MRI and neuropsychological differences in early- and late-life-onset geriatric depression.

abstract：:The authors report eight patients with primary dural lymphoma (PDL). All patients had extra-axial masses on MRI that diffusely enhanced after gadolinium. Pathology revealed low-grade non-Hodgkin lymphoma (marginal zone lymphoma of MALT [mucosa-associated lymphoid tissue] type) in all patients. All patients underwent r...

journal_title：Neurology

authors： Iwamoto FM,DeAngelis LM,Abrey LE

更新日期：2006-06-13 00:00:00

abstract：BACKGROUND:Patients with progressive supranuclear palsy (PSP) fall frequently, beginning early in the course of their disease. Abnormal vestibulospinal reflexes are suspected, but the angular vestibulo-ocular reflex, which is mediated by the labyrinthine semicircular canals, survives late into the course of the disease...

journal_title：Neurology

authors： Liao K,Wagner J,Joshi A,Estrovich I,Walker MF,Strupp M,Leigh RJ

更新日期：2008-03-04 00:00:00

abstract：:An anti-Purkinje cell antibody was found in the serum and CSF of a man with adenocarcinoma of the lung and paraneoplastic cerebellar degeneration (PCD). This antibody differed from the autoantibodies found in patients with gynecologic cancer and PCD in that it produced a different pattern of Purkinje cell cytoplasmic ...

journal_title：Neurology

authors： Anderson NE,Budde-Steffen C,Wiley RG,Thurman L,Rosenblum MK,Nadeau SE,Posner JB

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:It is uncertain whether patients with cardioembolic stroke and without a guidance-based indication for statin therapy should be administered a statin for prevention of subsequent vascular events. This study was performed to determine whether the statin therapy is beneficial in preventing major vascular events...

journal_title：Neurology

authors： Park HK,Lee JS,Hong KS,Cho YJ,Park JM,Kang K,Lee SJ,Kim JG,Cha JK,Kim DH,Nah HW,Han MK,Kim BJ,Park TH,Park SS,Lee KB,Lee J,Lee BC,Yu KH,Oh MS,Kim JT,Choi KH,Kim DE,Ryu WS,Choi JC,Kwon JH,Kim WJ,Shin

更新日期：2020-05-12 00:00:00

abstract：OBJECTIVES:To study the behavioral and neuroanatomic characteristics of perseverative behavior encountered on a target cancellation task in patients with neglect. METHODS:Motor perseverative behavior during line cancellation task was evaluated retrospectively in 60 patients with left hemispatial neglect from right hem...

journal_title：Neurology

authors： Na DL,Adair JC,Kang Y,Chung CS,Lee KH,Heilman KM

更新日期：1999-05-12 00:00:00

abstract：:As the substantia nigra degenerates in Parkinson's disease (PD), the nigrostriatal pathway is disrupted, reducing striatal dopamine and producing PD symptoms. Although dopamine does not readily cross the blood-brain barrier, its precursor, levodopa, does. Levodopa is absorbed in the small bowel and is rapidly cataboli...

journal_title：Neurology

authors： Koller WC,Rueda MG

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:To elucidate the phenotype, genotype, and MRI findings of Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and mutation carriers. METHODS:The authors studied 40 members of nine unrelated Korean CADASIL families. After genetic analysis o...

journal_title：Neurology

authors： Kim Y,Choi EJ,Choi CG,Kim G,Choi JH,Yoo HW,Kim JS

更新日期：2006-05-23 00:00:00

abstract：:In a previously unreported family with olivopontocerebellar atrophy, the kindred contained over 600 individuals in five generations. Of 83 offsping of affected individuals who over over 38.8 years of age (the mean age of the onset of disease in this family), 47 had ataxia; there was autosomal dominant transmission. Cl...

journal_title：Neurology

authors： Nino HE,Noreen HJ,Dubey DP,Resch JA,Namboodiri K,Elston RC,Yunis EJ

更新日期：1980-01-01 00:00:00

abstract：:Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood. Intermittent, biweekly hematin infusions given 1 month afte...

journal_title：Neurology

authors： Bosch EP,Pierach CA,Bossenmaier I,Cardinal R,Thorson M

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:In a previous study, the authors found that the risk of AD among mothers who were 35 years or younger when their children with Down syndrome (DS) were born was five times that of mothers of children with other forms of mental retardation. The current study investigated the specificity of the familial aggrega...

journal_title：Neurology

authors： Schupf N,Kapell D,Nightingale B,Lee JH,Mohlenhoff J,Bewley S,Ottman R,Mayeux R

更新日期：2001-09-25 00:00:00

abstract：OBJECTIVE:To cross-sectionally compare the regional white matter fractional anisotropy (FA) of cognitively normal (CN) older individuals and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), separately focusing on the normal-appearing white matter (NAWM) and white matter hyperintensities (WMH), ...

journal_title：Neurology

authors： Lee DY,Fletcher E,Martinez O,Ortega M,Zozulya N,Kim J,Tran J,Buonocore M,Carmichael O,DeCarli C

更新日期：2009-11-24 00:00:00

abstract：:This paper reviews the issue of hepatotoxicity with the use of the catechol-O-methly transferase (COMT) inhibitors tolcapone and entacapone. Neither drug caused hepatotoxicity in preclinical toxicity testing. However, in clinical trials of tolcapone, liver chemistry tests were elevated more than 3 times above the uppe...

journal_title：Neurology

authors： Watkins P

更新日期：2000-01-01 00:00:00

abstract：:Central nervous system (CNS) dysfunction in patients with systemic lupus erythematosus (SLE) is highly variable, although it is often described under a single heading of "neuropsychiatric" or "CNS" SLE. To clarify these CNS abnormalities, we studied 91 lupus patients, 63 of whom had CNS symptoms or signs, over 599 pat...

journal_title：Neurology

authors： Futrell N,Schultz LR,Millikan C

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:To determine black-white differences in 1-year recurrent stroke and 30-day case fatality after a recurrent stroke in older US adults. METHODS:We conducted a retrospective cohort study using a 5% random sample of Medicare beneficiaries with fee-for-service health insurance coverage who were hospitalized for i...

journal_title：Neurology

authors： Albright KC,Huang L,Blackburn J,Howard G,Mullen M,Bittner V,Muntner P,Howard V

更新日期：2018-11-06 00:00:00

abstract：OBJECTIVE:To examine whether blast exposure alone and blast-associated concussion result in similar neurologic and mental health symptoms. METHODS:A 14-item questionnaire was administered to male US Marines on their return from deployment in Iraq and/or Afghanistan. RESULTS:A total of 2,612 Marines (median age 22 yea...

journal_title：Neurology

authors： Tsao JW,Stentz LA,Rouhanian M,Howard RS,Perry BN,Haran FJ,Pasquina PF,Wolde M,Taylor CE,Lizardo R,Liu S,Flores E 3rd,Creason AH,Sher K

更新日期：2017-11-07 00:00:00

abstract：:Despite evidence for the efficacy of thrombolytic therapy in acute ischemic stroke, only 1 to 7% of patients receive this therapy. The authors sought to determine the reasons for exclusion from tissue plasminogen activator (tPA) in an acute setting and found avoidable causes in 18% of patients. Improvements in intraho...

journal_title：Neurology

authors： Cocho D,Belvís R,Martí-Fàbregas J,Molina-Porcel L,Díaz-Manera J,Aleu A,Pagonabarraga J,García-Bargo D,Mauri A,Martí-Vilalta JL

更新日期：2005-02-22 00:00:00

abstract：:We studied the effects of botulinum toxin A in 12 patients with spasticity and in eight patients with rigidity. The study design was a double-blind, placebo-controlled crossover trial with botulinum toxin A versus saline. Using the Ashworth Scale for spasticity and the Unified Parkinson's Disease Rating Scale for rigi...

journal_title：Neurology

authors： Grazko MA,Polo KB,Jabbari B

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVES:Observational and experimental studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer disease (AD); however, clinical trials and other observational studies, including the Adult Changes in Thought (ACT) study, show no protection or promotion of AD. The objective of t...

journal_title：Neurology

authors： Sonnen JA,Larson EB,Walker RL,Haneuse S,Crane PK,Gray SL,Breitner JC,Montine TJ

更新日期：2010-09-28 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) exerts many effects upon spinal cord function in animals, and may also play a role in human spinal cord function. We have used the technique of quantitative autoradiography to anatomically localize specific receptors for TRH within human spinal cord. Highest concentrations of TRH re...

journal_title：Neurology

authors： Manaker S,Winokur A,Rhodes CH,Rainbow TC

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:The annual relapse rate has been commonly used as a primary efficacy endpoint in phase III multiple sclerosis (MS) clinical trials. The aim of this study was to determine the relative contribution of different possible prognostic factors available at baseline to the on-study relapse rate in MS. METHODS:A to...

journal_title：Neurology

authors： Held U,Heigenhauser L,Shang C,Kappos L,Polman C,Sylvia Lawry Centre for MS Research.

更新日期：2005-12-13 00:00:00

abstract：:Clinical, electrodiagnostic, and pathologic studies indicate that the Guillain-Barre syndromes (GBSs) include both primary demyelinating and primary axonal forms. The axonal forms are usually thought to have a poorer prognosis, with less chance for rapid or complete recovery. In northern China, epidemics of one axonal...

journal_title：Neurology

authors： Ho TW,Li CY,Cornblath DR,Gao CY,Asbury AK,Griffin JW,McKhann GM

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the utility of MRI hippocampal and entorhinal cortex atrophy in predicting conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHODS:Baseline brain MRI was performed in 139 patients with MCI, broadly defined, and 63 healthy controls followed for an average of 5 years (ran...

journal_title：Neurology

authors： Devanand DP,Pradhaban G,Liu X,Khandji A,De Santi S,Segal S,Rusinek H,Pelton GH,Honig LS,Mayeux R,Stern Y,Tabert MH,de Leon MJ

更新日期：2007-03-13 00:00:00

abstract：:Although the long-term effects of acute anoxia have been studied, the effects of chronic hypoxia on the developing human brain have received little attention. We studied children with a cyanotic congenital heart defect to assess the impact of chronic hypoxia by eight measures: neurologic examination, visual evoked res...

journal_title：Neurology

authors： O'Dougherty M,Wright FS,Loewenson RB,Torres F

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:This study prospectively examined the relationships among late night salivary cortisol (NSC) levels and depressive symptoms, memory performance, and hippocampal volumes in patients with medically intractable temporal lobe epilepsy (TLE) and the potential mediating effects of cortisol in the relationships betw...

journal_title：Neurology

authors： Busch RM,Frazier T,Chapin JS,Hamrahian AH,Diehl B,Alexopoulos A,Unnwongse K,Naugle RI,Kubu CS,Tesar GE,Najm IM

更新日期：2012-04-03 00:00:00

abstract：BACKGROUND/OBJECTIVE:Apoptosis, or programmed cell death, is an evolutionary conserved mechanism essential for morphogenesis and tissue homeostasis, but it plays an important role also in pathologic conditions, including neurologic disorders. Its execution pathway is critically regulated at the mitochondrial level. Evi...

journal_title：Neurology

authors： Sciacco M,Fagiolari G,Lamperti C,Messina S,Bazzi P,Napoli L,Chiveri L,Prelle A,Comi GP,Bresolin N,Scarlato G,Moggio M

更新日期：2001-04-24 00:00:00

abstract：OBJECTIVE:We determined whether Gram-negative bacterial molecules are associated with Alzheimer disease (AD) neuropathology given that previous studies demonstrate Gram-negative Escherichia coli bacteria can form extracellular amyloid and Gram-negative bacteria have been reported as the predominant bacteria found in no...

journal_title：Neurology

authors： Zhan X,Stamova B,Jin LW,DeCarli C,Phinney B,Sharp FR

更新日期：2016-11-29 00:00:00

abstract：:We report the cases of 5 patients from 2 sibships with the "adult" or chronic form of GM2 gangliosidosis and 2 patients from another sibship with the juvenile form. We demonstrated hexosaminidase A deficiency in all cases but in 1 sibship the enzymatic profile was identical to that in Tay-Sachs disease, whereas in the...

journal_title：Neurology

authors： Specola N,Vanier MT,Goutières F,Mikol J,Aicardi J

更新日期：1990-01-01 00:00:00

abstract：:Reflex sympathetic dystrophy (RSD) is a relatively common disabling disorder of unknown pathophysiology. From a cohort of 52 patients, carefully selected to fulfill the recently formulated diagnostic criteria for RSD, venous blood samples were taken for typing of class I and II major histocompatibility antigens. The f...

journal_title：Neurology

authors： Kemler MA,van de Vusse AC,van den Berg-Loonen EM,Barendse GA,van Kleef M,Weber WE

更新日期：1999-10-12 00:00:00

abstract：:This study examined the frequency of epilepsy in a consecutive series of patients who received a definitive diagnosis of psychogenic nonepileptic seizures (PNES) after completing inpatient video-EEG (VEEG) monitoring. Of the 1,590 patients receiving definitive diagnosis, 514 (32.3%) were diagnosed with PNES. Twenty-ni...

journal_title：Neurology

authors： Martin R,Burneo JG,Prasad A,Powell T,Faught E,Knowlton R,Mendez M,Kuzniecky R

更新日期：2003-12-23 00:00:00

abstract：:T, B, and "null" lymphocytes were determined in peripheral blood obtained from 24 control subjects and 15 multiple sclerosis patients. The total number of lymphocytes and T lymphocytes were reduced significantly in multiple sclerosis patients as compared with those of controls. Although the percentage of B lymphocytes...

journal_title：Neurology

authors： Reddy MM,Goh KO

更新日期：1976-10-01 00:00:00