Abstract:
:In a 20-year-old patient with the classic form of Pelizaeus-Merzbacher disease, electroencephalograms during wakefulness were moderately diffusely abnormal, and an overnight polygraphic sleep recording showed distorted nonrapid eye movement sleep patterns without vertex sharp waves, K-complexes, spindles, or positive occipital sharp transients. Rapid eye movement sleep could be identified. Cerebral responses evoked by light flashes, clicks, and electric stimulation of the median nerves were abnormal.
journal_name
Neurologyjournal_title
Neurologyauthors
Wilkus RJ,Farrell DFdoi
10.1212/wnl.26.11.1042subject
Has Abstractpub_date
1976-11-01 00:00:00pages
1042-5issue
11eissn
0028-3878issn
1526-632Xjournal_volume
26pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::The epsilon 4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer's disease (AD). Because dementia in AD and Parkinson's disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.7.1330
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:To critically re-evaluate cases diagnosed as adult neuronal ceroid lipofuscinosis (ANCL) in order to aid clinicopathologic diagnosis as a route to further gene discovery. METHODS:Through establishment of an international consortium we pooled 47 unsolved cases regarded by referring centers as ANCL. Clinical a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002943
更新日期:2016-08-09 00:00:00
abstract::Dysfunction of NADH: ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport chain has been linked to the pathogenesis of Parkinson's disease. While simple assays of complex I activity are unlikely to be useful in the preclinical detection of Parkinson's disease, other more sophisticated physical...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.41.5_suppl_2.34
更新日期:1991-05-01 00:00:00
abstract::Gamma hydroxybutyrate was administered to adult cats by intravenous infusion at varying dosages while an electroencephalogram (EEG) was recorded from electrodes placed stereotactically in the right and left hippocampus and thalamic intralaminar nucleus and from cortical electrodes. Blood cerebrospinal fluid samples we...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.1.51
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:To investigate the association of PD with preceding head trauma using a case-control study design. METHODS:The medical records-linkage system of the Rochester Epidemiology Project was used to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000068008.78394.2c
更新日期:2003-05-27 00:00:00
abstract::Previous studies reported that a 2- to 3-week course of IV cyclophosphamide plus adrenocorticotropic hormone (ACTH) induction can temporarily halt progressive MS for a period of 12 months in the majority of patients treated, after which reprogression occurs. The Northeast Cooperative Multiple Sclerosis Treatment Group...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.43.5.910
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:To characterize a brainstem location specific to coma-causing lesions, and its functional connectivity network. METHODS:We compared 12 coma-causing brainstem lesions to 24 control brainstem lesions using voxel-based lesion-symptom mapping in a case-control design to identify a site significantly associated w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003404
更新日期:2016-12-06 00:00:00
abstract:BACKGROUND:Krabbe disease (globoid cell leukodystrophy [GLD]) is an autosomal recessive lysosomal disorder affecting the central and peripheral nervous system. The authors performed MRS to characterize metabolic alterations and their regional variation in brain tissue in GLD in vivo. METHODS:Abnormalities of cerebral ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000049469.29011.e9
更新日期:2003-03-11 00:00:00
abstract::There are multiple difficulties in evaluating new treatments for multiple sclerosis (MS). The clinical diagnosis is imprecise, and the correlation between lesion and clinical dysfunction is incomplete. The neurologic evaluation is complex and lacks full precision. The course of MS is complex and has limited predictabi...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.30.7_part_2.8
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVE:To study the brain activation pattern of coexisting experimental ongoing pain and brush-evoked allodynia (pain evoked by innocuous brush) with the use of PET. BACKGROUND:Neuropathic pain usually has two essential phenomena: ongoing pain and brush-evoked allodynia, which coexist and may influence each other. ...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.57.10.1817
更新日期:2001-11-27 00:00:00
abstract::In the same family, the generalized or infantile form of acid maltase deficiency (glycogenosis type II, Pompe disease) and the muscular or adult-onset form affected different individuals. Autosomal-recessive inheritance for the two clinical forms was demonstrated in this family by assay of acid alpha-glucosidase in mu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.10.1209
更新日期:1981-10-01 00:00:00
abstract::Factors affecting osmotic fragility were studied in red blood cells of patients with Duchenne muscular dystrophy. The mean osmotic fragility (MOF), operationally defined as the NaCl concentration for 50% hemolysis, was found to be higher by 3.63 +/- 0.51 mM in Duchenne cells than in normal cells having an MOF of 60.1 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.7.726
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVE:To estimate the US commercially insured multiple sclerosis (MS) annual prevalence from 2008 to 2012. METHODS:The study was a retrospective analysis using PharMetrics Plus, a nationwide claims database for over 42 million covered US representative lives. Annual point prevalence required insurance eligibility ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002469
更新日期:2016-03-15 00:00:00
abstract:BACKGROUND:Galantamine is a reversible, competitive cholinesterase inhibitor that also allosterically modulates nicotinic acetylcholine receptors. These mechanisms of action provided the rationale for a therapeutic trial of galantamine in AD. METHODS:A 6-month, multicenter, double-blind trial was undertaken in 636 pat...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.54.12.2261
更新日期:2000-06-27 00:00:00
abstract:OBJECTIVE:To examine the relationship between the degree of handedness and hemispheric language dominance in patients with epilepsy. METHODS:The authors examined the relationship between degree of handedness and hemispheric language dominance in 174 epilepsy surgery candidates using the intracarotid amobarbital proced...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000219623.28769.74
更新日期:2006-06-27 00:00:00
abstract::We performed proton magnetic resonance spectroscopic imaging (1H-MRSI) in patients with motor neuron disease (MND) to evaluate the distribution and extent of cortical neuron damage or loss as reflected by decreased N-acetyl (NA) to creatine (Cr) resonance intensity ratios. We examined premotor (superior frontal gyrus)...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.44.10.1933
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVE:To demonstrate whether the cerebral hemispheres (language dominant versus nondominant) affect immune function differentially in humans by delineating the effects of resections for epilepsy surgery on T-cell indices. BACKGROUND:Cerebral lateralization has been postulated to affect immunomodulation. Differenti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.6.1183
更新日期:1999-04-12 00:00:00
abstract:OBJECTIVE:To investigate whether arginine methylation is altered in patients with amyotrophic lateral sclerosis (ALS) and how it affects disease severity, progression, and prognosis. METHODS:We compared the immunoreactivity of protein arginine methyltransferase 1 (PRMT1) and its products, asymmetric dimethylated prote...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007311
更新日期:2019-04-16 00:00:00
abstract:OBJECTIVE:To compare the efficacy, tolerability, and safety of IV methylprednisolone (IV MP) vs oral methylprednisolone (oMP) at equivalent high doses in patients with multiple sclerosis (MS) experiencing a recent relapse. METHODS:Patients with a clinical relapse within the previous 2 weeks and at least 1 gadolinium (...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e3181c3fd5b
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To validate the ability of a specifically developed cognitive risk score to identify patients at risk of poststroke neurocognitive disorders (NCDs) who are eligible for a comprehensive cognitive assessment. METHODS:After assessing 404 patients (infarct 91.3%) in the Groupe de Réflexion pour l'Evaluation Cogn...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006544
更新日期:2018-11-20 00:00:00
abstract::Three children with cerebral oligodendrogliomas causing partial complex or generalized seizures presented with completely normal neurologic examinations. CT showed low-density, nonenhancing surface lesions. Although these CT features are usually associated with infarcts or cysts, neoplasm was suspected because of irre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.6.806
更新日期:1983-06-01 00:00:00
abstract::Central nervous system disorders may cause obstructive sleep apnea, but this sleep-related breathing disorder is rarely associated with a structural abnormality of the medulla. We present a patient with obstructive apnea resulting from autopsy-proven syringobulbia-myelia. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.8.1046
更新日期:1983-08-01 00:00:00
abstract::We investigated 185 families with ALS for evidence of anticipation and mitochondrial inheritance. Although initial analysis demonstrated significant anticipation of age at death between generations in patients with familial ALS, further analysis demonstrated features of regression to the mean, suggesting that the perc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000160395.43761.AC
更新日期:2005-05-10 00:00:00
abstract:OBJECTIVE:To compare in the Vertebral Artery Ischaemia Stenting Trial (VIST) the risks and benefits of vertebral angioplasty and stenting with best medical treatment (BMT) alone for symptomatic vertebral artery stenosis. METHODS:VIST was a prospective, randomized, open-blinded endpoint clinical trial performed in 14 h...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000004385
更新日期:2017-09-19 00:00:00
abstract:OBJECTIVE:To investigate residual function of the motor cortex corresponding to the hand of the amputated arm (MCamp). METHODS:Focal transcranial magnetic stimulation (TMS) of MCamp was performed in 10 patients 22 to 52 years after arm amputation to inhibit tonic muscle contraction in the intact hand ipsilateral to co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.4.984
更新日期:2000-02-22 00:00:00
abstract::We investigated the effects of estrogen replacement therapy (ERT) on the risk of development of dementia in 87 women with Parkinson's disease without dementia (PDND), 80 women with Parkinson's disease with dementia (PDD), and 989 nondemented healthy women from the same community. ERT was protective for the development...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.50.4.1141
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To establish a variant of sporadic prion disease as the sporadic form of fatal familial insomnia (FFI). BACKGROUND:FFI is a recently described prion disease characterized clinically by severe sleep impairment, dysautonomia, and motor signs, and pathologically by atrophy of thalamic nuclei, especially the med...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.9.1757
更新日期:1999-06-10 00:00:00
abstract::Use of neuroleptic medications is common among elderly patients. Using multivariate models, the authors found that use of antipsychotic medications, age, and disability were strong predictors of developing self-reported Parkinson disease (PD) in the subsequent year among 1992 to 2000 Medicare Current Beneficiary Surve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000203348.13337.89
更新日期:2006-03-28 00:00:00
abstract::We investigated the activation of frontal and occipital cortical areas in 14 normal volunteers during voluntary saccades in light or dark and during imagined saccades using functional magnetic resonance imaging (FMRI) with electro-oculogram monitoring. Voluntary saccades in light or dark and imagined saccades led to a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.2.416
更新日期:1997-08-01 00:00:00
abstract::This cross-sectional mail survey evaluated the prevalence and predictors of unconventional therapy (UT) utilization among 569 community-based people with MS. One-third reported having visited a UT practitioner in the last 6 months. Utilizers tended to report at least one medical comorbidity, earn at least $50,000 a ye...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.3.626
更新日期:1999-02-01 00:00:00