Abstract:
BACKGROUND:Cerebral microbleeds (CMB) may be indicative of a hemorrhage-prone microangiopathy. OBJECTIVE:To determine if increased numbers of these lesions are predictive of intracerebral hemorrhage (ICH), especially in terms of a distributional association. METHODS:The authors examined consecutively 227 patients with acute stroke. CMB were counted using T2*-weighted gradient echo MRI data, and old lacunes and leukoaraiosis were also evaluated. The associations between the vascular risk factors and ICH were analyzed. With use of multivariate logistic regression analysis, the locations of the CMB or the old lacunes, which were categorized as being in the corticosubcortical area, the deep gray matter area, or the infratentorial area, were examined with regard to their relationships to the locations of the ICH. RESULTS:The degrees of the CMB (r = 0.43, p < 0.01) and leukoaraiosis (r = 0.20, p < 0.01) were well correlated with the presence of ICH. Multivariate analysis revealed that the grades of the CMB were associated with the presence of ICH (p < 0.01, odds ratio [OR] = 2.67). CMB in the corticosubcortical area (p < 0.01, OR = 5.50) or deep gray matter (p < 0.01, OR = 2.55) were strongly associated with the presence of ICH in the same area, but no such association was observed in the case of CMB in the infratentorial area or in the case of old lacunes in any area. CONCLUSIONS:Cerebral microbleeds are strongly associated with the presence of intracerebral hemorrhage, and the distributional associations are also quite strong.
journal_name
Neurologyjournal_title
Neurologyauthors
Lee SH,Bae HJ,Kwon SJ,Kim H,Kim YH,Yoon BW,Roh JKdoi
10.1212/01.wnl.0000101463.50798.0dsubject
Has Abstractpub_date
2004-01-13 00:00:00pages
72-6issue
1eissn
0028-3878issn
1526-632Xjournal_volume
62pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:BACKGROUND:Alexander disease is most commonly associated with macrocephaly and, on MRI, a leukoencephalopathy with frontal preponderance. The disease is caused by mutation of the GFAP gene. Clinical and MRI phenotypic variation have been increasingly recognized. METHODS:The authors studied seven patients with Alexande...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000198770.80743.37
更新日期:2006-02-28 00:00:00
abstract:OBJECTIVE:To evaluate the effects of mitoxantrone (Mx) in progressive multiple sclerosis (MS) on MRI. METHODS:A total of 194 patients with worsening relapsing-remitting or secondary progressive MS were treated with Mx 12 mg/m2 (n = 34), Mx 5 mg/m2 (n = 40), or placebo (n = 36) at 3-month intervals IV over a 2-year per...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000174439.70369.7a
更新日期:2005-09-13 00:00:00
abstract::Educators of the next generation of neurologists will face several challenges, including changes in academic medical centers and hospitals, changes in the scope and practice of neurology itself, and changes in trainees, related to both access to information technology and professional goals. This article, which origin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000342516.08077.55
更新日期:2009-02-17 00:00:00
abstract:OBJECTIVE:To investigate whether cognitive function is related to incidence of stroke. METHODS:A population-based cohort of 1551 subjects with no clinical history or signs of stroke, age 75 years and over at baseline, were followed up for 3 years. Individuals with a first-ever stroke event that was recorded in the Sto...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.11.2103
更新日期:2000-06-13 00:00:00
abstract:OBJECTIVE:To assess whether exon deletions or duplications in CLCN1 are associated with recessive myotonia congenita (MC). METHODS:We performed detailed clinical and electrophysiologic characterization in 60 patients with phenotypes consistent with MC. DNA sequencing of CLCN1 followed by multiplex ligation-dependent p...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318259e19c
更新日期:2012-06-12 00:00:00
abstract::Epilepsy is associated with a high rate of premature mortality from direct and indirect effects of seizures, epilepsy, and antiseizure therapies. Sudden unexpected death in epilepsy (SUDEP) is the second leading neurologic cause of total lost potential life-years after stroke, yet SUDEP may account for less than half ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000002253
更新日期:2016-02-23 00:00:00
abstract::Although a neuromuscular syndrome has been induced experimentally by vitamin E deficiency, a human syndrome has not yet been documented. This report describes a 7-year-old boy with severe malabsorption since birth who presented with progressive external ophthalmoplegia, proximal muscle weakness, peripheral neuropathy,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.8.1182
更新日期:1979-08-01 00:00:00
abstract::Traditional side-by-side visual interpretation of ictal and interictal single-photon emission computed tomography (SPECT) scans can be difficult in identifying the surgical focus, particularly in patients with extratemporal or otherwise unlocalized intractable epilepsy. Computer-aided subtraction ictal SPECT co-regist...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.2.445
更新日期:1998-02-01 00:00:00
abstract::Research and development of the adenosine A2A receptor selective antagonist KW6002 have focused on developing a novel nondopaminergic therapy for Parkinson's disease (PD). Salient pharmacologic features of KW6002 were investigated in several animal models of PD. In rodent and primate models, KW6002 provides symptomati...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000095219.22086.31
更新日期:2003-12-09 00:00:00
abstract::People with AD have deficient contrast sensitivity and impaired face discrimination. The authors presented photographs of unfamiliar faces of three different sizes to enhance the low, middle, or high facial frequency information (cycles per face). Patients with AD demonstrated normal discrimination of small faces only...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.54.12.2316
更新日期:2000-06-27 00:00:00
abstract:OBJECTIVE:To analyze the impact of neutralizing antibodies (NAbs) on the clinical efficacy of IFNbeta. METHODS:This was an open-label study involving 78 patients with multiple sclerosis treated with Betaferon 8 million IU (MIU) subcutaneously (SC) every other day (n = 20), Rebif 22 micro g SC 3 times weekly (n = 25), ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000129265.73259.9e
更新日期:2004-06-08 00:00:00
abstract:OBJECTIVE:To describe the clinical, genetic and MR characteristics of patients with familial mesial temporal lobe epilepsy (MTLE). DESIGN/METHODS:The familial occurrence of MTLE was identified by a systematic search of family history of seizures in patients followed in the authors' epilepsy clinic. All probands and, w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.2.166
更新日期:2001-01-23 00:00:00
abstract:OBJECTIVE:To identify regional metabolic brain networks related specifically to the presence of tremor in PD. BACKGROUND:The pathophysiology of parkinsonian tremor is unknown. Because tremor in PD occurs mainly in repose, we used resting state PET with 18F-fluorodeoxyglucose (FDG) to identify specific metabolic brain ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.3.803
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:To identify gene mutations in patients with dystroglycanopathy and prove pathogenicity of those mutations using an in vitro cell assay. METHODS:We performed whole-exome sequencing on 20 patients, who were previously diagnosed with dystroglycanopathy by immunohistochemistry and/or Western blot analysis. We a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001162
更新日期:2015-01-20 00:00:00
abstract::We retrospectively examined the clinical courses of 20 children with severe near-drowning and divided their outcomes into 3 groups: normal (4), persistent vegetative state (9), and dead (7). We reviewed serial blood glucose levels and cerebral blood flow measured by stable xenon computed tomography within the 1st 48 h...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.5.820
更新日期:1990-05-01 00:00:00
abstract::Cytolytic T lymphocyte precursors (CTL-p) and natural killer precursors (NK-p) in the CSF of 15 MS patients and 11 patients with other neurologic disorders (OND) were quantitatively assessed, using a T-lymphocyte microculture system that allows clonal expansion of all human T cells. CSF CTL-p and NK-p frequencies were...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.3.419
更新日期:1987-03-01 00:00:00
abstract::We evaluated the effects of isoniazid on tremor in 13 patients with MS. Patients were evaluated before treatment, after 1 month of therapy (1,000 mg daily), and 1 month after the last dose. Ten patients improved on at least one of three methods of evaluation. Transient side effects were common, possibly because there ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.35.12.1772
更新日期:1985-12-01 00:00:00
abstract::The ability of two noninvasive diagnostic methods--oculoplethysmography-carotid phonoangiography (OPG/CPA) and directional Doppler ultrasonography--to detect extracranial cerebrovascular disease was examined in 400 consecutive studies. Cerebral arteriography was performed in 74 patients. Transient ischemic attack was ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.5.623
更新日期:1979-05-01 00:00:00
abstract::Cerebral necrosis following stroke exposes brain antigens to the immune system, potentially initiating an antibody response. The authors measured levels of antibodies to specific neuronal antigens, neurofilaments (NF), and a ubiquitous antigen, cardiolipin (CL), in 45 patients following an acute first-ever stroke, wit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.4.529
更新日期:2001-02-27 00:00:00
abstract:OBJECTIVE:This study correlated the extent of abnormalities detected by different magnetic resonance imaging (MRI) techniques [proton density (PD)-weighted, T1-weighted, and magnetization transfer imaging (MTI)] with the overall cognitive, frontal lobe, and memory impairments in patients with MS. PATIENTS:There were 3...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.6.1601
更新日期:1998-06-01 00:00:00
abstract::Mitoxantrone is the first drug approved for the treatment of secondary progressive multiple sclerosis (SPMS) in the United States. This assessment considers use of mitoxantrone in the treatment of MS. Mitoxantrone probably reduces the clinical attack rate and reduces attack-related MRI outcomes in patients with relaps...
journal_title:Neurology
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1212/01.wnl.0000095425.84407.39
更新日期:2003-11-25 00:00:00
abstract:OBJECTIVE:We describe a novel congenital motor neuron disease with early demise due to respiratory insufficiency with clinical overlap with spinal muscular atrophy with respiratory distress (SMARD) type 1 but lacking a mutation in the IGHMBP2 gene. METHODS:Exome sequencing was used to identify a de novo mutation in th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000305
更新日期:2014-04-15 00:00:00
abstract::The majority of patients with traumatic brain injury (TBI) are classified as having a mild TBI. Despite being categorized as mild, these individuals report ongoing and complex symptoms, which negatively affect their ability to complete activities of daily living and overall quality of life. Some of the major symptoms ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000010830
更新日期:2020-11-03 00:00:00
abstract:OBJECTIVES:(1) To assess the diagnostic accuracy of EMG in radiculopathy. (2) To evaluate the intrarater reliability and interrater reliability of EMG in radiculopathy. (3) To assess the presence of confirmation bias in EMG. METHODS:Three experienced academic electromyographers interpreted 3 compact discs with 20 EMG ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002292
更新日期:2016-01-19 00:00:00
abstract:OBJECTIVE:To evaluate the utility of "clinic room" case presentation in the ambulatory care setting. BACKGROUND:Neurology is increasingly an outpatient specialty. The transition from ward to clinic presents challenges for student and resident education. Interaction between attending physician and trainee is limited by...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-01-15 00:00:00
abstract:OBJECTIVE:To investigate long-term employment outcomes after resective epilepsy surgery in a national population-based cohort of adults. METHODS:In the Swedish National Epilepsy Surgery Register, all adults who were operated with resective epilepsy surgery from 1995 to 2010 were identified. Two-year follow-up was avai...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002069
更新日期:2015-10-27 00:00:00
abstract::Subacute encephalitis, characterized by demyelination, gliosis of the gray and white matter, focal necrosis, microglial nodules, atypical oligodendrocyte nuclei, and multinucleation of cells, was present in 27 of 30 (90%) autopsied patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Subac...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.4.562
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVE:To assess the medial plantar nerve action potential (NAP) and skin biopsy in the evaluation of suspected distal sensory neuropathies (SN) with normal routine nerve conduction studies (NCS). METHODS:A total of 110 consecutive patients with suspected distal SN and normal routine NCS underwent medial plantar NA...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000137036.26601.84
更新日期:2004-09-14 00:00:00
abstract::The clinical and genetic findings are described for 16 patients from a large Italian family with a variant form of hereditary spastic paraplegia and congenital arachnoid cysts inherited as an autosomal dominant trait. A molecular study has revealed a novel missense mutation, T614I, in exon 17 of SPG4, which may play a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000125324.32082.d9
更新日期:2004-05-25 00:00:00
abstract:OBJECTIVE:To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS). METHODS:A consensus committee comprising 140 key members of the international ALS community (ALS researchers, clinicians, patie...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章
doi:10.1212/WNL.0000000000007242
更新日期:2019-04-02 00:00:00