Residual function in motor cortex contralateral to amputated hand.

abstract：:Conditioning stimuli to the coronal gyrus or periventricular gray matter inhibit the activity of spinal trigeminal neurons. Valproate decreased the corticofugal inhibition of the spinal trigeminal nucleus, as did ethosuximide, trimethadione, and imipramine. Valproate and ethosuximide also decreased the periventricular...

journal_title：Neurology

authors： Fromm GH,Glass JD,Chattha AS,Martinez AJ,Silverman M

更新日期：1980-02-01 00:00:00

abstract：:The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly i...

journal_title：Neurology

authors： Seripa D,Matera MG,D'Andrea RP,Gravina C,Masullo C,Daniele A,Bizzarro A,Rinaldi M,Antuono P,Wekstein DR,Dal Forno G,Fazio VM

更新日期：2004-05-11 00:00:00

abstract：:Nerve root stimulation may be employed in patients with motor neuron disease (MND) to rule out motor neuropathy with conduction block. The diagnostic utility of these studies is unknown, in part because the range of amplitude changes across nerve root segments in patients with active neuronal degeneration has not been...

journal_title：Neurology

authors： Raynor EM,Shefner JM,Ross MH,Logigian EL,Hinchey JA

更新日期：1998-06-01 00:00:00

abstract：:We studied two families with an unusual variant of neurofibromatosis (NF). The first family had spinal neurofibromas and café au lait spots (CLS), the second spinal neurofibromas without CLS. Other signs of NF1 or NF2, such as cutaneous tumors, Lisch nodules, or acoustic tumors, were absent. The inheritance pattern in...

journal_title：Neurology

authors： Pulst SM,Riccardi VM,Fain P,Korenberg JR

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVE:To determine the diagnostic accuracy and prognostic value of ¹⁸FDG-PET in a recent series of patients operated for intractable partial epilepsy associated with histologically proven Taylor-type focal cortical dysplasia (TTFCD) and negative MRI. METHODS:Of 23 consecutive patients (12 male, 7-38 years old) wit...

journal_title：Neurology

authors： Chassoux F,Rodrigo S,Semah F,Beuvon F,Landre E,Devaux B,Turak B,Mellerio C,Meder JF,Roux FX,Daumas-Duport C,Merlet P,Dulac O,Chiron C

更新日期：2010-12-14 00:00:00

abstract：OBJECTIVE:To estimate the prevalence of childhood ataxia resulting from both genetic and acquired causes. METHODS:A systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement. Five databases were searched for articles reporting a frequency measur...

journal_title：Neurology

authors： Musselman KE,Stoyanov CT,Marasigan R,Jenkins ME,Konczak J,Morton SM,Bastian AJ

更新日期：2014-01-07 00:00:00

abstract：OBJECTIVE:To determine the prevalence and clinical effect of ophthalmologic symptoms in patients with Parkinson disease (PD), compared with controls, using a standardized questionnaire. METHODS:In this observational, cross-sectional, multicenter study, 848 patients with PD and 250 healthy controls completed the Visual...

journal_title：Neurology

authors： Borm CDJM,Visser F,Werkmann M,de Graaf D,Putz D,Seppi K,Poewe W,Vlaar AMM,Hoyng C,Bloem BR,Theelen T,de Vries NM

更新日期：2020-04-07 00:00:00

abstract：OBJECTIVE:To evaluate the impact of early blood pressure (BP) changes on diffusion-weighted imaging (DWI) lesion evolution and clinical outcome in patients with stroke treated with IV tissue plasminogen activator (tPA). METHODS:We prospectively evaluated 80 patients with stroke with a documented middle cerebral artery...

journal_title：Neurology

authors： Delgado-Mederos R,Ribo M,Rovira A,Rubiera M,Munuera J,Santamarina E,Delgado P,Maisterra O,Alvarez-Sabin J,Molina CA

更新日期：2008-08-19 00:00:00

abstract：:An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution infl...

journal_title：Neurology

authors： Martinez JV,Mazziotti JV,Efron ED,Bonardo P,Jordan R,Sevlever G,Martinez M,Verbanaz SC,Salazar ZS,Pardal MF,Reisin R

更新日期：2006-11-14 00:00:00

abstract：:People with AD have deficient contrast sensitivity and impaired face discrimination. The authors presented photographs of unfamiliar faces of three different sizes to enhance the low, middle, or high facial frequency information (cycles per face). Patients with AD demonstrated normal discrimination of small faces only...

journal_title：Neurology

authors： Cronin-Golomb A,Cronin-Golomb M,Dunne TE,Brown AC,Jain K,Cipolloni PB,Auerbach SH

更新日期：2000-06-27 00:00:00

abstract：:Degenerative diseases of the CNS, such as stiff-person syndrome (SPS), progressive cerebellar ataxia, and Rasmussen encephalitis, have been characterized by the presence of autoantibodies. Recent findings in individuals with Batten disease and in animal models for the disorder indicate that this condition may be assoc...

journal_title：Neurology

authors： Pearce DA,Atkinson M,Tagle DA

更新日期：2004-12-14 00:00:00

abstract：OBJECTIVES:To describe the frequency of cervical arterial abnormalities in children with acute arterial ischemic stroke (AIS), to examine predictors of this, and to characterize observed abnormalities in terms of specific diagnoses. METHODS:Review of case notes of children with AIS (2002-2009) and analysis of their ne...

journal_title：Neurology

authors： Ganesan V,Cox TC,Gunny R

更新日期：2011-01-11 00:00:00

abstract：OBJECTIVE:To understand the experience and identify drivers and mitigating factors of burnout and well-being among US neurologists. METHODS:Inductive data analysis was applied to free text comments (n = 676) from the 2016 American Academy of Neurology survey of burnout, career satisfaction, and well-being. RESULTS:Re...

journal_title：Neurology

authors： Miyasaki JM,Rheaume C,Gulya L,Ellenstein A,Schwarz HB,Vidic TR,Shanafelt TD,Cascino TL,Keran CM,Busis NA

更新日期：2017-10-17 00:00:00

abstract：OBJECTIVE:To use a combined neurogenetic-neuroimaging approach to examine the functional consequences of preclinical dopaminergic nigrostriatal dysfunction in the human motor system. Specifically, we examined how a single heterozygous mutation in different genes associated with recessively inherited Parkinson disease a...

journal_title：Neurology

authors： van Nuenen BF,Weiss MM,Bloem BR,Reetz K,van Eimeren T,Lohmann K,Hagenah J,Pramstaller PP,Binkofski F,Klein C,Siebner HR

更新日期：2009-03-24 00:00:00

abstract：OBJECTIVE:To investigate the temporal relationship between inflammation and cerebral atrophy in a longitudinal study of 19 patients with relapsing-remitting multiple sclerosis (RRMS) using serial monthly contrast enhanced MRI examinations and monthly measurements of brain fractional volume (BFV) for an average of 4 (ra...

journal_title：Neurology

authors： Richert ND,Howard T,Frank JA,Stone R,Ostuni J,Ohayon J,Bash C,McFarland HF

更新日期：2006-02-28 00:00:00

abstract：OBJECTIVES:The Stroke-Thrombolytic Predictive Instrument (Stroke-TPI) predicts the probability of good and bad outcomes with and without recombinant tissue plasminogen activator (rtPA). We sought to rebuild and externally validate a simpler Stroke-TPI to support implementation in routine clinical care. METHODS:Using t...

journal_title：Neurology

authors： Kent DM,Ruthazer R,Decker C,Jones PG,Saver JL,Bluhmki E,Spertus JA

更新日期：2015-09-15 00:00:00

abstract：OBJECTIVE:To describe the clinical features and outcome of anti-NMDA receptor (NMDAR) encephalitis in patients ≥45 years old. METHOD:Observational cohort study. RESULTS:In a cohort of 661 patients with anti-NMDAR encephalitis, we identified 31 patients ≥45 years old. Compared with younger adults (18-44 years), older ...

journal_title：Neurology

authors： Titulaer MJ,McCracken L,Gabilondo I,Iizuka T,Kawachi I,Bataller L,Torrents A,Rosenfeld MR,Balice-Gordon R,Graus F,Dalmau J

更新日期：2013-09-17 00:00:00

abstract：:We used electrophysiologic methods in the diagnosis of torsion dystonia and the evaluation of therapy in a 7-year-old child. Electromyographic (EMG) activity patterns in five leg muscles were recorded during specific voluntary and passive movements as well as during gait. We found patterns of coactivation in leg muscl...

journal_title：Neurology

authors： Richards CL,Bédard PJ,Fortin G,Malouin F

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Recent studies demonstrated an excess of winter births in children with brain tumors and in adults with various neurologic or psychiatric diseases relative to the general population. OBJECTIVE:To investigate a possible association between month of birth and risk of brain tumors in adults using data from a l...

journal_title：Neurology

authors： Brenner AV,Linet MS,Shapiro WR,Selker RG,Fine HA,Black PM,Inskip PD

更新日期：2004-07-27 00:00:00

abstract：OBJECTIVE:To investigate whether the presence of cerebral microbleeds, which present as focal lesions on imaging, is associated with a diffuse loss of white matter microstructural integrity in the brain. METHODS:In the prospective, population-based Rotterdam Scan Study, a total of 4,493 participants underwent brain MR...

journal_title：Neurology

authors： Akoudad S,de Groot M,Koudstaal PJ,van der Lugt A,Niessen WJ,Hofman A,Ikram MA,Vernooij MW

更新日期：2013-11-26 00:00:00

abstract：:Forty-seven consecutive patients presenting acutely with repetitive symptoms indicative of anterior circulation ischemia ("crescendo" transient ischemic attacks) were evaluated to identify clinical features that might reliably predict the presence of significant stenosis, ulceration, or both in the presumably symptoma...

journal_title：Neurology

authors： Rothrock JF,Lyden PD,Yee J,Wiederholt WC

更新日期：1988-02-01 00:00:00

abstract：:Thirty-one (23%) of 137 patients treated for leptomeningeal metastases (LM) achieved a sustained off-therapy response of at least 6 months' duration following treatment by a standard protocol. Of the 31 patients, equal distribution was found among various tumors: lymphoma, 13/44 (29%); breast carcinoma, 10/51 (20%); a...

journal_title：Neurology

authors： Siegal T,Lossos A,Pfeffer MR

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:To identify modifying factors that preserve functional independence among individuals at high dementia risk. METHODS:Health and Retirement Study participants aged 65 years or older without baseline activities of daily living (ADL) limitations (n = 4,922) were interviewed biennially for up to 12 years. Dement...

journal_title：Neurology

authors： Rist PM,Capistrant BD,Wu Q,Marden JR,Glymour MM

更新日期：2014-04-29 00:00:00

abstract：OBJECTIVE:To estimate rate of progression from normal cognition or mild impairment to dementia, and to identify potential risk and protective factors for incident dementia, based on age at dementia onset in a prospective study of a population-based cohort (n = 1,982) aged 65 years and older. METHODS:Following the coho...

journal_title：Neurology

authors： Ganguli M,Lee CW,Snitz BE,Hughes TF,McDade E,Chang CC

更新日期：2015-01-06 00:00:00

abstract：:T lymphocytes may play a central role in MS. The search for more targeted immunosuppression than is currently available has led to recent clinical trials of novel therapeutics. We studied 29 patients in a double-blind placebo-controlled trial of the chimeric monoclonal anti-CD4 antibody, cM-T412 (Centocor, Leiden, Hol...

journal_title：Neurology

authors： Llewellyn-Smith N,Lai M,Miller DH,Rudge P,Thompson AJ,Cuzner ML

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESUL...

journal_title：Neurology

authors： Hu G,Jousilahti P,Nissinen A,Antikainen R,Kivipelto M,Tuomilehto J

更新日期：2006-12-12 00:00:00

abstract：BACKGROUND:Patients with Parkinson disease (PD) may present with various types of pain. In some instances, no cause can be identified and pain is considered a primary disorder (primary central pain [PCP]). We hypothesized that PCP in patients with PD (PD-PCP) may be due to a dysfunction of pain pathways or the processi...

journal_title：Neurology

authors： Schestatsky P,Kumru H,Valls-Solé J,Valldeoriola F,Marti MJ,Tolosa E,Chaves ML

更新日期：2007-12-04 00:00:00

abstract：OBJECTIVE:To assess the predominant type of cerebral small vessel disease (SVD) and recurrence risk in patients who present with a combination of lobar and deep intracerebral hemorrhage (ICH)/microbleed locations (mixed ICH). METHODS:Of 391 consecutive patients with primary ICH enrolled in a prospective registry, 75 (...

journal_title：Neurology

authors： Pasi M,Charidimou A,Boulouis G,Auriel E,Ayres A,Schwab KM,Goldstein JN,Rosand J,Viswanathan A,Pantoni L,Greenberg SM,Gurol ME

更新日期：2018-01-09 00:00:00

abstract：:Epilepsy is associated with a high rate of premature mortality from direct and indirect effects of seizures, epilepsy, and antiseizure therapies. Sudden unexpected death in epilepsy (SUDEP) is the second leading neurologic cause of total lost potential life-years after stroke, yet SUDEP may account for less than half ...

journal_title：Neurology

authors： Devinsky O,Spruill T,Thurman D,Friedman D

更新日期：2016-02-23 00:00:00

abstract：OBJECTIVE:To determine whether patients with Alzheimer disease (AD) compensate for neuropathologic changes when performing a mnemonic task by recruiting 1) the same brain regions as age-matched, healthy controls, but to a greater extent; 2) additional brain regions not activated by controls; or 3) both. METHODS:Twelve...

journal_title：Neurology

authors： Gould RL,Arroyo B,Brown RG,Owen AM,Bullmore ET,Howard RJ

更新日期：2006-09-26 00:00:00