Abstract:
:Mitoxantrone is the first drug approved for the treatment of secondary progressive multiple sclerosis (SPMS) in the United States. This assessment considers use of mitoxantrone in the treatment of MS. Mitoxantrone probably reduces the clinical attack rate and reduces attack-related MRI outcomes in patients with relapsing MS (Type B recommendation). Also, mitoxantrone may have a beneficial effect on disease progression in patients with MS whose clinical condition is worsening (Type B recommendation). The potential for serious toxicity of mitoxantrone, however, must be taken into account when considering this therapy in individual patients. Moreover, because the potential clinical benefits on disease progression appear to be only modest, the results of the single phase III trial should be replicated in another (and hopefully much larger) clinical study before this agent is widely recommended for the treatment of patients with MS.
journal_name
Neurologyjournal_title
Neurologyauthors
Goodin DS,Arnason BG,Coyle PK,Frohman EM,Paty DW,Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.doi
10.1212/01.wnl.0000095425.84407.39subject
Has Abstractpub_date
2003-11-25 00:00:00pages
1332-8issue
10eissn
0028-3878issn
1526-632Xjournal_volume
61pub_type
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