Intermittent cyclophosphamide with prednisone versus placebo for polyneuropathy with IgM monoclonal gammopathy.

abstract：OBJECTIVE:To investigate whether vitamin D, smoking, and anti-Epstein-Barr virus (EBV) antibody concentrations predict long-term cognitive status and neuroaxonal injury in multiple sclerosis (MS). METHODS:This study was conducted among 278 patients with clinically isolated syndrome who participated in the clinical tri...

journal_title：Neurology

authors： Cortese M,Munger KL,Martínez-Lapiscina EH,Barro C,Edan G,Freedman MS,Hartung HP,Montalbán X,Foley FW,Penner IK,Hemmer B,Fox EJ,Schippling S,Wicklein EM,Kappos L,Kuhle J,Ascherio A,BENEFIT Study Group.

更新日期：2020-05-05 00:00:00

abstract：INTRODUCTION:As clinical trials move toward earlier intervention, we sought to redefine the β-amyloid (Aβ)-PET threshold based on the lowest point in a baseline distribution that robustly predicts future Aβ accumulation and cognitive decline in 3 independent samples of clinically normal individuals. METHODS:Sequential...

journal_title：Neurology

authors： Farrell ME,Jiang S,Schultz AP,Properzi MJ,Price JC,Becker JA,Jacobs HIL,Hanseeuw BJ,Rentz DM,Villemagne VL,Papp KV,Mormino EC,Betensky RA,Johnson KA,Sperling RA,Buckley RF,Alzheimer's Disease Neuroimaging Initiative and t

更新日期：2021-01-26 00:00:00

abstract：:Recent evidence suggests that the vasopressin analogue desglycinamide-arginine8-vasopressin (DGAVP) might specifically benefit mild brain trauma patients. We investigated the effect of intranasal DGAVP treatment in 32 patients who had sustained a mild head injury for 3 months in a double-blind, placebo-controlled, mat...

journal_title：Neurology

authors： Bohnen NI,Twijnstra A,Jolles J

更新日期：1993-01-01 00:00:00

abstract：:We report a Japanese Becker muscular dystrophy (BMD) patient with occasional myalgia and cramps during normal activity that developed at the age of 28 months. His family history was negative for neuromuscular diseases. Muscle biopsy analyses, including dystrophin immunostaining, disclosed no clinically relevant findin...

journal_title：Neurology

authors： Ishigaki C,Patria SY,Nishio H,Yabe M,Matsuo M

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:Pigmented orthochromatic leukodystrophy (POLD) and hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) are rare neurodegenerative disorders characterized by cerebral white matter abnormalities, myelin loss, and axonal swellings. The striking overlap of clinical and pathologic features of these...

journal_title：Neurology

authors： Nicholson AM,Baker MC,Finch NA,Rutherford NJ,Wider C,Graff-Radford NR,Nelson PT,Clark HB,Wszolek ZK,Dickson DW,Knopman DS,Rademakers R

更新日期：2013-03-12 00:00:00

abstract：:We assessed the severity and temporal profile of distant neuromuscular effects from a single dose (280 units) of botulinum neurotoxin injected into neck muscles for torticollis. We performed single-fiber EMG studies on the biceps brachii of six patients to measure jitter (20 pairs) and fiber density on the initial tre...

journal_title：Neurology

authors： Olney RK,Aminoff MJ,Gelb DJ,Lowenstein DH

更新日期：1988-11-01 00:00:00

abstract：:Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose. The authors reviewed 63 patients (30 men) with SE treated with IV VPA (average dose, 31.5 mg/kg). Analysis of demographic, clinical, and treatment infor...

journal_title：Neurology

authors： Limdi NA,Shimpi AV,Faught E,Gomez CR,Burneo JG

更新日期：2005-01-25 00:00:00

abstract：OBJECTIVE:Prospective memory (PM) describes the ability to fulfill previously planned intentions and is highly dependent on executive functions. Previous studies have shown deficits in executive functions in patients with juvenile myoclonic epilepsy (JME) and in their unaffected siblings. JME has a strong genetic predi...

journal_title：Neurology

authors： Wandschneider B,Kopp UA,Kliegel M,Stephani U,Kurlemann G,Janz D,Schmitz B

更新日期：2010-12-14 00:00:00

abstract：:Parenchymatous intracerebral hemorrhage (ICH) is a serious, infrequent complication of thrombolytic therapy for acute myocardial infarction. We studied the clinical and radiologic features, manner of presentation, associated factors, and temporal course in 23 patients with ICH associated with 150 mg or 100 mg recombin...

journal_title：Neurology

authors： Sloan MA,Price TR,Petito CK,Randall AM,Solomon RE,Terrin ML,Gore J,Collen D,Kleiman N,Feit F

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:We sought cognitive event-related potential (ERP) biomarkers of disease progression and subsequent conversion to dementia in mild cognitive impairment (MCI). BACKGROUND:Two ERP components, the P600 and N400, are sensitive to abnormal episodic/declarative memory and semantic processing. When congruous categor...

journal_title：Neurology

authors： Olichney JM,Taylor JR,Gatherwright J,Salmon DP,Bressler AJ,Kutas M,Iragui-Madoz VJ

更新日期：2008-05-06 00:00:00

abstract：OBJECTIVE:To clarify the genetic, clinicopathologic, and neuroimaging characteristics of patients with hereditary diffuse leukoencephalopathy with spheroids (HDLS) with the colony stimulating factor 1 receptor (CSF-1R) mutation. METHODS:We performed molecular genetic analysis of CSF-1R in patients with HDLS. Detailed ...

journal_title：Neurology

authors： Konno T,Tada M,Tada M,Koyama A,Nozaki H,Harigaya Y,Nishimiya J,Matsunaga A,Yoshikura N,Ishihara K,Arakawa M,Isami A,Okazaki K,Yokoo H,Itoh K,Yoneda M,Kawamura M,Inuzuka T,Takahashi H,Nishizawa M,Onodera O,Kakita

更新日期：2014-01-14 00:00:00

abstract：:The levels of plasma free carnitine and ketone bodies have been found to fluctuate inversely in fasting individuals without muscle disease. Circulating short-chain acyl-carnitines paralleled beta-hydroxybutyrate levels. A patient with lipid storage myopathy and muscle carnitine deficiency, and his two daughters, devel...

journal_title：Neurology

authors： DiDonato S,Cornelio F,Storchi G,Rimoldi M

更新日期：1979-06-01 00:00:00

abstract：:We describe three patients with acute chiasmal visual field loss caused by hemorrhage within an intrachiasmal arteriovenous malformation. One patient had five episodes; vision improved three times without treatment and twice after surgical decompression. Surgical intervention restored vision in two of the three patien...

journal_title：Neurology

authors： Lavin PJ,McCrary JA 3rd,Roessmann U,Ellenberger C Jr

更新日期：1984-08-01 00:00:00

abstract：:The authors recruited 19 nonambulant patients with Guillain-Barré syndrome into a pilot, double-blind, randomized, placebo-controlled safety trial of interferon beta 1a (IFN[beta]-1a) (Rebif). Participants received IFN[beta]-1a or placebo subcutaneously three times weekly, 22 microg for the first week and then 44 micr...

journal_title：Neurology

authors： Pritchard J,Gray IA,Idrissova ZR,Lecky BR,Sutton IJ,Swan AV,Willison HJ,Winer JB,Hughes RA

更新日期：2003-11-11 00:00:00

abstract：OBJECTIVE:To use a combined neurogenetic-neuroimaging approach to examine the functional consequences of preclinical dopaminergic nigrostriatal dysfunction in the human motor system. Specifically, we examined how a single heterozygous mutation in different genes associated with recessively inherited Parkinson disease a...

journal_title：Neurology

authors： van Nuenen BF,Weiss MM,Bloem BR,Reetz K,van Eimeren T,Lohmann K,Hagenah J,Pramstaller PP,Binkofski F,Klein C,Siebner HR

更新日期：2009-03-24 00:00:00

abstract：:The authors evaluated education attainment and neuropsychological deficits in children with sickle cell disease (SCD) and silent cerebral infarcts. Children with silent infarcts had twice the rate of school difficulties as children without infarcts. Eighty percent of silent infarct cases had clinically significant cog...

journal_title：Neurology

authors： Schatz J,Brown RT,Pascual JM,Hsu L,DeBaun MR

更新日期：2001-04-24 00:00:00

abstract：OBJECTIVE:To assess longitudinal follow-up of the incidence of multiple sclerosis (MS) through five decades and estimate the prevalence rate in Hordaland County, Norway, on January 1, 2003. METHODS:All patients with MS diagnosed from 1953 to 2003 were identified in the patient records of the Department of Neurology, H...

journal_title：Neurology

authors： Grytten N,Glad SB,Aarseth JH,Nyland H,Midgard R,Myhr KM

更新日期：2006-01-24 00:00:00

abstract：:The relationship between multiple sclerosis (MS) and primary Sjögren's syndrome (PSS) is ambiguous; it was suggested that some patients diagnosed with MS may instead have PSS. In a recent epidemiologic study, the prevalence of PSS was 2.7% in southern Sweden. We randomly selected 30 patients with definite MS from our ...

journal_title：Neurology

authors： Sandberg-Wollheim M,Axéll T,Hansen BU,Henricsson V,Ingesson E,Jacobsson L,Larsson A,Lieberkind K,Manthorpe R

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Apoptosis, or programmed cell death, is an evolutionary conserved mechanism essential for morphogenesis and tissue homeostasis, but it plays an important role also in pathologic conditions, including neurologic disorders. Its execution pathway is critically regulated at the mitochondrial level. Evi...

journal_title：Neurology

authors： Sciacco M,Fagiolari G,Lamperti C,Messina S,Bazzi P,Napoli L,Chiveri L,Prelle A,Comi GP,Bresolin N,Scarlato G,Moggio M

更新日期：2001-04-24 00:00:00

abstract：:Supporting young people with pediatric multiple sclerosis can be challenging for families and health care providers. Adolescents may be more resilient than adults in reaction to the diagnosis but can have more difficulty planning for their futures. Appropriate, sensitive, and focused health provision should include co...

journal_title：Neurology

authors： Krupp LB,Rintell D,Charvet LE,Milazzo M,Wassmer E

更新日期：2016-08-30 00:00:00

abstract：:Rats with unilateral lesions of the substantia nigra were treated with L-dopa 25 mg/kg subcutaneously 30 minutes after treatment with carbidopa 25 mg/kg intraperitoneally. In the ipsilateral striatum, dopamine levels achieved a peak of 1.57 +/- 0.63 micrograms/g (control 0.19 +/- 0.05 micrograms/g) at 20 minutes and d...

journal_title：Neurology

authors： Spencer SE,Wooten GF

更新日期：1984-08-01 00:00:00

abstract：:The effect of imipramine on the absorption of a single dose of levodopa was studied in male volunteers. By delaying gastric emptying and retarding delivery to intestinal absorptive sites, imipramine interfered with the absorption of levodopa. This action caused by the anticholinergic effect of imipramine. The retardat...

journal_title：Neurology

authors： Morgan JP,Rivera-Calimlim L,Messiha F,Sundaresan PR,Trabert N

更新日期：1975-11-01 00:00:00

abstract：:We measured the concentrations of the monoamines, their precursors, and their metabolites, and the activity of choline acetyltransferase (ChAT) in basal ganglia and cortical regions of postmortem brains from cases with histologically verified pure Alzheimer's disease (AD), AD with diffusely distributed Lewy bodies (Le...

journal_title：Neurology

authors： Langlais PJ,Thal L,Hansen L,Galasko D,Alford M,Masliah E

更新日期：1993-10-01 00:00:00

abstract：:One hundred and eight multiple sclerosis (MS) patients and 108 matched controls were studied for antibody levels and cellular immune responses to several viruses. There were significant increases in the mean titers of complement fixation (CF) or hemagglutination inhibition (HI), and complement-mediated cytotoxicity (C...

journal_title：Neurology

authors： Fuccillo DA,Madden DL,Castellano GA,Uhlig L,Traub RG,Mattson J,Krezlewicz A,Sever JL

更新日期：1978-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the utility of MRI hippocampal and entorhinal cortex atrophy in predicting conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHODS:Baseline brain MRI was performed in 139 patients with MCI, broadly defined, and 63 healthy controls followed for an average of 5 years (ran...

journal_title：Neurology

authors： Devanand DP,Pradhaban G,Liu X,Khandji A,De Santi S,Segal S,Rusinek H,Pelton GH,Honig LS,Mayeux R,Stern Y,Tabert MH,de Leon MJ

更新日期：2007-03-13 00:00:00

abstract：:We gave three adult rhesus monkeys seven IV injections of manganese chloride at approximately 1-week intervals. We evaluated neurologic status by serial clinical examinations and performed a levodopa test if the animal developed features of basal ganglia dysfunction. After the animals were killed, we performed neuropa...

journal_title：Neurology

authors： Olanow CW,Good PF,Shinotoh H,Hewitt KA,Vingerhoets F,Snow BJ,Beal MF,Calne DB,Perl DP

更新日期：1996-02-01 00:00:00

abstract：:Cisplatin, used to treat ovarian, bladder, and testicular cancers, causes a sensory dose-limiting neuropathy. Preliminary observations in humans and animals suggest that nerve damage may be prevented by ACTH analogs, particularly those belonging to the melanocortin class, and by nerve growth factor (NGF). We establish...

journal_title：Neurology

authors： Windebank AJ,Smith AG,Russell JW

更新日期：1994-03-01 00:00:00

abstract：:The authors describe the outcome of five patients with a cardiac thrombus selected among 183 patients with stroke (2.7 %) who were given IV tissue plasminogen activator (tPA). No early systemic or cerebral embolism occurred. Two patients made a complete recovery at 3 months. Two patients had a moderate outcome. One pa...

journal_title：Neurology

authors： Derex L,Nighoghossian N,Perinetti M,Honnorat J,Trouillas P

更新日期：2001-12-11 00:00:00

abstract：:We describe a 66-year-old woman with long-standing HTLV-I-associated myelopathy who developed multiple parenchymal hemorrhages and whose angiogram suggested cerebral vasculitis. After cyclophosphamide and glucocorticoid therapy, both her acute deficits and chronic paraparesis improved. HTLV-I may be an etiologic agent...

journal_title：Neurology

authors： Smith D,Lucas S,Jacewicz M

更新日期：1993-02-01 00:00:00

abstract：:The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial seizures. Three doses of talampanel were investigated based on differences in patients' concomitant antiepileptic drug usage. Talampanel showed efficacy in reducing seizure frequency (p = 0.001) ...

journal_title：Neurology

authors： Chappell AS,Sander JW,Brodie MJ,Chadwick D,Lledo A,Zhang D,Bjerke J,Kiesler GM,Arroyo S

更新日期：2002-06-11 00:00:00