persons but their relationship with dementia and cognitive function remains controversial. METHODS:Participants were 164 older Catholic nuns, priests, and brothers who underwent annual clinical evaluation and brain autopsy at death. The authors quantified number and ...

journal_title：Neurology

authors： Schneider JA,Wilson RS,Cochran EJ,Bienias JL,Arnold SE,Evans DA,Bennett DA

更新日期：2003-04-08 00:00:00

abstract：:The objective of our study was to assess the 5-year risk of and prognostic factors for the development of clinically definite multiple sclerosis (CDMS) following optic neuritis. In a prospective cohort study design, 388 patients, who did not have probable or definite MS at study entry enrolled in the Optic Neuritis Tr...

journal_title：Neurology

authors： Optic Neuritis Study Group.

更新日期：1997-11-01 00:00:00

abstract：:Progressive thoracic myelopathy occurred in a patient with AIDS. Concurrent opportunistic infections included disseminated systemic cytomegalovirus, aspergillosis, and cutaneous herpes simplex virus (HSV). At autopsy, immune stains indicated that the myelopathy was caused by HSV type 2 infection of the spinal cord. ...

journal_title：Neurology

authors： Britton CB,Mesa-Tejada R,Fenoglio CM,Hays AP,Garvey GG,Miller JR

更新日期：1985-07-01 00:00:00

abstract：OBJECTIVE:To estimate the US commercially insured multiple sclerosis (MS) annual prevalence from 2008 to 2012. METHODS:The study was a retrospective analysis using PharMetrics Plus, a nationwide claims database for over 42 million covered US representative lives. Annual point prevalence required insurance eligibility ...

journal_title：Neurology

authors： Dilokthornsakul P,Valuck RJ,Nair KV,Corboy JR,Allen RR,Campbell JD

更新日期：2016-03-15 00:00:00

abstract：OBJECTIVE:To apply multisequence MRI techniques to patients with clinically isolated syndromes, to document the pattern and frequency of abnormalities at baseline and early follow-up, and to determine their predictive values for the early development of clinical MS. BACKGROUND:Disseminated lesions on T2-weighted brain...

journal_title：Neurology

authors： Brex PA,O'Riordan JI,Miszkiel KA,Moseley IF,Thompson AJ,Plant GT,Miller DH

更新日期：1999-10-12 00:00:00

abstract：OBJECTIVE:To evaluate teriflunomide as add-on therapy to ongoing stable-dosed interferon-β (IFNβ) in patients with relapsing forms of multiple sclerosis (RMS). METHODS:A total of 118 patients with RMS were randomly assigned 1:1:1 to receive oral placebo or teriflunomide, 7 or 14 mg, once daily for 24 weeks; 86 patient...

journal_title：Neurology

authors： Freedman MS,Wolinsky JS,Wamil B,Confavreux C,Comi G,Kappos L,Olsson TP,Miller A,Benzerdjeb H,Li H,Simonson C,O'Connor PW,Teriflunomide Multiple Sclerosis Trial Group and the MRI Analysis Center.

更新日期：2012-06-05 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis (HS) and a history of febrile convulsions (HFC). The authors investigated 292 patients with TLE due to HS. Left HS occurred more frequently (57%) than right HS (43%, p = 0.01). Forty-seven percent of the patients had HFC. In patients with...

journal_title：Neurology

authors： Janszky J,Woermann FG,Barsi P,Schulz R,Halász P,Ebner A

更新日期：2003-04-08 00:00:00

abstract：BACKGROUND:Cervical artery dissection is often attributed to an underlying arteriopathy related to a generalized extracellular matrix defect. OBJECTIVE:The authors compared the hemodynamic and morphologic properties of the carotid artery, as assessed noninvasively by ultrasonography, in patients with spontaneous inter...

journal_title：Neurology

authors： Guillon B,Tzourio C,Biousse V,Adraï V,Bousser MG,Touboul PJ

更新日期：2000-09-12 00:00:00

abstract：BACKGROUND:Both AD and normal aging cause brain atrophy, limiting the ability of MRI to distinguish between AD and age-related brain tissue loss. MRS imaging (MRSI) measures the neuronal marker N-acetylaspartate (NAA), which could help assess brain change in AD and aging. OBJECTIVES:To determine the effects of AD on c...

journal_title：Neurology

authors： Schuff N,Capizzano AA,Du AT,Amend DL,O'Neill J,Norman D,Kramer J,Jagust W,Miller B,Wolkowitz OM,Yaffe K,Weiner MW

更新日期：2002-03-26 00:00:00

abstract：OBJECTIVE:To estimate whole-brain microinfarct burden from microinfarct counts in routine postmortem examination. METHODS:We developed a simple mathematical method to estimate the total number of cerebral microinfarcts from counts obtained in the small amount of tissue routinely examined in brain autopsies. We derived...

journal_title：Neurology

authors： Westover MB,Bianchi MT,Yang C,Schneider JA,Greenberg SM

更新日期：2013-04-09 00:00:00

abstract：:In six patients with cryptococcal meningitis, diagnosis was made by routine cytologic examination of cerebrospinal fluid (CSF). A seventh patient had a false-positive cryptococcal antigen titer, and no organism was seen on SCF examination. The patient had herpes simplex encephalitis on brain biopsy. Cytologic examinat...

journal_title：Neurology

authors： Bernad PG,Szyfelbein WM,Weiss HD,Richardson EP Jr

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:We sought to determine the range and extent of neurologic complications due to pandemic influenza A (H1N1) 2009 infection (pH1N1'09) in children hospitalized with influenza. METHODS:Active hospital-based surveillance in 6 Australian tertiary pediatric referral centers between June 1 and September 30, 2009, f...

journal_title：Neurology

authors： Khandaker G,Zurynski Y,Buttery J,Marshall H,Richmond PC,Dale RC,Royle J,Gold M,Snelling T,Whitehead B,Jones C,Heron L,McCaskill M,Macartney K,Elliott EJ,Booy R

更新日期：2012-10-02 00:00:00

abstract：:We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson's disease (5) and parkinsonism with dementia (PD) (5). We found similar, but less extensive, pathology in the substantia nigra of six of ni...

journal_title：Neurology

authors： McGeer PL,Itagaki S,Boyes BE,McGeer EG

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVE:To determine with greater precision the map location of the locus associated with familial cavernous hemangiomas. BACKGROUND:Cavernous malformations of the brain are a significant cause of seizures, progressive or apoplectic neurologic deficit, and headache. Prevalence estimates from autopsy series vary from...

journal_title：Neurology

authors： Polymeropoulos MH,Hurko O,Hsu F,Rubenstein J,Basnet S,Lane K,Dietz H,Spetzler RF,Rigamonti D

更新日期：1997-03-01 00:00:00

abstract：:In the Clinical/Scientific Note “CNS neutrophilic vasculitis in neuro-Sweet disease” by R. Charlson et al. (Neurology® 2015;85:829–830), there is an error in the discussion and the references. The last name of the first author of reference 2 should be Hisanaga, not Hisanga as originally published. The authors regret t...

journal_title：Neurology

authors：

更新日期：2015-11-17 00:00:00

abstract：:We performed a randomized double-blind crossover therapeutic bioequivalency study of a generic (Epitol) versus a brand name (Tegretol) carbamazepine product under steady-state conditions in 40 epileptic patients. Each patient received 90-day supplies of Epitol or Tegretol and placebo, which replaced the usual dosage o...

journal_title：Neurology

authors： Oles KS,Penry JK,Smith LD,Anderson RL,Dean JC,Riela AR

更新日期：1992-06-01 00:00:00

abstract：:The incidence of MS was assessed in a nationwide cohort study of 31,990 employees of Danish utility companies between 1900 and 1993. Overall, 32 cases of MS were diagnosed, as compared with 23.7 expected from national incidence rates, to yield a standardized incidence ratio of 1.35 (95% confidence interval, 0.92 to 1....

journal_title：Neurology

authors： Johansen C,Koch-Henriksen N,Rasmussen S,Olsen JH

更新日期：1999-04-12 00:00:00

abstract：OBJECTIVES:To describe the frequency of cervical arterial abnormalities in children with acute arterial ischemic stroke (AIS), to examine predictors of this, and to characterize observed abnormalities in terms of specific diagnoses. METHODS:Review of case notes of children with AIS (2002-2009) and analysis of their ne...

journal_title：Neurology

authors： Ganesan V,Cox TC,Gunny R

更新日期：2011-01-11 00:00:00

abstract：BACKGROUND:Few population-based studies with long-term follow-up have compared risk of recurrent stroke and cardiac events after first ischemic stroke. The relative risk of these two outcomes may inform treatment decisions. METHODS:In the population-based Northern Manhattan Study, first ischemic stroke patients age 40...

journal_title：Neurology

authors： Dhamoon MS,Sciacca RR,Rundek T,Sacco RL,Elkind MS

更新日期：2006-03-14 00:00:00

abstract：OBJECTIVE:To review the disciplinary process by which the American Academy of Neurology (AAN) enforces its formalized standards of professional conduct. METHODS:We reviewed the AAN's Disciplinary Action Policy. We tracked the elapsed time from receipt to final decision of all allegations ("complaints") of improper con...

journal_title：Neurology

authors： Hutchins JC,Sagsveen MG,Larriviere D

更新日期：2010-12-14 00:00:00

abstract：:Manipulation of afferent inputs may temporarily modulate dystonic spasms. Ten patients with writer's cramp were enrolled in a double-blind, randomized, crossover study in which the effects of transcutaneous electrical stimulation (TENS) and placebo treatment were compared. Patients were evaluated using four measures o...

journal_title：Neurology

authors： Tinazzi M,Farina S,Bhatia K,Fiaschi A,Moretto G,Bertolasi L,Zarattini S,Smania N

更新日期：2005-06-14 00:00:00

abstract：BACKGROUND:In acute cerebral ischemia, two variables characterize the extent of hypoperfusion: the volume of hypoperfused tissue and the intensity of hypoperfusion within these regions. We evaluated the determinants of the intensity of hypoperfusion within oligemic regions among patients who were eligible for recanaliz...

journal_title：Neurology

authors： Bang OY,Saver JL,Alger JR,Starkman S,Ovbiagele B,Liebeskind DS,UCLA Collateral Investigators.

更新日期：2008-11-25 00:00:00

abstract：:A 14-year-old boy with exercise-related myalgia and cramps had several episodes of myoglobinuria since early childhood. An episode at 2 years of age caused acute renal failure. Histochemical and biochemical analysis of muscle showed a combined defect of phosphofructokinase (PFK) and adenosine monophosphate (AMP) deami...

journal_title：Neurology

authors： Bruno C,Minetti C,Shanske S,Morreale G,Bado M,Cordone G,DiMauro S

更新日期：1998-01-01 00:00:00

abstract：:Original reports on temporal arteritis and polymyalgia rheumatica were reviewed before and after the introduction of steroid therapy to prevent blindness in temporal arteritis. In some cases, the original data were reworked. There is evidence that both diseases have become more benign. As a result, the perceived risk ...

journal_title：Neurology

authors： Turnbull J

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Some patients with prosopagnosia have covert recognition, meaning that they retain some familiarity or knowledge of facial identity of which they are not aware. OBJECTIVE:To test the hypothesis that prosopagnosic patients with right occipitotemporal lesions and impaired face perception lack covert processin...

journal_title：Neurology

authors： Barton JJ,Cherkasova M,O'Connor M

更新日期：2001-10-09 00:00:00