Abstract:
:It is generally believed that a diet high in carbohydrate improves exercise tolerance in patients with carnitine palmitoyltransferase II (CPT II) deficiency, but it has never been systematically investigated. The authors investigated the effect of a high- vs low-carbohydrate diet on exercise tolerance in four patients with CPT II, who cycled at a constant workload of 50% of VO2max. Exercise tolerance, assessed by exercise duration and perceived exertion, improved on the carbohydrate-rich diet.
journal_name
Neurologyjournal_title
Neurologyauthors
Ørngreen MC,Ejstrup R,Vissing Jdoi
10.1212/01.wnl.0000078195.05396.20subject
Has Abstractpub_date
2003-08-26 00:00:00pages
559-61issue
4eissn
0028-3878issn
1526-632Xjournal_volume
61pub_type
临床试验,杂志文章,随机对照试验相关文献
NEUROLOGY文献大全abstract::To assess the role of current weekly alcohol consumption as a risk factor for cerebral infarction, we administered a pretested questionnaire to 205 middle-aged and elderly acute ischemic stroke patients and 410 outpatient controls matched by age, sex, race, and method of hospital payment. The frequency of hypertension...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.3.339
更新日期:1989-03-01 00:00:00
abstract::We performed brain MRIs on 21 patients with CNS sarcoidosis. Brain CTs were performed in 18 of these. Parenchymal lesions were seen in 17 of 21 with MRI, compared with 9 of 18 with CT. MRI detected a greater number of parenchymal lesions in cases where both CT and MRI were positive, and some lesions appeared more exte...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.3.378
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:To report long-term safety and efficacy outcomes of a large cohort of patients with medically refractory isolated dystonia treated with subthalamic nucleus (STN) deep brain stimulation (DBS). METHODS:Twenty patients (12 male, 8 female; mean age 49 ± 16.3 years) with medically refractory isolated dystonia wer...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003451
更新日期:2017-01-03 00:00:00
abstract::We describe a 43-year-old neurologically intact patient who reported episodes of diplopia and oscillopsia associated with a right-beating nystagmus and a skew deviation. These symptoms and signs were related to a left posterior epileptic EEG discharge. We suggest that these ocular motor signs derived from an ictal act...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.5.1469
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To investigate the genetic and physiologic basis of the neuromuscular symptoms of hypotonia-cystinuria syndrome (HCS) and isolated PREPL deficiency, and their response to therapy. METHODS:We performed molecular genetic, histochemical, immunoblot, and ultrastructural studies, investigated neuromuscular transm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000295
更新日期:2014-04-08 00:00:00
abstract::Using the centralized diagnostic data resource for the population of Rochester, Minnesota, we determined the prevalence of medically diagnosed dementia for this community. There were 289 individuals with dementia who were residing in Rochester on January 1, 1975: 208 women and 81 men. The overall age- and sex-adjusted...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.6.773
更新日期:1989-06-01 00:00:00
abstract::Studies of automobile accident frequency among drivers with AD have yielded conflicting results about the risk of accidents. To develop a practice parameter regarding driving and AD the authors performed a systematic review of the literature. The authors identified well-designed, controlled studies of driving and AD u...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.54.12.2205
更新日期:2000-06-27 00:00:00
abstract::We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson's disease (5) and parkinsonism with dementia (PD) (5). We found similar, but less extensive, pathology in the substantia nigra of six of ni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.8.1285
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:To visualize the sites involved in audiovestibular dysfunction during bacterial meningitis in adults and to relate these findings to the extent of hearing impairment and vestibular dysfunction. BACKGROUND:Hearing impairment is among the most frequent complications of bacterial meningitis. METHODS:High-resol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.5.1003
更新日期:1999-03-23 00:00:00
abstract::A 60-year-old man presented with progressive large fiber sensory loss in the right first three fingers and, to a lesser extent, in both fourth and fifth fingers. Electrophysiologic studies were characteristic of chronic sensory demyelinating polyneuropathy, a variant of chronic inflammatory demyelinating polyneuropath...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.1.253
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:To examine the long-term cognitive trajectories of individuals with normal cognition at baseline and distinct amyloid/tau/neurodegeneration (ATN) profiles. METHODS:Pooling data across 4 cohort studies, 814 cognitively normal participants (mean baseline age = 59.6 years) were classified into 8 ATN groups usin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007248
更新日期:2019-04-02 00:00:00
abstract::Three neuropathologists evaluated brain sections from 43 aged subjects for the presence of Alzheimer's disease. Moderate-to-substantial agreement was obtained. After discussion of disparate diagnoses, agreement was almost perfect for standardized and substantial for personal criteria. We conclude that reproducibility ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.2.329
更新日期:1992-02-01 00:00:00
abstract::We treated 36 patients with motor fluctuations and dyskinesias on chronic levodopa therapy with cabergoline (CBG) once a day for a mean period of 14.2 +/- 5.8 months. There was a significant increase in the "on" hours and a reduction in "off-period" dystonia. Ten patients continued to show a marked improvement after 2...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.12.2587
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To determine whether, and to what degree, preclinical Alzheimer disease (AD) confounds studies of healthy aging where "healthy" is based on cognitive normality alone. METHODS:We examined the effects of preclinical AD in cognitively normal older individuals using resting-state functional connectivity MRI. We ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000939
更新日期:2014-10-28 00:00:00
abstract::We report longitudinal data on a group of 29 male patients 50 years of age or older who were initially diagnosed as having idiopathic REM sleep behavior disorder (RBD) after extensive polysomnographic and neurologic evaluations. Thirty-eight percent (11/29) were eventually diagnosed as having a parkinsonian disorder (...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.2.388
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Optimal treatment remains uncertain for patients with cognitive impairment that persists or returns after standard IV antibiotic therapy for Lyme disease. METHODS:Patients had well-documented Lyme disease, with at least 3 weeks of prior IV antibiotics, current positive IgG Western blot, and objective memory...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.WNL.0000284604.61160.2d
更新日期:2008-03-25 00:00:00
abstract:BACKGROUND:The cytokine interferon beta (IFNbeta) is successfully used in the treatment of multiple sclerosis (MS), although there is a high degree of variability in the response. A common mechanism involved in the modulation of responsiveness to cytokines is represented by regulation of their receptor expression throu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000327340.50284.8d
更新日期:2008-12-09 00:00:00
abstract:OBJECTIVE:To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity. METHODS:We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity. RESULTS:A single session of 1 Hz rTM...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000257818.16952.62
更新日期:2007-03-27 00:00:00
abstract::We report the cases of three siblings homozygous for a mutated transthyretin (TTR) gene that causes type I familial amyloidotic polyneuropathy (FAP), in whom we made the diagnosis by identifying both the mutated TTR gene and a variant TTR in their sera. Their serum levels for the variant TTR are twice those of patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.10.2045
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To determine the role of circulating microvesicles (MV) on long-term cardiovascular outcomes after stroke, we measured them in patients with first-ever stroke with a 3-year follow-up. METHODS:In the Prospective Cohort With Incident Stroke Berlin (PROSCIS-B), patients with first-ever ischemic stroke were foll...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011223
更新日期:2020-11-12 00:00:00
abstract:OBJECTIVE:The authors imaged the medial longitudinal fasciculus (MLF) in 58 patients with MS and chronic internuclear ophthalmoparesis (INO) to determine which MRI technique best shows the characteristic lesion associated with this ocular motor syndrome. METHODS:Using quantitative infrared oculography, the authors det...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.5.762
更新日期:2001-09-11 00:00:00
abstract:OBJECTIVE:To identify independent predictors of clinical or cerebral lesion progression in a large sample of adult patients with moyamoya angiopathy (MMA) prior to decisions regarding revascularization surgery. METHODS:Ninety participants (median age, 37.5 years) were assessed at baseline and followed for a median tim...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007819
更新日期:2019-07-23 00:00:00
abstract::The disease locus for the clinically heterogeneous childhood spinal muscular atrophies (SMA) maps to the chromosome 5 subregion, 5q11.2-13.3. The beta-subunit of beta-D-N-acetylhexosaminidase (hexosaminidase) (EC 3.2.1.52) (Hex B) maps to the same region, and the protein required for substrate recognition by this enzy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.9.1418
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Hereditary neuralgic amyotrophy (HNA) is an autosomal-dominant disorder associated with recurrent, episodic, painful, brachial neuropathy. The gene for HNA has been mapped to chromosome 17q25. Characteristic features including hypotelorism, short stature, and cleft palate occur in some patients. OBJECTIVE:T...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.11.1963
更新日期:2001-12-11 00:00:00
abstract::To gain insight into the historical features relevant to the diagnosis of cardiac embolic strokes, we studied the 1,290 patients with cerebral infarcts in the NINCDS Stroke Data Bank. Based solely on the presence of cardiac sources of embolism, we divided the patients into groups of high (n = 250), medium (n = 166), a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.2.281
更新日期:1990-02-01 00:00:00
abstract::We investigated levodopa intravenous infusion rates, plasma concentrations, and clinical responses in 23 parkinsonian patients with a fluctuating response to the drug. There was a linear relationship between rate of levodopa infusion and plasma concentration when carbidopa was coadministered. Minimum-therapeutically e...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.6.739
更新日期:1986-06-01 00:00:00
abstract::We evaluated four formulas for estimating the intra-blood-brain barrier (IBBB) synthesis of IgG in a computer model of two types of BBB damage and in 1,629 consecutively received pairs of CSF and serum. These four formulas were the IgG synthesis rate (SR), IgG(loc) (ie, local), IgG index, and IgG extended index. Resul...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.3.510
更新日期:1992-03-01 00:00:00
abstract::We performed a randomized double-blind crossover therapeutic bioequivalency study of a generic (Epitol) versus a brand name (Tegretol) carbamazepine product under steady-state conditions in 40 epileptic patients. Each patient received 90-day supplies of Epitol or Tegretol and placebo, which replaced the usual dosage o...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.42.6.1147
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVE:To report outcomes of pregnancies that occurred during the fingolimod clinical development program. METHODS:Pregnancy outcomes from phase II, phase III, and phase IV clinical studies (with optional extensions) were reported by clinical trial investigators. Fingolimod exposure in utero was defined as fingolim...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000137
更新日期:2014-02-25 00:00:00
abstract:OBJECTIVES:The aim of the current study was, first, to determine the critical causative vestibular areas that in exceptional cases manifest with transient vertigo or dizziness in acute strokes of the middle cerebral artery, and second, to try to explain why in most cases unilateral lesions of these areas manifest witho...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0000000000001501
更新日期:2015-04-21 00:00:00