Incidence of acquired demyelination of the CNS in Canadian children.


BACKGROUND:The incidence of acquired demyelination of the CNS (acquired demyelinating syndromes [ADS]) in children is unknown. It is important that physicians recognize the features of ADS to facilitate care and to appreciate the future risk of multiple sclerosis (MS). OBJECTIVE:To determine the incidence, clinical features, familial autoimmune history, and acute management of Canadian children with ADS. METHODS:Incidence and case-specific data were obtained through the Canadian Pediatric Surveillance Program from April 1, 2004, to March 31, 2007. Before study initiation, a survey was sent to all pediatric health care providers to determine awareness of MS as a potential outcome of ADS in children. RESULTS:Two hundred nineteen children with ADS (mean age 10.5 years, range 0.66-18.0 years; female to male ratio 1.09:1) were reported. The most common presentations were optic neuritis (ON; n = 51, 23%), acute disseminated encephalomyelitis (ADEM; n = 49, 22%), and transverse myelitis (TM; n = 48, 22%). Children with ADEM were more likely to be younger than 10 years, whereas children with monolesional ADS (ON, TM, other) were more likely to be older than 10 years (p < 0.001). There were 73 incident cases per year, leading to an annual incidence of 0.9 per 100,000 Canadian children. A family history of MS was reported in 8%. Before study initiation, 65% of physicians indicated that they considered MS as a possible outcome of ADS in children. This increased to 74% in year 1, 81% in year 2, and 87% in year 3. CONCLUSION:The incidence of pediatric acquired demyelinating syndromes (ADS) is 0.9 per 100,000 Canadian children. ADS presentations are influenced by age.






Banwell B,Kennedy J,Sadovnick D,Arnold DL,Magalhaes S,Wambera K,Connolly MB,Yager J,Mah JK,Shah N,Sebire G,Meaney B,Dilenge ME,Lortie A,Whiting S,Doja A,Levin S,MacDonald EA,Meek D,Wood E,Lowry N,Buckley D,Yim




Has Abstract


2009-01-20 00:00:00














  • Volumetric MRI, pathological, and neuropsychological progression in hippocampal sclerosis.

    abstract:OBJECTIVE:To examine the relationships between age at onset and duration of seizure disorder with severity of hippocampal sclerosis (HS) and cognitive functioning in patients with HS and unilateral temporal lobe epilepsy. METHODS:Twenty-six subjects had left temporal lobe seizure onset; 20 had right temporal onset. Me...


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    authors: Fuerst D,Shah J,Kupsky WJ,Johnson R,Shah A,Hayman-Abello B,Ergh T,Poore Q,Canady A,Watson C

    更新日期:2001-07-24 00:00:00

  • Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort.

    abstract:BACKGROUND:Antiretroviral therapy has improved survival for HIV-1-infected individuals. The neuroepidemiologic implications of HIV-1 in an aging population are not well known, particularly the prevalence of HIV-associated dementia (HAD). METHODS:The authors report a baseline cross-sectional analysis of 202 HIV-1-serop...


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    authors: Valcour V,Shikuma C,Shiramizu B,Watters M,Poff P,Selnes O,Holck P,Grove J,Sacktor N

    更新日期:2004-09-14 00:00:00

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    abstract:OBJECTIVE:Current prehospital scales used to detect large vessel occlusion reveal very low endovascular thrombectomy (EVT) rates among selected patients. We developed a novel prehospital scale, the Madrid-Direct Referral to Endovascular Center (M-DIRECT), to identify EVT candidates for direct transfer to EVT-capable ce...


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    authors: Rodríguez-Pardo J,Riera-López N,Fuentes B,Alonso de Leciñana M,Secades-García S,Álvarez-Fraga J,Busca-Ostolaza P,Carneado-Ruiz J,Díaz-Guzmán J,Egido-Herrero J,Gil-Núñez A,Masjuan-Vallejo J,Real-Martínez V,Vivancos-Mora J,Díez

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    authors: Pongmoragot J,Bharatha A,Saposnik G

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    abstract::We reviewed the clinical and laboratory features of 81 patients who had trigeminal sensory neuropathy (TSN) and a connective tissue disease (CTD). The neuropathy developed before the symptoms of CTD in 6/81 patients (7%), and in 38/81 patients (47%) TSN and CTD were diagnosed concurrently. The most frequently associat...


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    authors: Hagen NA,Stevens JC,Michet CJ Jr

    更新日期:1990-06-01 00:00:00

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    authors: Hotson JR

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    authors: Jenner P

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    authors: DiDonato S,Cornelio F,Storchi G,Rimoldi M

    更新日期:1979-06-01 00:00:00

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    authors: Dhand A,Engstrom J,Dhaliwal G

    更新日期:2013-10-15 00:00:00

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    authors: Nygaard TG,Duvoisin RC

    更新日期:1986-11-01 00:00:00

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    authors: Mercuri E,Yuva Y,Brown SC,Brockington M,Kinali M,Jungbluth H,Feng L,Sewry CA,Muntoni F

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    authors: Spencer SS,Spencer DD,Williamson PD,Sass K,Novelly RA,Mattson RH

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    authors: McGarvey ML,Ferrante FM,Patel RS,Maljian JA,Stecker M

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    authors: Wakayama Y,Schotland DL,Bonilla E

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    authors: Kanemoto K,Takeuchi J,Kawasaki J,Kawai I

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    authors: Minshew NJ,Sung K,Jones BL,Furman JM

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    authors: Mitchell P,Wang JJ,Wong TY,Smith W,Klein R,Leeder SR

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    authors: Strom T,Schneck SA

    更新日期:1991-02-01 00:00:00

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    authors: Hinkle DA,Raizen DM,McGarvey ML,Liu GT

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    authors: Zhu L,Fratiglioni L,Guo Z,Winblad B,Viitanen M

    更新日期:2000-06-13 00:00:00

  • SEPT9 gene sequencing analysis reveals recurrent mutations in hereditary neuralgic amyotrophy.

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    authors: Hannibal MC,Ruzzo EK,Miller LR,Betz B,Buchan JG,Knutzen DM,Barnett K,Landsverk ML,Brice A,LeGuern E,Bedford HM,Worrall BB,Lovitt S,Appel SH,Andermann E,Bird TD,Chance PF

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  • Surgery for intracerebral hemorrhage.

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    authors: Scott SA,DeKosky ST,Scheff SW

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    authors: Arbusow V,Strupp M,Dieterich M,Jäger L,Hischa A,Schulz P,Brandt T

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    authors: Peter JB,Bowman RL

    更新日期:1992-03-01 00:00:00

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    authors: Calne DB

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    authors: Ortiz-Pérez S,Martínez-Lapiscina EH,Gabilondo I,Fraga-Pumar E,Martínez-Heras E,Saiz A,Sanchez-Dalmau B,Villoslada P

    更新日期:2013-09-03 00:00:00

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    pub_type: 杂志文章


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    更新日期:1992-05-01 00:00:00

  • Mapping brain recovery after concussion: From acute injury to 1 year after medical clearance.

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    pub_type: 杂志文章


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    更新日期:2019-11-19 00:00:00