Abstract:
:We report the cases of three siblings homozygous for a mutated transthyretin (TTR) gene that causes type I familial amyloidotic polyneuropathy (FAP), in whom we made the diagnosis by identifying both the mutated TTR gene and a variant TTR in their sera. Their serum levels for the variant TTR are twice those of patients heterozygous for the gene, but two have late-onset FAP and the third is an elderly asymptomatic carrier. TTR abnormality is a necessary condition for the development of FAP, but there may be other factors that retard or prevent its clinical development.
journal_name
Neurologyjournal_title
Neurologyauthors
Yoshinaga T,Nakazato M,Ikeda S,Ohnishi Adoi
10.1212/wnl.42.10.2045subject
Has Abstractpub_date
1992-10-01 00:00:00pages
2045-7issue
10eissn
0028-3878issn
1526-632Xjournal_volume
42pub_type
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