Abstract:
:We studied brain sections from 10 patients with the acquired immunodeficiency syndrome (AIDS) and progressive multifocal leukoencephalopathy (PML) by in situ hybridization with a biotin-labeled JC virus (JCV) DNA probe and by immunohistochemistry using antibody against the JCV capsid antigen. We compared the results with brain sections studied in the same fashion from 10 PML patients without AIDS. The pathology of JCV infection in AIDS was similar to non-AIDS PML except for minor differences in degree. AIDS-associated pathologic material showed a greater tendency toward necrosis and a higher density of JCV-infected cells. Replication of JCV was restricted to glial cells in all tissue studied. Bizarre astrocytes were less frequent in the AIDS patients, and perivascular inflammatory cells were more frequent. We could not demonstrate JCV in macrophages or microglial cells known to harbor HIV infection. In situ hybridization with nonradioactive probes serves as a useful technique for the confirmation of PML in AIDS.
journal_name
Neurologyjournal_title
Neurologyauthors
Aksamit AJ,Gendelman HE,Orenstein JM,Pezeshkpour GHdoi
10.1212/wnl.40.7.1073subject
Has Abstractpub_date
1990-07-01 00:00:00pages
1073-8issue
7eissn
0028-3878issn
1526-632Xjournal_volume
40pub_type
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