Abstract:
OBJECTIVE:To evaluate the clinical, electrophysiologic, and treatment outcome features of orthostatic tremor (OT) in a large case series. METHODS:We performed medical record review of 184 patients who met clinical and electrodiagnostic criteria for OT from 1976 to 2013 at the Mayo Clinic. Demographic, clinical, electrophysiologic, and treatment data were extracted. RESULTS:The majority of OT cases were female (63.6%) and mean age at onset was 59.3 years (range 13-85 years). Diagnosis was delayed by a mean of 7.2 years (range 0-44 years). The average tremor frequency was 15.7 Hz (range 12.5-20 Hz), and transmitted to the arms on weight-bearing (95.5%). Patients reported a spectrum of progressive orthostatic leg symptoms, relieved by sitting or leaning. Falls were reported in 24.1%. Coexistent neurologic disorders included essential tremor (22.8%), other tremor (4.9%), and parkinsonism (8.7%). Family history of OT was noted in 4.9%. Of 46 medications trialed, 24 failed to provide any benefit. Benzodiazepines provided at least mild benefit in 55.9%, and moderate to marked benefit in 31.5%; β-blockers (31.0%) and anticonvulsants (25.0%) provided mild benefit, and the remainder were largely ineffective. Medication benefit waned over time. Deep brain stimulation (DBS) was effective in 2 cases. CONCLUSION:OT predominantly affects female seniors, and the diagnosis should be considered with any orthostatic-induced leg symptoms, and confirmed by surface EMG. Benzodiazepines are the most efficacious treatment, followed by β-blockers and anticonvulsants. DBS should be further explored for treatment.
journal_name
Neurologyjournal_title
Neurologyauthors
Hassan A,Ahlskog JE,Matsumoto JY,Milber JM,Bower JH,Wilkinson JRdoi
10.1212/WNL.0000000000002328subject
Has Abstractpub_date
2016-02-02 00:00:00pages
458-64issue
5eissn
0028-3878issn
1526-632Xpii
WNL.0000000000002328journal_volume
86pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.3.294
更新日期:1975-03-01 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) is a neuroactive cytokine found in Schwann cells, which appears to be released in response to nerve injury. The ALS CNTF Treatment Study (ACTS) clinical trial was a phase II-III randomized, placebo-controlled, double-blind study designed to evaluate the safety, tolerability, and effi...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.46.5.1244
更新日期:1996-05-01 00:00:00
abstract::All Olmsted County, Minnesota, residents who experienced brain injury from 1935 through 1979 were identified and their medical records reviewed for survival and neurologic outcome. Minimum inclusion criteria included loss of consciousness or post-traumatic amnesia or neurologic evidence of brain injury or skull fractu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.1.96
更新日期:1989-01-01 00:00:00
abstract::Neurofibromatosis 2 (NF2), a dominantly inherited disorder, typically manifests as bilateral vestibular schwannomas and predisposes to other nervous system tumors. In this study, we present a large pedigree with a benign course of NF2 (mild Gardner type) characterized by slowly growing vestibular schwannomas but few o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.7.1314
更新日期:1995-07-01 00:00:00
abstract::Increased urinary levels of the polyamines, putrescine, spermidine, and spermine are present in Duchenne muscular dystrophy (DMD) patients. Alterations in excretion are detectable when based on nanomoles per milligram creatinine, micromoles per 24-hour urine collection, or nanomoles per kilogram body weight per 24-hou...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Genetic factors are important in Alzheimer disease (AD) and Parkinson disease but have not been well characterized in Lewy body dementia (LBD). The authors obtained family history in patients from an autopsy series of AD and LBD and in living healthy controls. A family history of dementia was more common in both LBD a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000219812.20616.b3
更新日期:2006-06-27 00:00:00
abstract:OBJECTIVE:To determine the effect of erenumab, a human monoclonal antibody targeting the calcitonin gene-related peptide receptor, on health-related quality of life (HRQoL), headache impact, and disability in patients with chronic migraine (CM). METHODS:In this double-blind, placebo-controlled study, 667 adults with C...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000007452
更新日期:2019-05-07 00:00:00
abstract::The authors investigated the PRNP Met129Val polymorphism in 1,393 subjects including 482 patients with Alzheimer disease (AD) and two independent control groups. In patients, PRNP Met homozygosity conferred increasing risk with decreasing age at onset (onset: 61 to 70 years, n = 151, p = 0.02, odds ratio [OR] = 1.72, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000130198.72589.69
更新日期:2004-07-27 00:00:00
abstract::This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs develope...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.7.1235
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVE:To examine associations of average and change in late-life blood pressure (BP) with cerebrovascular and Alzheimer disease (AD) neuropathology in a large group of decedents followed longitudinally in vivo. METHODS:This clinical-pathologic study was derived from prospective, community-based cohort studies of a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005951
更新日期:2018-08-07 00:00:00
abstract:OBJECTIVE:To assess the prevalence of brain MRI abnormalities in people with epilepsy in rural China and to compare it with that of individuals in the United Kingdom. METHODS:Brain MRI scans were obtained in people with epilepsy who participated in a rural community-based program in China between July 2010 and Decembe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010171
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Huntington's disease (HD) is a fatal and progressive neurodegenerative disease that is accompanied by involuntary movements, cognitive dysfunction, and psychiatric symptoms. Although progressive striatal degeneration is known to occur, little is known about how the disease affects the cortex, including which...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.5.695
更新日期:2002-03-12 00:00:00
abstract:OBJECTIVE:To characterize a brainstem location specific to coma-causing lesions, and its functional connectivity network. METHODS:We compared 12 coma-causing brainstem lesions to 24 control brainstem lesions using voxel-based lesion-symptom mapping in a case-control design to identify a site significantly associated w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003404
更新日期:2016-12-06 00:00:00
abstract:OBJECTIVE:In the North Dublin Population Stroke Study, we investigated the risk of recurrent stroke within the 14-day time window recommended for endarterectomy. METHODS:In a population-based prospective cohort study, all ischemic stroke patients were identified over 1 year and categorized into those with (CS-positive...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e31822b00cf
更新日期:2011-08-23 00:00:00
abstract:OBJECTIVE:To describe factors associated with survival in Alzheimer disease (AD) in a multiethnic, population-based longitudinal study. METHODS:AD cases were identified in the Washington Heights Inwood Columbia Aging Project, a longitudinal, community-based study of cognitive aging in Northern Manhattan. The sample co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000334278.11022.42
更新日期:2008-11-04 00:00:00
abstract:OBJECTIVE:To evaluate if mental fatigue is a symptom that appears independently from other clinical features in patients with Parkinson disease (PD), and to study if fatigue is persistent over time in these patients. METHODS:In 1993, 233 patients with PD were included in a community-based study of fatigue and followed...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000144277.06917.cc
更新日期:2004-11-23 00:00:00
abstract:OBJECTIVE:To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD). METHODS:Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007968
更新日期:2019-08-20 00:00:00
abstract:OBJECTIVE:To study the usefulness of corticospinally mediated excitatory responses and transcallosal inhibition (TI) elicited by transcranial magnetic stimulation (TMS) as a surrogate marker of disability in patients with different courses of MS. METHODS:Focal TMS of the motor cortex was performed in 118 patients with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.8.1218
更新日期:2002-10-22 00:00:00
abstract:OBJECTIVE:To evaluate the retinal nerve fiber layer (RNFL) thickness and macular volume in neuromyelitis optica (NMO) spectrum patients using optical coherence tomography (OCT). BACKGROUND:OCT can quantify damage to retinal ganglion cell axons and can identify abnormalities in multiple sclerosis and optic neuritis (ON...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181af78b8
更新日期:2009-07-28 00:00:00
abstract:BACKGROUND:Several lines of evidence suggest that inflammatory mechanisms contribute to AD. OBJECTIVE:To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. METHODS:The authors studied 3,031 African-American and white men and wom...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073620.42047.d7
更新日期:2003-07-08 00:00:00
abstract::Pearson syndrome is a systemic disorder of oxidative phosphorylation in infants, predominantly affecting the bone marrow and exocrine pancreas and associated with single deletions in mitochondrial DNA (mtDNA). CNS involvement may occur in patients who survive the infantile hematopoietic disorder. We describe a Pearson...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.5.1320
更新日期:1996-11-01 00:00:00
abstract::We studied the effects of bromocriptine on periodic limb movements in sleep (PLMS) of narcoleptic patients. Bromocriptine significantly reduced the number and index of PLMS without improving the nocturnal sleep disruption in that disorder. These results support the hypothesis that dopaminergic mechanisms are involved ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.10.2134
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that patients with multiple sclerosis (MS) with intereye asymmetry on low contrast letter acuity, and thickness of the retinal nerve fiber layer (RNFL), would exhibit corresponding changes in cortical timing and amplitude responses on pattern reversal multifocal visual evoked potentials...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182661edc
更新日期:2012-08-21 00:00:00
abstract:OBJECTIVES:The Stroke-Thrombolytic Predictive Instrument (Stroke-TPI) predicts the probability of good and bad outcomes with and without recombinant tissue plasminogen activator (rtPA). We sought to rebuild and externally validate a simpler Stroke-TPI to support implementation in routine clinical care. METHODS:Using t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001925
更新日期:2015-09-15 00:00:00
abstract::This double-blind, placebo-controlled, multicenter, crossover study investigated the efficacy and tolerability of sumatriptan administered for up to three separate migraine attacks. One hundred twenty adults received sumatriptan (SC, 6 mg; three attacks) and placebo (one attack). Patients completed questionnaires asse...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.43.7.1363
更新日期:1993-07-01 00:00:00
abstract::Idiopathic cervical dystonia (CD) is the most common of the adult-onset focal dystonias. It manifests as involuntary muscle contractions that cause twisting or turning of the neck. The resulting abnormal head and neck postures are heterogeneous in their presentation. Because of the variable presentation of the disease...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::A prospective trial of plasmapheresis and azathioprine or azathioprine alone was carrier out on 20 patients with chronic progressive MS. Seven of 10 patients in each group continued therapy for 12 months. When the groups were compared by disability ratings, the combination of plasmapheresis and azathioprine was no bet...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.7.739
更新日期:1982-07-01 00:00:00
abstract::Neurogenic left ventricular dysfunction is a recognized complication of subarachnoid hemorrhage, but this condition has not been reported after seizure activity. The authors present two cases of neurogenic stunned myocardium after convulsive seizures, suggesting that ictal activity can lead to sympathetically mediated...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000163858.77494.7A
更新日期:2005-06-14 00:00:00
abstract:BACKGROUND:Metals are suspected of being involved in the pathogenesis of various neurologic diseases. We previously found a complex imbalance in serum chemical elements and oxidative status in patients with clinically definite multiple sclerosis (CDMS). OBJECTIVE:To understand whether this imbalance affects people wit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820af7de
更新日期:2011-02-08 00:00:00
abstract::A 47-year-old woman had myasthenia gravis with only moderate weakness and a consistently poor response to anticholinesterase medication. She was investigated with routine electrophysiologic studies and single-fiber electromyography. The studies showed a limited effect of anticholinesterase medication. There was a decr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.1.80
更新日期:1975-01-01 00:00:00