Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD.

Abstract:

BACKGROUND:The neurodegenerative process in Alzheimer's disease (AD) and in the Lewy body variant of AD (LBV) patients is characterized by cholinergic dysfunction and deposition of amyloid beta-peptide (Abeta) 1-40 and 1-42; however, the differential effects of Abeta species on the cholinergic system are not completely clear. OBJECTIVE:To better understand the relationship between levels of Abeta1-40 and 1-42 on cholinergic deficits in AD and LBV patients. METHODS:Levels of choline acetyltransferase (ChAT) activity and ChAT immunoreactivity in the plaques in the frontal cortex of patients with AD and LBV were correlated with Abeta1-42 and 1-40 levels determined by ELISA and with neuropathologic and neurologic markers. RESULTS:Although the overall levels of ChAT activity were reduced in AD and LBV cases, there was a direct correlation with Abeta1-42 levels. Furthermore, patients with high Abeta1-42 levels had more abundant cholinergic dystrophic neurites in the plaques than cases with lower Abeta1-42. CONCLUSION:Abeta1-42 may also trigger cholinergic dysfunction by promoting aberrant neuritic sprouting.

journal_name

Neurology

journal_title

Neurology

authors

Masliah E,Alford M,Adame A,Rockenstein E,Galasko D,Salmon D,Hansen LA,Thal LJ

doi

10.1212/01.wnl.0000073987.79060.4b

subject

Has Abstract

pub_date

2003-07-22 00:00:00

pages

206-11

issue

2

eissn

0028-3878

issn

1526-632X

journal_volume

61

pub_type

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