Postmenopausal estrogen use and Parkinson's disease with and without dementia.

abstract：:The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory loss followed by good recovery. A return of activation in ipsilesional primary and bilateral secondary somatosensory cortic...

journal_title：Neurology

authors： Carey LM,Abbott DF,Puce A,Jackson GD,Syngeniotis A,Donnan GA

更新日期：2002-09-10 00:00:00

abstract：:Essential tremor (ET) is a common movement disorder that often causes functional disability, potentially leading to physical and emotional difficulties. The paucity of data available regarding the underlying pathophysiologic mechanism of ET hinders the development of innovative approaches to pharmacotherapeutic treatm...

journal_title：Neurology

authors： Koller WC,Hristova A,Brin M

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To determine whether the pathologic mechanisms of AD alter the brain networks subserving performance of a verbal recognition task. BACKGROUND:Functional imaging studies comparing task-related activation in AD patients and controls generally have not used network analysis and have not controlled for task diff...

journal_title：Neurology

authors： Stern Y,Moeller JR,Anderson KE,Luber B,Zubin NR,DiMauro AA,Park A,Campbell CE,Marder K,Bell K,Van Heertum R,Sackeim HA

更新日期：2000-11-14 00:00:00

abstract：OBJECTIVE:To quantify disease progression in individuals with Duchenne muscular dystrophy (DMD) using magnetic resonance biomarkers of leg muscles. METHODS:MRI and magnetic resonance spectroscopy (MRS) biomarkers were acquired from 104 participants with DMD and 51 healthy controls using a prospective observational stu...

journal_title：Neurology

authors： Rooney WD,Berlow YA,Triplett WT,Forbes SC,Willcocks RJ,Wang DJ,Arpan I,Arora H,Senesac C,Lott DJ,Tennekoon G,Finkel R,Russman BS,Finanger EL,Chakraborty S,O'Brien E,Moloney B,Barnard A,Sweeney HL,Daniels MJ,Walter

更新日期：2020-04-14 00:00:00

abstract：:We tested the efficacy of coenzyme Q10 (ubidecarenone, CoQ10) therapy in patients with Kearns-Sayre syndrome and other mitochondrial myopathies with chronic progressive external ophthalmoplegia (CPEO). We treated seven patients for 1 year with daily oral administration of 120 mg of CoQ10. Throughout the treatment most...

journal_title：Neurology

authors： Bresolin N,Bet L,Binda A,Moggio M,Comi G,Nador F,Ferrante C,Carenzi A,Scarlato G

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVE:To determine the influence of all possible imaging strategies on the appropriateness ratings for carotid endarterectomy, because less accurate noninvasive techniques are replacing contrast angiography, which was used in the major efficacy trials. METHODS:An expert panel, using appropriateness methodology, ra...

journal_title：Neurology

authors： Kennedy J,Quan H,Ghali WA,Feasby TE

更新日期：2004-03-23 00:00:00

abstract：OBJECTIVE:To investigate the role of blocking antibodies in neonatal Guillain-Barré syndrome (GBS) occurring 12 days postpartum in a child born to a mother with ongoing GBS. METHODS:We studied plasma filtrate, purified IgG, and monovalent Fab fragments from the affected mother and serum from the neonate as well as ser...

journal_title：Neurology

authors： Buchwald B,de Baets M,Luijckx GJ,Toyka KV

更新日期：1999-10-12 00:00:00

abstract：OBJECTIVE:To determine whether changes in cerebral structure are present after preeclampsia that may explain increased cerebrovascular risk in these women. METHODS:We conducted a case control study in women between 5 and 15 years after either a preeclamptic or normotensive pregnancy. Brain MRI was performed. Analysis ...

journal_title：Neurology

authors： Siepmann T,Boardman H,Bilderbeck A,Griffanti L,Kenworthy Y,Zwager C,McKean D,Francis J,Neubauer S,Yu GZ,Lewandowski AJ,Sverrisdottir YB,Leeson P

更新日期：2017-03-28 00:00:00

abstract：:We evaluated the ability of nurse clinicians to assess parkinsonian signs in older persons with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS). After completing a structured training protocol, three nurse clinicians and a neurologist with expertise in movement disorders...

journal_title：Neurology

authors： Bennett DA,Shannon KM,Beckett LA,Goetz CG,Wilson RS

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:To investigate the possible association of persistent enterovirus (EV) infection with the development of ALS. BACKGROUND:Although ALS is a clinically well-defined motor neuron disease, little is known about the etiology and pathogenesis of the sporadic cases. Among the different causes that have been hypothe...

journal_title：Neurology

authors： Berger MM,Kopp N,Vital C,Redl B,Aymard M,Lina B

更新日期：2000-01-11 00:00:00

abstract：OBJECTIVE:To identify modifying factors that preserve functional independence among individuals at high dementia risk. METHODS:Health and Retirement Study participants aged 65 years or older without baseline activities of daily living (ADL) limitations (n = 4,922) were interviewed biennially for up to 12 years. Dement...

journal_title：Neurology

authors： Rist PM,Capistrant BD,Wu Q,Marden JR,Glymour MM

更新日期：2014-04-29 00:00:00

abstract：OBJECTIVE:The purpose of this cross-sectional study was to determine the prevalence and potential significance of stroke symptoms among end-stage renal disease (ESRD) patients without a prior diagnosis of stroke or TIA. METHODS:We enrolled 148 participants with ESRD from 5 clinics. Stroke symptoms and functional statu...

journal_title：Neurology

authors： Kurella Tamura M,Meyer JB,Saxena AB,Huh JW,Wadley VG,Schiller B

更新日期：2012-09-04 00:00:00

abstract：:Stuttering is an action-induced speech disorder with involuntary, audible, or silent repetitions or prolongations in the utterance of short speech elements (sounds, syllables) and words. Symptomatic treatment programs frequently have initial success; persistent benefit is variable and many patients remain disabled. St...

journal_title：Neurology

authors： Brin MF,Stewart C,Blitzer A,Diamond B

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:To investigate whether impaired spatial memory contributes to cognitive deficits in idiopathic cervical dystonia (ICD). METHODS:The authors tested 16 untreated patients with ICD and 16 healthy controls with four variants of a classic spatial memory task, in which subjects were requested to recall the locatio...

journal_title：Neurology

authors： Ploner CJ,Stenz U,Fassdorf K,Arnold G

更新日期：2005-05-24 00:00:00

abstract：:We measured the concentrations of the monoamines, their precursors, and their metabolites, and the activity of choline acetyltransferase (ChAT) in basal ganglia and cortical regions of postmortem brains from cases with histologically verified pure Alzheimer's disease (AD), AD with diffusely distributed Lewy bodies (Le...

journal_title：Neurology

authors： Langlais PJ,Thal L,Hansen L,Galasko D,Alford M,Masliah E

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Several studies indicate semantic fluency more sensitively discriminates patients with Alzheimer disease (AD) from normal elderly persons, with disproportionate impairment of semantic over phonemic fluency. OBJECTIVE:To determine the ability of abbreviated fluency measures in the clinic setting (1-minute le...

journal_title：Neurology

authors： Canning SJ,Leach L,Stuss D,Ngo L,Black SE

更新日期：2004-02-24 00:00:00

abstract：OBJECTIVE:There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. METHODS:We assessed a cohort of participants at r...

journal_title：Neurology

authors： Cubo E,Ramos-Arroyo MA,Martinez-Horta S,Martínez-Descalls A,Calvo S,Gil-Polo C,European HD Network.

更新日期：2016-08-09 00:00:00

abstract：BACKGROUND:Brodmann brain maps, assembled in 1909, are still in use, but understanding of their animal-human homology is uncertain. Furthermore, in 1909, Brodmann did not identify human area 12 (BA12), a location now important to understanding of frontotemporal lobar degeneration (FTLD). METHODS:We re-examined Brodman...

journal_title：Neurology

authors： Kawamura M,Miller MW,Ichikawa H,Ishihara K,Sugimoto A

更新日期：2011-05-03 00:00:00

abstract：OBJECTIVE:To investigate the association of PD with preceding head trauma using a case-control study design. METHODS:The medical records-linkage system of the Rochester Epidemiology Project was used to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched ...

journal_title：Neurology

authors： Bower JH,Maraganore DM,Peterson BJ,McDonnell SK,Ahlskog JE,Rocca WA

更新日期：2003-05-27 00:00:00

abstract：OBJECTIVE:To assess resting cerebral blood flow (CBF) in the whole-brain and cerebral white matter (WM) and gray matter (GM) of adults with Fabry disease (FD), using arterial spin labeling (ASL) MRI, and to investigate CBF correlations with WM hyperintensity (WMH) volume and the circulating biomarker lyso-Gb3. METHODS...

journal_title：Neurology

authors： Phyu P,Merwick A,Davagnanam I,Bolsover F,Jichi F,Wheeler-Kingshott C,Golay X,Hughes D,Cipolotti L,Murphy E,Lachmann RH,Werring DJ

更新日期：2018-04-17 00:00:00

abstract：:Central nervous system (CNS) dysfunction in patients with systemic lupus erythematosus (SLE) is highly variable, although it is often described under a single heading of "neuropsychiatric" or "CNS" SLE. To clarify these CNS abnormalities, we studied 91 lupus patients, 63 of whom had CNS symptoms or signs, over 599 pat...

journal_title：Neurology

authors： Futrell N,Schultz LR,Millikan C

更新日期：1992-09-01 00:00:00

abstract：:We retrospectively studied the effects of changing antiepileptic drug levels on patterns of seizure discharge in 8 patients investigated with intracerebral electrodes during presurgical evaluation. We compared seizures recorded at high levels of medication to seizures recorded at low levels for changes in seizure dura...

journal_title：Neurology

authors： So N,Gotman J

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:To distinguish, in patients with Korsakoff syndrome (KS), the structural brain abnormalities shared with alcoholic patients without KS (AL), from those specific to KS. METHODS:MRI data were collected in 11 alcoholic patients with KS, 34 alcoholic patients without KS, and 25 healthy control subjects (CS). Gra...

journal_title：Neurology

authors： Pitel AL,Chételat G,Le Berre AP,Desgranges B,Eustache F,Beaunieux H

更新日期：2012-04-24 00:00:00

abstract：OBJECTIVE:To track cognitive and language changes over time in patients with logopenic (lv-PPA) and semantic (sv-PPA) variants of primary progressive aphasia (PPA). METHODS:Thirteen consecutive patients with lv-PPA and 11 patients with sv-PPA underwent yearly evaluation for a mean of 3 years. Nineteen patients (11 lv-...

journal_title：Neurology

authors： Leyton CE,Hsieh S,Mioshi E,Hodges JR

更新日期：2013-03-05 00:00:00

abstract：:A 48-year-old woman became totally deaf after a head injury. Magnetic resonance imaging showed bilateral contusions around the inferior colliculi and the brainstem auditory evoked potentials (BAEP) failed to show any abnormality. This case demonstrates that small, symmetrical, bilateral lesions around the inferior col...

journal_title：Neurology

authors： Hu CJ,Chan KY,Lin TJ,Hsiao SH,Chang YM,Sung SM

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Abnormal insulin metabolism may contribute to the clinical symptoms and pathophysiology of AD. In vitro studies show that insulin enhances the release of beta-amyloid protein (Abeta) or inhibits its degradation, either of which might increase amyloid burden. METHODS:On separate mornings, 16 healthy older ad...

journal_title：Neurology

authors： Watson GS,Peskind ER,Asthana S,Purganan K,Wait C,Chapman D,Schwartz MW,Plymate S,Craft S

更新日期：2003-06-24 00:00:00

abstract：:We compared the neurologic and cognitive performance of 15 young veterans who suffered unilateral penetrating missile wounds to the basal forebrain 15 years ago in the Vietnam War with uninjured controls and patients with lesions elsewhere in the brain. The subjects performed worse on tests of episodic memory, reasoni...

journal_title：Neurology

authors： Salazar AM,Grafman J,Schlesselman S,Vance SC,Mohr JP,Carpenter M,Pevsner P,Ludlow C,Weingartner H

更新日期：1986-04-01 00:00:00

abstract：:Antibodies to myelin-associated glycoprotein (MAG) are found in patients with both monoclonal gammopathy and sensorimotor peripheral neuropathy but almost never in patients with amyotrophic lateral sclerosis (ALS). Ninety percent of patients with anti-MAG activity also have antibodies to sulfated glucuronic acid parag...

journal_title：Neurology

authors： Rowland LP,Sherman WL,Hays AP,Lange DJ,Latov N,Trojaborg W,Younger DS

更新日期：1995-04-01 00:00:00

abstract：:In this study, the 24-hour pattern of blood pressure (BP), heart rate, and urinary catecholamine (CA) excretion and the response of BP and plasma CA to the tilt test have been investigated in 13 untreated patients affected by Parkinson's disease (PD) and in 11 age-matched healthy controls. Seven of the 13 PD subjects ...

journal_title：Neurology

authors： Micieli G,Martignoni E,Cavallini A,Sandrini G,Nappi G

更新日期：1987-03-01 00:00:00

abstract：:Titus Lucretius Carus was an ancient Roman philosopher of the Epicurean school whose epic poem On the Nature of Things described numerous aspects of the natural world. In fact, much contemporary scientific understanding is consistent with or inspired by his work. Among Lucretius's contributions to neurology were his d...

journal_title：Neurology

authors： Hyam JA,Paterson DJ,Aziz TZ,Green AL

更新日期：2011-09-06 00:00:00