Association of Time of Day When Endovascular Therapy for Stroke Starts and Functional Outcome.


OBJECTIVE:To investigate the association between EVT start time in acute ischemic stroke (AIS) and mid-term functional outcome. METHODS:This retrospective cohort study included all AIS cases treated with EVT from two stroke center registries from January 2012 to December 2018. The primary outcome was the score on the modified Rankin Scale (mRS) and the utility-weighted mRS (uw-mRS) at 90 days. A proportional odds model was used to calculate the common odds ratio as a measure of the likelihood that the intervention at a given EVT start time would lead to lower scores on the mRS (shift analysis). RESULTS:One thousand five hundred fifty-eight cases were equally allotted into twelve EVT-start-time periods. The primary outcome favored EVT start times in the morning at 08:00-10:20 and 10:20-11:34 (common odds ratio (OR), 0.53; 95% confidence interval (CI), 0.38 to 0.75; P<0.001; OR, 0.62; 95% CI, 0.44 to 0.87; P=0.006, respectively), while it disfavored EVT start times at the end of the working day at 15:55-17:15 and 18:55-20:55 (OR, 1.47; 95% CI, 1.03 to 2.09; P=0.034; OR, 1.49; 95% CI, 1.03 to 2.15; P=0.033). Symptom onset-to-EVT start time was significantly higher and use of IV t-PA significantly lower between 10:20-11:34 (P<0.004 and P=0.012, respectively). CONSLUSION:EVT for AIS in the morning leads to better mid-term functional outcome, while EVT at the end of the work day leads to poorer mid-term functional outcome. Neither difference in baseline factors, standard workflow and technical efficacy metrics could be identified as potential mediators of this effect.






Hajdu SD,Kaesmacher J,Michel PP,Sirimarco G,Knebel JF,Bartolini B,Kurmann CC,Puccinelli F,Mosimann PJ,Bonvin C,Arnold PM,Niederhäuser J,Eskandari A,Mordasini P,Gralla PJ,Fischer PU,Saliou PG




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2021-01-04 00:00:00








  • Leukoencephalopathy in childhood leukemia.

    abstract::A 14-year-old boy survived for 7 years after the initial diagnosis and treatment of acute lymphocytic leukemia. Neurologic deterioration occured repeatedly throughout his complicated clinical course but it was most severe and only partially reversible following orally administered pyrimethamine. The neuropathologic le...


    pub_type: 杂志文章


    authors: Devivo DC,Malas D,Nelson JS,Land VJ

    更新日期:1977-07-01 00:00:00

  • The unruptured intracranial aneurysm treatment score: a multidisciplinary consensus.

    abstract:OBJECTIVE:We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making in the management of UIAs and to assess agreement for this model among specialists in UIA management and research. METHODS:An internat...


    pub_type: 共识发展会议,杂志文章


    authors: Etminan N,Brown RD Jr,Beseoglu K,Juvela S,Raymond J,Morita A,Torner JC,Derdeyn CP,Raabe A,Mocco J,Korja M,Abdulazim A,Amin-Hanjani S,Al-Shahi Salman R,Barrow DL,Bederson J,Bonafe A,Dumont AS,Fiorella DJ,Gruber A,H

    更新日期:2015-09-08 00:00:00

  • Three-Tesla MRI does not improve the diagnosis of multiple sclerosis: A multicenter study.

    abstract:OBJECTIVE:In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer a higher lesion detection than 1.5T, but it remains unclear whether this affects the fulfilment of the diagnostic criteria for multiple sclerosis (MS). METHODS:We recruited 66 patients with CIS within 6 months...


    pub_type: 杂志文章,多中心研究


    authors: Hagens MHJ,Burggraaff J,Kilsdonk ID,de Vos ML,Cawley N,Sbardella E,Andelova M,Amann M,Lieb JM,Pantano P,Lissenberg-Witte BI,Killestein J,Oreja-Guevara C,Ciccarelli O,Gasperini C,Lukas C,Wattjes MP,Barkhof F,MAGNIMS St

    更新日期:2018-07-17 00:00:00

  • Diagnosis of thymoma in myasthenics using anti-striated muscle antibodies: predictive value and gain in diagnostic certainty.

    abstract::Assay of anti-striated muscle antibodies (StrAb) is used as a diagnostic test for thymoma in individuals with myasthenia gravis. Unfortunately, false positive results are common, and their effect on test accuracy is magnified by the relatively low frequency of thymoma in myasthenics. We estimated the predictive values...


    pub_type: 杂志文章


    authors: Lanska DJ

    更新日期:1991-04-01 00:00:00

  • Seizures accelerate forgetting in patients with left-sided temporal lobe epilepsy.

    abstract::Ten patients with refractory temporal lobe epilepsy performed a word-position association learning task every 24 hours during video EEG monitoring. On 55 occasions recall performance was tested 30 minutes and 24 hours after the initial learning phase. Patients with left- but not right-sided temporal lobe epilepsy exhi...


    pub_type: 杂志文章


    authors: Jokeit H,Daamen M,Zang H,Janszky J,Ebner A

    更新日期:2001-07-10 00:00:00

  • Methylphenidate for gait impairment in Parkinson disease: a randomized clinical trial.

    abstract:BACKGROUND:There is a paucity of therapies for gait impairment in Parkinson disease (PD). Open-label studies have suggested improved gait after treatment with methylphenidate (MPD). OBJECTIVE:To evaluate the efficacy of MPD for the treatment of gait impairment in PD. METHODS:Twenty-seven subjects with PD and moderate...


    pub_type: 杂志文章,随机对照试验


    authors: Espay AJ,Dwivedi AK,Payne M,Gaines L,Vaughan JE,Maddux BN,Slevin JT,Gartner M,Sahay A,Revilla FJ,Duker AP,Shukla R

    更新日期:2011-04-05 00:00:00

  • Caffeinated clues and the promise of adenosine A(2A) antagonists in PD.

    abstract::Large prospective epidemiologic studies have linked the consumption of coffee and other caffeinated beverages to a reduced risk of subsequently developing PD. Caffeine as well as more specific antagonists of the adenosine A(2A) receptor have also now been found to attenuate neurotoxicity in a mouse model of PD. The co...


    pub_type: 杂志文章,评审


    authors: Schwarzschild MA,Chen JF,Ascherio A

    更新日期:2002-04-23 00:00:00

  • Spatial disorientation in Alzheimer's disease: the remembrance of things passed.

    abstract:BACKGROUND:Patients with Alzheimer's disease (AD) and many older adults become lost even in familiar surroundings. This is commonly attributed to memory impairment, but it may reflect impaired spatial cognition. METHODS:The authors examined the role of memory, perceptual, and cognitive mechanisms in spatial disorienta...


    pub_type: 杂志文章


    authors: Monacelli AM,Cushman LA,Kavcic V,Duffy CJ

    更新日期:2003-12-09 00:00:00

  • Measurement of tissue oxygen consumption in patients with mitochondrial myopathy by noninvasive tissue oximetry.

    abstract::We measured oxygen consumption in the exercising lower limb by using noninvasive tissue oximetry with the near-infrared spectra of hemoglobin in the quadriceps muscle during bicycle ergometer exercise in four normal controls and three patients with chronic progressive external ophthalmoplegia (CPEO) as well as one pat...


    pub_type: 杂志文章


    authors: Abe K,Matsuo Y,Kadekawa J,Inoue S,Yanagihara T

    更新日期:1997-09-01 00:00:00

  • Specificity of the fivefold increase in AD in mothers of adults with Down syndrome.

    abstract:BACKGROUND:In a previous study, the authors found that the risk of AD among mothers who were 35 years or younger when their children with Down syndrome (DS) were born was five times that of mothers of children with other forms of mental retardation. The current study investigated the specificity of the familial aggrega...


    pub_type: 杂志文章


    authors: Schupf N,Kapell D,Nightingale B,Lee JH,Mohlenhoff J,Bewley S,Ottman R,Mayeux R

    更新日期:2001-09-25 00:00:00

  • Prevalence of AD among whites: a summary by levels of severity.

    abstract:OBJECTIVE:To determine age- and sex-specific AD prevalence rates for whites using each of four severity-based definitions of a case: a person diagnosed as having at least questionable AD, one diagnosed as having at least mild AD, one diagnosed as having moderate or severe AD, and one diagnosed as having severe AD. MET...


    pub_type: 杂志文章


    authors: Hy LX,Keller DM

    更新日期:2000-07-25 00:00:00

  • Osteopenia and osteoporosis in idiopathic benign positional vertigo.

    abstract:OBJECTIVE:Causes of benign positional vertigo (BPV) are mostly unknown. The aim of this study was to elucidate an association of osteoporosis with idiopathic BPV. METHODS:Two hundred nine consecutive patients with a confirmed diagnosis of idiopathic BPV underwent bone mineral densitometry of anterior-posterior lumbar ...


    pub_type: 杂志文章


    authors: Jeong SH,Choi SH,Kim JY,Koo JW,Kim HJ,Kim JS

    更新日期:2009-03-24 00:00:00

  • Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1.

    abstract:OBJECTIVE:To evaluate the safety and efficacy of l-serine in humans with hereditary sensory autonomic neuropathy type I (HSAN1). METHODS:In this randomized, placebo-controlled, parallel-group trial with open-label extension, patients aged 18-70 years with symptomatic HSAN1 were randomized to l-serine (400 mg/kg/day) o...


    pub_type: 杂志文章,随机对照试验


    authors: Fridman V,Suriyanarayanan S,Novak P,David W,Macklin EA,McKenna-Yasek D,Walsh K,Aziz-Bose R,Oaklander AL,Brown R,Hornemann T,Eichler F

    更新日期:2019-01-22 00:00:00

  • A representational vertical bias.

    abstract::We attempted to determine whether separable components underlie normal subjects' upward bias in bisecting vertical and radial lines under visual guidance. Twelve normal subjects indicated the midpoint of visually presented lines oriented vertically, radially, and horizontally. We placed directional labels ("TOP" and "...


    pub_type: 杂志文章


    authors: Jeerakathil TJ,Kirk A

    更新日期:1994-04-01 00:00:00

  • Cerebellar reorganization following cortical injury in humans: effects of lesion size and age.

    abstract:OBJECTIVE:The authors investigated chronic cerebellar reorganization following unilateral cortical lesions in children and adults using PET to measure benzodiazepine receptor (BZR) binding with [11C]flumazenil (FMZ) and glucose metabolism with 2-deoxy-2[18F]fluoro-D-glucose (FDG). BACKGROUND:Crossed cerebellar diaschi...


    pub_type: 杂志文章


    authors: Niimura K,Chugani DC,Muzik O,Chugani HT

    更新日期:1999-03-10 00:00:00

  • Correlates of disability in multiple sclerosis detected by transcranial magnetic stimulation.

    abstract:OBJECTIVE:To study the usefulness of corticospinally mediated excitatory responses and transcallosal inhibition (TI) elicited by transcranial magnetic stimulation (TMS) as a surrogate marker of disability in patients with different courses of MS. METHODS:Focal TMS of the motor cortex was performed in 118 patients with...


    pub_type: 杂志文章


    authors: Schmierer K,Irlbacher K,Grosse P,Röricht S,Meyer BU

    更新日期:2002-10-22 00:00:00

  • A major locus for several phenotypes of myoclonus--dystonia on chromosome 7q.

    abstract::Myoclonus--dystonia is a genetically heterogeneous autosomal dominant disorder caused by a mutation in the D2 dopamine receptor on chromosome 11 and a locus on chromosome 7q21-q31. The authors tested linkage to the chromosome 7q candidate region in four families with either myoclonic dystonia (n = 3) or essential myoc...


    pub_type: 杂志文章


    authors: Vidailhet M,Tassin J,Durif F,Nivelon-Chevallier A,Agid Y,Brice A,Dürr A

    更新日期:2001-05-08 00:00:00

  • 'Crescendo' transient ischemic attacks: clinical and angiographic correlations.

    abstract::Forty-seven consecutive patients presenting acutely with repetitive symptoms indicative of anterior circulation ischemia ("crescendo" transient ischemic attacks) were evaluated to identify clinical features that might reliably predict the presence of significant stenosis, ulceration, or both in the presumably symptoma...


    pub_type: 杂志文章


    authors: Rothrock JF,Lyden PD,Yee J,Wiederholt WC

    更新日期:1988-02-01 00:00:00

  • Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients.

    abstract::Juvenile myoclonic epilepsy (JME) is a distinct subform of idiopathic generalized epilepsy of adolescence. Linkage studies with Bf and serologic HLA markers in families of JME patients have shown a tight linkage on chromosome 6. We present a linkage analysis with HLA-DQ restriction fragment length polymorphisms on mor...


    pub_type: 杂志文章


    authors: Durner M,Sander T,Greenberg DA,Johnson K,Beck-Mannagetta G,Janz D

    更新日期:1991-10-01 00:00:00

  • Meningeal gliomatosis with "negative" CSF cytology: the value of GFAP staining.

    abstract::We report a patient with meningeal gliomatosis who had signs of meningitis, hypoglycorrhachia, and an intracranial mass. Despite suspicion of a primary intracranial neoplasm, repeated CSF cytologies were not diagnostic and led to a brain biopsy for diagnosis. Immunoperoxidase staining for glial fibrillary acidic prote...


    pub_type: 杂志文章


    authors: Wechsler LR,Gross RA,Miller DC

    更新日期:1984-12-01 00:00:00

  • Associative and predictive biomarkers of dementia in HIV-1-infected patients.

    abstract:BACKGROUND:Infection with HIV can result in a debilitating CNS disorder known as HIV dementia (HIV-D). Since the advent of highly active antiretroviral therapy (HAART), the incidence of HIV-D has declined, but the prevalence continues to increase. In this new era of HIV-D, traditional biomarkers such as CSF viral load ...


    pub_type: 杂志文章


    authors: Bandaru VV,McArthur JC,Sacktor N,Cutler RG,Knapp EL,Mattson MP,Haughey NJ

    更新日期:2007-05-01 00:00:00

  • Molecular basis of hypokalemic myopathy caused by 17alpha-hydroxylase/17,20-lyase deficiency.

    abstract::We describe a 28-year-old woman presenting with hypokalemic myopathy caused by 17alpha-hydroxylase/17,20-lyase deficiency caused by a homozygous mutation consisting of a G-to-C transition in the initiation codon in exon 1 of the CYP17 gene resulting in expression of an enzymatically inactive truncated P450c17 protein....


    pub_type: 杂志文章


    authors: Satoh J,Kuroda Y,Nawata H,Yanase T

    更新日期:1998-12-01 00:00:00

  • Whole-brain diffusion MR histograms differ between MS subtypes.

    abstract:OBJECTIVE:To determine whether quantitative whole-brain MR diffusion histograms in patients with MS differ from those of normal control subjects. BACKGROUND:MRI detects macroscopic cerebral lesions in MS, but the white matter lesion burden on MRI correlates imperfectly to clinical disability. Previous reports have fur...


    pub_type: 临床试验,杂志文章


    authors: Nusbaum AO,Tang CY,Wei T,Buchsbaum MS,Atlas SW

    更新日期:2000-04-11 00:00:00

  • Branch occlusive disease: clinical and magnetic resonance angiography findings.

    abstract:BACKGROUND:We evaluated the clinicoradiologic characteristics of patients with branch occlusive disease (BOD)-type intracranial atherosclerotic stroke (ICAS) compared with those of patients with non-BOD-type ICAS or with small artery disease (SAD). METHODS:We analyzed 201 consecutive patients with acute infarcts withi...


    pub_type: 杂志文章


    authors: Ryoo S,Park JH,Kim SJ,Kim GM,Chung CS,Lee KH,Kim JS,Bang OY

    更新日期:2012-03-20 00:00:00

  • Cranial dystonia: double-blind crossover study of anticholinergics.

    abstract::In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishab...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nutt JG,Hammerstad JP,deGarmo P,Carter J

    更新日期:1984-02-01 00:00:00

  • Lumbosacral plexus neuritis.

    abstract::We studied four patients with neurologic disorders of the lumbosacral plexus. Except for location of symptoms, the disorder confirmed to criteria established for the clinical diagnosis of brachial plexus neuritis. Acute onset of pain in one or both legs was followed by weakness, loss of stretch reflexes, and sometimes...


    pub_type: 杂志文章


    authors: Sander JE,Sharp FR

    更新日期:1981-04-01 00:00:00

  • Treatment of AIDS-associated myelopathy with L-methionine: a placebo-controlled study.

    abstract:BACKGROUND:The histopathology of AIDS-associated myelopathy (AM) closely resembles that of myelopathies due to cobalamin or folate deficiency, with white matter vacuolization in the spinal cord. The pathogenesis of AM appears unrelated to direct HIV infection of the spinal cord. There is abnormal trans-methylation meta...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Di Rocco A,Werner P,Bottiglieri T,Godbold J,Liu M,Tagliati M,Scarano A,Simpson D

    更新日期:2004-10-12 00:00:00

  • Imaging outcome measures of neuroprotection and repair in MS: A consensus statement from NAIMS.

    abstract:OBJECTIVE:To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each technique in clinical trial settings. METHODS:Clinicians and scientists with expertise in the use of MRI i...


    pub_type: 共识发展会议,杂志文章,评审


    authors: Oh J,Ontaneda D,Azevedo C,Klawiter EC,Absinta M,Arnold DL,Bakshi R,Calabresi PA,Crainiceanu C,Dewey B,Freeman L,Gauthier S,Henry R,Inglese M,Kolind S,Li DKB,Mainero C,Menon RS,Nair G,Narayanan S,Nelson F,Pelleti

    更新日期:2019-03-12 00:00:00

  • Infections and course of disease in mild forms of Guillain-Barré syndrome.

    abstract:OBJECTIVE:Twenty-eight percent of patients with the Guillain-Barré syndrome remain able to walk unaided. Studying patients with the mild form of Guillain-Barré syndrome can further contribute to knowledge of the spectrum of the syndrome and explore whether this subgroup may need treatment with IV immunoglobulin. METHO...


    pub_type: 杂志文章,多中心研究


    authors: Van Koningsveld R,Schmitz PI,Ang CW,Groen J,Osterhaus AD,Van der Meché FG,Van Doorn PA

    更新日期:2002-02-26 00:00:00

  • Practice Parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:Nonmotor symptoms (sleep dysfunction, sensory symptoms, autonomic dysfunction, mood disorders, and cognitive abnormalities) in Parkinson disease (PD) are a major cause of morbidity, yet are often underrecognized. This evidence-based practice parameter evaluates treatment options for the nonmotor symptoms of P...


    pub_type: 杂志文章,实务指引


    authors: Zesiewicz TA,Sullivan KL,Arnulf I,Chaudhuri KR,Morgan JC,Gronseth GS,Miyasaki J,Iverson DJ,Weiner WJ,Quality Standards Subcommittee of the American Academy of Neurology.

    更新日期:2010-03-16 00:00:00