Neuroanatomic correlates of visual hallucinations in poststroke hemianopic patients.

Abstract:

OBJECTIVES:Homonymous hemianopia (HH) is the most frequent visual-field defect after a stroke. Some of these patients also have visual hallucinations, the origin and frequency of which remain largely unknown. The aims of this work were to determine the occurrence of visual hallucinations among poststroke hemianopic patients in function of the location (Brodmann areas) of the brain lesion, as determined by MRI, and to study the neuroanatomic correlates of these hallucinations by nature, frequency, and type. METHODS:One hundred sixteen patients with HH who had had a stroke in the posterior region, including the occipital lobe, participated in the study. We evaluated the frequency and nature of visual hallucinations with the Questionnaire for Hallucinations in Homonymous Hemianopia. The volume of each patient's brain lesion was modeled in 3 dimensions. RESULTS:Of 116 patients with an HH from a cortical infarction, 85 were excluded due to confounding factors associated with hallucinations. In the final cohort of 31 patients matched for lesion location and etiology, 58% had experienced hallucinations. A significant inverse correlation between lesion size and the frequency of visual hallucinations emerged. The presence of visual hallucinations in poststroke hemianopic patients requires a relatively small lesion that includes, at the very least, loss of the striate cortex but that spares Brodmann area 19, 20, and 37. CONCLUSION:Our results suggest that visual hallucinations might be due to complex interactions between damaged areas and intact areas of the visual cortex. We discuss these findings regarding models of perception and of visual recognition. Our results also have implications for the clinical care of patients with HH who have had a stroke.

journal_name

Neurology

journal_title

Neurology

authors

Martinelli F,Perez C,Caetta F,Obadia M,Savatovsky J,Chokron S

doi

10.1212/WNL.0000000000009366

subject

Has Abstract

pub_date

2020-05-05 00:00:00

pages

e1885-e1891

issue

18

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000009366

journal_volume

94

pub_type

杂志文章
  • Effect of white matter lesions on manual dexterity in healthy middle-aged persons.

    abstract:OBJECTIVES:We hypothesized that integrated motor-visual functions measured by manipulative manual dexterity are affected by white matter lesion (WML) burden as measured on cranial MRI across relevant brain regions in subjects at risk of preclinical occult vascular disease. METHODS:A real-time cross-sectional study of ...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/WNL.0000000000001557

    authors: Nyquist PA,Yanek LR,Bilgel M,Cuzzocreo JL,Becker LC,Chevalier-Davis K,Yousem D,Prince J,Kral BG,Vaidya D,Becker DM

    更新日期:2015-05-12 00:00:00

  • Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

    abstract:OBJECTIVE:To conduct a validation study of 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS:Patients >60 years of age with dementia who had undergone 123I-FP-...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003512

    authors: Thomas AJ,Attems J,Colloby SJ,O'Brien JT,McKeith I,Walker R,Lee L,Burn D,Lett DJ,Walker Z

    更新日期:2017-01-17 00:00:00

  • Clinical and electrophysiologic correlates of elevated anti-GM1 antibody titers.

    abstract::We reviewed the clinical and electrophysiologic features of 36 patients with increased titers of IgM anti-GM1 antibodies. Mildly elevated titers of up to 3,200 were not associated with any particular clinical syndrome or disease. Clinically, 14 of 16 patients with highly elevated titers of 6,400 or higher had progress...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.7.1278

    authors: Kinsella LJ,Lange DJ,Trojaborg W,Sadiq SA,Younger DS,Latov N

    更新日期:1994-07-01 00:00:00

  • Contrast agent overdose causing brain retention of contrast, seizures and parkinsonism.

    abstract::A patient received an overdose of intravascular contrast medium and experienced protracted seizures associated with radiographic evidence of prolonged retention of the contrast agent in the cerebral cortex, basal ganglia, and thalami. This is only the second report and the first survivor of a similar neurologic syndro...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.43.4.836

    authors: May EF,Ling GS,Geyer CA,Jabbari B

    更新日期:1993-04-01 00:00:00

  • The medial brachial fascial compartment syndrome following axillary arteriography.

    abstract:OBJECTIVE:To review clinical and electrodiagnostic features of the medial brachial fascial compartment syndrome, a complication of percutaneous axillary vessel puncture. METHODS:The authors reviewed electrodiagnostic examinations over a 20-year period. RESULTS:This syndrome presents with weakness, pain, and numbness ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000089488.35632.08

    authors: Tsao BE,Wilbourn AJ

    更新日期:2003-10-28 00:00:00

  • Initial treatment of epilepsy: special issues in treating the elderly.

    abstract::The incidence of new-onset epilepsy is higher among the elderly, the most rapidly growing segment of the population, than in any other age group. New-onset seizures in elderly patients are typically cryptogenic or symptomatic partial seizures that require long-term treatment. Because seizures in the elderly are often ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.63.10_suppl_4.s40

    authors: Bergey GK

    更新日期:2004-11-23 00:00:00

  • Subarachnoid and intracerebral hemorrhage: natural history, prognosis, and precursive factors in the Framingham Study.

    abstract::No uniformly accepted hypothesis explains the genesis and rupture of intracranial aneurysms. We followed 5,184 men and women prospectively for 26 years; 36 cases of aneurysmal subarachnoid hemorrhage (SAH) accounted for 62% of all intracranial hemorrhages. Blood pressure before SAH was higher in these patients than in...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.7.847

    authors: Sacco RL,Wolf PA,Bharucha NE,Meeks SL,Kannel WB,Charette LJ,McNamara PM,Palmer EP,D'Agostino R

    更新日期:1984-07-01 00:00:00

  • Effects of subthalamic nucleus (STN) stimulation on motor cortex excitability.

    abstract:BACKGROUND:Deep brain stimulation of the internal global pallidus (GPi) and the subthalamic nucleus (STN) has become a treatment alternative in advanced PD. Although the effects of GPi stimulation have been examined recently, little is known about STN stimulation effects on motor cortex excitability. METHODS:The effec...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.59.5.700

    authors: Däuper J,Peschel T,Schrader C,Kohlmetz C,Joppich G,Nager W,Dengler R,Rollnik JD

    更新日期:2002-09-10 00:00:00

  • Frontal abnormalities in a patient with obsessive-compulsive disorder: the role of structural lesions in obsessive-compulsive behavior.

    abstract::A man with onset of obsessive-compulsive disorder (OCD) at age 62 had a large right posterior frontal infarct and occlusion of the ipsilateral internal carotid artery. We review additional cases from the literature with obsessive or compulsive behaviors and structural lesions. OCD may have a structural correlate, and ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.45.12.2130

    authors: Swoboda KJ,Jenike MA

    更新日期:1995-12-01 00:00:00

  • A presenilin 1 R278I mutation presenting with language impairment.

    abstract::Presenilin (PSEN)1 mutations are responsible for many cases of autosomal dominant Alzheimer disease (AD), although the clinical spectrum has not been fully defined. The authors describe two members of a kindred with a novel PSEN1 mutation (R278I) presenting with language impairment and relative preservation of memory....

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000143060.98164.1a

    authors: Godbolt AK,Beck JA,Collinge J,Garrard P,Warren JD,Fox NC,Rossor MN

    更新日期:2004-11-09 00:00:00

  • Trigeminal sensory neuropathy associated with connective tissue diseases.

    abstract::We reviewed the clinical and laboratory features of 81 patients who had trigeminal sensory neuropathy (TSN) and a connective tissue disease (CTD). The neuropathy developed before the symptoms of CTD in 6/81 patients (7%), and in 38/81 patients (47%) TSN and CTD were diagnosed concurrently. The most frequently associat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.6.891

    authors: Hagen NA,Stevens JC,Michet CJ Jr

    更新日期:1990-06-01 00:00:00

  • Spinocerebellar ataxia type 6. Molecular and clinical features of 35 Japanese patients including one homozygous for the CAG repeat expansion.

    abstract::Spinocerebellar ataxia type 6 (SCA6) is a newly classified autosomal-dominant cerebellar ataxia (ADCA) associated with CAG repeat expansion. We screened 111 patients with cerebellar ataxia for the SCA6 mutation. Of these, 35 patients were found to have expanded CAG repeats in the SCA6 gene, indicating that second to S...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.49.5.1238

    authors: Matsumura R,Futamura N,Fujimoto Y,Yanagimoto S,Horikawa H,Suzumura A,Takayanagi T

    更新日期:1997-11-01 00:00:00

  • Relationship of vascular risk to the progression of Alzheimer disease.

    abstract:OBJECTIVE:To test the hypothesis that patients with Alzheimer disease (AD) who have vascular risk factors have a worse prognosis over 18 months vs those without such risk factors. METHODS:A sample of 224 people with AD and their caregivers were recruited purposively to be representative of people with dementia in term...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000240129.46080.53

    authors: Regan C,Katona C,Walker Z,Hooper J,Donovan J,Livingston G

    更新日期:2006-10-24 00:00:00

  • Undetermined stroke genesis and hidden cardiomyopathies determined by cardiac magnetic resonance.

    abstract:OBJECTIVE:To determine whether cardiac magnetic resonance imaging (CMR) could be useful in identifying previously undiagnosed cardiomyopathies in a cohort of patients with ischemic stroke who underwent standard etiologic investigation and to describe the type and frequency of these cardiomyopathies. METHODS:We perform...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008698

    authors: Fonseca AC,Marto JP,Pimenta D,Guimarães T,Alves PN,Inácio N,Viana-Baptista M,Pinho E Melo T,Pinto FJ,Ferro JM,Almeida AG

    更新日期:2020-01-07 00:00:00

  • Cerebral microbleeds are regionally associated with intracerebral hemorrhage.

    abstract:BACKGROUND:Cerebral microbleeds (CMB) may be indicative of a hemorrhage-prone microangiopathy. OBJECTIVE:To determine if increased numbers of these lesions are predictive of intracerebral hemorrhage (ICH), especially in terms of a distributional association. METHODS:The authors examined consecutively 227 patients wit...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000101463.50798.0d

    authors: Lee SH,Bae HJ,Kwon SJ,Kim H,Kim YH,Yoon BW,Roh JK

    更新日期:2004-01-13 00:00:00

  • Benign prognosis of never-symptomatic carotid occlusion.

    abstract:OBJECTIVE:To determine the prognosis of asymptomatic carotid artery occlusion. BACKGROUND:As opposed to symptomatic carotid occlusion, little information is available on the prognosis of asymptomatic carotid occlusion. METHOD:Thirty never-symptomatic and 81 symptomatic patients with carotid occlusion underwent baseli...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.4.878

    authors: Powers WJ,Derdeyn CP,Fritsch SM,Carpenter DA,Yundt KD,Videen TO,Grubb RL Jr

    更新日期:2000-02-22 00:00:00

  • Familial typical migraine: linkage to chromosome 19p13 and evidence for genetic heterogeneity.

    abstract::Migraine is a frequent familial disorder that, in common with most multifactorial disorders, has an unknown etiology. The authors identified several families with multiple individuals affected by typical migraine using a single set of diagnostic criteria and studied these families for cosegregation between the disorde...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.5.1428

    authors: Nyholt DR,Lea RA,Goadsby PJ,Brimage PJ,Griffiths LR

    更新日期:1998-05-01 00:00:00

  • Broca's area aphasias: aphasia after lesions including the frontal operculum.

    abstract::We report 9 cases of aphasia following lesions in the region of the left frontal operculum. It is not possible to capture their variety of clinical manifestations with the simple labels of "Broca's area aphasia." or "Broca's area aphasia." Analysis of the breakdown of various components of speech and language in these...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.2.353

    authors: Alexander MP,Naeser MA,Palumbo C

    更新日期:1990-02-01 00:00:00

  • Head injury does not alter disease progression or neuropathologic outcomes in ALS.

    abstract:OBJECTIVES:To study the effects of head injury on disease progression and on neuropathologic outcomes in amyotrophic lateral sclerosis (ALS). METHODS:Patients with ALS were surveyed to obtain head injury history, and medical records were reviewed. Linear regression was performed to determine if head injury was a predi...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000001522

    authors: Fournier CN,Gearing M,Upadhyayula SR,Klein M,Glass JD

    更新日期:2015-04-28 00:00:00

  • Prevalence of Alzheimer's disease and other dementias in rural India: the Indo-US study.

    abstract:OBJECTIVE:To determine the prevalence of AD and other dementias in a rural elderly Hindi-speaking population in Ballabgarh in northern India. DESIGN:The authors performed a community survey of a cohort of 5,126 individuals aged 55 years and older, 73.3% of whom were illiterate. Hindi cognitive and functional screening...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.51.4.1000

    authors: Chandra V,Ganguli M,Pandav R,Johnston J,Belle S,DeKosky ST

    更新日期:1998-10-01 00:00:00

  • Pediatric multiple sclerosis: Perspectives from adolescents and their families.

    abstract::Supporting young people with pediatric multiple sclerosis can be challenging for families and health care providers. Adolescents may be more resilient than adults in reaction to the diagnosis but can have more difficulty planning for their futures. Appropriate, sensitive, and focused health provision should include co...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002879

    authors: Krupp LB,Rintell D,Charvet LE,Milazzo M,Wassmer E

    更新日期:2016-08-30 00:00:00

  • Practical utility of amyloid and FDG-PET in an academic dementia center.

    abstract:OBJECTIVE:To evaluate the effect of amyloid imaging on clinical decision making. METHODS:We conducted a retrospective analysis of 140 cognitively impaired patients (mean age 65.0 years, 46% primary β-amyloid (Aβ) diagnosis, mean Mini-Mental State Examination 22.3) who underwent amyloid (Pittsburgh compound B [PiB]) PE...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000000032

    authors: Sánchez-Juan P,Ghosh PM,Hagen J,Gesierich B,Henry M,Grinberg LT,O'Neil JP,Janabi M,Huang EJ,Trojanowski JQ,Vinters HV,Gorno-Tempini M,Seeley WW,Boxer AL,Rosen HJ,Kramer JH,Miller BL,Jagust WJ,Rabinovici GD

    更新日期:2014-01-21 00:00:00

  • The "sinister" Tolosa-Hunt syndrome.

    abstract::Four patients with presumed Tolosa-Hunt syndrome ultimately proved to have a parasellar tumor. All four had manifestations of a cavernous sinus syndrome, normal radiologic and medical investigations, and response to steroid therapy. The Tolosa-Hunt syndrome is a diagnosis of exclusion; many other lesions can simulate ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.36.2.198

    authors: Spector RH,Fiandaca MS

    更新日期:1986-02-01 00:00:00

  • Pharmacokinetics, pharmacodynamics, and tolerability of tolcapone: a review of early studies in volunteers.

    abstract::Tolcapone is a potent, reversible inhibitor of catechol O-methyltransferase (COMT) intended for use as an adjunct to levodopa therapy for Parkinson's disease (PD). Findings from the first pharmacokinetics/pharmacodynamics and tolerability studies of tolcapone in volunteers are reviewed. Following linear and dose-propo...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.50.5_suppl_5.s31

    authors: Jorga KM

    更新日期:1998-05-01 00:00:00

  • Mortality in epilepsy: driving fatalities vs other causes of death in patients with epilepsy.

    abstract:OBJECTIVES:To estimate the risk to public safety posed by drivers with epilepsy, the authors compared annual totals and disease-specific risk for fatal crashes associated with seizures and other medical conditions. They compared individual risks for fatal crashes due to seizures and other causes of mortality in patient...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000138590.00074.9a

    authors: Sheth SG,Krauss G,Krumholz A,Li G

    更新日期:2004-09-28 00:00:00

  • Proportional anterior commissure area in humans and monkeys.

    abstract::Behavioral testing following division of the corpus callosum has shown that the anterior commissure can transfer information related to visual tasks interhemispherically in nonhuman primates but not in humans. We have found that the ratio of anterior commissure cross-sectional area to total neocortical commissural are...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.36.11.1513

    authors: Foxman BT,Oppenheim J,Petito CK,Gazzaniga MS

    更新日期:1986-11-01 00:00:00

  • A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders.

    abstract::Cognitive impairment is a frequent manifestation of advanced human immunodeficiency virus (HIV) infection. The response to antiretroviral medication is often partial and poorly sustained. Recent studies suggest that free radical production within the CNS and neuronal apoptosis may play important roles in the pathogene...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.50.3.645

    authors:

    更新日期:1998-03-01 00:00:00

  • Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort.

    abstract:BACKGROUND:Antiretroviral therapy has improved survival for HIV-1-infected individuals. The neuroepidemiologic implications of HIV-1 in an aging population are not well known, particularly the prevalence of HIV-associated dementia (HAD). METHODS:The authors report a baseline cross-sectional analysis of 202 HIV-1-serop...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000134665.58343.8d

    authors: Valcour V,Shikuma C,Shiramizu B,Watters M,Poff P,Selnes O,Holck P,Grove J,Sacktor N

    更新日期:2004-09-14 00:00:00

  • Subacute sclerosing panencephalitis: clinical and immunologic study of 23 patients.

    abstract::Lymphocyte subpopulations ("active' T cells, total T cells, and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, and C4), and immune complexes in serum and cerebrospinal fluid were studied in 23 patients with subacute sclerosing panencephalitis. The percentage of active T cells was norm...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.31.2.177

    authors: Derakhshan I,Massoud A,Foroozanfar N,Nikbin B,Lotfi J,Shakib N,Ala F

    更新日期:1981-02-01 00:00:00

  • Epidemiology of brain tumors: the national survey of intracranial neoplasms.

    abstract::A national survey, based on a probability sample of patients admitted to short-term hospitals in the United States during 1973 to 1974 with a discharge diagnosis of an intracranial neoplasm, was conducted in 157 hospitals. The annual incidence was estimated at 17,000 for primary intracranial neoplasms and 17,400 for s...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.35.2.219

    authors: Walker AE,Robins M,Weinfeld FD

    更新日期:1985-02-01 00:00:00