Abstract:
OBJECTIVE:Glatiramer acetate (formerly known as copolymer 1) is the major noninterferon immunomodulatory agent used in the treatment of relapsing-remitting multiple sclerosis. Its mechanism of action over the past 40 years has evolved with our understanding of the immune response. METHODS:We review the various mechanisms that have been proposed for this random polymer over the years, with emphasis on recent methods that utilize modern immunologic techniques. RESULTS:Studies describing processes such as immune deviation and effects on regulatory T cells and antigen-presenting cells are presented. CONCLUSIONS:Effects of glatiramer acetate on the immune response have evolved as our technical abilities and knowledge of the immune response itself have developed.
journal_name
Neurologyjournal_title
Neurologyauthors
Racke MK,Lovett-Racke AE,Karandikar NJdoi
10.1212/WNL.0b013e3181c97e39subject
Has Abstractpub_date
2010-01-05 00:00:00pages
S25-30eissn
0028-3878issn
1526-632Xpii
74/1_Supplement_1/S25journal_volume
74 Suppl 1pub_type
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