Primary intramedullary spinal cord lymphoma.

Abstract:

OBJECTIVE:Among the rare causes of myelopathies is primary intramedullary spinal cord lymphoma (PISCL). As PISCL is often underrecognized, delaying appropriate treatment, we sought to describe its presentation, imaging characteristics, and outcomes. METHODS:Mayo Clinic medical records, lymphoma database, and autopsies from 1996 to 2009 were searched. Inclusion criteria were clinical myelopathic presentation, intramedullary spinal cord abnormalities, and pathologically confirmed CNS lymphoma. Exclusion criteria were extramedullary lymphoma, secondary intramedullary lymphoma, or other myelopathic etiology. Clinical features, diagnostic methods, neuroimaging, treatment, and outcomes were assessed. RESULTS:The 14 patients' median age at presentation was 62.5 years (range 41-82 years) and 10 were men (71%). Two had lymphoma risk factors (HIV infection 1; chronic immunosuppression postorgan transplant 1). Most had initial presumptive diagnoses of CNS demyelinating disease and definitive diagnosis of lymphoma was delayed a median of 8 months (range 1-22 months). CNS lymphoma was pathologically confirmed by biopsy (brain 6; spinal cord 4), CSF cytology (3), and autopsy (1). Most patients had multifocal, persistently enhancing lesions on spinal MRI and 8 had involvement of conus medullaris, cauda equina, or both. IV methotrexate was the initial treatment in 9 of 12 (75%) but lymphoma recurred in the majority. Half of the patients were wheelchair-dependent at 10 months and 2-year survival was 36%. CONCLUSIONS:PISCL mimics other causes of myelopathy. Spinal MRI demonstrating multifocal lesions, persistent gadolinium enhancement, and conus medullaris or cauda equina involvement is characteristic. Pathologic confirmation often requires CNS biopsy. Despite chemotherapy, morbidity and mortality is high.

journal_name

Neurology

journal_title

Neurology

authors

Flanagan EP,O'Neill BP,Porter AB,Lanzino G,Haberman TM,Keegan BM

doi

10.1212/WNL.0b013e31822b00b9

subject

Has Abstract

pub_date

2011-08-23 00:00:00

pages

784-91

issue

8

eissn

0028-3878

issn

1526-632X

pii

WNL.0b013e31822b00b9

journal_volume

77

pub_type

杂志文章
  • Relationship between mesial temporal seizure focus and elevated serum prolactin in temporal lobe epilepsy.

    abstract::We evaluated the relationship between mesial temporal seizure focus and serum prolactin (PRL) in patients before and after they underwent anterior temporal lobectomy (ATL) for medically intractable temporal lobe epilepsy (TLE). These patients had a confirmed unilateral epileptogenic focus in mesial temporal structures...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.2.528

    authors: Lin YY,Su MS,Yiu CH,Shih YH,Yen DJ,Kwan SY,Wu ZA,Chan SH

    更新日期:1997-08-01 00:00:00

  • Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures.

    abstract:OBJECTIVE:To investigate the added value of hippocampal atrophy rates over whole brain volume measurements on MRI in patients with Alzheimer disease (AD), patients with mild cognitive impairment (MCI), and controls. METHODS:We included 64 patients with AD (67 +/- 9 years; F/M 38/26), 44 patients with MCI (71 +/- 6 yea...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000344568.09360.31

    authors: Henneman WJ,Sluimer JD,Barnes J,van der Flier WM,Sluimer IC,Fox NC,Scheltens P,Vrenken H,Barkhof F

    更新日期:2009-03-17 00:00:00

  • Interleukin-6 and risk of cognitive decline: MacArthur studies of successful aging.

    abstract:OBJECTIVE:To investigate whether plasma interleukin-6 (IL-6) is cross-sectionally related to poorer cognitive function and whether a baseline plasma IL-6 measurement can predict risk for decline in cognitive function in longitudinal follow-up of a population-based sample of nondisabled elderly people. METHODS:A prospe...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/wnl.59.3.371

    authors: Weaver JD,Huang MH,Albert M,Harris T,Rowe JW,Seeman TE

    更新日期:2002-08-13 00:00:00

  • Local cerebral metabolism during partial seizures.

    abstract::Interictal and ictal fluorodeoxyglucose scans were obtained with positron CT from four patients with spontaneous recurrent partial seizures, one with epilepsia partialis continua, and one with a single partial seizure induced by electrical stimulation of the hippocampus. Ictal metabolic patterns were different for eac...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.33.4.400

    authors: Engel J Jr,Kuhl DE,Phelps ME,Rausch R,Nuwer M

    更新日期:1983-04-01 00:00:00

  • Intramedullary spinal cysticercosis.

    abstract::Intramedullary cysticercosis of the spinal cord is rare; there have been only 26 previous cases. We describe a patient with low back pain, paraparesis, lumbosacral sensory loss, and signs of meningeal irritation. The clinical diagnosis was spinal cord tumor, but at surgery there was a cysticercus cyst within the lumbo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.29.11.1531

    authors: Akiguchi I,Fujiwara T,Matsuyama H,Muranaka H,Kameyama M

    更新日期:1979-11-01 00:00:00

  • Vitamin D, cognition, and dementia: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To examine the association between cognitive function and dementia with vitamin D concentration in adults. METHODS:Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of glo...

    journal_title:Neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1212/WNL.0b013e31826c197f

    authors: Balion C,Griffith LE,Strifler L,Henderson M,Patterson C,Heckman G,Llewellyn DJ,Raina P

    更新日期:2012-09-25 00:00:00

  • Functional neurology after the Second World War: The beginnings of neurology on screen (III).

    abstract::Treatment of functional symptoms has a long history, and interventions were often used in soldiers returning from battle. On the 75th anniversary of the end of the Second World War, I review the portrayal of neurology in documentary film. Two documentaries were released in 1946 and 1948 (Let There Be Light and Shades ...

    journal_title:Neurology

    pub_type: 历史文章,杂志文章

    doi:10.1212/WNL.0000000000009593

    authors: Wijdicks EFM

    更新日期:2020-06-09 00:00:00

  • Craniofacial and cutaneous findings expand the phenotype of hereditary neuralgic amyotrophy.

    abstract:BACKGROUND:Hereditary neuralgic amyotrophy (HNA) is an autosomal-dominant disorder associated with recurrent, episodic, painful, brachial neuropathy. The gene for HNA has been mapped to chromosome 17q25. Characteristic features including hypotelorism, short stature, and cleft palate occur in some patients. OBJECTIVE:T...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.11.1963

    authors: Jeannet PY,Watts GD,Bird TD,Chance PF

    更新日期:2001-12-11 00:00:00

  • Predicting developmental outcomes in preterm infants: A simple white matter injury imaging rule.

    abstract:OBJECTIVE:To develop a simple imaging rule to predict neurodevelopmental outcomes at 4.5 years in a cohort of preterm neonates with white matter injury (WMI) based on lesion location and examine whether clinical variables enhance prediction. METHODS:Sixty-eight preterm neonates born 24-32 weeks' gestation (median 27.7...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008172

    authors: Cayam-Rand D,Guo T,Grunau RE,Benavente-Fernández I,Synnes A,Chau V,Branson H,Latal B,McQuillen P,Miller SP

    更新日期:2019-09-24 00:00:00

  • Physical activity, but not body mass index, predicts less disability before and after stroke.

    abstract:OBJECTIVE:To determine whether physical activity and body mass index (BMI) predict instrumental or basic activities of daily living (I/ADL) trajectories before or after stroke compared to individuals who remained stroke-free. METHODS:Using a prospective cohort, the Health and Retirement Study, we followed adults witho...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003888

    authors: Rist PM,Capistrant BD,Mayeda ER,Liu SY,Glymour MM

    更新日期:2017-05-02 00:00:00

  • Auditory system degeneration in Alzheimer's disease.

    abstract::We observed a highly topographically specific and consistent pattern of degeneration in the auditory system of Alzheimer's disease (AD) patients. Senile plaques (SP) and neurofibrillary tangles (NFT) were distributed throughout the ventral nucleus of the medial geniculate body (MGB) and the central nucleus of the infe...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.4.779

    authors: Sinha UK,Hollen KM,Rodriguez R,Miller CA

    更新日期:1993-04-01 00:00:00

  • A controlled study of progabide in partial seizures: methodology and results.

    abstract::The results of a multicenter, double-blind, placebo-controlled clinical trial of the efficacy and safety of progabide (PGB) in the treatment of partial seizures are presented. This study was performed with a number of rigorous controls not usually present in clinical trials. These included uniform co-medication in whi...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.37.6.963

    authors: Leppik IE,Dreifuss FE,Porter R,Bowman T,Santilli N,Jacobs M,Crosby C,Cloyd J,Stackman J,Graves N

    更新日期:1987-06-01 00:00:00

  • Cerebral processing in the minimally conscious state.

    abstract::We studied a patient in a minimally conscious state using PET and cognitive evoked potentials. Cerebral metabolism was below half of normal values. Auditory stimuli with emotional valence (infant cries and the patient's own name) induced a much more widespread activation than did meaningless noise; the activation patt...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000137421.30792.9b

    authors: Laureys S,Perrin F,Faymonville ME,Schnakers C,Boly M,Bartsch V,Majerus S,Moonen G,Maquet P

    更新日期:2004-09-14 00:00:00

  • Increase of arginine dimethylation correlates with the progression and prognosis of ALS.

    abstract:OBJECTIVE:To investigate whether arginine methylation is altered in patients with amyotrophic lateral sclerosis (ALS) and how it affects disease severity, progression, and prognosis. METHODS:We compared the immunoreactivity of protein arginine methyltransferase 1 (PRMT1) and its products, asymmetric dimethylated prote...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000007311

    authors: Ikenaka K,Atsuta N,Maeda Y,Hotta Y,Nakamura R,Kawai K,Yokoi D,Hirakawa A,Taniguchi A,Morita M,Mizoguchi K,Mochizuki H,Kimura K,Katsuno M,Sobue G

    更新日期:2019-04-16 00:00:00

  • Correlation between NF1 genotype and imaging phenotype on whole-body MRI: NF1 radiogenomics.

    abstract:OBJECTIVE:To investigate the genotype-phenotype correlation between neurofibromatosis 1 (NF1) germline mutations and imaging features of neurofibromas on whole-body MRI (WBMRI) by using radiomics image analysis techniques. MATERIALS AND METHODS:Twenty-nine patients with NF1 who had known germline mutations determined ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000009490

    authors: Liu Y,Jordan JT,Bredella MA,Erdin S,Walker JA,Vangel M,Harris GJ,Plotkin SR,Cai W

    更新日期:2020-06-16 00:00:00

  • Childhood absence epilepsy: poor attention is more than seizures.

    abstract::Dr. Masur and colleagues(1) from the Childhood Absence Epilepsy Study Group tried to answer a few important questions regarding childhood absence epilepsy (CAE) in their article "Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy." First, they wanted to know whether childr...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000436060.67147.25

    authors: Thio LL

    更新日期:2013-10-29 00:00:00

  • 3-Methylglutaconic aciduria type I redefined: a syndrome with late-onset leukoencephalopathy.

    abstract:OBJECTIVE:3-Methylglutaconic aciduria type I is a rare inborn error of leucine catabolism. It is thought to present in childhood with nonspecific symptoms; it was even speculated to be a nondisease. The natural course of disease is unknown. METHODS:This is a study on 10 patients with 3-methylglutaconic aciduria type I...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181f39a8a

    authors: Wortmann SB,Kremer BH,Graham A,Willemsen MA,Loupatty FJ,Hogg SL,Engelke UF,Kluijtmans LA,Wanders RJ,Illsinger S,Wilcken B,Cruysberg JR,Das AM,Morava E,Wevers RA

    更新日期:2010-09-21 00:00:00

  • Osteopenia and osteoporosis in idiopathic benign positional vertigo.

    abstract:OBJECTIVE:Causes of benign positional vertigo (BPV) are mostly unknown. The aim of this study was to elucidate an association of osteoporosis with idiopathic BPV. METHODS:Two hundred nine consecutive patients with a confirmed diagnosis of idiopathic BPV underwent bone mineral densitometry of anterior-posterior lumbar ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000345016.33983.e0

    authors: Jeong SH,Choi SH,Kim JY,Koo JW,Kim HJ,Kim JS

    更新日期:2009-03-24 00:00:00

  • The syndrome of frontal lobe epilepsy: characteristics and surgical management.

    abstract::We reviewed the historical features, preoperative diagnostic evaluation, operative procedure, and surgical outcome in 16 patients with refractory frontal lobe epilepsy. Clinical expression of the epilepsy varied widely, particularly with respect to seizure characteristics, although high monthly seizure frequency and a...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.4.780

    authors: Laskowitz DT,Sperling MR,French JA,O'Connor MJ

    更新日期:1995-04-01 00:00:00

  • Elevated risk of Alzheimer's disease among workers with likely electromagnetic field exposure.

    abstract::We conducted a case-control study of the possible association of occupations with likely exposure to electromagnetic fields and Alzheimer's disease (AD) with patients from the Alzheimer Disease Treatment and Diagnostic Center, Rancho Los Amigos Medical Center, Downey, CA. Patients with definite or probable AD were the...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.47.6.1477

    authors: Sobel E,Dunn M,Davanipour Z,Qian Z,Chui HC

    更新日期:1996-12-01 00:00:00

  • Semantic memory activation in individuals at risk for developing Alzheimer disease.

    abstract:OBJECTIVE:To determine whether whole-brain, event-related fMRI can distinguish healthy older adults with known Alzheimer disease (AD) risk factors (family history, APOE epsilon4) from controls using a semantic memory task involving discrimination of famous from unfamiliar names. METHODS:Sixty-nine cognitively asymptom...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181b389ad

    authors: Seidenberg M,Guidotti L,Nielson KA,Woodard JL,Durgerian S,Antuono P,Zhang Q,Rao SM

    更新日期:2009-08-25 00:00:00

  • Monoamine metabolites in the CSF of epileptic patients.

    abstract::To assess the possible role of amine neurotransmitters in human epilepsy, we measured metabolites of serotonin (5-hydroxyindoleacetic acid [5-HIAA]), dopamine (homovanillic acid [HVA]), and norepinephrine (3-methoxy-4-hydroxyphenylethylene glycol [MHPG]) in the lumbar cerebrospinal fluid (CSF) of patients with partial...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.29.8.1157

    authors: Laxer KD,Sourkes TL,Fang TY,Young SN,Gauthier SG,Missala K

    更新日期:1979-08-01 00:00:00

  • Muscle Na+ channelopathies: MRI detects intracellular 23Na accumulation during episodic weakness.

    abstract:BACKGROUND:Muscle channelopathies such as paramyotonia, hyperkalemic periodic paralysis, and potassium-aggravated myotonia are caused by gain-of-function Na+ channel mutations. METHODS:Methods: Implementation of a three-dimensional radial 23Na magnetic resonance (MR) sequence with ultra-short echo times allowed the au...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000233841.75824.0f

    authors: Weber MA,Nielles-Vallespin S,Essig M,Jurkat-Rott K,Kauczor HU,Lehmann-Horn F

    更新日期:2006-10-10 00:00:00

  • Diffusion-weighted MRI in sporadic Creutzfeldt-Jakob disease.

    abstract::Diffusion-weighted MRI (DWI) was used in three patients with autopsy-proven sporadic Creutzfeldt-Jakob disease (CJD) to provide a rapid noninvasive way to make this sometimes confusing diagnosis. DWI prompted the diagnosis of CJD at an early stage and appears to be particularly useful for monitoring the progression of...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.52.1.205

    authors: Demaerel P,Heiner L,Robberecht W,Sciot R,Wilms G

    更新日期:1999-01-01 00:00:00

  • Decline of frontal lobe functions in subjects with age-associated memory impairment.

    abstract:OBJECTIVE:To assess frontal lobe functions of subjects with age-associated memory impairment (AAMI) and to examine whether performance on neuropsychological tests is correlated with the volume of the frontal lobes in magnetic resonance imaging. DESIGN:Cross-sectional two-group comparison. SETTING:The Memory Research ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.48.1.148

    authors: Hänninen T,Hallikainen M,Koivisto K,Partanen K,Laakso MP,Riekkinen PJ Sr,Soininen H

    更新日期:1997-01-01 00:00:00

  • Double-blind, randomized, placebo-controlled study of oral, high-dose methylprednisolone in attacks of MS.

    abstract:OBJECTIVE:There is only limited evidence from adequately controlled clinical trials to support high-dose methylprednisolone therapy for attacks of multiple sclerosis (MS) and none supporting oral administration. We assessed the effect of oral high-dose methylprednisolone therapy in attacks of MS. METHODS:Twenty-five p...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.51.2.529

    authors: Sellebjerg F,Frederiksen JL,Nielsen PM,Olesen J

    更新日期:1998-08-01 00:00:00

  • The anatomic basis of delusions after right cerebral infarction.

    abstract::We studied the nature and causes of delusions after infarction of the right cerebral hemisphere. Delusions involved orientation in time and place, events in the recent past, and the identities of familiar individuals. Some were transient and disorganized, and others were more fixed. No particular site in the right hem...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.5.577

    authors: Levine DN,Grek A

    更新日期:1984-05-01 00:00:00

  • The predictive value of CSF oligoclonal banding for MS 5 years after optic neuritis. Optic Neuritis Study Group.

    abstract::The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the res...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.51.3.885

    authors: Cole SR,Beck RW,Moke PS,Kaufman DI,Tourtellotte WW

    更新日期:1998-09-01 00:00:00

  • Clinical and MRI characteristics of acute migrainous infarction.

    abstract:OBJECTIVE:Migrainous infarction is considered a rare complication of migraine. Although several studies reported silent brain lesions on neuroimaging in patients with migraine with aura, knowledge about lesion patterns in acute migrainous infarction is scarce. We investigated clinical and MRI characteristics in a serie...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31821d74d5

    authors: Wolf ME,Szabo K,Griebe M,Förster A,Gass A,Hennerici MG,Kern R

    更新日期:2011-05-31 00:00:00

  • Recovery of behavioral abnormalities after right hemisphere stroke.

    abstract::We studied recovery of function in 41 patients with right hemisphere stroke. Recovery was rapid for left neglect, prosopagnosia, anosognosia, and unilateral spatial neglect on drawing (USN). Recovery was slower for h mianopia, hemiparesis, motor impersistence, and extinction. Rates of recovery were intermediate for co...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.33.3.345

    authors: Hier DB,Mondlock J,Caplan LR

    更新日期:1983-03-01 00:00:00