Abstract:
:Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose. The authors reviewed 63 patients (30 men) with SE treated with IV VPA (average dose, 31.5 mg/kg). Analysis of demographic, clinical, and treatment information indicated an overall efficacy of 63.3% and favorable tolerance of rapid administration.
journal_name
Neurologyjournal_title
Neurologyauthors
Limdi NA,Shimpi AV,Faught E,Gomez CR,Burneo JGdoi
10.1212/01.WNL.0000149527.47600.5Asubject
Has Abstractpub_date
2005-01-25 00:00:00pages
353-5issue
2eissn
0028-3878issn
1526-632Xpii
64/2/353journal_volume
64pub_type
杂志文章,评审相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To report five stroke patients with sensory deficits including prominent chest discomfort mimicking angina. BACKGROUND:Chest wall sensory discomfort, as a part of unilateral sensory dysfunction, has seldom been recognized as a potential imitator of cardiac ischemia. METHODS:A retrospective review of stroke ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.2.548
更新日期:1996-02-01 00:00:00
abstract::We studied 35 patients with nonseptic cardiogenic cerebral emboli. In 28 cases, there was sudden onset with maximal neurologic deficit within 1 hour; in 7 cases, there was progression in 24 hours. In six cases, neurologic abnormality worsened in the first week after an initial period of stabilization. CT showed eviden...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.6.896
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:Quantitative head impulse test (HIT) measures the gain of the angular vestibulo-ocular reflex (VOR) during head rotation as the ratio of eye to head acceleration. Bedside HIT identifies subsequent catch-up saccades after the head rotation as indirect signs of VOR deficit. OBJECTIVE:To determine the VOR defi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000299117.48935.2e
更新日期:2008-02-05 00:00:00
abstract::A striking behavioral abnormality is described in three individuals who had severe head trauma. At a point when general mnestic capabilities had returned to a near normal level, the patients persistently relocated the hospital at another geographical site, even in the face of compelling counter-evidence. The strong pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.2.147
更新日期:1976-02-01 00:00:00
abstract::In Swiss mice, muscimol (3 mg per kilogram, intraperitoneally) caused myoclonic jerks of the hindquarters. These jerks were strong, repetitive, more or less regular, and of high frequency (peak response, 76 per minute). Pretreatment with sodium gamma-hydroxybutyrate (50 to 200 mg per kilogram) caused a dose-dependent ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.4.434
更新日期:1982-04-01 00:00:00
abstract::We studied the nature and causes of delusions after infarction of the right cerebral hemisphere. Delusions involved orientation in time and place, events in the recent past, and the identities of familiar individuals. Some were transient and disorganized, and others were more fixed. No particular site in the right hem...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.5.577
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:To determine whether serum Zic4 antibodies associate with paraneoplastic neurologic disorders (PND) and small-cell lung cancer (SCLC), and the association of these antibodies with other onconeuronal immunities associated with SCLC. DESIGN/METHODS:The authors studied 498 patients (215 with PND and 283 without...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000113749.77217.01
更新日期:2004-03-09 00:00:00
abstract::A group of 204 muscular dystrophy patients were screened for immunohistochemical and biochemical alpha-sarcoglycan defect and their DNA was analyzed for pathogenetic mutation in the four sarcoglycan genes. We identified 21 patients with alpha-, beta-, or gamma-sarcoglycan gene mutations. Patients with alpha-sarcoglyca...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.1.176
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:SCN8A encodes the sodium channel voltage-gated α8-subunit (Nav1.6). SCN8A mutations have recently been associated with epilepsy and neurodevelopmental disorders. We aimed to delineate the phenotype associated with SCN8A mutations. METHODS:We used high-throughput sequence analysis of the SCN8A gene in 683 pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001211
更新日期:2015-02-03 00:00:00
abstract:OBJECTIVE:To describe the phenotype and phenotype-genotype correlations in patients with amyotrophic lateral sclerosis (ALS) with TARDBP gene mutations. METHODS:French TARDBP+ patients with ALS (n = 28) were compared first to 3 cohorts: 737 sporadic ALS (SALS), 192 nonmutated familial ALS (FALS), and 58 SOD1 + FALS, a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182553c88
更新日期:2012-05-08 00:00:00
abstract::We report 9 patients with an isolated infarct of the anterior part of the rostral cerebellum, ie, the territory of the lateral branch of the superior cerebellar artery. Clinicoanatomic correlations are based on CT, MRI, or both in 8 patients and on pathologic data in the ninth. The main clinical features were ipsilate...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.2_part_1.253
更新日期:1991-02-01 00:00:00
abstract::The apolipoprotein E gene has been associated with various types of dementia. We studied the connection between the APOE gene and the risk and onset of disease in 34 patients with clinically diagnosed frontal lobe dementia (FLD) derived from a population-based study in the Netherlands. A significant increased risk of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.6.1526
更新日期:1997-06-01 00:00:00
abstract::We studied 30 necropsy cases of vascular dementia with a lacunar state. Manifestations included dementia, lack of volition, emotional lability, small-stepped gait, dysarthria, urinary incontinence, grasp reflex, pyramidal signs, paraplegia in flexion, and akinetic mutism. Pathologically, there was diffuse incomplete s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.3.340
更新日期:1986-03-01 00:00:00
abstract::The authors identified a novel mtDNA mutation (T9176G) in the ATPase 6 gene in a family in which a 10-year-old girl had a severe neurodegenerative disorder, her elder sister had died of Leigh syndrome (LS), and a maternal uncle had a spinocerebellar disorder. Biochemical studies disclosed a reduced rate of ATP synthes...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.5.687
更新日期:2001-03-13 00:00:00
abstract::Dysfunction of NADH: ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport chain has been linked to the pathogenesis of Parkinson's disease. While simple assays of complex I activity are unlikely to be useful in the preclinical detection of Parkinson's disease, other more sophisticated physical...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.41.5_suppl_2.34
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:To use punch skin biopsies to evaluate the loss of intra-epidermal nerve fibers in sensory neuropathies. BACKGROUND:Previous assessments of epidermal nerve fibers have been constrained by relatively insensitive staining techniques and variability in quantification. METHODS:Punch skin biopsies were performed...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.10.1848
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:After Pokémon viewing triggered an epidemic of seizures in Japan, many efforts have been made to design safety guidelines and systems to protect subjects with photosensitivity. The authors developed a new method based upon nonlinear diffusion techniques capable of filtering the epileptogenic content of a vid...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000152875.67527.61
更新日期:2005-03-08 00:00:00
abstract:OBJECTIVE:Glatiramer acetate (formerly known as copolymer 1) is the major noninterferon immunomodulatory agent used in the treatment of relapsing-remitting multiple sclerosis. Its mechanism of action over the past 40 years has evolved with our understanding of the immune response. METHODS:We review the various mechani...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3181c97e39
更新日期:2010-01-05 00:00:00
abstract::Of 49 patients with nonconvulsive seizures studied with continuous EEG monitoring, the overall mortality was 33% (16/49). Of the 23 patients with nonconvulsive status epilepticus (NCSE), 13 died (mortality 57%). Individual variables significantly associated with mortality were age, presence of NCSE, seizure duration, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.1.83
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:Aiming to detect associations between neuroradiologic and EEG evaluations and long-term clinical outcome in order to detect possible prognostic factors, a detailed clinical and neuroimaging characterization of 67 cases of Aicardi syndrome (AIC), collected through a multicenter collaboration, was performed. M...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011237
更新日期:2020-12-04 00:00:00
abstract:OBJECTIVE:Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterized by recurrent attacks of hyperkinetic movements. PKD can be isolated or associated with benign infantile seizures as part of the infantile convulsions with choreoathetosis (ICCA) syndrome. Mutations in the PRRT2 gene were recently identif...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31825f06c3
更新日期:2012-07-10 00:00:00
abstract::We investigated the activation of frontal and occipital cortical areas in 14 normal volunteers during voluntary saccades in light or dark and during imagined saccades using functional magnetic resonance imaging (FMRI) with electro-oculogram monitoring. Voluntary saccades in light or dark and imagined saccades led to a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.2.416
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:To determine the relative risk (RR) and cumulative incidence of idiopathic Parkinson's disease (PD) in first-degree relatives of PD patients compared with relatives of controls from the same geographic region. DESIGN:A family history questionnaire was used to obtain information on all first-degree relatives ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.1.155
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:The objective of the present work is to examine images of the brain dissection by Flemish-born anatomist Andreas Vesalius (1514-1564) as originally represented in the Fabrica (1543), and later copied without Vesalius' permission by Spanish anatomist Juan Valverde de Hamusco (c1525-c1587) in Historia de la com...
journal_title:Neurology
pub_type: 传,历史文章,杂志文章
doi:10.1212/WNL.0b013e31828407dc
更新日期:2013-02-26 00:00:00
abstract::In many parkinsonian syndromes, neuromelanin (NM)-containing dopaminergic neurons of the substantia nigra (SN) are selectively targeted by the noxius pathogens. Studies of the constitutional and functional features of human NM allow the formulation of a logical hypothesis on its role in parkinsonian syndromes. In the ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.67.7_suppl_2.s8
更新日期:2006-10-10 00:00:00
abstract::We present a method for graphically reporting the results of brainstem auditory evoked response examinations on the basis of multiple parameters. The method is based on a transform that normalizes the many latency and amplitude measures obtained from the averaged evoked responses of normal subjects tested under standa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.242
更新日期:1979-02-01 00:00:00
abstract::We studied the efficacy, pharmacokinetics, and brain entry of lorazepam in the treatment of status epilepticus (SE) using a rat model of secondarily generalized convulsive SE. Lorazepam entered the bloodstream rapidly following intraperitoneal injection. Brain concentrations peaked 10 minutes after peak serum levels w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.6.990
更新日期:1990-06-01 00:00:00
abstract::A patient with clinical and radiographic findings initially suggesting a neoplasm was diagnosed as having Hodgkin disease. Computerized axial tomography demonstrated profound diffuse decreased density similar to that seen in cases of cerebral edema or leukomalacia. Cerebral angiography showed blood vessels with a bead...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.6.588
更新日期:1977-06-01 00:00:00
abstract::We reviewed retrospectively 114 prednisone dose reduction attempts in 63 myasthenic patients. Dose reduction was considered successful if a patient remained asymptomatic for more than 1 year on no prednisone or a stable low dose of prednisone. Successful dose reduction attempts were more common in patients taking azat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.6.919
更新日期:1991-06-01 00:00:00
abstract::The association of APOE genotypes with cerebral microbleeds (CMBs) was examined on the basis of the location of CMBs in 414 patients who were admitted primarily because of stroke. With respect to possession of the epsilon2 or epsilon4 allele, the adjusted odds ratio was 1.94 (1.05 to 3.58) for lobar CMBs but 1.21 (0.6...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000183311.48144.7f
更新日期:2005-11-08 00:00:00