Abstract:
BACKGROUND:The Babinski sign is a well-known sign of upper motor neuron dysfunction that is widely considered an essential element of a complete neurologic examination. Little is known about reliability and validity of this sign. A less well-known sign of upper motor neuron dysfunction, decreased speed of foot tapping, also has not been carefully evaluated. Scientific evaluation of findings of the physical examination is crucial in directing busy clinicians. METHODS:Ten physicians (five neurologists and five non-specialists) examined each foot of 10 subjects, 8 of whom had known unilateral upper motor neuron weakness, 1 had bilateral leg weakness secondary to ALS, and 1 had no known neurologic deficits. Our main outcome measures were inter-rater reliability (kappa values) and accuracy (agreement with known upper motor neuron weakness). RESULTS:The reliability of the Babinski sign was fair (kappa 0.30) and was substantial for foot tapping (kappa 0.73). Agreement with known weakness was 56% for Babinski sign and 85% for foot tapping. Reliability and accuracy for both tests were similar for neurologists and non-specialists. CONCLUSIONS:The interobserver reliability and validity of the Babinski sign for identifying upper motor neuron weakness are limited. Slowness of foot tapping may be a more useful sign.
journal_name
Neurologyjournal_title
Neurologyauthors
Miller TM,Johnston SCdoi
10.1212/01.wnl.0000180608.76190.10subject
Has Abstractpub_date
2005-10-25 00:00:00pages
1165-8issue
8eissn
0028-3878issn
1526-632Xpii
65/8/1165journal_volume
65pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::We evaluated the therapeutic efficacy and toxicity of high-dose monotherapy, using carbamazepine or phenytoin, in patients with previously uncontrolled seizures. Treatment with a single drug was equal to or better than polypharmacy, but only a few patients became free of seizures. Toxicity was mild and associated with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.6.707
更新日期:1984-06-01 00:00:00
abstract::Large prospective epidemiologic studies have linked the consumption of coffee and other caffeinated beverages to a reduced risk of subsequently developing PD. Caffeine as well as more specific antagonists of the adenosine A(2A) receptor have also now been found to attenuate neurotoxicity in a mouse model of PD. The co...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.58.8.1154
更新日期:2002-04-23 00:00:00
abstract::We describe a 43-year-old neurologically intact patient who reported episodes of diplopia and oscillopsia associated with a right-beating nystagmus and a skew deviation. These symptoms and signs were related to a left posterior epileptic EEG discharge. We suggest that these ocular motor signs derived from an ictal act...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.5.1469
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To examine the relationship of migraine and other severe headaches with panic disorder. METHODS:Representative samples of persons with migraine, non-migrainous severe headaches, and controls with no history of severe headaches, identified by a telephone survey, were interviewed in person, using a standardize...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.3.350
更新日期:2001-02-13 00:00:00
abstract::Self-reported versus informant-reported memory problems in nondemented elderly adults and in individuals with very mild and mild dementia of the Alzheimer type (DAT) were correlated with cognitive outcomes. No significant correlations were found between self-reported memory complaints and cognitive performance or (in ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.11.1724
更新日期:2000-12-12 00:00:00
abstract::Serum ratios of monoclonal immunoglobulin (Ig) to total protein, monoclonal immunoglobulin to albumin, CSF/serum Ig-albumin index, and CSF to serum monoclonal immunoglobulin were obtained in 21 patients with multiple myeloma and 2 with Waldenström's macroglobulinemia. Twelve patients (3 with CNS complications) showed ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.11.1411
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:A number of familial temporal lobe epilepsies (TLE) have been recently recognized. Mutations in LGI1 (leucine-rich, glioma-inactivated 1 gene) have been found in a few families with the syndrome of autosomal dominant partial epilepsy with auditory features (ADPEAF). The authors aimed to determ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000118213.94650.81
更新日期:2004-04-13 00:00:00
abstract::We used [18F]-2-fluoro-2-deoxy-D-glucose (FDG) and PET to study regional cerebral glucose utilization in seven patients with fatal familial insomnia (FFI), an inherited prion disease with a mutation at codon 178 of the prion protein gene. Four patients were methionine/methionine homozygotes at codon 129 (symptom durat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.1.126
更新日期:1997-07-01 00:00:00
abstract::Ischemic stroke subtype distribution was compared between Mexican Americans (MAs) and non-Hispanic whites (NHWs) in a community-based stroke surveillance study in Nueces County, TX. There was no difference in the distribution of stroke subtype by ethnicity (p = 0.19). There was a similar proportion of small-vessel and...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000133212.99040.07
更新日期:2004-08-10 00:00:00
abstract:BACKGROUND:Primary angiitis of the CNS (PACNS) is a diagnostically challenging disorder. In patients whose diagnosis is ascertained solely by cerebral angiography without histologic verification, a benign monophasic clinical course with favorable response to a brief course of immunosuppressive therapy is often reported...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.1.183
更新日期:1998-07-01 00:00:00
abstract::We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson's disease (5) and parkinsonism with dementia (PD) (5). We found similar, but less extensive, pathology in the substantia nigra of six of ni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.8.1285
更新日期:1988-08-01 00:00:00
abstract::The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, l...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.10.952
更新日期:1976-10-01 00:00:00
abstract:OBJECTIVE:To study the brain activation pattern of coexisting experimental ongoing pain and brush-evoked allodynia (pain evoked by innocuous brush) with the use of PET. BACKGROUND:Neuropathic pain usually has two essential phenomena: ongoing pain and brush-evoked allodynia, which coexist and may influence each other. ...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.57.10.1817
更新日期:2001-11-27 00:00:00
abstract:OBJECTIVE:To characterize patterns of cognitive functioning in a well-defined group of patients with MRI-identified coexisting left temporal lobe developmental malformations (TLDM) and mesial temporal sclerosis (MTS), and to examine neuropsychological outcome in this dual-pathology group following epilepsy surgery. ME...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.4.709
更新日期:1999-09-11 00:00:00
abstract:OBJECTIVE:To investigate the efficacy and safety of aceneuramic acid extended-release (Ace-ER), a treatment intended to replace deficient sialic acid, in patients with GNE myopathy. METHODS:UX001-CL301 was a phase 3, double-blind, placebo-controlled, randomized, international study evaluating the efficacy and safety o...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000006932
更新日期:2019-04-30 00:00:00
abstract::A subset of human B lymphocytes expresses Leu-1 (CD5), a pan-T cell marker, which is the equivalent of the murine Lyt-1 molecule. CD5+ B cells produce autoantibodies in vitro; therefore, they may play a role in the pathogenesis of autoimmune disorders. In myasthenia gravis (MG), autoantibodies are directed against the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.7.1120
更新日期:1990-07-01 00:00:00
abstract::Alzheimer disease (AD) has a significant impact on caregivers. Administering and managing medications is one of their many daily tasks. More effective modes of drug administration may benefit patient and caregiver, and may improve compliance. A prospective outcome of the IDEAL (Investigation of TransDermal Exelon in A...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000281848.25142.11
更新日期:2007-07-24 00:00:00
abstract::We describe a case of West Nile virus (WNV) infection in an HIV-infected patient who presented with an isolated flaccid monoparesis of the right upper extremity. To our knowledge, this is the first reported case of flaccid paralysis caused by WNV infection in an HIV-infected patient. We then review the medical literat...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000253223.07720.bb
更新日期:2007-02-13 00:00:00
abstract::The most consistent electroencephalographic finding in 16 cases of Sturge-Weber syndrome was a unilateral reduction of background amplitude in the waking record. Comparable asymmetries were noted in those patients in whom sleep recording also was done. Physiologic responses (to hyperventilation and photic driving) usu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.7.629
更新日期:1976-07-01 00:00:00
abstract:OBJECTIVE:To cross-sectionally compare the regional white matter fractional anisotropy (FA) of cognitively normal (CN) older individuals and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), separately focusing on the normal-appearing white matter (NAWM) and white matter hyperintensities (WMH), ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c33afb
更新日期:2009-11-24 00:00:00
abstract::We tested the efficacy of coenzyme Q10 (ubidecarenone, CoQ10) therapy in patients with Kearns-Sayre syndrome and other mitochondrial myopathies with chronic progressive external ophthalmoplegia (CPEO). We treated seven patients for 1 year with daily oral administration of 120 mg of CoQ10. Throughout the treatment most...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.6.892
更新日期:1988-06-01 00:00:00
abstract::The authors found serum immunoglobulin M (IgM) autoantibody in a patient with typical acute cerebellar ataxia (ACA) and identified the antigen molecule as triosephosphate isomerase (TPI). TPI antigenicity to the patient's antibody was the highest in the cerebellar tissue. Eight of 23 patients with ACA had increased Ig...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000178802.38268.1e
更新日期:2005-10-11 00:00:00
abstract:BACKGROUND:Over 50% of persons with idiopathic REM sleep behavior disorder (RBD) will develop Parkinson disease (PD) or dementia. At present, there is no way to predict who will develop disease. Since polysomnography is performed in all patients with idiopathic RBD at diagnosis, there is an opportunity to analyze if ba...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181ca0166
更新日期:2010-01-19 00:00:00
abstract::A term neonate was being treated with intravenous phenytoin. To maintain a serum level above 10 micrograms per milliliter and abolish seizure activity, it was necessary to carry out repeated serum concentration measurements, administer several loading doses, and administer an unusually large maintenance dose (25 mg pe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.1.106
更新日期:1983-01-01 00:00:00
abstract::The authors examined the neural function of a postmeningitic deaf-blind patient who regained his hearing with a multichannel cochlear implant. Auditory stimuli activated the temporal cortices of both sides in a manner similar to that of controls, reflecting the successful recruitment of the auditory cortex after impla...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000234141.72891.13
更新日期:2006-09-12 00:00:00
abstract::A 71-year-old man developed severe limb, bulbar, and respiratory weakness over 18 months. A muscle biopsy showed only a moderate degree of type 2 atrophy, but immunocytochemistry showed absence of chondroitin sulfate C glycosaminoglycan in the endomysium. Prednisone produced a marked increase in strength. Diffuse loss...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.2.526
更新日期:1998-02-01 00:00:00
abstract::Thirteen consecutive patients with thalamic deep brain stimulation (DBS) were examined serially for 3 to 5 years. Initially, all demonstrated at least 50% improvement in contralateral tremor. At last follow-up, three of eight patients with Parkinson disease no longer used DBS because tremor had markedly improved, and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000096012.07360.1c
更新日期:2003-12-09 00:00:00
abstract::An infant with Pena-Shokeir phenotype was born to a cocaine-using mother. The pathologic findings included polyhydramnios, facial anomalies, arthrogryposis, camptodactyly, pulmonary hypoplasia, and tetralogy of Fallot. The neuropathologic findings were diffuse brainstem and spinal cord neuronal degeneration and focal ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.9.1467
更新日期:1991-09-01 00:00:00
abstract::The triad of normal-pressure hydrocephalus, parkinsonism, and primary empty sella appeared in a 70-year-old woman. There was dramatic resolution of the extrapyramidal signs and symptoms on treatment with levodopa-carbidopa and ventriculojugular shunt. The syndrome may be the result of several mechanisms, but an altera...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.11.1191
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:Despite convenience, accessibility, and strong correlation to severity of Alzheimer disease (AD) pathology, medial temporal lobe atrophy (MTA) has not been used as a criterion in the diagnosis of prodromal and probable AD. METHODS:Using a newly validated visual rating system, mean MTA scores of three bilate...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000336925.79704.9f
更新日期:2008-12-09 00:00:00