Abstract:
:Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor. L-5HTP combined with MK 486 were potent long-term therapeutic agents for postanoxic intention myoclonus, but had no effect on intention tremor or cerebral palsy. These drugs were well-tolerated by the patients, and more effective than any other known therapy for intention myoclonus. Cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid, the main catabolite of serotonin, appeared low in two patients with intention myoclonus and increased markedly during drug therapy. Postanoxic intention myoclonus may be causally related to a deficiency of brain serotonin.
journal_name
Neurologyjournal_title
Neurologyauthors
Van Woert MH,Sethy VHdoi
10.1212/wnl.25.2.135subject
Has Abstractpub_date
1975-02-01 00:00:00pages
135-40issue
2eissn
0028-3878issn
1526-632Xjournal_volume
25pub_type
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