Relationship between mesial temporal seizure focus and elevated serum prolactin in temporal lobe epilepsy.

Abstract:

:We evaluated the relationship between mesial temporal seizure focus and serum prolactin (PRL) in patients before and after they underwent anterior temporal lobectomy (ATL) for medically intractable temporal lobe epilepsy (TLE). These patients had a confirmed unilateral epileptogenic focus in mesial temporal structures, a postictal rise in serum PRL 15 to 20 minutes after onset of complex partial seizures, and were refractory for more than 2 years to antiepileptic drugs. Presurgical interictal serum PRL levels were significantly elevated (16.47 +/- 0.85 ng/mL, n = 62) and declined after ATL to normal values (patients, 9.63 +/- 0.55 ng/mL, n = 54; normal subjects, 8.99 +/- 0.57 ng/mL, n = 52). Serial evaluations indicated that normalization was seen 3 months after surgery (9.42 +/- 1.22 ng/mL, n = 9). The postsurgical reduction in serum PRL was similar in men and women, in patients with epileptogenic focus on either side of mesial temporal structures, and was unaffected by antiepileptic medication. We conclude that PRL is elevated following seizures and that a seizure focus in mesial temporal structures may exert a sustained excitatory influence on PRL release in patients with medically intractable TLE.

journal_name

Neurology

journal_title

Neurology

authors

Lin YY,Su MS,Yiu CH,Shih YH,Yen DJ,Kwan SY,Wu ZA,Chan SH

doi

10.1212/wnl.49.2.528

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

528-32

issue

2

eissn

0028-3878

issn

1526-632X

journal_volume

49

pub_type

杂志文章
  • Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers.

    abstract:OBJECTIVE:Glucocerebrosidase (GBA) gene mutations represent a strong risk factor for Parkinson disease (PD). PD penetrance in GBA mutation carriers, which represents a key issue for genetic counseling, especially for relatives of patients with Gaucher disease (GD), is unknown. Our objective was to estimate PD penetranc...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318245f476

    authors: Anheim M,Elbaz A,Lesage S,Durr A,Condroyer C,Viallet F,Pollak P,Bonaïti B,Bonaïti-Pellié C,Brice A,French Parkinson Disease Genetic Group.

    更新日期:2012-02-07 00:00:00

  • Cerebrovascular disease in childhood cancer survivors: A Children's Oncology Group Report.

    abstract:BACKGROUND:Curative therapy for childhood cancer has dramatically improved over past decades. Therapeutic radiation has been instrumental in this success. Unfortunately, irradiation is associated with untoward effects, including stroke and other cerebrovascular disease (CVD). The Children's Oncology Group (COG) has dev...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0b013e3181c17ea8

    authors: Morris B,Partap S,Yeom K,Gibbs IC,Fisher PG,King AA

    更新日期:2009-12-01 00:00:00

  • Nerve ultrasound improves detection of treatment-responsive chronic inflammatory neuropathies.

    abstract:OBJECTIVE:To examine the diagnostic accuracy of nerve ultrasound in a prospective cohort of consecutive patients with a clinical suspicion of chronic inflammatory neuropathies, including chronic inflammatory demyelinating polyneuropathy, Lewis-Sumner syndrome, and multifocal motor neuropathy, and to determine the added...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008978

    authors: Herraets IJT,Goedee HS,Telleman JA,van Eijk RPA,van Asseldonk JT,Visser LH,van den Berg LH,van der Pol WL

    更新日期:2020-04-07 00:00:00

  • Varicella optic neuritis.

    abstract::A 14-year-old girl developed severe bilateral optic neuritis 1 week after the onset of chickenpox. Though previous case reports state that complete recovery is the rule, this child had a persistent decrease in visual acuity in the right eye and loss of color vision and defects in visual fields in both eyes. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.3.501

    authors: Purvin V,Hrisomalos N,Dunn D

    更新日期:1988-03-01 00:00:00

  • The effects of acute and chronic ethanol administration on twitch and tetanic force production by rat gastrocnemius muscle in situ.

    abstract::The effects of acute ethanol injection on force production were measured in normal and chronic alcoholic rats. Acutely injected normal rats, acutely injected chronic alcoholic rats, and noninjected chronic alcoholic rats were compared with control groups: normal nonalcoholic rats and a dietetically deprived control gr...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.30.2.139

    authors: Martyn DA,Munsat TL

    更新日期:1980-02-01 00:00:00

  • Identification of distinctive interferon gene signatures in different types of myositis.

    abstract:OBJECTIVE:Activation of the type 1 interferon (IFN1) pathway is a prominent feature of dermatomyositis (DM) muscle and may play a role in the pathogenesis of this disease. However, the relevance of the IFN1 pathway in patients with other types of myositis such as the antisynthetase syndrome (AS), immune-mediated necrot...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008128

    authors: Pinal-Fernandez I,Casal-Dominguez M,Derfoul A,Pak K,Plotz P,Miller FW,Milisenda JC,Grau-Junyent JM,Selva-O'Callaghan A,Paik J,Albayda J,Christopher-Stine L,Lloyd TE,Corse AM,Mammen AL

    更新日期:2019-09-17 00:00:00

  • Central nervous system disease in patients with systemic lupus erythematosus.

    abstract::Central nervous system (CNS) dysfunction in patients with systemic lupus erythematosus (SLE) is highly variable, although it is often described under a single heading of "neuropsychiatric" or "CNS" SLE. To clarify these CNS abnormalities, we studied 91 lupus patients, 63 of whom had CNS symptoms or signs, over 599 pat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.9.1649

    authors: Futrell N,Schultz LR,Millikan C

    更新日期:1992-09-01 00:00:00

  • Reduced contrast sensitivity in compressive lesions of the anterior visual pathway.

    abstract::A clinical procedure for determining contrast sensitivity was performed on patients with suspected sella area masses. The test consisted of a series of six plates, each containing a bar pattern of fixed sinusoidal spatial frequency in which contrast varies along the length of the bar. Patients with compressive lesions...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.31.5.550

    authors: Kupersmith MJ,Siegel IM,Carr RE

    更新日期:1981-05-01 00:00:00

  • Absence of cystatin C mutation in sporadic cerebral amyloid angiopathy-related hemorrhage.

    abstract::In Icelandic pedigrees a cystatin C mutation, glutamine 68 (L68Q), causes autosomal dominant cerebral amyloid angiopathy-related hemorrhage (CAAH). We examined 33 patients with sporadic CAAH for this mutation. None carried L68Q and, including this report, only one of 52 published cases of sporadic CAAH has had the cys...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.1.242

    authors: McCarron MO,Nicoll JA,Stewart J,Ironside JW,Mann DM,Love S,Graham DI,Grubb A

    更新日期:2000-01-11 00:00:00

  • Sudomotor function in human poikilothermia.

    abstract::Hypohidrosis predisposes to hyperthermia and may indicate generalized thermoregulatory failure. To assess the sweating capacity in human poikilothermia, we performed a quantitative analysis of the central and peripheral sudomotor pathways in four women with acquired poikilothermia (aged 29 to 38 years) and nine contro...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.8.1602

    authors: MacKenzie MA,Schönbaum E,Hermus AR,Wollersheim HC,Thien T,Smals AG,Kloppenborg PW

    更新日期:1995-08-01 00:00:00

  • Epilepsy and sleep apnea syndrome.

    abstract::We identified seven patients with refractory partial epilepsy and sleep apnea. Treatment of the sleep apnea with nasal continuous positive airway pressure (CPAP), protriptyline, trazodone, acetazolamide, or tracheostomy reduced seizure frequency and severity in six patients. Success with CPAP depended largely on compl...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.11.2060

    authors: Devinsky O,Ehrenberg B,Barthlen GM,Abramson HS,Luciano D

    更新日期:1994-11-01 00:00:00

  • Restless legs syndrome: a predictor of lower physical function.

    abstract::Restless legs syndrome (RLS) is characterized by an urge to move the legs. The symptoms are more intense in the evening and during periods of inactivity. RLS symptoms are relieved by movement. It is classified as a sleep disorder, but in many ways it is actually a disorder of wakefulness that seems to intrude upon the...

    journal_title:Neurology

    pub_type: 评论,社论

    doi:10.1212/WNL.0000000000000298

    authors: Auerbach S,Walters AS

    更新日期:2014-04-08 00:00:00

  • Proof of genetic heterogeneity in X-linked Charcot-Marie-Tooth disease.

    abstract:OBJECTIVE:To characterize a large family with X-linked Charcot-Marie-Tooth (CMT) neuropathy without mutations in the gap junction protein B1 (GJB1) gene, which has an unusual phenotype that is different in some aspects from classic CMTX1. METHODS:We tested CMT families consistent with X-linked inheritance for GJB1 mut...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000247271.40782.b7

    authors: Huttner IG,Kennerson ML,Reddel SW,Radovanovic D,Nicholson GA

    更新日期:2006-12-12 00:00:00

  • Presymptomatic DNA and MRI diagnosis of neurofibromatosis 2 with mild clinical course in an extended pedigree.

    abstract::Neurofibromatosis 2 (NF2), a dominantly inherited disorder, typically manifests as bilateral vestibular schwannomas and predisposes to other nervous system tumors. In this study, we present a large pedigree with a benign course of NF2 (mild Gardner type) characterized by slowly growing vestibular schwannomas but few o...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.7.1314

    authors: Sainio M,Strachan T,Blomstedt G,Salonen O,Setälä K,Palotie A,Palo J,Pyykkö I,Peltonen L,Jääskeläinen J

    更新日期:1995-07-01 00:00:00

  • Magnetic cortical stimulation in acute spinal cord injury.

    abstract::We studied 25 patients within 6 hours of acute spinal cord injury using magnetically evoked cortical motor evoked potentials (MEPs). The subjects included 16 quadriplegics with cervical spine injuries and eight paraplegics. MEPs were recorded from abductor digiti minimi (ADM), biceps, flexor hallucis brevis, and tibia...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.45.2.303

    authors: Macdonell RA,Donnan GA

    更新日期:1995-02-01 00:00:00

  • Delivery of epilepsy care to adults with intellectual and developmental disabilities.

    abstract::Epilepsy is common in people with intellectual and developmental disabilities (IDD). In adulthood, patients with IDD and epilepsy (IDD-E) have neurologic, psychiatric, medical, and social challenges compounded by fragmented and limited care. With increasing neurologic disability, there is a higher frequency of epileps...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0000000000002060

    authors: Devinsky O,Asato M,Camfield P,Geller E,Kanner AM,Keller S,Kerr M,Kossoff EH,Lau H,Kothare S,Singh BK,Wirrell E

    更新日期:2015-10-27 00:00:00

  • Abnormal ocular motor function predicts clinical diagnosis of familial ataxia.

    abstract::Ocular motor performance was significantly impaired in familial ataxia patients as compared with normal controls. Ataxic patients showed prolonged saccadic latencies, longer saccadic refixation times, reduced visual tracking performance, and increased hypermetria. Cutoff values were derived and applied to 15 subjects ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.4.698

    authors: Hutton JT,Albrecht JW,Kuskowski M,Schut LJ

    更新日期:1987-04-01 00:00:00

  • Preclinical detection of Parkinson's disease: biochemical approaches.

    abstract::Dysfunction of NADH: ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport chain has been linked to the pathogenesis of Parkinson's disease. While simple assays of complex I activity are unlikely to be useful in the preclinical detection of Parkinson's disease, other more sophisticated physical...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.41.5_suppl_2.34

    authors: Parker WD Jr

    更新日期:1991-05-01 00:00:00

  • Landry-Guillain-Barré syndrome with abnormal pupils and normal eye movements: a case report.

    abstract::A 66-year-old woman with acute idiopathic polyneuritis (Landry-Guillain-Barré [LGB] syndrome) had normal extraocular movements, but her pupils did not react to light or accommodation. This is the first such case to be reported. Pharmacologic testing pointed to postganglionic involvement of parasympathetic and sympathe...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.29.7.1033

    authors: Williams D,Brust JC,Abrams G,Challenor Y,Devereaux M

    更新日期:1979-07-01 00:00:00

  • Clinical spectrum of episodic ataxia type 2.

    abstract::The authors searched for mutations in CACNA1A in patients with episodic ataxia and describe the clinical spectrum in genetically defined patients. Eighteen families and nine sporadic cases of episodic ataxia were evaluated for mutations in CACNA1A. The families were first genotyped to check for linkage to the chromoso...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000101675.61074.50

    authors: Jen J,Kim GW,Baloh RW

    更新日期:2004-01-13 00:00:00

  • Neuroanatomic correlates of visual hallucinations in poststroke hemianopic patients.

    abstract:OBJECTIVES:Homonymous hemianopia (HH) is the most frequent visual-field defect after a stroke. Some of these patients also have visual hallucinations, the origin and frequency of which remain largely unknown. The aims of this work were to determine the occurrence of visual hallucinations among poststroke hemianopic pat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000009366

    authors: Martinelli F,Perez C,Caetta F,Obadia M,Savatovsky J,Chokron S

    更新日期:2020-05-05 00:00:00

  • Double-blind crossover comparison of Tegretol-XR and Tegretol in patients with epilepsy. The Tegretol OROS Osmotic Release Delivery System Study Group.

    abstract::This multicenter, double-blind, crossover study compared Tegretol-XR and Tegretol tablets with respect to trough plasma carbamazepine (CBZ) concentrations, seizure control, tolerability, and safety. We randomized 96 patients with epilepsy to 56-day monotherapy with their usual daily CBZ dose administered as (1) Tegret...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1212/wnl.45.9.1703

    authors:

    更新日期:1995-09-01 00:00:00

  • Efficacy of rapid IV administration of valproic acid for status epilepticus.

    abstract::Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose. The authors reviewed 63 patients (30 men) with SE treated with IV VPA (average dose, 31.5 mg/kg). Analysis of demographic, clinical, and treatment infor...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.WNL.0000149527.47600.5A

    authors: Limdi NA,Shimpi AV,Faught E,Gomez CR,Burneo JG

    更新日期:2005-01-25 00:00:00

  • Immunologic studies of patients with chronic encephalitis induced by post-exposure Semple rabies vaccine.

    abstract::Neurologic complications of brain tissue-derived rabies vaccine may be chronic or progressive. Lymphocytes and serum from three patients with this form of encephalitis were studied. Two patients had positive lymphoproliferation to purified myelin, two had antibody to white matter, and one had antibody to myelin basic ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.1.42

    authors: Hemachudha T,Griffin DE,Johnson RT,Giffels JJ

    更新日期:1988-01-01 00:00:00

  • Irreversible spinal cord injury as a complication of subarachnoid ethanol neurolysis.

    abstract::Subarachnoid neurolysis using ethanol to destroy selectively the posterior roots of the spinal cord is a method for providing pain relief in patients with advanced cancer. Weakness of the extremities is a complication of the procedure that has been attributed to spread of the neurolytic agent to the anterior roots. Th...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.7.1522

    authors: McGarvey ML,Ferrante FM,Patel RS,Maljian JA,Stecker M

    更新日期:2000-04-11 00:00:00

  • Effectiveness of opicapone and switching from entacapone in fluctuating Parkinson disease.

    abstract:OBJECTIVE:To evaluate the effectiveness of opicapone as add-on to levodopa and the effects of switching from entacapone over 1 year of treatment in patients with fluctuating Parkinson disease. METHODS:After completion of a placebo- and entacapone-controlled double-blind study of opicapone (5, 25, or 50 mg), 495 patien...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000005557

    authors: Ferreira JJ,Lees AJ,Poewe W,Rascol O,Rocha JF,Keller B,Soares-da-Silva P

    更新日期:2018-05-22 00:00:00

  • Modulation of neural activation following treatment of hepatic encephalopathy.

    abstract:OBJECTIVE:To measure changes in psychometric state, neural activation, brain volume (BV), and cerebral metabolite concentrations during treatment of minimal hepatic encephalopathy. METHODS:As proof of principle, 22 patients with well-compensated, biopsy-proven cirrhosis of differing etiology and previous minimal hepat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31828726e1

    authors: McPhail MJ,Leech R,Grover VP,Fitzpatrick JA,Dhanjal NS,Crossey MM,Pflugrad H,Saxby BK,Wesnes K,Dresner MA,Waldman AD,Thomas HC,Taylor-Robinson SD

    更新日期:2013-03-12 00:00:00

  • Dapsone motor neuropathy--an axonal disease.

    abstract::Dapsone produces a potentially reversible toxic neuropathy, with its primary effect on the soma and axons of motor neurons as opposed to myelin. There is very little evidence to suggest involvement of sensory axons in most cases; if present, it would appear minimal. A "dying back" of motor axons is postulated to produ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.26.6.514

    authors: Gutmann L,Martin JD,Welton W

    更新日期:1976-06-01 00:00:00

  • Varicella-zoster virus DNA in CSF and arteries in delayed contralateral hemiplegia: evidence for viral invasion of cerebral arteries.

    abstract::A 78-year-old woman presented with a right basal ganglia infarct 6 weeks after a left herpes zoster ophthalmicus. MR angiography showed focal segmental stenosis of the proximal segments of the anterior, middle, and posterior cerebral arteries. Varicella DNA was detected in the CSF by polymerase chain reaction (PCR). T...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.47.2.569

    authors: Melanson M,Chalk C,Georgevich L,Fett K,Lapierre Y,Duong H,Richardson J,Marineau C,Rouleau GA

    更新日期:1996-08-01 00:00:00

  • Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes.

    abstract:OBJECTIVE:To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes. METHODS:This is a prospective cohort study at 3 Division I National Collegiate Athletic Association athletic programs. Participants were 214 Division I ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182582fe7

    authors: McAllister TW,Flashman LA,Maerlender A,Greenwald RM,Beckwith JG,Tosteson TD,Crisco JJ,Brolinson PG,Duma SM,Duhaime AC,Grove MR,Turco JH

    更新日期:2012-05-29 00:00:00