Abstract:
:We treated 36 patients with motor fluctuations and dyskinesias on chronic levodopa therapy with cabergoline (CBG) once a day for a mean period of 14.2 +/- 5.8 months. There was a significant increase in the "on" hours and a reduction in "off-period" dystonia. Ten patients continued to show a marked improvement after 28.3 months of treatment (mean dose, 11.3 +/- 4.5 mg). In 23 patients, increased dyskinesias (daily CBG dose, 11 +/- 4.3 mg) had complicated the positive effect after 17.2 +/- 4.8 months. Three patients (daily CBG dose, 14.3 mg) were therapeutic failures, and administration of CBG was stopped. Side effects leading to CBG discontinuation were visual hallucinations (n = 5), heart failure (n = 5), and nausea and vomiting (n = 1). Plasma CBG levels, measured in seven patients taking 3, 5, or 7 mg daily (po), showed fairly stable concentrations throughout the 24 hours. We concluded that CBG is an efficient dopamine agonist that can provide continuous dopaminergic stimulation when taken orally once a day.
journal_name
Neurologyjournal_title
Neurologyauthors
Lera G,Vaamonde J,Rodriguez M,Obeso JAdoi
10.1212/wnl.43.12.2587subject
Has Abstractpub_date
1993-12-01 00:00:00pages
2587-90issue
12eissn
0028-3878issn
1526-632Xjournal_volume
43pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:BACKGROUND:Idiopathic REM sleep behavior disorder (RBD) is characterized by loss of atonia during REM sleep, resulting in motor activity during dreams. Studies estimate that approximately half of patients with RBD will eventually develop Parkinson disease (PD), so RBD may be an indicator of presymptomatic PD. Several p...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000203648.80727.5b
更新日期:2006-03-28 00:00:00
abstract::Previous studies have suggested that an abnormal release of potassium from muscle may accompany attacks of paramyotonic weakness. We investigated 3 patients with paramyotonia congenita before and after the induction of forearm muscle weakness by exercise in cold water. Two of these patients had paralysis periodica par...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.7.952
更新日期:1989-07-01 00:00:00
abstract::Use of neuroleptic medications is common among elderly patients. Using multivariate models, the authors found that use of antipsychotic medications, age, and disability were strong predictors of developing self-reported Parkinson disease (PD) in the subsequent year among 1992 to 2000 Medicare Current Beneficiary Surve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000203348.13337.89
更新日期:2006-03-28 00:00:00
abstract::We tested the effect of bovine cortex phosphatidylserine (BC-PS), a membrane phospholipid known to inhibit the release of the cytokine tumor necrosis factor (TNF), in SJL/J mice sensitized for adoptively transferred experimental autoimmune encephalomyelitis (EAE). Control, sensitized mice developed severe clinical and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.1_part_1.153
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD). METHODS:Twenty-year follow-up data from the Kuopio Osteoporosis Risk Factor and Prevention study cohort were used. Self-administered questionnaires were sent to all women aged 47-56 years, residing in Kuopio Pr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003696
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:Brodmann brain maps, assembled in 1909, are still in use, but understanding of their animal-human homology is uncertain. Furthermore, in 1909, Brodmann did not identify human area 12 (BA12), a location now important to understanding of frontotemporal lobar degeneration (FTLD). METHODS:We re-examined Brodman...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0b013e3182190cd8
更新日期:2011-05-03 00:00:00
abstract:BACKGROUND:Breastfeeding is known to have beneficial effects, but there is concern that breastfeeding during antiepileptic drug (AED) therapy may be harmful to cognitive development. Animal and human studies have demonstrated that some AEDs can adversely affect the immature brain. However, no investigation has examined...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e3181ffe4a9
更新日期:2010-11-30 00:00:00
abstract::A 33-year-old man with complex partial seizures developed de novo hypertension after the initiation of carbamazepine, which resolved on discontinuation. Although rare, a variety of cardiovascular effects including hypertension have been reported with carbamazepine. Numerous mechanisms may be responsible; however, shar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.2.275
更新日期:2002-07-23 00:00:00
abstract::Lubag (X-linked dystonia-parkinsonism) has been considered a sex-linked recessive trait and has been mapped to the pericentromeric region of the X chromosome. We studied a 54-year-old man with lubag and two of his female first cousins. Genetic typing was carried out using X chromosome markers. Fluorodopa PET was perfo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.8.1555
更新日期:1993-08-01 00:00:00
abstract::To elucidate the possible role of vitamin E in the pathogenesis of Parkinson's disease (PD), we compared serum levels of alpha-tocopherol (vitamin E), measured by high-performance liquid chromatography, and the vitamin E/cholesterol ratio of 42 Parkinson's disease (PD) patients using their spouses as the control group...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.5.1064
更新日期:1992-05-01 00:00:00
abstract::We studied two patients with Meige syndrome who developed alpha-methyldopa-induced parkinsonism. Opposite responses of parkinsonian and dystonic symptoms to antiparkinson drugs in some cases suggest a functionally reciprocal relationship between these disorders. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.11.1668
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinical, electrophysiologic, and treatment outcome features of orthostatic tremor (OT) in a large case series. METHODS:We performed medical record review of 184 patients who met clinical and electrodiagnostic criteria for OT from 1976 to 2013 at the Mayo Clinic. Demographic, clinical, electr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002328
更新日期:2016-02-02 00:00:00
abstract::Several drugs that inhibit the effects of serotonin may reduce or prevent experimental CNS ischemic damage, but these drugs are not approved for human use in the United States. Administration of cyproheptadine (which is available for clinical use) 15 minutes before or 5 minutes after the onset increased the duration o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.4.584
更新日期:1985-04-01 00:00:00
abstract::Many studies have demonstrated that dipyridamole is not purely an antiplatelet agent but also exerts its antithrombotic properties through the vessel wall. Using a laboratory model in which bovine endothelial cells are seeded to form a subendothelial matrix (SEM), investigators have shown that dipyridamole enhances th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.suppl_2.s20
更新日期:2001-01-01 00:00:00
abstract::We previously compared the diagnostic capabilities of MRI of the head with CT, evoked potentials, and CSF oligoclonal banding (OB) analysis in a prospective evaluation of 200 patients with suspected multiple sclerosis (MS). To examine the ability of MRI and other paraclinical tests to predict the diagnosis of clinical...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.5.657
更新日期:1991-05-01 00:00:00
abstract::Rats were intoxicated with acrylamide monomer at 50 mg per kilogram per day; lumbar dorsal root ganglia and distal sural and tibial nerves were studied morphologically. At the sixth day of intoxication, large and small neuronal cell bodies showed a spectrum of remodeling changes that included nuclear eccentricity, cyt...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.9.1023
更新日期:1982-09-01 00:00:00
abstract::IV immunoglobulin therapy can lead to vascular events through increased serum viscosity and possibly other mechanisms. The authors describe the successful use of tissue plasminogen activator in three of four patients who developed cerebral and peripheral arterial thrombosis after treatment with IV immunoglobulin. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000068334.04500.08
更新日期:2003-06-10 00:00:00
abstract:OBJECTIVE:To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of antiepileptic drugs (AE...
journal_title:Neurology
pub_type: 杂志文章,实务指引,评审
doi:10.1212/WNL.0b013e3181a6b325
更新日期:2009-07-14 00:00:00
abstract:BACKGROUND:Periodic paralyses and paramyotonia congenita are rare disorders causing disabling weakness and myotonia. Mutations in sodium, calcium, and potassium channels have been recognized as causing disease. OBJECTIVE:To analyze the clinical phenotype of patients with and without discernible genotype and to identif...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000143383.91137.00
更新日期:2004-11-09 00:00:00
abstract::Serum ratios of monoclonal immunoglobulin (Ig) to total protein, monoclonal immunoglobulin to albumin, CSF/serum Ig-albumin index, and CSF to serum monoclonal immunoglobulin were obtained in 21 patients with multiple myeloma and 2 with Waldenström's macroglobulinemia. Twelve patients (3 with CNS complications) showed ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.11.1411
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:To evaluate the time course of major vessel recanalization under IV thrombolysis in relation to functional outcome in acute ischemic stroke. METHODS:A total of 99 patients with an acute anterior circulation vessel occlusion who underwent IV thrombolysis were included. All patients had a standardized admissi...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/01.wnl.0000260604.26469.8e
更新日期:2007-04-24 00:00:00
abstract::Factors affecting osmotic fragility were studied in red blood cells of patients with Duchenne muscular dystrophy. The mean osmotic fragility (MOF), operationally defined as the NaCl concentration for 50% hemolysis, was found to be higher by 3.63 +/- 0.51 mM in Duchenne cells than in normal cells having an MOF of 60.1 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.7.726
更新日期:1980-07-01 00:00:00
abstract:BACKGROUND:Optimal treatment remains uncertain for patients with cognitive impairment that persists or returns after standard IV antibiotic therapy for Lyme disease. METHODS:Patients had well-documented Lyme disease, with at least 3 weeks of prior IV antibiotics, current positive IgG Western blot, and objective memory...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.WNL.0000284604.61160.2d
更新日期:2008-03-25 00:00:00
abstract::In the present study we compared the efficacy and safety of the new dopamine agonist cabergoline (CBG) with bromocriptine (BCR) in Parkinson's disease (PD). CBG has a very long half-life and can be administered as a single daily dose. Forty-four PD patients with uncontrolled motor fluctuations participated in the stud...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.47.3.785
更新日期:1996-09-01 00:00:00
abstract::Thyrotropin-releasing hormone (TRH) exerts many effects upon spinal cord function in animals, and may also play a role in human spinal cord function. We have used the technique of quantitative autoradiography to anatomically localize specific receptors for TRH within human spinal cord. Highest concentrations of TRH re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.3.328
更新日期:1985-03-01 00:00:00
abstract::Intramedullary cysticercosis of the spinal cord is rare; there have been only 26 previous cases. We describe a patient with low back pain, paraparesis, lumbosacral sensory loss, and signs of meningeal irritation. The clinical diagnosis was spinal cord tumor, but at surgery there was a cysticercus cyst within the lumbo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.11.1531
更新日期:1979-11-01 00:00:00
abstract::Successful screening for neuropathy in patients with diabetes is available using the 10 g Semmes-Weinstein monofilament (Mid-Delta Health Systems, Inc., Belzoni, MS) (touch/pressure sensation) and the Neurothesiometer (Horwell Scientific, London, UK; vibration perception threshold). In healthy volunteers and patients ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.59.4.611
更新日期:2002-08-27 00:00:00
abstract:BACKGROUND:In cerebral small vessel disease, the core MRI findings include white matter lesions (WML) and lacunar infarcts. While the clinical significance of WML is better understood, the contribution of lacunes to the rate of cognitive decline has not been established. This study investigated whether incident lacunes...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31821d752f
更新日期:2011-05-31 00:00:00
abstract:OBJECTIVE:To determine if progressive brain atrophy could be detected over 1- and 2-year intervals in relapsing MS, based on annual MR studies from the Multiple Sclerosis Collaborative Research Group (MSCRG) trial of interferon beta-1a (Avonex). METHODS:All subjects had mild to moderate disability, with baseline expan...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.53.1.139
更新日期:1999-07-13 00:00:00
abstract::We evaluated the therapeutic efficacy and toxicity of high-dose monotherapy, using carbamazepine or phenytoin, in patients with previously uncontrolled seizures. Treatment with a single drug was equal to or better than polypharmacy, but only a few patients became free of seizures. Toxicity was mild and associated with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.6.707
更新日期:1984-06-01 00:00:00