Abstract:
:Ullrich disease is a form of congenital muscular dystrophy characterized clinically by generalized muscle weakness, contractures of the proximal joints, and hyperflexibility of the distal joints from birth or early infancy. Recently, mutations of the collagen VI gene have been associated with Ullrich disease. The authors report on a boy with Ullrich disease who has complete deficiency of collagen VI and harbors compound heterozygous mutations in the collagen VI alpha 2 gene. Absence of microfibrils on EM, together with normal collagen fibrils and basal lamina, suggests that loss of a link between interstitium and basal lamina may be a new molecular pathomechanism of muscular dystrophy.
journal_name
Neurologyjournal_title
Neurologyauthors
Ishikawa H,Sugie K,Murayama K,Ito M,Minami N,Nishino I,Nonaka Idoi
10.1212/wnl.59.6.920subject
Has Abstractpub_date
2002-09-24 00:00:00pages
920-3issue
6eissn
0028-3878issn
1526-632Xjournal_volume
59pub_type
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