Abstract:
BACKGROUND:Despite convenience, accessibility, and strong correlation to severity of Alzheimer disease (AD) pathology, medial temporal lobe atrophy (MTA) has not been used as a criterion in the diagnosis of prodromal and probable AD. METHODS:Using a newly validated visual rating system, mean MTA scores of three bilateral medial temporal lobe structures were compared for subjects with no cognitive impairment (NCI) (n = 117), nonamnestic mild cognitive impairment (MCI) (n = 46), amnestic MCI (n = 45), and probable AD (n = 53). Correlations between MTA scores and neuropsychological test scores at baseline, and predictors of change in diagnosis at 1-year follow-up were evaluated. RESULTS:With NCI as the reference group, a mean MTA cut score of 1.33 yielded an optimal sensitivity/specificity of 85%/82% for probable AD subjects and 80%/82% for amnestic MCI subjects. MTA and Clinical Dementia Rating Sum of Boxes scores at baseline were independent and additive predictors of diagnosis at baseline, and of transition from NCI to MCI or from MCI to dementia at 1-year follow-up. CONCLUSION:Medial temporal lobe atrophy (MTA) scores 1) distinguish probable Alzheimer disease (AD) and amnestic mild cognitive impairment (MCI) subjects from nonamnestic MCI and no cognitive impairment (NCI) subjects, 2) help predict diagnosis at baseline, and 3) predict transition from NCI to MCI and from MCI to probable AD. MTA scores should be used as a criterion in the clinical diagnosis of AD.
journal_name
Neurologyjournal_title
Neurologyauthors
Duara R,Loewenstein DA,Potter E,Appel J,Greig MT,Urs R,Shen Q,Raj A,Small B,Barker W,Schofield E,Wu Y,Potter Hdoi
10.1212/01.wnl.0000336925.79704.9fsubject
Has Abstractpub_date
2008-12-09 00:00:00pages
1986-92issue
24eissn
0028-3878issn
1526-632Xpii
71/24/1986journal_volume
71pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Current medical educational theory encourages the development of competency-based curricula. The Accreditation Council for Graduate Medical Education's 6 core competencies for resident education (medical knowledge, patient care, professionalism, interpersonal and communication skills, practice-based learning, and syst...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000646
更新日期:2014-07-29 00:00:00
abstract:OBJECTIVES:Assuming the involvement of homocysteine in a generalized small-vessel disease, we investigated the association of homocysteine levels with progression of white matter lesions, lacunar infarcts, and kidney disease. METHODS:Within the SMART-MR (Second Manifestations of ARTerial disease-Magnetic Resonance) St...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000168
更新日期:2014-03-04 00:00:00
abstract:OBJECTIVE:To investigate the association between discordant β-amyloid (Aβ) PET and CSF biomarkers at baseline and the emergence of tau pathology 5 years later. METHODS:We included 730 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants without dementia (282 cognitively normal, 448 mild cognitive impairment...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010739
更新日期:2020-11-10 00:00:00
abstract:OBJECTIVE:To study the brain activation pattern of coexisting experimental ongoing pain and brush-evoked allodynia (pain evoked by innocuous brush) with the use of PET. BACKGROUND:Neuropathic pain usually has two essential phenomena: ongoing pain and brush-evoked allodynia, which coexist and may influence each other. ...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.57.10.1817
更新日期:2001-11-27 00:00:00
abstract::A young girl who initially presented with jaw hypomobility at age 4 years subsequently developed signs of a slowly progressive myopathy. Rods were found in all sampled muscles, and were associated with fibrous contractures in the temporomandibular joint muscles. Rods in fibers undergoing necrosis displayed a pattern o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.9.971
更新日期:1980-09-01 00:00:00
abstract::Call-Fleming syndrome is a reversible segmental vasoconstriction of cerebral arteries manifested by a "thunderclap" headache and focal neurologic symptoms. Although of unknown etiology, it has been reported in association with vasoactive sympathomimetic drugs. The authors report Call-Fleming syndrome in two patients w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000223648.76430.27
更新日期:2006-07-11 00:00:00
abstract::The authors investigated whether the lack of effect of tirilazad on clinical outcome in patients with acute ischemic stroke is explained by failure of tirilazad to reduce infarct volume. Overall, tirilazad had no significant effect on infarct volume. In the subgroups of male patients and of those with a cortical infar...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.58.1.133
更新日期:2002-01-08 00:00:00
abstract::The authors have developed an MG activities of daily living (ADL) profile (MG-ADL)-a simple eight-question survey of MG symptoms. In 254 consecutive encounters with established MG patients, the authors compared scores from the MG-ADL to the quantitative MG score (QMG)-a standardized, reliable scale used in clinical tr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.7.1487
更新日期:1999-04-22 00:00:00
abstract:BACKGROUND:After 1 to 4 years, seizure-free children with epilepsy are encouraged to stop daily antiepileptic drug (AED) treatment. Approximately 70% are successful. The authors examined how often intractable epilepsy follows discontinuation of AED treatment in a population-based cohort of children with epilepsy. METH...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000154517.82748.A7
更新日期:2005-03-22 00:00:00
abstract::A seismic shift in our understanding of the ability to diagnose Alzheimer disease (AD) is occurring. For the last several decades, AD has been a clinical-pathologic diagnosis, and this conceptualization of the disease has served the field well. Typically, the clinician would identify a syndrome such as mild cognitive ...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0000000000006088
更新日期:2018-08-28 00:00:00
abstract:OBJECTIVE:To study the usefulness of corticospinally mediated excitatory responses and transcallosal inhibition (TI) elicited by transcranial magnetic stimulation (TMS) as a surrogate marker of disability in patients with different courses of MS. METHODS:Focal TMS of the motor cortex was performed in 118 patients with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.8.1218
更新日期:2002-10-22 00:00:00
abstract:BACKGROUND:Charcot Marie Tooth type 1a (CMT1a) is a primarily demyelinating neuropathy, characterized by slowly progressive muscle weakness, atrophy, and sensory loss, and is most pronounced in both feet and hands. There is increasing evidence that muscle weakness is determined by motor axonal dysfunction. OBJECTIVE:T...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000327643.05073.eb
更新日期:2008-10-14 00:00:00
abstract:BACKGROUND:Multiple system atrophy (MSA) is an atypical parkinsonian syndrome including cerebellar impairment and poor response to levodopa. We assessed right hand motor activation in patients with MSA before and after an acute levodopa challenge in comparison with patients with PD and healthy volunteers (HVs). METHOD...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181f4d78f
更新日期:2010-09-28 00:00:00
abstract::We performed magnetic resonance imaging (MRI), before and after the administration of gadolinium-DTPA (Gd-DTPA), in 23 patients with medically refractory partial epilepsy who subsequently had surgical treatment for their seizure disorder. In most patients, 61%, unenhanced and enhanced MRI studies were negative. In 26%...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.8.1115
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:Microvascular brain injury, typically measured by extent of white matter hyperintensity (WMH) on MRI, is an important contributor to cognitive impairment in the elderly. Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease. METHODS:The auth...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000191403.95453.6a
更新日期:2006-01-10 00:00:00
abstract:OBJECTIVE:To analyze the frequency of neurologic events during commercial airline flights and to assess whether onboard emergency medical kits are adequate for in-flight neurologic emergencies. METHODS:Collaboration of the Mayo Clinic's Departments of Emergency Medicine and Medical Transportation Service and the Divis...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.58.12.1739
更新日期:2002-06-25 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of opicapone as add-on to levodopa and the effects of switching from entacapone over 1 year of treatment in patients with fluctuating Parkinson disease. METHODS:After completion of a placebo- and entacapone-controlled double-blind study of opicapone (5, 25, or 50 mg), 495 patien...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005557
更新日期:2018-05-22 00:00:00
abstract::Ullrich disease is a form of congenital muscular dystrophy characterized clinically by generalized muscle weakness, contractures of the proximal joints, and hyperflexibility of the distal joints from birth or early infancy. Recently, mutations of the collagen VI gene have been associated with Ullrich disease. The auth...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.6.920
更新日期:2002-09-24 00:00:00
abstract:OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31829c5ed5
更新日期:2013-07-23 00:00:00
abstract::A 12-year-old girl developed simple partial motor and sensory seizures due to a right perirolandic astrocytoma. Subdural EEG recording and functional stimulation disclosed close correlation between EEG-clinical manifestations of focal seizures and functional responses to cortical stimulation. This case supports the id...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.3.642
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVE:Given the limited information on cognitive function before Parkinson disease (PD) clinical onset in the general population, we sought to assess prodromal PD (pPD) probability and relate it to detailed cognitive performance in a community cohort. METHODS:In a population-based cohort of 1,629 dementia-free and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007453
更新日期:2019-05-07 00:00:00
abstract:OBJECTIVE:To examine the relation of nonsteroidal anti-inflammatory drugs (NSAIDs) to incident Alzheimer disease (AD), change in cognition, and AD pathology. METHODS:Participants were 1,019 older Catholic clergy followed up annually for up to 12 years (mean baseline age = 75.0 years, education = 18.1 years, Mini-Menta...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000313813.48505.86
更新日期:2008-06-03 00:00:00
abstract::Four patients developed postural tremor after ingestion of sodium valproate. The tremor was recorded by a variable-capacitance transducer and was of the "benign essential" type. The dosages of sodium valproate varied between 1000 mg and 2000 mg daily and serum levels were between 34.9 microgram per milliliter and 154....
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.8.1177
更新日期:1979-08-01 00:00:00
abstract::Cerebral cavernous malformations (CCM) are CNS vascular anomalies associated with seizures, headaches, and hemorrhagic strokes. The CCM1 gene was screened in 35 sporadic cases with either single or multiple CCM. It was found that 29% of the individuals with multiple CCM have a CCM1 mutation, whereas cases with only on...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000118299.55857.bb
更新日期:2004-04-13 00:00:00
abstract::There is evidence that treatment with an antibody to tumor necrosis factor alpha (TNF alpha) improves an animal model of multiple sclerosis (MS) and is beneficial in two systemic inflammatory disease in humans, but there are no reports about anti-TNF treatment of MS. Therefore, we treated two rapidly progressive MS pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.6.1531
更新日期:1996-12-01 00:00:00
abstract::We describe a case of West Nile virus (WNV) infection in an HIV-infected patient who presented with an isolated flaccid monoparesis of the right upper extremity. To our knowledge, this is the first reported case of flaccid paralysis caused by WNV infection in an HIV-infected patient. We then review the medical literat...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000253223.07720.bb
更新日期:2007-02-13 00:00:00
abstract::This paper reviews the issue of hepatotoxicity with the use of the catechol-O-methly transferase (COMT) inhibitors tolcapone and entacapone. Neither drug caused hepatotoxicity in preclinical toxicity testing. However, in clinical trials of tolcapone, liver chemistry tests were elevated more than 3 times above the uppe...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::A decade of empirical work in brain imaging, genomics, and other areas of research has yielded new knowledge about the frequency of incidental findings, investigator responsibility, and risks and benefits of disclosure. Straightforward guidance for handling such findings of possible clinical significance, however, has...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000280469.17461.94
更新日期:2008-01-29 00:00:00
abstract:OBJECTIVES:1) To reassess the prevalence of migraine in the United States; 2) to assess patterns of migraine treatment in the population; and 3) to contrast current patterns of preventive treatment use with recommendations for use from an expert headache panel. METHODS:A validated self-administered headache questionna...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000252808.97649.21
更新日期:2007-01-30 00:00:00
abstract::In an attempt to determine the opinions and practices of neurologists regarding the use of antithrombotic drugs in the treatment of acute ischemic stroke, we conducted a survey of 349 randomly selected neurologists from throughout the United States. Responses were received from 247 (71%), and 219 identified themselves...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.12.1631
更新日期:1989-12-01 00:00:00