Phase II study of monthly pasireotide LAR (SOM230C) for recurrent or progressive meningioma.

abstract：BACKGROUND:Oculopharyngodistal myopathy (OPDM) has been reported as a rare, adult-onset hereditary muscle disease with putative autosomal dominant and autosomal recessive inheritance. Patients with OPDM present with progressive ocular, pharyngeal, and distal limb muscle involvement. The genetic defect causing OPDM has ...

journal_title：Neurology

authors： Durmus H,Laval SH,Deymeer F,Parman Y,Kiyan E,Gokyigiti M,Ertekin C,Ercan I,Solakoglu S,Karcagi V,Straub V,Bushby K,Lochmüller H,Serdaroglu-Oflazer P

更新日期：2011-01-18 00:00:00

abstract：:The authors pooled four population-based European studies to determine the risk for institutionalization and death after stroke. Risk for institutionalization was assessed in 13,095 subjects. Survival was calculated for prevalent stroke in 7929 individuals and incident stroke in 8550 individuals. The adjusted risk of ...

journal_title：Neurology

authors： Schmidt R,Breteler MM,Inzitari D,Fratiglioni L,Hofman A,Launer LJ

更新日期：2000-01-01 00:00:00

abstract：:In a cohort of 337 patients with subarachnoid hemorrhage (SAH), we investigated the relationship between blood glucose levels, baseline characteristics, and outcome by means of Student's t-test and multivariate logistic regression. The mean glucose levels on admission and from day 1 to 10 were significantly higher in ...

journal_title：Neurology

authors： Dorhout Mees SM,van Dijk GW,Algra A,Kempink DR,Rinkel GJ

更新日期：2003-10-28 00:00:00

abstract：BACKGROUND:Given that vagal afferents project to brainstem regions that promote alertness, the authors tested the hypothesis that vagus nerve stimulation (VNS) would improve daytime sleepiness in patients with epilepsy. METHODS:Sixteen subjects with medically refractory seizures underwent polysomnography and multiple ...

journal_title：Neurology

authors： Malow BA,Edwards J,Marzec M,Sagher O,Ross D,Fromes G

更新日期：2001-09-11 00:00:00

abstract：INTRODUCTION:As clinical trials move toward earlier intervention, we sought to redefine the β-amyloid (Aβ)-PET threshold based on the lowest point in a baseline distribution that robustly predicts future Aβ accumulation and cognitive decline in 3 independent samples of clinically normal individuals. METHODS:Sequential...

journal_title：Neurology

authors： Farrell ME,Jiang S,Schultz AP,Properzi MJ,Price JC,Becker JA,Jacobs HIL,Hanseeuw BJ,Rentz DM,Villemagne VL,Papp KV,Mormino EC,Betensky RA,Johnson KA,Sperling RA,Buckley RF,Alzheimer's Disease Neuroimaging Initiative and t

更新日期：2021-01-26 00:00:00

abstract：OBJECTIVE:To model the temporal trajectory of β-amyloid accumulation using serial amyloid PET imaging. METHODS:Participants, aged 70-92 years, were enrolled in either the Mayo Clinic Study of Aging (n = 246) or the Mayo Alzheimer's Disease Research Center (n = 14). All underwent 2 or more serial amyloid PET examinatio...

journal_title：Neurology

authors： Jack CR Jr,Wiste HJ,Lesnick TG,Weigand SD,Knopman DS,Vemuri P,Pankratz VS,Senjem ML,Gunter JL,Mielke MM,Lowe VJ,Boeve BF,Petersen RC

更新日期：2013-03-05 00:00:00

abstract：:This article presents the findings relating to the European subgroup of 91 patients in an international survey of the current diagnosis and treatment of patients with amyotrophic lateral sclerosis (ALS). The mean time between first symptoms and first consultation with a physician was 4.9 months, and mean delay in seei...

journal_title：Neurology

authors： Dengler R

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To examine the role of mutations in GABRB3 encoding the β3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. METHODS:We performed massive parallel sequencing of GABRB3 in 416 patient...

journal_title：Neurology

authors： Møller RS,Wuttke TV,Helbig I,Marini C,Johannesen KM,Brilstra EH,Vaher U,Borggraefe I,Talvik I,Talvik T,Kluger G,Francois LL,Lesca G,de Bellescize J,Blichfeldt S,Chatron N,Holert N,Jacobs J,Swinkels M,Betzler C,Syr

更新日期：2017-01-31 00:00:00

abstract：:Restless legs syndrome (RLS) involves abnormal limb sensations that diminish with motor activity, worsen at rest, have a circadian peak in expression in the evening and at night, and can severely disrupt sleep. Primary treatment is directed at CNS dopaminergic systems, particularly activation of D(2)-like (D(2), D(3),...

journal_title：Neurology

authors： Clemens S,Rye D,Hochman S

更新日期：2006-07-11 00:00:00

abstract：BACKGROUND:On proton magnetic resonance spectroscopic imaging ((1)H MRSI), there is a decrease in cerebellar N-acetylaspartate/total creatine (NAA/tCr) in essential tremor (ET), signifying cerebellar neuronal dysfunction or degeneration. Harmane, which is present in the human diet, is a potent tremor-producing neurotox...

journal_title：Neurology

authors： Louis ED,Zheng W,Mao X,Shungu DC

更新日期：2007-08-07 00:00:00

abstract：:We tested three serotonin antagonists--lysergic acid diethylamide (LSD), 2-bromolysergic acid diethylamide (BOL), and cinanserin--for effects on experimental spinal cord ischemia in the rabbit. Blood flow to spinal cord was obstructed. Drugs were administered before or after initiation of occlusion, and flow was later...

journal_title：Neurology

authors： Zivin JA,Venditto JA

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVE:To investigate whether admission hyperglycemia predicts poststroke infections and, if so, whether poststroke infections modify the effect of admission hyperglycemia on functional outcome in ischemic stroke. METHODS:We used data from acute ischemic stroke patients in the Preventive Antibiotics in Stroke Study...

journal_title：Neurology

authors： Zonneveld TP,Nederkoorn PJ,Westendorp WF,Brouwer MC,van de Beek D,Kruyt ND,PASS Investigators.

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Biomarker levels in blood after traumatic brain injury (TBI) may offer diagnostic and prognostic tools in addition to clinical indices. This study aims to validate glial fibrillary acidic protein (GFAP) and S100B concentrations in blood as outcome predictors of TBI using cutoff levels of 1.5 μg/L for GFAP an...

journal_title：Neurology

authors： Vos PE,Jacobs B,Andriessen TM,Lamers KJ,Borm GF,Beems T,Edwards M,Rosmalen CF,Vissers JL

更新日期：2010-11-16 00:00:00

abstract：:We studied the length of stay needed to record a certain number of seizures in a highly selected group of patients with intractable epilepsy in the final stages of presurgical monitoring. The mean length of stay needed to record one seizure was 2.9 to 3.7 days, depending on the recording technique, 4.5 to 5.5 monitori...

journal_title：Neurology

authors： Todorov AB,Lesser RP,Uematsu SS,Yankov YA,Todorov AA Jr

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:To describe neural autoantibody profiles and outcomes in patients with neurologic autoimmunity associated with immune checkpoint inhibitor (ICI) cancer immunotherapy. METHODS:In this retrospective descriptive study, 63 patients with ICI-related neurologic autoimmunity were included: 39 seen at the Mayo Clini...

journal_title：Neurology

authors： Sechi E,Markovic SN,McKeon A,Dubey D,Liewluck T,Lennon VA,Lopez-Chiriboga AS,Klein CJ,Mauermann M,Pittock SJ,Flanagan EP,Zekeridou A

更新日期：2020-10-27 00:00:00

abstract：OBJECTIVE:To report pathologic findings in 124 Australian and North American cases of primary nemaline myopathy. METHODS:Results of 164 muscle biopsies from 124 Australian and North American patients with primary nemaline myopathy were reviewed, including biopsies from 19 patients with nemaline myopathy due to alpha-a...

journal_title：Neurology

authors： Ryan MM,Ilkovski B,Strickland CD,Schnell C,Sanoudou D,Midgett C,Houston R,Muirhead D,Dennett X,Shield LK,De Girolami U,Iannaccone ST,Laing NG,North KN,Beggs AH

更新日期：2003-02-25 00:00:00

abstract：:This double-blind, placebo-controlled, multicenter, crossover study investigated the efficacy and tolerability of sumatriptan administered for up to three separate migraine attacks. One hundred twenty adults received sumatriptan (SC, 6 mg; three attacks) and placebo (one attack). Patients completed questionnaires asse...

journal_title：Neurology

authors： Cady RK,Dexter J,Sargent JD,Markley H,Osterhaus JT,Webster CJ

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS:Patients with symptomatic nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic autonomic neuropathy underwent open-label droxidopa ...

journal_title：Neurology

authors： Kaufmann H,Freeman R,Biaggioni I,Low P,Pedder S,Hewitt LA,Mauney J,Feirtag M,Mathias CJ,NOH301 Investigators.

更新日期：2014-07-22 00:00:00

abstract：:The aim of this randomized, double-blind, placebo-controlled cross-over study was to test whether valproic acid relieves painful polyneuropathy. Thirty-one patients completed two treatment phases of 4 weeks' duration with valproic acid (1,500 mg daily) and placebo. There was no significant difference between valproic ...

journal_title：Neurology

authors： Otto M,Bach FW,Jensen TS,Sindrup SH

更新日期：2004-01-27 00:00:00

abstract：:We determined the gene frequencies for the alleles of the HLA-linked complement markers C2, properdin factor B (BF), C4A (Rodgers) and C4B (Chido), and the red cell enzyme glyoxalase-I in 38 unrelated patients with senile dementia of the Alzheimer type, 42 patients with idiopathic Parkinson's disease, and 59 unaffecte...

journal_title：Neurology

authors： Nerl C,Mayeux R,O'Neill GJ

更新日期：1984-03-01 00:00:00

abstract：:We evaluated 85 patients with serologic evidence of Borrelia burgdorferi infection. Manifestations included encephalopathy (41), neuropathy (27), meningitis (2), multiple sclerosis (MS) (6), and psychiatric disorders (3). We performed lumbar punctures in 53, brain MRI in 33, and evoked potentials (EPs) in 33. Only pat...

journal_title：Neurology

authors： Halperin JJ,Luft BJ,Anand AK,Roque CT,Alvarez O,Volkman DJ,Dattwyler RJ

更新日期：1989-06-01 00:00:00

abstract：:Postmortem studies of patients with progressive supranuclear palsy (PSP) have demonstrated loss of cholinergic neurons in the striatum, nucleus basalis of Meynert, and the pedunculopontine nucleus. These findings suggest that cholinergic drugs might be an effective treatment for this disease. We studied the efficacy o...

journal_title：Neurology

authors： Foster NL,Aldrich MS,Bluemlein L,White RF,Berent S

更新日期：1989-02-01 00:00:00

abstract：:This nested case-control study assessed the putative protective effect of human herpesvirus-8 (HHV-8) against HIV-1-related dementia (dementia). The HHV-8 seropositivity of 210 male age- and HIV disease stage-matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HI...

journal_title：Neurology

authors： Polk S,Muñoz A,Sacktor NC,Jenkins FJ,Cohen B,Miller EN,Jacobson LP

更新日期：2002-09-24 00:00:00

abstract：:The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of ma...

journal_title：Neurology

authors： Diav-Citrin O,Shechtman S,Arnon J,Ornoy A

更新日期：2001-07-24 00:00:00

abstract：:We assayed serum folate levels of 60 patients with chronic fatigue syndrome (CFS) and found that 50% had values below 3.0 micrograms/l. Some patients with CFS are deficient in folic acid. ...

journal_title：Neurology

authors： Jacobson W,Saich T,Borysiewicz LK,Behan WM,Behan PO,Wreghitt TG

更新日期：1993-12-01 00:00:00

abstract：:The mechanism by which prednisone improves muscle strength and function in Duchenne muscular dystrophy (DMD) is unknown. We addressed the possibility that clinical improvement was related to prednisone-induced alterations in skeletal muscle dystrophin. We performed muscle biopsies on patients at the conclusion of a ra...

journal_title：Neurology

authors： Burrow KL,Coovert DD,Klein CJ,Bulman DE,Kissel JT,Rammohan KW,Burghes AH,Mendell JR

更新日期：1991-05-01 00:00:00

abstract：:Diffusion-weighted MRI (DWI) was used in three patients with autopsy-proven sporadic Creutzfeldt-Jakob disease (CJD) to provide a rapid noninvasive way to make this sometimes confusing diagnosis. DWI prompted the diagnosis of CJD at an early stage and appears to be particularly useful for monitoring the progression of...

journal_title：Neurology

authors： Demaerel P,Heiner L,Robberecht W,Sciot R,Wilms G

更新日期：1999-01-01 00:00:00

abstract：:Dialysis encephalopathy is a progressive, fatal condition that occurs in patients receiving hemodialysis. It is characterized by abnormalities in speech, myoclonic jerks, and striking changes on the electroencephalogram. We observed dramatic reversal of the clinical symptoms and electroencephalographic abnormalities i...

journal_title：Neurology

authors： Nadel AM,Wilson WP

更新日期：1976-12-01 00:00:00

abstract：:A 41-year-old man presented with bilateral posterior cerebral artery infarcts. He had visual object agnosia and prosopagnosia with preservation of reading abilities. There was also defective visual memory, topographic orientation, and color perception, as well as simultanagnosia. From the clinical facts and CT finding...

journal_title：Neurology

authors： Gomori AJ,Hawryluk GA

更新日期：1984-07-01 00:00:00

abstract：:We describe a 66-year-old woman with long-standing HTLV-I-associated myelopathy who developed multiple parenchymal hemorrhages and whose angiogram suggested cerebral vasculitis. After cyclophosphamide and glucocorticoid therapy, both her acute deficits and chronic paraparesis improved. HTLV-I may be an etiologic agent...

journal_title：Neurology

authors： Smith D,Lucas S,Jacewicz M

更新日期：1993-02-01 00:00:00