Abstract:
:In many parkinsonian syndromes, neuromelanin (NM)-containing dopaminergic neurons of the substantia nigra (SN) are selectively targeted by the noxius pathogens. Studies of the constitutional and functional features of human NM allow the formulation of a logical hypothesis on its role in parkinsonian syndromes. In the early stages, NM synthesis and iron-chelating properties may act as a powerful protective mechanism, delaying symptom appearance and/or slowing disease progression. Once these systems have been exhausted, the pathogenic mechanisms affecting cytoplasmic organelles other than NM destroy NM-harboring neurons, with consequent pouring out of NM granules. These in turn activate microglia, causing release of nitric oxide, interleukin-6 and tumor necrosis factor-alpha, thus becoming an important determinant of disease aggravation. Neuromelanin appears to be a suitable target for devising chemical agents that might modify the course of these diseases.
journal_name
Neurologyjournal_title
Neurologyauthors
Zecca L,Zucca FA,Albertini A,Rizzio E,Fariello RGdoi
10.1212/wnl.67.7_suppl_2.s8subject
Has Abstractpub_date
2006-10-10 00:00:00pages
S8-11issue
7 Suppl 2eissn
0028-3878issn
1526-632Xpii
67/7_suppl_2/S8journal_volume
67pub_type
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