Abstract:
:A patient with clinical and radiographic findings initially suggesting a neoplasm was diagnosed as having Hodgkin disease. Computerized axial tomography demonstrated profound diffuse decreased density similar to that seen in cases of cerebral edema or leukomalacia. Cerebral angiography showed blood vessels with a beaded appearance. A diagnosis of granulomatous angitis was made on the basis of brain biopsy specimens. Viral cultures were negative. Skin testing revealed poor response to antigens. The patient improved dramatically following a combination of radiotherapy and steroid therapy. Resolution of the low-density abnormally seen on serial EMI scanning and resolution of the vasculitis demonstrated in the post-therapy brain biopsy specimen was dramatic. This is the first case of granulomatous angitis of the brain diagnosed during life, and it points out the value of radiation and steroid therapy for relief of neurologic symptoms.
journal_name
Neurologyjournal_title
Neurologyauthors
Rajjoub RK,Wood JH,Ommaya AKdoi
10.1212/wnl.27.6.588subject
Has Abstractpub_date
1977-06-01 00:00:00pages
588-91issue
6eissn
0028-3878issn
1526-632Xjournal_volume
27pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To investigate the efficacy and safety of aceneuramic acid extended-release (Ace-ER), a treatment intended to replace deficient sialic acid, in patients with GNE myopathy. METHODS:UX001-CL301 was a phase 3, double-blind, placebo-controlled, randomized, international study evaluating the efficacy and safety o...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000006932
更新日期:2019-04-30 00:00:00
abstract:OBJECTIVE:To report the CNS syndromes of patients ≥60 years of age with antibodies against neuronal surface antigens but no evidence of brain MRI and CSF inflammatory changes. METHODS:This was a retrospective clinical analysis of patients with antibodies against neuronal surface antigens who fulfilled 3 criteria: age ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004541
更新日期:2017-10-03 00:00:00
abstract::A 16-year-old male with a 9-year history of spontaneously arrested hydrocephalus was noted to have hydrosyringomyelia and increased intracranial pressure shortly after sustaining minor head trauma. His symptoms resolved completely following ventriculoperitoneal shunt replacement. Hydrosyringomyelia may occur in the se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.4.652
更新日期:1988-04-01 00:00:00
abstract::The progressive myoclonus epilepsies (PMEs) are a devastating group of rare disorders(1) that manifest with increasing action myoclonus, which is also present at rest but activates with stimuli such as noise, light, or touch. Ultimately, patients become wheelchair-bound and experience early death. Neurologic signs tha...
journal_title:Neurology
pub_type: 评论,杂志文章
doi:10.1212/WNL.0000000000000091
更新日期:2014-02-04 00:00:00
abstract::Fourteen patients with Alzheimer's disease were evaluated by psychometric testing, fluorodeoxyglucose positron emission tomography (PET), and EEG. They were divided into two groups according to the EEG findings. Group A (seven patients) had normal alpha backgrounds and group B (seven patients) had decreased alpha back...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.5.747
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:The neurodegenerative process in Alzheimer's disease (AD) and in the Lewy body variant of AD (LBV) patients is characterized by cholinergic dysfunction and deposition of amyloid beta-peptide (Abeta) 1-40 and 1-42; however, the differential effects of Abeta species on the cholinergic system are not completely...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073987.79060.4b
更新日期:2003-07-22 00:00:00
abstract:OBJECTIVE:To incorporate standardized documentation into an epilepsy clinic and to use these standardized data to compare patients' perception of epilepsy diagnosis to provider documentation. METHODS:Using quality improvement methodology, we implemented interventions to increase documentation of epilepsy diagnosis, se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009778
更新日期:2020-07-14 00:00:00
abstract:OBJECTIVE:To report eight cases of sensory Guillain-Barré syndrome (GBS). BACKGROUND:The concept of sensory equivalent to ascending paralysis of GBS was raised in 1958, and the diagnostic criteria for a sensory loss and areflexia variant of GBS were proposed in 1981. However, clinical cases meeting these criteria have...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.56.1.82
更新日期:2001-01-09 00:00:00
abstract:BACKGROUND:While stable xenon CT (Xe-CT) cerebral blood flow (CBF) is an accepted standard for quantitative assessment of cerebral hemodynamics, the accuracy of magnetic resonance perfusion-weighted imaging (PWI-MRI) is unclear. The Improved PWI Methodology in Acute Clinical Stroke Study compares PWI findings with Xe-C...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000345372.49233.e3
更新日期:2009-03-31 00:00:00
abstract:BACKGROUND:Bilateral absent N20 responses of median nerve somatosensory evoked potentials (SEPs) reliably predict poor prognosis after cardiac arrest. However, the studies supporting this fact were carried out before hypothermia was established as standard treatment. Recent evidence suggests that hypothermia treatment ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181d5a631
更新日期:2010-03-23 00:00:00
abstract::Cognitive impairment is a frequent manifestation of advanced human immunodeficiency virus (HIV) infection. The response to antiretroviral medication is often partial and poorly sustained. Recent studies suggest that free radical production within the CNS and neuronal apoptosis may play important roles in the pathogene...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.50.3.645
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To better understand the epileptogenesis of symptomatic generalized epilepsy in patients with hypothalamic hamartoma and intractable epilepsy, many of whom experience remission of generalized seizures and slow spike-wave discharges following surgery. METHODS:The authors documented the evolution of symptomati...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000049457.05670.7d
更新日期:2003-03-11 00:00:00
abstract:OBJECTIVES:To study the effects of head injury on disease progression and on neuropathologic outcomes in amyotrophic lateral sclerosis (ALS). METHODS:Patients with ALS were surveyed to obtain head injury history, and medical records were reviewed. Linear regression was performed to determine if head injury was a predi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001522
更新日期:2015-04-28 00:00:00
abstract:OBJECTIVE:To report five stroke patients with sensory deficits including prominent chest discomfort mimicking angina. BACKGROUND:Chest wall sensory discomfort, as a part of unilateral sensory dysfunction, has seldom been recognized as a potential imitator of cardiac ischemia. METHODS:A retrospective review of stroke ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.2.548
更新日期:1996-02-01 00:00:00
abstract::Oligoclonal bands ( OCBs ) were examined in CSF from 23 normal controls, 8 cases of inflammatory neurologic diseases, 24 cases of noninflammatory neurologic diseases, 27 sporadic cases of MS, and the 29 MS twin pairs, by isoelectric focusing followed by silver staining or western transblotting and immunoperoxidase sta...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.6.769
更新日期:1984-06-01 00:00:00
abstract:OBJECTIVE:To assess alterations in brain metabolites of patients with Pelizaeus-Merzbacher disease (PMD) with the proteolipid protein gene 1 (PLP1) duplications using quantitative proton MRS. METHODS:Five unrelated male Japanese patients with PMD with PLP1 duplications were analyzed using automated proton brain examin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.2.237
更新日期:2002-01-22 00:00:00
abstract:OBJECTIVE:In this study, we aimed to investigate the effect of hypoglycemia on cardiovascular outcomes in a sample of patients with chronic kidney disease (CKD). METHODS:Information about study participants was extracted from the National Health Insurance Research Database of Taiwan for the years 1998 through 2008. We...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000711
更新日期:2014-08-19 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of yoga as an adjuvant to conventional medical management on clinical outcomes in patients with migraine. METHODS:CONTAIN was a prospective, randomized, open-label superiority trial with blinded endpoint assessment carried out at a single tertiary care academic hospital in New D...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000009473
更新日期:2020-05-26 00:00:00
abstract:OBJECTIVES:To examine associations between 1H magnetic resonance spectroscopic imaging (1H MRSI)-detected hippocampal creatine to N-acetylaspartate (Cr/NAA) ratios and neuropsychological measures sensitive to mesial temporal lobe function. BACKGROUND:The measurement of 1H MRSI-detected hippocampal metabolites has prov...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.9.2052
更新日期:1999-12-10 00:00:00
abstract:OBJECTIVE:In children with and without infantile spasms, this study determined brain volumes and cell densities in epilepsy surgery patients with tuberous sclerosis complex (TSC) and cortical dysplasia with balloon cells (CD). METHODS:We compared TSC (n = 18) and CD (n = 17) patients with normal/autopsy controls (n = ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000252952.62543.20
更新日期:2007-02-06 00:00:00
abstract:BACKGROUND:Among patients with a patent foramen ovale (PFO) and a prior cryptogenic ischemic stroke or TIA, the absolute and relative risk of recurrent events is unclear. METHODS:We conducted a systematic review and meta-analysis of clinical studies in any language published up to February 2008. We included studies re...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0b013e3181aa2a19
更新日期:2009-07-14 00:00:00
abstract::Two patients with similar courses of neurologic impairment and subsequent recovery after cerebral air embolism complicating cardiac ablation procedures are described. Hyperbaric oxygen therapy, combined with aggressive resuscitative efforts, appears to have contributed to each patient's recovery. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.6.792
更新日期:2001-03-27 00:00:00
abstract:OBJECTIVE:To evaluate the clinical, electrophysiologic, and treatment outcome features of orthostatic tremor (OT) in a large case series. METHODS:We performed medical record review of 184 patients who met clinical and electrodiagnostic criteria for OT from 1976 to 2013 at the Mayo Clinic. Demographic, clinical, electr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002328
更新日期:2016-02-02 00:00:00
abstract::We recorded interictal spikes with closely spaced scalp electrodes and sphenoidal electrodes in four patients with temporal lobe epilepsy. We used multiple dipole modeling to study the number, three-dimensional intracerebral location, time activity, and functional relationship of the neuronal sources underlying the ep...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.45.1.118
更新日期:1995-01-01 00:00:00
abstract::E.C. Seguin was one of the early, influential 19th-century neurologists who participated in the development of neurology as a specialty in the United States. Born in France, but raised from early childhood in the United States, Seguin published widely, developed a high-profile New York City practice, and was named Cli...
journal_title:Neurology
pub_type: 传,历史文章,杂志文章
doi:10.1212/WNL.0b013e3182904f55
更新日期:2013-04-30 00:00:00
abstract:OBJECTIVES/METHODS:To examine evidence for effectiveness of anteromesial temporal lobe and localized neocortical resections for disabling complex partial seizures by systematic review and analysis of the literature since 1990. RESULTS:One intention-to-treat Class I randomized, controlled trial of surgery for mesial te...
journal_title:Neurology
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1212/01.wnl.0000055086.35806.2d
更新日期:2003-02-25 00:00:00
abstract:OBJECTIVE:To evaluate patients with early HIV-cognitive motor complex (HIV-CMC) for possible regional cerebral blood flow (rCBF) abnormalities on perfusion MRI (pMRI). BACKGROUND:Nuclear medicine techniques have demonstrated global and focal cerebral perfusion abnormalities in patients with HIV dementia. Ultrafast pMR...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.2.389
更新日期:2000-01-25 00:00:00
abstract:BACKGROUND:The incidence of acquired demyelination of the CNS (acquired demyelinating syndromes [ADS]) in children is unknown. It is important that physicians recognize the features of ADS to facilitate care and to appreciate the future risk of multiple sclerosis (MS). OBJECTIVE:To determine the incidence, clinical fe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000339482.84392.bd
更新日期:2009-01-20 00:00:00
abstract::Acute myopathy and myoglobinuria with markedly elevated creatine kinase (CK) activity developed in an 18-year-old boy on two occasions after gasoline sniffing. No signs of CNS involvement were seen, and the symptoms receded in a few days. The amount of lead in blood and urine exceeded the reference value for subjects ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.5.629
更新日期:1983-05-01 00:00:00
abstract:OBJECTIVE:To assess the possible abnormalities in the baroreflex modulation of both the heart and the arterial vasculature, in order to better evaluate the role of baroreflex abnormalities in the generation of the cardiovascular symptoms and complications affecting the familial dysautonomia (FD) patient. METHODS:Twent...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000142034.92124.6a
更新日期:2004-10-26 00:00:00