Experimental spinal cord injury: effects of trauma or ischemia on TRH and muscarinic receptors.

abstract：:Recurrent stroke is a major public health concern and new treatment strategies are needed. While modulation of the renin angiotensin aldosterone system (RAAS) has proven effective in reducing recurrent cardiac events, its role in preventing recurrent cerebrovascular events remains unclear. RAAS is both a circulating a...

journal_title：Neurology

authors： Sokol SI,Portnay EL,Curtis JP,Nelson MA,Hebert PR,Setaro JF,Foody JM

更新日期：2004-07-27 00:00:00

abstract：OBJECTIVES:To evaluate the frequency, clinical and etiologic features, and short- and long-term outcomes of early recurrent TIA. METHODS:This prospective observational cohort study enrolled all consecutive patients with TIA referred to our emergency department and diagnosed by a vascular neurologist. Expedited assessm...

journal_title：Neurology

authors： Foschi M,Pavolucci L,Rondelli F,Spinardi L,Favaretto E,Filippini M,Degli Esposti D,Strocchi E,Faggioli G,Cortelli P,Guarino M,Bologna TIA Study-Group.

更新日期：2020-09-22 00:00:00

abstract：OBJECTIVE:To investigate clinical differences in warm and cold complex regional pain syndrome (CRPS) phenotypes. BACKGROUND:CRPS represents inhomogeneous chronic pain conditions; approximately 70% patients with CRPS have "warm" affected limbs and 30% have "cold" affected limbs. METHODS:We examined 50 patients with "c...

journal_title：Neurology

authors： Eberle T,Doganci B,Krämer HH,Geber C,Fechir M,Magerl W,Birklein F

更新日期：2009-02-10 00:00:00

abstract：BACKGROUND:Plasma exchange (PE) is used to treat severe episodes of CNS demyelination unresponsive to corticosteroids. Predictors of long-term response are not well known. METHODS:We retrospectively reviewed the medical records of 41 patients consecutively treated by PE between January 1995 and July 2007. The primary ...

journal_title：Neurology

authors： Llufriu S,Castillo J,Blanco Y,Ramió-Torrentà L,Río J,Vallès M,Lozano M,Castellà MD,Calabia J,Horga A,Graus F,Montalban X,Saiz A

更新日期：2009-09-22 00:00:00

abstract：:Intravenous tissue plasminogen activator (tPA) is an effective therapy for treatment of acute ischemic stroke when administered within 3 hours of symptom onset. Three large randomized clinical trials that have attempted to extend the time window for tPA treatment beyond 3 hours have failed to demonstrate convincing ev...

journal_title：Neurology

authors： Albers GW

更新日期：2001-01-01 00:00:00

abstract：:We have identified large-scale deletions in muscle mitochondrial DNA (mtDNA) in seven of seven patients with Kearns-Sayre syndrome (KSS). We found no detectable deletions in the mtDNA of ten non-KSS patients with other mitochondrial myopathies or encephalomyopathies, or three normal controls. The deletions ranged in s...

journal_title：Neurology

authors： Zeviani M,Moraes CT,DiMauro S,Nakase H,Bonilla E,Schon EA,Rowland LP

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVE:To characterize patterns of cognitive functioning in a well-defined group of patients with MRI-identified coexisting left temporal lobe developmental malformations (TLDM) and mesial temporal sclerosis (MTS), and to examine neuropsychological outcome in this dual-pathology group following epilepsy surgery. ME...

journal_title：Neurology

authors： Martin R,Dowler R,Gilliam F,Faught E,Morawetz R,Kuzniecky R

更新日期：1999-09-11 00:00:00

abstract：OBJECTIVE:To report a case of Lambert-Eaton myasthenic syndrome (LEMS) in a child and review the existing literature of LEMS in children. METHODS:We report a pediatric case of LEMS with the classic clinical triad of proximal weakness, autonomic dysfunction, and areflexia; the characteristic increment in compound motor...

journal_title：Neurology

authors： Morgan-Followell B,de Los Reyes E

更新日期：2013-05-21 00:00:00

abstract：BACKGROUND:Cerebrovascular disease (CVD) may contribute to mild cognitive impairment (MCI). We sought to determine the relation of white matter hyperintensity (WMH) volume and infarcts in brain MRI to MCI in a community-based sample. METHODS:A total of 679 elderly persons without dementia underwent brain MRI. WMH and ...

journal_title：Neurology

authors： Luchsinger JA,Brickman AM,Reitz C,Cho SJ,Schupf N,Manly JJ,Tang MX,Small SA,Mayeux R,DeCarli C,Brown TR

更新日期：2009-08-11 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) registries can provide valuable insights into the natural history of MS. Key observational findings of the registries include MS patient disability progression rate, predictors of increased disability, and changes in lifespan. MS registries have been established in Canada, the United ...

journal_title：Neurology

authors： Hurwitz BJ

更新日期：2011-01-04 00:00:00

abstract：:Dyskinesias are usually seen in Parkinson's disease (PD) patients after several years of L-dopa therapy. Their presence has been attributed to supersensitivity of striatal D1 and D2 receptors. We have used PET to assess striatal D2 receptor binding in untreated PD patients and striatal D1 and D2 binding in L-dopa-trea...

journal_title：Neurology

authors： Turjanski N,Lees AJ,Brooks DJ

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To determine the efficacy of acetyl-l-carnitine (ALCAR) on the rate of decline in early-onset AD patients. METHODS:A 1-year, multicenter, double-blind, placebo-controlled, randomized trial was conducted. Subjects were 45 to 65 years old, with a diagnosis of probable AD according to National Institute of Neur...

journal_title：Neurology

authors： Thal LJ,Calvani M,Amato A,Carta A

更新日期：2000-09-26 00:00:00

abstract：:Age at 1st risk for seizures may predict anomia following dominant anterior temporal lobectomy. We assessed confrontation naming before and 2 to 3 weeks after surgery in 45 right-handed patients grouped by side of focus and presence or absence of early (less than or equal to 5 years) risk factors. After left lobectomy...

journal_title：Neurology

authors： Stafiniak P,Saykin AJ,Sperling MR,Kester DB,Robinson LJ,O'Connor MJ,Gur RC

更新日期：1990-10-01 00:00:00

abstract：:Hypohidrosis predisposes to hyperthermia and may indicate generalized thermoregulatory failure. To assess the sweating capacity in human poikilothermia, we performed a quantitative analysis of the central and peripheral sudomotor pathways in four women with acquired poikilothermia (aged 29 to 38 years) and nine contro...

journal_title：Neurology

authors： MacKenzie MA,Schönbaum E,Hermus AR,Wollersheim HC,Thien T,Smals AG,Kloppenborg PW

更新日期：1995-08-01 00:00:00

abstract：:We describe a 43-year-old neurologically intact patient who reported episodes of diplopia and oscillopsia associated with a right-beating nystagmus and a skew deviation. These symptoms and signs were related to a left posterior epileptic EEG discharge. We suggest that these ocular motor signs derived from an ictal act...

journal_title：Neurology

authors： Galimberti CA,Versino M,Sartori I,Manni R,Martelli A,Tartara A

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVES:To investigate whether the human sciatic nerve might have a consistent somatotopic organization according to proximal fascicle input by spinal nerves. METHODS:Twelve patients (55.3 ± 15.5 years) with confirmed lesions of either the L5 or S1 spinal nerve root underwent magnetic resonance neurography of sciat...

journal_title：Neurology

authors： Bäumer P,Weiler M,Bendszus M,Pham M

更新日期：2015-04-28 00:00:00

abstract：:The association of APOE genotypes with cerebral microbleeds (CMBs) was examined on the basis of the location of CMBs in 414 patients who were admitted primarily because of stroke. With respect to possession of the epsilon2 or epsilon4 allele, the adjusted odds ratio was 1.94 (1.05 to 3.58) for lobar CMBs but 1.21 (0.6...

journal_title：Neurology

authors： Kim M,Bae HJ,Lee J,Kang L,Lee S,Kim S,Lee JE,Lee KM,Yoon BW,Kwon O,Koo JS,Kim BK

更新日期：2005-11-08 00:00:00

abstract：OBJECTIVE:Nonmotor symptoms (sleep dysfunction, sensory symptoms, autonomic dysfunction, mood disorders, and cognitive abnormalities) in Parkinson disease (PD) are a major cause of morbidity, yet are often underrecognized. This evidence-based practice parameter evaluates treatment options for the nonmotor symptoms of P...

journal_title：Neurology

authors： Zesiewicz TA,Sullivan KL,Arnulf I,Chaudhuri KR,Morgan JC,Gronseth GS,Miyasaki J,Iverson DJ,Weiner WJ,Quality Standards Subcommittee of the American Academy of Neurology.

更新日期：2010-03-16 00:00:00

abstract：OBJECTIVE:To understand the experience and identify drivers and mitigating factors of burnout and well-being among US neurologists. METHODS:Inductive data analysis was applied to free text comments (n = 676) from the 2016 American Academy of Neurology survey of burnout, career satisfaction, and well-being. RESULTS:Re...

journal_title：Neurology

authors： Miyasaki JM,Rheaume C,Gulya L,Ellenstein A,Schwarz HB,Vidic TR,Shanafelt TD,Cascino TL,Keran CM,Busis NA

更新日期：2017-10-17 00:00:00

abstract：BACKGROUND:An inverse association between cigarette smoking and the risk of idiopathic PD has been found in many epidemiologic studies. The therapeutic and possible neuroprotective effects of nicotine formulations on parkinsonian symptoms are controversial. METHODS:In a 12-week, randomized, double-blind, placebo-contr...

journal_title：Neurology

authors： Vieregge A,Sieberer M,Jacobs H,Hagenah JM,Vieregge P

更新日期：2001-09-25 00:00:00

abstract：OBJECTIVE:To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab. METHODS:In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in c...

journal_title：Neurology

authors： Calabresi PA,Giovannoni G,Confavreux C,Galetta SL,Havrdova E,Hutchinson M,Kappos L,Miller DH,O'Connor PW,Phillips JT,Polman CH,Radue EW,Rudick RA,Stuart WH,Lublin FD,Wajgt A,Weinstock-Guttman B,Wynn DR,Lynn F,Panzar

更新日期：2007-10-02 00:00:00

abstract：:Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic...

journal_title：Neurology

authors： Eerola J,Hernandez D,Launes J,Hellström O,Hague S,Gulick C,Johnson J,Peuralinna T,Hardy J,Tienari PJ,Singleton AB

更新日期：2003-10-14 00:00:00

abstract：:We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. Orally administered THIP (4,5,6,7-tetrahydroisoxazolo-[5,4,-c] pyridin-3-ol), a novel GABA receptor agonist, failed to improve motor o...

journal_title：Neurology

authors： Foster NL,Chase TN,Denaro A,Hare TA,Tamminga CA

更新日期：1983-05-01 00:00:00

abstract：:Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose. The authors reviewed 63 patients (30 men) with SE treated with IV VPA (average dose, 31.5 mg/kg). Analysis of demographic, clinical, and treatment infor...

journal_title：Neurology

authors： Limdi NA,Shimpi AV,Faught E,Gomez CR,Burneo JG

更新日期：2005-01-25 00:00:00

abstract：:Apraxia is the loss of the ability to perform learned skilled movements correctly. In right-handers, apraxia and aphasia are most frequently associated with left-hemisphere lesions. When they are dissociated, however, aphasia is more common in the absence of apraxia than vice versa. There are two hypotheses that can a...

journal_title：Neurology

authors： Foundas AL,Henchey R,Gilmore RL,Fennell EB,Heilman KM

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to identify risk factors for rupture of unruptured cerebral aneurysms (UCAs) in elderly Japanese patients aged 70 years or older. METHODS:The participants included all patients 70 years of age or older in 3 prospective studies in Japan (the Unruptured Cerebral Aneurysm Study of Jap...

journal_title：Neurology

authors： Hishikawa T,Date I,Tokunaga K,Tominari S,Nozaki K,Shiokawa Y,Houkin K,Murayama Y,Ishibashi T,Takao H,Kimura T,Nakayama T,Morita A,For UCAS Japan and UCAS II Investigators.

更新日期：2015-11-24 00:00:00

abstract：OBJECTIVE:To determine the prevalence, incidence, and predictors of epilepsy among older adults in the Cardiovascular Health Study (CHS). METHODS:We analyzed data prospectively collected in CHS and merged with data from outpatient Medicare administrative claims. We identified cases with epilepsy using self-report, ant...

journal_title：Neurology

authors： Choi H,Pack A,Elkind MS,Longstreth WT Jr,Ton TG,Onchiri F

更新日期：2017-02-28 00:00:00

abstract：:Estrogen have been reported in animal studies to both enhance and block central dopaminergic activity and in one clinical report to improve tardive dyskinesia. In the present study estrogen (Premarin, 2.5 mg per day) administration caused varying degrees of improvement in less than one-third of 21 patients with chorea...

journal_title：Neurology

authors： Koller WC,Barr A,Biary N

更新日期：1982-05-01 00:00:00

abstract：:We report on the prevalence of dementia in Canadians age 85 years and older. The purpose of this study was to determine whether the prevalence of dementia continued to increase in the very old, and to define the types of dementia and their relative proportions in this age group. We collected data as part of the Canadi...

journal_title：Neurology

authors： Ebly EM,Parhad IM,Hogan DB,Fung TS

更新日期：1994-09-01 00:00:00

abstract：:We investigated the association of PD with a recently reported I93M mutation of the ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene, and with a new and common polymorphic variant S18Y of the same gene. We did not identify the I93M mutation in any of 139 unrelated PD cases or 113 controls. However, S18Y polymorph...

journal_title：Neurology

authors： Maraganore DM,Farrer MJ,Hardy JA,Lincoln SJ,McDonnell SK,Rocca WA

更新日期：1999-11-10 00:00:00