Abstract:
OBJECTIVE:The presence of cranial autonomic symptoms often leads to a misdiagnosis of "sinus headache" in adult migraineurs, leading to unnecessary treatments and delaying appropriate migraine therapy. In this study, we examined the frequency of cranial autonomic symptoms in pediatric/adolescent patients with migraine. METHODS:This cross-sectional study included all pediatric and adolescent patients with migraine evaluated by a single investigator at 4 different sites over the course of the study period. RESULTS:Of 125 pediatric migraineurs, 62% had at least one cranial autonomic symptom based on current International Classification of Headache Disorders, second edition (ICHD-II) criteria, and 70% based on proposed ICHD-III criteria. The majority had more than one cranial autonomic symptom and the symptoms tended to be bilateral. Age, sex, laterality of headache, presence of aura, and whether migraine was episodic vs chronic did not influence the likelihood of having cranial autonomic symptoms. CONCLUSIONS:In pediatric/adolescent migraine, the presence of cranial autonomic symptoms appears to be the rule rather than the exception. Clinicians should be careful to consider migraine when evaluating a child with headache and associated ocular or nasal symptoms so as to avoid giving a misdiagnosis of sinus headache.
journal_name
Neurologyjournal_title
Neurologyauthors
Gelfand AA,Reider AC,Goadsby PJdoi
10.1212/WNL.0b013e31829d872asubject
Has Abstractpub_date
2013-07-30 00:00:00pages
431-6issue
5eissn
0028-3878issn
1526-632Xpii
WNL.0b013e31829d872ajournal_volume
81pub_type
杂志文章,多中心研究相关文献
NEUROLOGY文献大全abstract::Acetylcholinesterase (AChE) inhibitors were first administered in Europe to human subjects in the 1860s, and synthetic derivatives of the natural alkaloid inhibitors were developed in the 1930s to modulate peripheral cholinergic function. However, only within the last decade have these agents been systematically studi...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.1_suppl_1.s30
更新日期:1998-07-01 00:00:00
abstract::Coenzyme Q10 (CoQ10) transfers electrons from complexes I and II of the mitochondrial respiratory chain to complex III. There is one published report of human CoQ10 deficiency describing two sisters with encephalopathy, proximal weakness, myoglobinuria, and lactic acidosis. We report a patient who had delayed motor mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.5.1238
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:Brain changes occurring early in HIV infection are not well characterized. The Chicago Early HIV Infection Study aimed to evaluate the presence and extent of structural brain alterations using quantitative MRI. METHODS:Forty-three HIV and 21 control subjects were enrolled. Mean length of infection was estima...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318278b5b4
更新日期:2012-12-11 00:00:00
abstract::Spontaneous arm levitation (SAL) is well-recognized in cortical-basal ganglionic degeneration, but not in other neurodegenerative diseases. We report six cases of progressive supranuclear palsy (PSP) with SAL. Pathologic examination in four revealed the classic features of PSP with additional areas of focal cortical d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.4.879
更新日期:1999-03-10 00:00:00
abstract::Ten patients are presented with severe dysarthria from a right hemisphere stroke, 4 with autopsies, emphasizing that this lesion alone is compatible with severely slurred speech. Most had oropharyngeal weakness; the accompanying hemiparesis was of variable severity. Superficial or deep infarctions were responsible, th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.6.1061
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Optimal treatment remains uncertain for patients with cognitive impairment that persists or returns after standard IV antibiotic therapy for Lyme disease. METHODS:Patients had well-documented Lyme disease, with at least 3 weeks of prior IV antibiotics, current positive IgG Western blot, and objective memory...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.WNL.0000284604.61160.2d
更新日期:2008-03-25 00:00:00
abstract:OBJECTIVE:To assess pathologic changes in prospectively characterized subjects with essential tremor (ET). METHODS:Subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program were examined annually by a movement disorders neurologist, and semiannually by a behavioral neurologist and neuropsy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000310425.76205.02
更新日期:2008-04-15 00:00:00
abstract:OBJECTIVE:To investigate evidence of the potential role of early cortical vulnerability in the development of primary progressive aphasia (PPA). METHOD:A woman with a diagnosis of PPA and her 9 adult siblings, 7 with developmental language disabilities, underwent neuropsychological testing, structural MRI, and resting...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009842
更新日期:2020-08-18 00:00:00
abstract::Five men with degenerative neuromuscular diseases (three with amyotrophic lateral sclerosis [ALS] and two with Duchenne's muscular dystrophy [DMD]) who had respiratory failure were treated with intermittent negative pressure ventilation (NPV). One patient with ALS in severe acute respiratory failure was successfully t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.12.1874
更新日期:1987-12-01 00:00:00
abstract::Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between attacks in 35 patients suffering from migraine without aura (MO, n = 25) or with aura (MA, n = 10) and in 25 healthy vo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.5.1404
更新日期:1996-05-01 00:00:00
abstract::Three children with cerebral oligodendrogliomas causing partial complex or generalized seizures presented with completely normal neurologic examinations. CT showed low-density, nonenhancing surface lesions. Although these CT features are usually associated with infarcts or cysts, neoplasm was suspected because of irre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.6.806
更新日期:1983-06-01 00:00:00
abstract::The effects of a single oral dose of levodopa administered in a randomized, double-blind, placebo-controlled cross-over design on formation of a motor memory were studied by a training protocol in patients with chronic stroke. Levodopa enhanced the ability of motor training to encode an elementary motor memory relativ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000172340.56307.5e
更新日期:2005-08-09 00:00:00
abstract::Titus Lucretius Carus was an ancient Roman philosopher of the Epicurean school whose epic poem On the Nature of Things described numerous aspects of the natural world. In fact, much contemporary scientific understanding is consistent with or inspired by his work. Among Lucretius's contributions to neurology were his d...
journal_title:Neurology
pub_type: 传,历史文章,杂志文章
doi:10.1212/WNL.0b013e31822cfa34
更新日期:2011-09-06 00:00:00
abstract::We investigated the possible role of potassium deficiency, a recognized cause of myopathy, in the pathogenesis of experimental acute alcoholic myopathy (EAM) in the rat. Alcohol-treated animals receiving the same dietary potassium as controls developed mild hypokalemia; however, muscle potassium was preserved or eleva...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.4.529
更新日期:1984-04-01 00:00:00
abstract:OBJECTIVES:Homonymous hemianopia (HH) is the most frequent visual-field defect after a stroke. Some of these patients also have visual hallucinations, the origin and frequency of which remain largely unknown. The aims of this work were to determine the occurrence of visual hallucinations among poststroke hemianopic pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009366
更新日期:2020-05-05 00:00:00
abstract::We performed morphologic studies on regeneration of the cat's hind limb nerves, following simultaneous ligation of the aorta and right femoral artery. There were 2 regeneration patterns depending on the extent of ischemic necrosis. When nerve infarcts were limited only to intrafascicular regions, there was no basic ch...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.7.932
更新日期:1989-07-01 00:00:00
abstract::We report the cases of 5 patients from 2 sibships with the "adult" or chronic form of GM2 gangliosidosis and 2 patients from another sibship with the juvenile form. We demonstrated hexosaminidase A deficiency in all cases but in 1 sibship the enzymatic profile was identical to that in Tay-Sachs disease, whereas in the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.1.145
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:To report the safety and long-term efficacy of ventro-oral thalamotomy for 171 consecutive patients with task-specific focal hand dystonia. METHODS:Between October 2003 and February 2017, 171 consecutive patients with task-specific focal hand dystonia underwent unilateral ventro-oral thalamotomy. Etiologies ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006818
更新日期:2019-01-22 00:00:00
abstract:OBJECTIVE:It is uncertain whether patients with cardioembolic stroke and without a guidance-based indication for statin therapy should be administered a statin for prevention of subsequent vascular events. This study was performed to determine whether the statin therapy is beneficial in preventing major vascular events...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000009397
更新日期:2020-05-12 00:00:00
abstract::A 32-year-old patient with seizures experienced decreased right-ear hearing during electrocortical stimulation mapping of the left lateral superior temporal gyrus. Audiometric testing under headphones confirmed a reversible, moderate unilateral hearing loss. Under binaural listening conditions, auditory comprehension ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000149524.11371.B1
更新日期:2005-01-25 00:00:00
abstract::Since cytomegalovirus (CMV) has been implicated in the pathogenesis of Rasmussen's syndrome, we treated four patients with ganciclovir, a potent anti-CMV drug. A 7-year-old girl with seizures escalating to 60/day over 3 months despite triple antiepileptic drug therapy became seizure-free 5 days after initiation of tre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.4.925
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:In the setting of severe immunosuppression, the polyomavirus JC (JCV) can cause a lytic infection of oligodendrocytes. This demyelinating disease of the CNS white matter (WM) is called progressive multifocal leukoencephalopathy (PML). JCV has a very narrow host-cell range and productive infection of neurons ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000081306.86961.33
更新日期:2003-09-23 00:00:00
abstract:OBJECTIVE:To assess the attitudes, knowledge, and practice patterns of US neurologists regarding migraine management relative to the US Headache Consortium Guidelines (the Guidelines). METHODS:Two samples of 600 neurologists each were selected from the American Academy of Neurology membership database. The first group...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.62.11.1926
更新日期:2004-06-08 00:00:00
abstract::Mapping eloquent language cortex in presurgical patients typically is accomplished using highly invasive direct cortical stimulation techniques. Functional imaging during language activation using positron emission tomography (PET) is a promising, noninvasive alternative that requires validation. In seven patients und...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.4.1056
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:To determine (1) if mortality among patients with idiopathic intracranial hypertension (IIH) enrolled in the Intracranial Hypertension Registry (IHR) is different from that of the general population of the United States and (2) what the leading underlying causes of death are among this cohort. METHODS:Mortal...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009312
更新日期:2020-08-18 00:00:00
abstract::A 27-year-old man, recent visitor to the Middle East, presented with 6-week history of fever (up to 102°F) followed by altered behavior and left hemiparesis. CSF was acellular with raised protein (138 mg/dL). CSF bacterial culture was sterile; adenosine deaminase normal (3 U/L); cryptococcal antigen, Venereal Disease ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827deb63
更新日期:2013-01-15 00:00:00
abstract:OBJECTIVE:To assess the possible abnormalities in the baroreflex modulation of both the heart and the arterial vasculature, in order to better evaluate the role of baroreflex abnormalities in the generation of the cardiovascular symptoms and complications affecting the familial dysautonomia (FD) patient. METHODS:Twent...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000142034.92124.6a
更新日期:2004-10-26 00:00:00
abstract::Serum levels of creatine phosphokinase (CPK) and pyruvic kinase (PK) were determined in 42 controls, 57 patients with various neuromuscular disorders, and 23 female relatives of Duchenne dystrophy patients. CPK and PK enzyme activities were increased in comparable numbers of muscle disease patients and female carriers...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.10.1047
更新日期:1978-10-01 00:00:00
abstract:OBJECTIVE:To assess frontal lobe functions of subjects with age-associated memory impairment (AAMI) and to examine whether performance on neuropsychological tests is correlated with the volume of the frontal lobes in magnetic resonance imaging. DESIGN:Cross-sectional two-group comparison. SETTING:The Memory Research ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.48.1.148
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To develop a simple imaging rule to predict neurodevelopmental outcomes at 4.5 years in a cohort of preterm neonates with white matter injury (WMI) based on lesion location and examine whether clinical variables enhance prediction. METHODS:Sixty-eight preterm neonates born 24-32 weeks' gestation (median 27.7...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008172
更新日期:2019-09-24 00:00:00