Autopsy-proven amyotrophic lateral sclerosis, Waldenström's macroglobulinemia, and antibodies to sulfated glucuronic acid paragloboside.

Abstract:

:Antibodies to myelin-associated glycoprotein (MAG) are found in patients with both monoclonal gammopathy and sensorimotor peripheral neuropathy but almost never in patients with amyotrophic lateral sclerosis (ALS). Ninety percent of patients with anti-MAG activity also have antibodies to sulfated glucuronic acid paragloboside (SGPG). We studied a patient with autopsy-proven ALS who had high titers of anti-SGPG but normal anti-MAG--one more unexplained immunologic abnormality in ALS.

journal_name

Neurology

journal_title

Neurology

authors

Rowland LP,Sherman WL,Hays AP,Lange DJ,Latov N,Trojaborg W,Younger DS

doi

10.1212/wnl.45.4.827

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

827-9

issue

4

eissn

0028-3878

issn

1526-632X

journal_volume

45

pub_type

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