Abstract:
OBJECTIVE:To apply multisequence MRI techniques to patients with clinically isolated syndromes, to document the pattern and frequency of abnormalities at baseline and early follow-up, and to determine their predictive values for the early development of clinical MS. BACKGROUND:Disseminated lesions on T2-weighted brain MRI confer an increased risk of progression to clinically definite MS. Newer MRI techniques increase detection of lesions in both brain and spinal cord, and clarify further their pathology. The predictive value of such techniques for the development of clinical MS needs to be defined. METHODS:Brain and spinal MRI were performed on 60 patients after their first demyelinating event. A total of 50 patients were followed for 1 year, and 49 underwent repeat brain MRI 3 months after the initial scan. RESULTS:At baseline, 73% of patients had lesions on T2-weighted fast spin-echo (FSE) brain images and 42% had asymptomatic spinal cord lesions. Fast fluid-attenuated inversion-recovery brain did not improve detection of brain lesions. Repeat brain MRI demonstrated new FSE lesions in 43% of patients. After 1 year, 26% of patients developed MS. The MRI features that provided the best combination of sensitivity and specificity for the development of MS were the presence of new FSE lesions at follow-up and enhancing lesions at baseline. The frequency of developing clinical MS was higher for those with both brain and spinal cord lesions at baseline (48%) than brain lesions alone (18%). CONCLUSIONS:The combination of baseline MRI abnormalities and new lesions at follow-up, indicating dissemination in space and time, was associated with a high sensitivity and specificity for the early development of clinical MS. These data suggest a potential role for new diagnostic criteria for MS based on early MRI activity. Such criteria may be useful in selecting patients for therapeutic trials at this early clinical stage.
journal_name
Neurologyjournal_title
Neurologyauthors
Brex PA,O'Riordan JI,Miszkiel KA,Moseley IF,Thompson AJ,Plant GT,Miller DHdoi
10.1212/wnl.53.6.1184subject
Has Abstractpub_date
1999-10-12 00:00:00pages
1184-90issue
6eissn
0028-3878issn
1526-632Xjournal_volume
53pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::We studied 35 patients with nonseptic cardiogenic cerebral emboli. In 28 cases, there was sudden onset with maximal neurologic deficit within 1 hour; in 7 cases, there was progression in 24 hours. In six cases, neurologic abnormality worsened in the first week after an initial period of stabilization. CT showed eviden...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.6.896
更新日期:1985-06-01 00:00:00
abstract::CSF does not normally contain motile cells within flagella or cilia. When motile cells are seen in the CSF, they may be incorrectly assumed to be amebae. We studied a patient with a traumatic mucocele, in whom motile ciliated respiratory epithelial cells were seen in the CSF and within a frontal lobe brain abscess. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.10.1487
更新日期:1985-10-01 00:00:00
abstract::We studied the effect of a single oral intake of 30 to 40 grams of alcohol in 4 consecutive patients presenting with Ramsay Hunt syndrome, the most common type of degenerative progressive myoclonic epilepsy (PME) encountered in southern Europe. Clinical and polygraphic monitoring demonstrated abatement of myoclonus in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.9.1412
更新日期:1990-09-01 00:00:00
abstract::Lubag (X-linked dystonia-parkinsonism) has been considered a sex-linked recessive trait and has been mapped to the pericentromeric region of the X chromosome. We studied a 54-year-old man with lubag and two of his female first cousins. Genetic typing was carried out using X chromosome markers. Fluorodopa PET was perfo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.8.1555
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVES:To learn caregivers' preferences for the treatment of AD with a disease-slowing therapy, and to identify relationships between these preferences and the characteristics of caregivers and patients. METHODS:A structured interview with 40 caregivers of patients with AD. Preferences were measured for an AD-slow...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.7.1008
更新日期:2000-10-10 00:00:00
abstract:BACKGROUND:The best treatment for polyneuropathy associated with IgM monoclonal gammopathy (MGUS) is unknown. Oral cyclophosphamide combined with prednisone showed limited efficacy in a previous open label pilot study. We therefore performed a double-blind, randomized, placebo-controlled study of combined oral cyclopho...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000265055.28218.cc
更新日期:2007-07-03 00:00:00
abstract:OBJECTIVE:To study the long-term dual inhibitory effects of rivastigmine on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in patients with AD. METHODS:Eleven patients with mild AD received rivastigmine for 12 months. Cholinesterase (ChE) activities in the CSF and plasma were assessed colorimetrically. ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.59.4.563
更新日期:2002-08-27 00:00:00
abstract::A comprehensive sequence analysis of 29 exons that code for the functional domains of LRRK2 in 160 nondominant Parkinson disease (PD) patients was performed. Novel variant screening in a further 470 sporadic PD patients and 630 controls revealed two novel variants (R1067Q and IVS33 + 6 T>A), which are likely to be pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000180517.70572.37
更新日期:2005-10-25 00:00:00
abstract:OBJECTIVE:Among the rare causes of myelopathies is primary intramedullary spinal cord lymphoma (PISCL). As PISCL is often underrecognized, delaying appropriate treatment, we sought to describe its presentation, imaging characteristics, and outcomes. METHODS:Mayo Clinic medical records, lymphoma database, and autopsies...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31822b00b9
更新日期:2011-08-23 00:00:00
abstract:OBJECTIVE:To evaluate whether the burden of deep and lobar lacunes differs between patients with intracerebral hemorrhage (ICH) with definite/probable cerebral amyloid angiopathy (CAA) per the Boston criteria and hypertensive small vessel disease (HTN-SVD; ICH in basal ganglia, thalami, brainstem). METHODS:We defined ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004007
更新日期:2017-06-06 00:00:00
abstract::Over the past 5 years, and especially within the last year, there has been a rapid expansion of vagus nerve stimulation (VNS)-related preclinical research, as well as clinical studies in indications other than epilepsy. The research advances in understanding VNS are occurring in the midst of a blossoming of other form...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.59.6_suppl_4.s56
更新日期:2002-09-24 00:00:00
abstract::Five women are presented with a subacute pure pancerebellar syndrome of ataxia and dysarthria to emphasize that this illness may occur without anti-Purkinje-cell or anti-Yo antibodies, or associated systemic cancer. The syndrome evolved over weeks or less and stabilized in four of the patients. Three had had a precedi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.8.1602
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVE:Physician prediction of outcome in critically ill neurologic patients impacts treatment decisions and goals of care. In this observational study, we prospectively compared predictions by neurointensivists to patient outcomes at 6 months. METHODS:Consecutive neurologic patients requiring mechanical ventilatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181d8197f
更新日期:2010-04-06 00:00:00
abstract:OBJECTIVE:To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). METHODS:We performed a systematic review of the literature from 1960 to August 2008 and classified the studies according to the American Academy of Neurology classificati...
journal_title:Neurology
pub_type: 指南,杂志文章,评审
doi:10.1212/WNL.0b013e3182166ebe
更新日期:2011-05-17 00:00:00
abstract::We evaluated ventilation during cycle exercise in four men lacking myophosphorylase. In submaximal exercise of similar relative intensity, ventilation was higher relative to oxygen uptake in McArdle patients than in normal men. The exercise ventilatory response returned to normal after glucose infusion, by fasting to ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.5.716
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:To review clinical and electrodiagnostic features of the medial brachial fascial compartment syndrome, a complication of percutaneous axillary vessel puncture. METHODS:The authors reviewed electrodiagnostic examinations over a 20-year period. RESULTS:This syndrome presents with weakness, pain, and numbness ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000089488.35632.08
更新日期:2003-10-28 00:00:00
abstract::The intracarotid amobarbital test (IAT) is used to lateralize language function and assess hemispheric memory. In this study 23 non-lesional epileptic patients were evaluated. The magnitude of the difference in IAT scores between the two hemispheres was significantly greater in the patients whose seizures lateralized ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.52.2.409
更新日期:1999-01-15 00:00:00
abstract:OBJECTIVE:To investigate the prevalence of headaches in a Chinese elderly population. BACKGROUND:There are few headache surveys in the elderly. Previous studies have shown a low headache prevalence in Chinese. METHODS: TARGET POPULATION:eligible registered residents > or = 65 years old (N = 2,003) in two townships o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.1.195
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:To determine the latency, magnitude, and duration of the long-duration response (LDR) to levodopa in PD in relationship to the administration of levodopa at different interdose intervals. METHODS:In six patients with PD, two different 15-day treatment regimens were used in which the drug was administered wit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.3.557
更新日期:1999-08-11 00:00:00
abstract::Previous studies reported that a 2- to 3-week course of IV cyclophosphamide plus adrenocorticotropic hormone (ACTH) induction can temporarily halt progressive MS for a period of 12 months in the majority of patients treated, after which reprogression occurs. The Northeast Cooperative Multiple Sclerosis Treatment Group...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.43.5.910
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:To assess frontal lobe functions of subjects with age-associated memory impairment (AAMI) and to examine whether performance on neuropsychological tests is correlated with the volume of the frontal lobes in magnetic resonance imaging. DESIGN:Cross-sectional two-group comparison. SETTING:The Memory Research ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.48.1.148
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To determine whether comorbidity is associated with clinical (relapses, disability worsening) and MRI outcomes in multiple sclerosis (MS) by conducting a secondary analysis of the CombiRx clinical trial. METHODS:CombiRx compared interferon beta-1a, glatiramer acetate, and the combination of these agents. For...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000010024
更新日期:2020-08-04 00:00:00
abstract:OBJECTIVE:To assess the impact of intracranial arterial stenosis on the progression from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHODS:A total of 423 participants with MCI were included and evaluated with clinical and neuropsychological examinations annually for 4 years. The incidence of dementia ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000185
更新日期:2014-03-11 00:00:00
abstract:OBJECTIVE:To investigate specificity and significance of dynamic changes of the cervical dural sac and spinal cord during neck flexion in juvenile muscular atrophy of the distal upper extremity. BACKGROUND:The disorder affects young people-predominantly men-and is progressive for several years. One autopsy case showed...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.10.1922
更新日期:2000-05-23 00:00:00
abstract::Although psychological distress and cognitive dysfunction are well documented in adults with multiple sclerosis (MS), they are poorly understood in children with the disease. Psychosocial difficulty experienced by children and adolescents with MS involves factors common to all chronic illnesses in children, as well as...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000259420.54635.63
更新日期:2007-04-17 00:00:00
abstract::Sera from patients with multiple sclerosis (MS), patients with neurologic diseases other than MS, controls (adult and newborn), and rabbits immunized with bovine oligodendrocytes were assayed for antioligodendrocyte antibodies by a binding test with 125I-protein A. The mean binding of 125I-protein A to oligodendrocyte...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.5.540
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:This study investigated the sex difference in prevalence of depression at 90 days after first-ever stroke. METHODS:Patients with first-ever stroke (n = 786) were identified from the population-based Brain Attack Surveillance in Corpus Christi project (2011-2016). Poststroke depressive symptoms were assessed ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009394
更新日期:2020-05-12 00:00:00
abstract::The present study sought to evaluate the validity and generality of the Mini-Mental State Examination (MMSE) and its subsection scores. We gave the MMSE and other neuropsychological tests to 51 patients with probable Alzheimer's disease. On the basis of correlational and factor analyses, overall performance on the MMS...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.12.1894
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVE:Carotid endarterectomy (CEA) is frequently performed based solely on noninvasive vascular imaging (NVI) results (duplex ultrasound, DU; magnetic resonance angiography, MRA; CT angiography, CTA). The authors determined how often intra-arterial contrast angiography (ANGIO) alters a CEA decision as compared to N...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/wnl.56.8.1009
更新日期:2001-04-24 00:00:00
abstract::A 60-year-old woman suffered from recurrent episodes of fever, hypertension, facial flushing, vomiting, stridor, slowly progressive symptoms of hypohidrosis, and orthostatic hypotension. The episodes were synchronous with elevated catecholamine concentration in plasma and urine. This is an example of paroxysmal autono...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.9.1823
更新日期:1993-09-01 00:00:00