Association of Time of Day When Endovascular Therapy for Stroke Starts and Functional Outcome.


OBJECTIVE:To investigate the association between EVT start time in acute ischemic stroke (AIS) and mid-term functional outcome. METHODS:This retrospective cohort study included all AIS cases treated with EVT from two stroke center registries from January 2012 to December 2018. The primary outcome was the score on the modified Rankin Scale (mRS) and the utility-weighted mRS (uw-mRS) at 90 days. A proportional odds model was used to calculate the common odds ratio as a measure of the likelihood that the intervention at a given EVT start time would lead to lower scores on the mRS (shift analysis). RESULTS:One thousand five hundred fifty-eight cases were equally allotted into twelve EVT-start-time periods. The primary outcome favored EVT start times in the morning at 08:00-10:20 and 10:20-11:34 (common odds ratio (OR), 0.53; 95% confidence interval (CI), 0.38 to 0.75; P<0.001; OR, 0.62; 95% CI, 0.44 to 0.87; P=0.006, respectively), while it disfavored EVT start times at the end of the working day at 15:55-17:15 and 18:55-20:55 (OR, 1.47; 95% CI, 1.03 to 2.09; P=0.034; OR, 1.49; 95% CI, 1.03 to 2.15; P=0.033). Symptom onset-to-EVT start time was significantly higher and use of IV t-PA significantly lower between 10:20-11:34 (P<0.004 and P=0.012, respectively). CONSLUSION:EVT for AIS in the morning leads to better mid-term functional outcome, while EVT at the end of the work day leads to poorer mid-term functional outcome. Neither difference in baseline factors, standard workflow and technical efficacy metrics could be identified as potential mediators of this effect.






Hajdu SD,Kaesmacher J,Michel PP,Sirimarco G,Knebel JF,Bartolini B,Kurmann CC,Puccinelli F,Mosimann PJ,Bonvin C,Arnold PM,Niederhäuser J,Eskandari A,Mordasini P,Gralla PJ,Fischer PU,Saliou PG




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2021-01-04 00:00:00








  • A randomized trial of rizatriptan in migraine attacks in children.

    abstract:OBJECTIVE:To examine the efficacy of rizatriptan and the consistency of treatment response in migraine attacks of children and adolescents. METHODS:We conducted a double-blind, placebo-controlled three-way crossover trial in patients ages 6 to 17 years diagnosed with migraine in two pediatric hospital outpatient clini...


    pub_type: 杂志文章,随机对照试验


    authors: Ahonen K,Hämäläinen ML,Eerola M,Hoppu K

    更新日期:2006-10-10 00:00:00

  • A prospective study on the incidence and prognosis of Guillain-Barré syndrome in Emilia-Romagna region, Italy (1992-1993). Emilia-Romagna Study Group on Clinical and Epidemiological Problems in Neurology.

    abstract::We performed a multicenter prospective study on the incidence and prognosis of Guillain-Barré syndrome (GBS) in the Emilia-Romagna region (3,909,512 inhabitants), Italy, over a 2-year period (1992-1993). The case finding method was based on a surveillance system including neurologic departments, all private and public...


    pub_type: 杂志文章



    更新日期:1997-01-01 00:00:00

  • Dietary treatment in adults with refractory epilepsy: a review.

    abstract::We review adjunctive ketogenic diet (KD) and modified Atkins diet (MAD) treatment of refractory epilepsy in adults. Only a few studies have been published, all open-label. Because of the disparate, uncontrolled nature of the studies, we analyzed all studies individually, without a meta-analysis. Across all studies, 32...


    pub_type: 杂志文章,评审


    authors: Klein P,Tyrlikova I,Mathews GC

    更新日期:2014-11-18 00:00:00

  • Treatable neurotransmitter deficiency in mild phenylketonuria.

    abstract::The authors describe a case of neurologic involvement in mild hyperphenylalaninemia (HPA), not due to tetrahydrobiopterin (BH(4)) deficiency, with low levels of monoamine neurotransmitter metabolites in CSF. The combined BH(4)-Phe loading test suggested a BH(4) response, confirmed by clinical improvement after BH(4) t...


    pub_type: 杂志文章


    authors: Bonafé L,Blau N,Burlina AP,Romstad A,Güttler F,Burlina AB

    更新日期:2001-09-11 00:00:00

  • Summary of evidence-based guideline update: evaluation and management of concussion in sports: report of the Guideline Development Subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:To update the 1997 American Academy of Neurology (AAN) practice parameter regarding sports concussion, focusing on 4 questions: 1) What factors increase/decrease concussion risk? 2) What diagnostic tools identify those with concussion and those at increased risk for severe/prolonged early impairments, neurolo...


    pub_type: 杂志文章,评审


    authors: Giza CC,Kutcher JS,Ashwal S,Barth J,Getchius TS,Gioia GA,Gronseth GS,Guskiewicz K,Mandel S,Manley G,McKeag DB,Thurman DJ,Zafonte R

    更新日期:2013-06-11 00:00:00

  • CSF cyclic nucleotides and somatostatin in Parkinson's disease.

    abstract::Concentrations of cyclic adenosine 3',5' monophosphate (cAMP) were significantly lower in parkinsonian patients than in controls, but concentrations of guanosine 3',5' monophosphate (cGMP) were not altered. Both cAMP and cGMP levels were lower in patients with more severe symptoms on the left side of the body. Somatos...


    pub_type: 杂志文章


    authors: Volicer L,Beal MF,Direnfeld LK,Marquis JK,Albert ML

    更新日期:1986-01-01 00:00:00

  • Treatment of status epilepticus in children.

    abstract::In children, seizures associated with status epilepticus (SE) include a number of types that are age-related. These types of seizures are not associated with SE in older patients. Likewise, etiologies of SE in children are also unique to this patient population, in particular those responsible for SE in the neonate. C...


    pub_type: 杂志文章,评审


    authors: Lockman LA

    更新日期:1990-05-01 00:00:00

  • Predictive value of the intracarotid amobarbital test in bihemispheric seizure onset.

    abstract::The intracarotid amobarbital test (IAT) is used to lateralize language function and assess hemispheric memory. In this study 23 non-lesional epileptic patients were evaluated. The magnitude of the difference in IAT scores between the two hemispheres was significantly greater in the patients whose seizures lateralized ...


    pub_type: 临床试验,杂志文章


    authors: Swearer JM,Kane KJ,Phillips CA,Weaver JP,Anderson TD,Lavoie MS

    更新日期:1999-01-15 00:00:00

  • Antimyoclonic effects of alcohol in progressive myoclonus epilepsy.

    abstract::We studied the effect of a single oral intake of 30 to 40 grams of alcohol in 4 consecutive patients presenting with Ramsay Hunt syndrome, the most common type of degenerative progressive myoclonic epilepsy (PME) encountered in southern Europe. Clinical and polygraphic monitoring demonstrated abatement of myoclonus in...


    pub_type: 杂志文章


    authors: Genton P,Guerrini R

    更新日期:1990-09-01 00:00:00

  • Whole-brain diffusion MR histograms differ between MS subtypes.

    abstract:OBJECTIVE:To determine whether quantitative whole-brain MR diffusion histograms in patients with MS differ from those of normal control subjects. BACKGROUND:MRI detects macroscopic cerebral lesions in MS, but the white matter lesion burden on MRI correlates imperfectly to clinical disability. Previous reports have fur...


    pub_type: 临床试验,杂志文章


    authors: Nusbaum AO,Tang CY,Wei T,Buchsbaum MS,Atlas SW

    更新日期:2000-04-11 00:00:00

  • Incidence of contrast nephropathy from cerebral CT angiography and CT perfusion imaging.

    abstract::The incidence of contrast-induced nephropathy was examined in 1,075 patients receiving routine CT angiography and CT perfusion brain imaging at a single institution. Fifty-two patients had a creatinine rise of > or =0.5 mg/dL. In four patients (0.37%), the administration of IV contrast medium possibly contributed to r...


    pub_type: 杂志文章


    authors: Josephson SA,Dillon WP,Smith WS

    更新日期:2005-05-24 00:00:00

  • Vimentin and desmin in maturing skeletal muscle and developmental myopathies.

    abstract::I studied vimentin and desmin immunoreactivities in the skeletal muscle of 30 human fetuses and children ranging from 8 weeks' gestation to 2 years of age, and in 45 infants and children and five adults with developmental neuromuscular diseases. Acridine orange-RNA fluorescence also identified regenerating myofibers i...


    pub_type: 杂志文章


    authors: Sarnat HB

    更新日期:1992-08-01 00:00:00

  • Linking MRI to daily life experience: the example of poststroke depression.

    abstract:OBJECTIVE:The state-of-the-art tools of neurology, in particular modern neuroimaging techniques, have yet to benefit from the revolution in mobile technologies that provide new insights into the mechanisms underlying clinical syndromes. This study demonstrates the manner in which mobile technologies may provide informa...


    pub_type: 杂志文章


    authors: Lassalle-Lagadec S,Allard M,Dilharreguy B,Schweitzer P,Swendsen J,Sibon I

    更新日期:2012-01-31 00:00:00

  • Longitudinal study of blood pressure and white matter hyperintensities: the EVA MRI Cohort.

    abstract:OBJECTIVE:To investigate the relationship between baseline hypertension and severity of white matter hyperintensities (WMH) at 4-year follow-up in a sample of subjects aged 59 to 71 years old at entry. METHODS:Subjects were participants in the Epidemiology of Vascular Ageing study, a longitudinal study on vascular agi...


    pub_type: 杂志文章


    authors: Dufouil C,de Kersaint-Gilly A,Besançon V,Levy C,Auffray E,Brunnereau L,Alpérovitch A,Tzourio C

    更新日期:2001-04-10 00:00:00

  • Intensity dependence of auditory evoked potentials is pronounced in migraine: an indication of cortical potentiation and low serotonergic neurotransmission?

    abstract::Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between attacks in 35 patients suffering from migraine without aura (MO, n = 25) or with aura (MA, n = 10) and in 25 healthy vo...


    pub_type: 杂志文章


    authors: Wang W,Timsit-Berthier M,Schoenen J

    更新日期:1996-05-01 00:00:00

  • Phenotypic variability of aprataxin gene mutations.

    abstract::The clinical and genetic features of three non-Portuguese and non-Japanese patients with aprataxin gene mutations are reported. Patient 1 came from Italy and presented with typical ataxia with ocular motor apraxia (OMA). She was homozygous for the W279X nonsense mutation, which is associated with the Portuguese foundi...


    pub_type: 杂志文章


    authors: Tranchant C,Fleury M,Moreira MC,Koenig M,Warter JM

    更新日期:2003-03-11 00:00:00

  • Natural history of nonketotic hyperglycinemia in 65 patients.

    abstract:BACKGROUND:Glycine encephalopathy, also known as nonketotic hyperglycinemia (NKH), is an autosomal recessive disorder caused by a defect in the glycine cleavage system. NKH is classically associated with neonatal apnea, lethargy, hypotonia, and seizures, followed by severe psychomotor retardation in those who survive. ...


    pub_type: 杂志文章


    authors: Hoover-Fong JE,Shah S,Van Hove JL,Applegarth D,Toone J,Hamosh A

    更新日期:2004-11-23 00:00:00

  • Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsy.

    abstract:OBJECTIVE:To describe the clinical, genetic and MR characteristics of patients with familial mesial temporal lobe epilepsy (MTLE). DESIGN/METHODS:The familial occurrence of MTLE was identified by a systematic search of family history of seizures in patients followed in the authors' epilepsy clinic. All probands and, w...


    pub_type: 杂志文章


    authors: Kobayashi E,Lopes-Cendes I,Guerreiro CA,Sousa SC,Guerreiro MM,Cendes F

    更新日期:2001-01-23 00:00:00

  • Autoantibodies in postinfectious acute cerebellar ataxia.

    abstract::The authors found serum immunoglobulin M (IgM) autoantibody in a patient with typical acute cerebellar ataxia (ACA) and identified the antigen molecule as triosephosphate isomerase (TPI). TPI antigenicity to the patient's antibody was the highest in the cerebellar tissue. Eight of 23 patients with ACA had increased Ig...


    pub_type: 杂志文章


    authors: Uchibori A,Sakuta M,Kusunoki S,Chiba A

    更新日期:2005-10-11 00:00:00

  • Altered functional connectivity in the motor network after traumatic brain injury.

    abstract:BACKGROUND:A large proportion of survivors of traumatic brain injury (TBI) have persistent cognitive impairments, the profile of which does not always correspond to the size and location of injuries. One possible explanation could be that TBI-induced damage extends beyond obvious lesion sites to affect remote brain net...


    pub_type: 杂志文章


    authors: Kasahara M,Menon DK,Salmond CH,Outtrim JG,Taylor Tavares JV,Carpenter TA,Pickard JD,Sahakian BJ,Stamatakis EA

    更新日期:2010-07-13 00:00:00

  • Vestibular thalamus: Two distinct graviceptive pathways.

    abstract:OBJECTIVE:To determine whether there are distinct thalamic regions statistically associated with either contraversive or ipsiversive disturbance of verticality perception measured by subjective visual vertical (SVV). METHODS:We used modern statistical lesion behavior mapping on a sample of 37 stroke patients with isol...


    pub_type: 杂志文章


    authors: Baier B,Conrad J,Stephan T,Kirsch V,Vogt T,Wilting J,Müller-Forell W,Dieterich M

    更新日期:2016-01-12 00:00:00

  • Seeing ophthalmologic problems in Parkinson disease: Results of a visual impairment questionnaire.

    abstract:OBJECTIVE:To determine the prevalence and clinical effect of ophthalmologic symptoms in patients with Parkinson disease (PD), compared with controls, using a standardized questionnaire. METHODS:In this observational, cross-sectional, multicenter study, 848 patients with PD and 250 healthy controls completed the Visual...


    pub_type: 杂志文章,多中心研究


    authors: Borm CDJM,Visser F,Werkmann M,de Graaf D,Putz D,Seppi K,Poewe W,Vlaar AMM,Hoyng C,Bloem BR,Theelen T,de Vries NM

    更新日期:2020-04-07 00:00:00

  • Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype.

    abstract:OBJECTIVE:To use a combined neurogenetic-neuroimaging approach to examine the functional consequences of preclinical dopaminergic nigrostriatal dysfunction in the human motor system. Specifically, we examined how a single heterozygous mutation in different genes associated with recessively inherited Parkinson disease a...


    pub_type: 杂志文章


    authors: van Nuenen BF,Weiss MM,Bloem BR,Reetz K,van Eimeren T,Lohmann K,Hagenah J,Pramstaller PP,Binkofski F,Klein C,Siebner HR

    更新日期:2009-03-24 00:00:00

  • Further characterization of patients with amnesia after cardiac arrest: preserved recognition memory.

    abstract::We observed that patients with amnesia after cardiac arrest had preserved recognition memory despite profound loss of recall memory. In the present study, rate of forgetting was measured in six amnesic subjects for both recall and recognition memory of verbal material. The data show that recall decayed significantly f...


    pub_type: 杂志文章


    authors: Volpe BT,Holtzman JD,Hirst W

    更新日期:1986-03-01 00:00:00

  • Late-onset anti-NMDA receptor encephalitis.

    abstract:OBJECTIVE:To describe the clinical features and outcome of anti-NMDA receptor (NMDAR) encephalitis in patients ≥45 years old. METHOD:Observational cohort study. RESULTS:In a cohort of 661 patients with anti-NMDAR encephalitis, we identified 31 patients ≥45 years old. Compared with younger adults (18-44 years), older ...


    pub_type: 杂志文章


    authors: Titulaer MJ,McCracken L,Gabilondo I,Iizuka T,Kawachi I,Bataller L,Torrents A,Rosenfeld MR,Balice-Gordon R,Graus F,Dalmau J

    更新日期:2013-09-17 00:00:00

  • A novel autosomal dominant limb-girdle muscular dystrophy (LGMD 1F) maps to 7q32.1-32.2.

    abstract::In 2001, the authors described the clinical features of a genetically distinct autosomal dominant limb-girdle muscular dystrophy (LGMD; LGMD 1F). Using a genome-wide screen with more than 400 microsatellite markers, the authors identified a novel LGMD disease locus at chromosome 7q32.1-32.2. Within this chromosomal re...


    pub_type: 杂志文章


    authors: Palenzuela L,Andreu AL,Gàmez J,Vilà MR,Kunimatsu T,Meseguer A,Cervera C,Fernandez Cadenas I,van der Ven PF,Nygaard TG,Bonilla E,Hirano M

    更新日期:2003-08-12 00:00:00

  • Failure of copolymer I to inhibit the human T-cell response to myelin basic protein.

    abstract::In clinical trials, copolymer I (Cop 1) appears to reduce the number of exacerbations in early relapsing-remitting multiple sclerosis. The mechanism of this effect is uncertain, but Cop 1 also reduces the severity of experimental allergic encephalomyelitis and inhibits the response of murine myelin basic protein (MBP)...


    pub_type: 杂志文章


    authors: Burns J,Littlefield K

    更新日期:1991-08-01 00:00:00

  • Primary cervical dystonia and scoliosis: a multicenter case-control study.

    abstract:OBJECTIVE:To study the distribution of prior scoliosis among patients with primary adult-onset cervical dystonia (CD) and matched control subjects. METHODS:Case and control subjects were selected among consecutive outpatients attending four Italian centers. Control outpatients were matched for age (+/-5 years), sex, a...


    pub_type: 杂志文章,多中心研究


    authors: Defazio G,Abbruzzese G,Girlanda P,Buccafusca M,Currà A,Marchese R,Martino D,Masi G,Mazzella L,Vacca L,Livrea P,Berardelli A

    更新日期:2003-03-25 00:00:00

  • Accuracy of Calculated Free Valproate Levels in Adult Patients With Status Epilepticus.

    abstract:OBJECTIVE:To test the accuracy of an equation in adult patients with status epilepticus that calculates the free concentration of serum valproic acid (fVPA) from the total concentration of serum valproic acid (tVPA) and serum albumin. METHODS:All adult patients with status epilepticus who were treated at a Swiss acade...


    pub_type: 杂志文章


    authors: Fisch U,Baumann SM,Semmlack S,Marsch S,Rüegg S,Sutter R

    更新日期:2021-01-05 00:00:00

  • The impact of neuropathic pain on health-related quality of life: review and implications.

    abstract::A number of high-quality studies have recently been published that examine the association between neuropathic pain and health-related quality of life (HRQoL). The current review identified 52 such studies in patients with six neuropathic pain conditions associated with lesions of either the peripheral (postsurgical n...


    pub_type: 杂志文章,meta分析,评审


    authors: Jensen MP,Chodroff MJ,Dworkin RH

    更新日期:2007-04-10 00:00:00