Sudomotor function in human poikilothermia.


:Hypohidrosis predisposes to hyperthermia and may indicate generalized thermoregulatory failure. To assess the sweating capacity in human poikilothermia, we performed a quantitative analysis of the central and peripheral sudomotor pathways in four women with acquired poikilothermia (aged 29 to 38 years) and nine controls. Heat challenge in a climatic chamber (ambient temperature 40 degrees C, 50% relative humidity) for 180 minutes revealed that both sweat secretion and evaporative weight loss were significantly lower in the patients than in the controls (p < 0.01). Temperature thresholds for thermal sweating were markedly elevated in at least two patients, whereas a third patient showed no sweating response. Stimulation of the eccrine sweat glands by intradermally injected acetylcholine during reduced core temperature (34.9 +/- 0.7 degrees C) revealed a significantly reduced sweating response in all patients (p < 0.01); the sudomotor response to pilocarpine iontophoresis was reduced or absent in three patients. We conclude that the generalized thermoregulatory sudomotor failure in these patients was attributable primarily to disorders of the central sudomotor drive; the impaired postganglionic sudomotor response is temperature related and possibly secondary to (long-standing) poikilothermia. Quantification of heat-dissipating capacity is pivotal for diagnosing severe thermolability and may help to prevent serious heat illness.






MacKenzie MA,Schönbaum E,Hermus AR,Wollersheim HC,Thien T,Smals AG,Kloppenborg PW




Has Abstract


1995-08-01 00:00:00












  • A subtype of sporadic prion disease mimicking fatal familial insomnia.

    abstract:OBJECTIVE:To establish a variant of sporadic prion disease as the sporadic form of fatal familial insomnia (FFI). BACKGROUND:FFI is a recently described prion disease characterized clinically by severe sleep impairment, dysautonomia, and motor signs, and pathologically by atrophy of thalamic nuclei, especially the med...


    pub_type: 杂志文章


    authors: Parchi P,Capellari S,Chin S,Schwarz HB,Schecter NP,Butts JD,Hudkins P,Burns DK,Powers JM,Gambetti P

    更新日期:1999-06-10 00:00:00

  • Spared awareness for the left side of internal visual images in patients with left-sided extrapersonal neglect.

    abstract::Two patients with neglect for extrapersonal space following right-hemisphere stroke both demonstrated retained ability to attend to the left side of internally generated visual images. The attentional system for extrapersonal space may not be identical to the attentional system for intrapersonal space. ...


    pub_type: 杂志文章


    authors: Anderson B

    更新日期:1993-01-01 00:00:00

  • Hemiballism and metastatic brain tumor.

    abstract::We describe a 78-year-old man with right hemiballism as the presenting symptom of a metastatic occult adenocarcinoma of the lung. CT demonstrated two contrast-enhancing lesions: one in the left subthalamic region and the other in the left parietal region. Metastatic tumor was confirmed at autopsy. ...


    pub_type: 杂志文章


    authors: Glass JP,Jankovic J,Borit A

    更新日期:1984-02-01 00:00:00

  • Focused ultrasound thalamotomy in Parkinson disease: Nonmotor outcomes and quality of life.

    abstract:OBJECTIVE:To examine nonmotor outcomes and correlates of quality of life (QoL) 3 and 12 months after unilateral focused ultrasound thalamotomy in tremor-dominant Parkinson disease (TDPD). METHODS:Twenty-seven patients with TDPD in a double-blind, sham-controlled, randomized clinical trial underwent comprehensive neuro...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Sperling SA,Shah BB,Barrett MJ,Bond AE,Huss DS,Gonzalez Mejia JA,Elias WJ

    更新日期:2018-10-02 00:00:00

  • A novel mitochondrial tRNAPhe mutation causes MERRF syndrome.

    abstract::A woman with typical features of myoclonic epilepsy with ragged red fibers (MERRF) had a novel heteroplasmic mutation (G611A) in the mitochondrial DNA tRNA phenylalanine gene. The mutation was heteroplasmic (91%) in muscle but undetectable in accessible tissues from the patient and her maternal relatives. Single-fiber...


    pub_type: 杂志文章


    authors: Mancuso M,Filosto M,Mootha VK,Rocchi A,Pistolesi S,Murri L,DiMauro S,Siciliano G

    更新日期:2004-06-08 00:00:00

  • Cerebral hemodynamic impairment: methods of measurement and association with stroke risk.

    abstract::Stenosis or occlusion of the major arteries of the head and neck may cause hemodynamic impairment of the distal cerebral circulation. Hemodynamic factors may play an important role in the pathogenesis of ischemic stroke for patients with cerebrovascular disease. Several neuroimaging methods are currently available for...


    pub_type: 杂志文章,评审


    authors: Derdeyn CP,Grubb RL Jr,Powers WJ

    更新日期:1999-07-22 00:00:00

  • The childhood type of dermatomyositis.

    abstract::The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, l...


    pub_type: 杂志文章


    authors: Carpenter S,Karpati G,Rothman S,Watters G

    更新日期:1976-10-01 00:00:00

  • Dystonic postures generated from complex repetitive discharges.

    abstract::We report a woman with a chronic inflammatory myopathy who developed muscle stiffness and dystonic postures of both upper extremities. Electromyography demonstrated that involuntary complex repetitive discharges of muscle caused the posture. Rare cases of dystonic posturing may be of peripheral, and not central system...


    pub_type: 杂志文章


    authors: Preston DC,Finkleman RS,Munsat TL

    更新日期:1996-01-01 00:00:00

  • Effect of rebleeding on the course and incidence of vasospasm after subarachnoid hemorrhage.

    abstract:OBJECTIVE:Rebleeding of an aneurysm is a leading cause of morbidity and mortality after subarachnoid hemorrhage (SAH). Whereas numerous studies have demonstrated the risk factors associated with rebleeding, few data on complications of rebleeding, including its effect on the development of delayed cerebral ischemia (DC...


    pub_type: 杂志文章


    authors: Lord AS,Fernandez L,Schmidt JM,Mayer SA,Claassen J,Lee K,Connolly ES,Badjatia N

    更新日期:2012-01-03 00:00:00

  • Environmental antecedents of young-onset Parkinson's disease.

    abstract::We conducted an exploratory study of young-onset Parkinson's disease (YOPD) to examine occupational and environmental factors associated with disease risk. This case-control study included 63 YOPD patients (diagnosis on or before age 50); controls (n = 68) were diagnosed with rheumatoid arthritis. Crude odds ratios (O...


    pub_type: 杂志文章


    authors: Butterfield PG,Valanis BG,Spencer PS,Lindeman CA,Nutt JG

    更新日期:1993-06-01 00:00:00

  • Blinded evaluation confirms long-term asymmetric effect of unilateral thalamotomy or subthalamotomy on tremor in Parkinson's disease.

    abstract::In the past, stereotactic surgery was a regular treatment for prominent unilateral tremor in Parkinson's disease (PD), but follow-up studies were usually short-term and always unblinded. We examined 17 PD patients in long-term follow-up (mean, 10.9 years after surgery) and used videotapes and the Unified Parkinson's D...


    pub_type: 杂志文章


    authors: Diederich N,Goetz CG,Stebbins GT,Klawans HL,Nittner K,Koulosakis A,Sanker P,Sturm V

    更新日期:1992-07-01 00:00:00

  • Polygenic risk of Alzheimer disease is associated with early- and late-life processes.

    abstract:OBJECTIVE:To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers in stages preceding the clinical symptoms of dementia using data from 2 large observational cohort studies. METHODS:We computed polygenic risk scores (PGRS) using summary statistics from the International Genomics of Al...


    pub_type: 杂志文章


    authors: Mormino EC,Sperling RA,Holmes AJ,Buckner RL,De Jager PL,Smoller JW,Sabuncu MR,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2016-08-02 00:00:00

  • Long-term cerebral white and gray matter changes after preeclampsia.

    abstract:OBJECTIVE:To determine whether changes in cerebral structure are present after preeclampsia that may explain increased cerebrovascular risk in these women. METHODS:We conducted a case control study in women between 5 and 15 years after either a preeclamptic or normotensive pregnancy. Brain MRI was performed. Analysis ...


    pub_type: 杂志文章


    authors: Siepmann T,Boardman H,Bilderbeck A,Griffanti L,Kenworthy Y,Zwager C,McKean D,Francis J,Neubauer S,Yu GZ,Lewandowski AJ,Sverrisdottir YB,Leeson P

    更新日期:2017-03-28 00:00:00

  • Significance of circadian rhythms in severely brain-injured patients: A clue to consciousness?

    abstract:OBJECTIVE:To investigate the relationship between the presence of a circadian body temperature rhythm and behaviorally assessed consciousness levels in patients with disorders of consciousness (DOC; i.e., vegetative state/unresponsive wakefulness syndrome or minimally conscious state). METHODS:In a cross-sectional stu...


    pub_type: 杂志文章


    authors: Blume C,Lechinger J,Santhi N,del Giudice R,Gnjezda MT,Pichler G,Scarpatetti M,Donis J,Michitsch G,Schabus M

    更新日期:2017-05-16 00:00:00

  • Nigral dysfunction in drug-induced parkinsonism: an 18F-dopa PET study.

    abstract::We studied 13 patients with severe drug-induced parkinsonism (DIP) using L-6-[18F]fluorodopa positron emission tomography (18F-dopa PET) to investigate the integrity of their dopaminergic nigrostriatal projections. Twelve of these patients were subsequently followed clinically for a median of 23.5 months (range, 6 to ...


    pub_type: 杂志文章


    authors: Burn DJ,Brooks DJ

    更新日期:1993-03-01 00:00:00

  • A double-blind, placebo-controlled trial of high doses of gangliosides in amyotrophic lateral sclerosis.

    abstract::We performed a 3-month, double-blind, placebo-controlled trial of 300 mg of gangliosides (Cronassial) in 40 outpatients with amyotrophic lateral sclerosis (ALS). We evaluated drug effect through physical examinations and symptom scales. Though this dosage had no major toxic effect, Cronassial treatment did not signifi...


    pub_type: 临床试验,杂志文章


    authors: Lacomblez L,Bouche P,Bensimon G,Meininger V

    更新日期:1989-12-01 00:00:00

  • Airborne rabies encephalitis: demonstration of rabies virus in the human central nervous system.

    abstract::A veterinarian contracted rabies in the course of laboratory work with homogenates of rabid goat brain. Epidemiologic study determined a respiratory mode of transmission. After a fulminant encephalitic illness, formed rabies virions were identified in the synaptic zones of the olfactory glomeruli. Identification, isol...


    pub_type: 杂志文章


    authors: Conomy JP,Leibovitz A,McCombs W,Stinson J

    更新日期:1977-01-01 00:00:00

  • Nonoperative management of cubital tunnel syndrome: an 8-year prospective study.

    abstract::This study reports the results of a prospective trial of nonoperative management of the cubital tunnel syndrome in 128 patients. Forty-three of the patients had bilateral ulnar nerve compression. At study's end, information was available on 94% of patients and 164 managed extremities, at a mean of 58.6 months of follo...


    pub_type: 杂志文章


    authors: Dellon AL,Hament W,Gittelshon A

    更新日期:1993-09-01 00:00:00

  • Imipramine in absence and myoclonic-astatic seizures.

    abstract::A double-blind crossover study with imipramine was conducted in 10 patients with absence and myoclonic-astatic seizures who had not responded to conventional medications. Imipramine produced a significant initial decrease in seizure frequency in 5 of the 10 patients, and in 2 patients the beneficial effect was maintai...


    pub_type: 临床试验,杂志文章


    authors: Fromm GH,Wessel HB,Glass JD,Alvin JD,Van Horn G

    更新日期:1978-09-01 00:00:00

  • Regulatory and reimbursement issues in treating patients with immune-mediated neuropathies.

    abstract::Neurologists are prescribing intravenous immunoglobulin (IVIg) with increasing frequency to treat many neurologic conditions that have a proven or presumed autoimmune or inflammatory pathogenesis. Although IVIg is not FDA approved for any neurologic condition, physicians can safely prescribe it for several disorders w...


    pub_type: 杂志文章,评审


    authors: Donofrio PD,Busis NA

    更新日期:2002-12-24 00:00:00

  • Long-term follow-up of thalamic deep brain stimulation for essential and parkinsonian tremor.

    abstract::Thirteen consecutive patients with thalamic deep brain stimulation (DBS) were examined serially for 3 to 5 years. Initially, all demonstrated at least 50% improvement in contralateral tremor. At last follow-up, three of eight patients with Parkinson disease no longer used DBS because tremor had markedly improved, and ...


    pub_type: 杂志文章


    authors: Kumar R,Lozano AM,Sime E,Lang AE

    更新日期:2003-12-09 00:00:00

  • Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease.

    abstract::The presence of the APOE epsilon 4 allele encoding apolipoprotein E4 (apoE4) is the major genetic risk factor for late-onset Alzheimer's disease (AD). However, the molecular and cellular mechanisms by which APOE epsilon 4 renders AD risk are unclear. In this report, we present genetic evidence that an apoE receptor, L...


    pub_type: 杂志文章


    authors: Kang DE,Saitoh T,Chen X,Xia Y,Masliah E,Hansen LA,Thomas RG,Thal LJ,Katzman R

    更新日期:1997-07-01 00:00:00

  • Memory complaints and APOE-epsilon4 accelerate cognitive decline in cognitively normal elderly.

    abstract:OBJECTIVE:To investigate to what extent subjective memory complaints and APOE-epsilon4 allele carriage predict future cognitive decline in cognitively intact elderly persons, by evaluating both their separate and combined effects. METHODS:We selected 1,168 subjects from the population-based Longitudinal Aging Study Am...


    pub_type: 杂志文章


    authors: Dik MG,Jonker C,Comijs HC,Bouter LM,Twisk JW,van Kamp GJ,Deeg DJ

    更新日期:2001-12-26 00:00:00

  • A reliable method for localizing deep intracranial sources of the EEG.

    abstract::We have demonstrated the reliability of a noninvasive method for successfully localizing the intracranial origin of the EEG. The dipole localization method (DLM) is a computer-assisted, mathematical method based on electrical field theory and is similar to localization methods currently used by electrocardiologists. I...


    pub_type: 杂志文章


    authors: Smith DB,Sidman RD,Flanigin H,Henke J,Labiner D

    更新日期:1985-12-01 00:00:00

  • PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome.

    abstract:OBJECTIVE:To investigate the genetic and physiologic basis of the neuromuscular symptoms of hypotonia-cystinuria syndrome (HCS) and isolated PREPL deficiency, and their response to therapy. METHODS:We performed molecular genetic, histochemical, immunoblot, and ultrastructural studies, investigated neuromuscular transm...


    pub_type: 杂志文章


    authors: Régal L,Shen XM,Selcen D,Verhille C,Meulemans S,Creemers JW,Engel AG

    更新日期:2014-04-08 00:00:00

  • Steroid-sparing maintenance immunotherapy for MOG-IgG associated disorder.

    abstract:OBJECTIVE:Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) associated disorder (MOGAD) often manifests with recurrent CNS demyelinating attacks. The optimal treatment for reducing relapses is unknown. To help determine the efficacy of long-term immunotherapy in preventing relapse in patients with MOGAD, w...


    pub_type: 杂志文章


    authors: Chen JJ,Flanagan EP,Bhatti MT,Jitprapaikulsan J,Dubey D,Lopez Chiriboga ASS,Fryer JP,Weinshenker BG,McKeon A,Tillema JM,Lennon VA,Lucchinetti CF,Kunchok A,McClelland CM,Lee MS,Bennett JL,Pelak VS,Van Stavern G,Adesina

    更新日期:2020-07-14 00:00:00

  • Striatal D2 receptors in symptomatic and asymptomatic carriers of dopa-responsive dystonia measured with [11C]-raclopride and positron-emission tomography.

    abstract::We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. We examined striatal D2-receptor binding in (1) symptomatic subjects (treated and untreated) and (2) ...


    pub_type: 杂志文章


    authors: Kishore A,Nygaard TG,de la Fuente-Fernandez R,Naini AB,Schulzer M,Mak E,Ruth TJ,Calne DB,Snow BJ,Stoessl AJ

    更新日期:1998-04-01 00:00:00

  • Phenotype of adult Refsum disease due to a defect in peroxin 7.

    abstract::The biochemical hallmark of adult Refsum disease (ARD) is an isolated deficiency in the breakdown of phytanic acid. This usually results from a PHYH gene defect, although some cases have been found to carry a PEX7 defect. We describe the phenotype of such a patient, indistinguishable from that of classic ARD. Hence, w...


    pub_type: 杂志文章


    authors: Horn MA,van den Brink DM,Wanders RJ,Duran M,Poll-The BT,Tallaksen CM,Stokke OH,Moser H,Skjeldal OH

    更新日期:2007-02-27 00:00:00

  • Cardiac sources of embolism and cerebral infarction--clinical consequences and vascular concomitants: the Lausanne Stroke Registry.

    abstract::We studied clinical characteristics and coexisting causes of stroke in 305 patients admitted to a population-based primary care center with an initial ischemic stroke and a potential cardiac source of embolism (PCSE). Using systematic standardized cardiac, arterial, and cerebral investigations and the logistics of the...


    pub_type: 杂志文章


    authors: Bogousslavsky J,Cachin C,Regli F,Despland PA,Van Melle G,Kappenberger L

    更新日期:1991-06-01 00:00:00

  • Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD.

    abstract:BACKGROUND:Abeta42-immunization reduces plaque burden and improves cognition in transgenic mouse models of Alzheimer disease (AD). This phase 1 study evaluated the safety, tolerability, and immunogenicity of AN1792 (human aggregated Abeta42) in patients with mild to moderate AD. METHODS:Twenty patients were enrolled i...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Bayer AJ,Bullock R,Jones RW,Wilkinson D,Paterson KR,Jenkins L,Millais SB,Donoghue S

    更新日期:2005-01-11 00:00:00