Abstract:
:Eighteen patients with congenital nystagmus were studied with the techniques of electronystagmography and computer analysis. We found several complex wave forms of congenital nystagmus in the primary position of gaze above those of jerk and pendular nystagmus as defined clinically. An etiologic classification of motor fixation defect and sensory fixation defect nystagmus based on waveforms is not justified. Ocular tracking studies demonstrate that the smooth pursuit system is operational in congenital nystagmus and substantiate the belief that the fast component of jerk nystagmus is a corrective movement generated by the saccadic system. Patients with congenital nystagmus are able to produce voluntary saccades with normal velocity-amplitude relationships.
journal_name
Neurologyjournal_title
Neurologyauthors
Yee RD,Wong EK,Baloh RW,Honrubia Vdoi
10.1212/wnl.26.4.326subject
Has Abstractpub_date
1976-04-01 00:00:00pages
326-33issue
4eissn
0028-3878issn
1526-632Xjournal_volume
26pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::The major glycoprotein P0 from human and bovine peripheral nerves carries the L2/HNK-1 and L3 carbohydrate epitopes and is recognized by serum from patients with IgM gammopathy and polyneuropathy. Only serum from patients with reactivity toward the myelin-associated glycoprotein (MAG) was reactive with P0, while serum...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.8.1266
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between visual hallucinations in Parkinson disease (PD) and levels of γ-aminobutyric acid (GABA) in the primary visual cortex. METHODS:We utilized magnetic resonance spectroscopy to investigate occipital GABA levels in 36 participants with PD, 19 with and 17 without complex vi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006007
更新日期:2018-08-14 00:00:00
abstract:OBJECTIVE:In children with sickle cell disease (SCD), silent cerebral infarcts are the most frequent cause of neurologic injury. We determined the sensitivity and specificity of selective neurocognitive measures when separating children with silent cerebral infarcts and SCD from sibling controls. Additionally, we teste...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.6.1678
更新日期:1998-06-01 00:00:00
abstract::Subacute sclerosing panencephalitis (SSPE) is characterized by a hyperimmune state toward the polypeptides of measles virus except the matrix (M) protein. Using cloned (3H)-labeled complementary DNA probes for in situ hybridization, we found the M protein and nucleocapsid (NP) protein nucleotide sequences in glial cel...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.11.1605
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:To characterize children with new-onset seizures presenting as status epilepticus at a tertiary care children's hospital. METHODS:Prospectively collected data were reviewed from a database derived from a mandated critical care pathway. A total of 1,382 patients presented with new-onset seizures between 2001 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181d0cca2
更新日期:2010-02-23 00:00:00
abstract:OBJECTIVE:To investigate the relationship between cerebral amyloid angiopathy (CAA), dementia, and cognitive function in an autopsy sample of 211 Japanese-American men from the population-based Honolulu-Asia Aging Study. METHODS:Starting in 1991, participants were assessed with the Cognitive Abilities Screening Instru...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.11.1629
更新日期:2002-06-11 00:00:00
abstract::The authors describe two patients with clinical manifestations of the osmotic demyelination syndrome (ODS) and unusual MRI findings of gadolinium-enhancing peripheral cortical abnormalities. They propose that these represent extrapontine manifestations of ODS because neither patient had a notable hypoxic-ischemic insu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.7.1048
更新日期:2000-10-10 00:00:00
abstract:OBJECTIVE:Among the rare causes of myelopathies is primary intramedullary spinal cord lymphoma (PISCL). As PISCL is often underrecognized, delaying appropriate treatment, we sought to describe its presentation, imaging characteristics, and outcomes. METHODS:Mayo Clinic medical records, lymphoma database, and autopsies...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31822b00b9
更新日期:2011-08-23 00:00:00
abstract:OBJECTIVE:To localize a gene predisposing to benign epilepsy of childhood with centrotemporal spikes (BECTS). BACKGROUND:BECTS, or rolandic epilepsy, is the most prevalent idiopathic epilepsy syndrome in childhood. Functional relevant defects in the alpha 4 subunit of the neuronal nicotinic acetylcholine receptor (ACh...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.6.1608
更新日期:1998-12-01 00:00:00
abstract::We analyzed ictal features of psychogenic seizures using video-EEG recordings in 47 patients and reviewed the medical records to determine if patients received antiepileptic drug therapy and whether they were treated pharmacologically for status epilepticus. Unresponsive behavior in the absence of motor manifestations...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.1.95
更新日期:1992-01-01 00:00:00
abstract::This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.3.294
更新日期:1975-03-01 00:00:00
abstract:OBJECTIVE:To describe neural autoantibody profiles and outcomes in patients with neurologic autoimmunity associated with immune checkpoint inhibitor (ICI) cancer immunotherapy. METHODS:In this retrospective descriptive study, 63 patients with ICI-related neurologic autoimmunity were included: 39 seen at the Mayo Clini...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010632
更新日期:2020-10-27 00:00:00
abstract::We analyzed EEGs performed over a 6-month period on patients with impaired consciousness following acute hypoxia or anoxia. There were 17 EEGs performed on 14 patients. Nine of the 17 records contained spindle activity. Spindles were present in 6/8 EEGs in stuporous patients, in 3/9 EEGs in comatose patients, in 6/10 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.4.758
更新日期:1994-04-01 00:00:00
abstract::We reviewed the records of all patients with optic neuritis (ON) in Olmsted County, Minnesota, identified through the comprehensive records-linkage system at the Mayo Clinic, and identified 156 ON patients from 1935 to 1991 who had onset of the disease while residing in Olmsted County (incidence cases). Poisson regres...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.2.244
更新日期:1995-02-01 00:00:00
abstract::We recorded interictal spikes with closely spaced scalp electrodes and sphenoidal electrodes in four patients with temporal lobe epilepsy. We used multiple dipole modeling to study the number, three-dimensional intracerebral location, time activity, and functional relationship of the neuronal sources underlying the ep...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.45.1.118
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Hereditary neuralgic amyotrophy (HNA) is an autosomal-dominant disorder associated with recurrent, episodic, painful, brachial neuropathy. The gene for HNA has been mapped to chromosome 17q25. Characteristic features including hypotelorism, short stature, and cleft palate occur in some patients. OBJECTIVE:T...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.11.1963
更新日期:2001-12-11 00:00:00
abstract::This study concerns the expression of Met-enkephalin (MEnk) in the striatum and the external segment of the globus pallidus proper (GPe) in normal controls, idiopathic Parkinson's disease (PD), and striatonigral degeneration (SND). For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.7.1051
更新日期:1990-07-01 00:00:00
abstract::A patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1.2 and Kv1.6) antibodies by immunoprecipitation and rat brain immunolabeling was treated successfully with immunoadsorption and cyclophosphamide. Curiously, glutamic acid decarboxylase antibodies, absent at onset, appeared later. S...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000156945.39471.2C
更新日期:2005-04-12 00:00:00
abstract::Sensorimotor polyneuropathy developed in two workers who had been exposed to ethylene oxide gas repeatedly for several months. Sural nerve biopsies revealed axonal degeneration with mild changes of the myelin sheath. Unmyelinated fibers were also involved. Muscle biopsies showed typical denervation atrophy. Symptoms i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.3.377
更新日期:1983-03-01 00:00:00
abstract::We reviewed the clinical and electrophysiologic features of 36 patients with increased titers of IgM anti-GM1 antibodies. Mildly elevated titers of up to 3,200 were not associated with any particular clinical syndrome or disease. Clinically, 14 of 16 patients with highly elevated titers of 6,400 or higher had progress...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.7.1278
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to apply the HIV-associated neurocognitive disorders (HAND) criteria for diagnosing HAND in HIV-infected adults, in a cohort of HIV-infected youth to thus establish whether this system is able to detect a spectrum of neurocognitive disorders (ND) in HIV-infected youth. METHODS:We us...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002669
更新日期:2016-07-05 00:00:00
abstract:OBJECTIVE:To systematically review the evidence concerning the diagnostic yield of genetic and metabolic evaluation of children with global developmental delay or intellectual disability (GDD/ID). METHODS:Relevant literature was reviewed, abstracted, and classified according to the 4-tiered American Academy of Neurolo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3182345896
更新日期:2011-10-25 00:00:00
abstract:OBJECTIVE:Diverse autolysosomal proteins were quantified in neurally derived blood exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered neuronal autophagy. METHODS:Blood exosomes obtained once from patients with AD (n = 26) or frontotemporal dementia (n = 16), other patients with A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001702
更新日期:2015-07-07 00:00:00
abstract::Cytolytic T lymphocyte precursors (CTL-p) and natural killer precursors (NK-p) in the CSF of 15 MS patients and 11 patients with other neurologic disorders (OND) were quantitatively assessed, using a T-lymphocyte microculture system that allows clonal expansion of all human T cells. CSF CTL-p and NK-p frequencies were...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.3.419
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:In families with autosomal dominant partial epilepsy with auditory features (ADPEAF) with mutations in the LGI1 gene, we evaluated clustering of mutations within the gene and associations of penetrance and phenotypic features with mutation location and predicted effect (truncation or missense). METHODS:We ab...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318247ccbf
更新日期:2012-02-21 00:00:00
abstract::Four men with evidence of hemiatrophy resulting from early-life hemispheral injury developed unilateral hemiparkinsonism on the side of the hemiatrophy. The parkinsonism began in the fourth decade and has remained unilateral for 5 to 35 years. In all four patients, the parkinsonism was slowly progressive, but the clin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.5.625
更新日期:1981-05-01 00:00:00
abstract::We investigated the effects of estrogen replacement therapy (ERT) on the risk of development of dementia in 87 women with Parkinson's disease without dementia (PDND), 80 women with Parkinson's disease with dementia (PDD), and 989 nondemented healthy women from the same community. ERT was protective for the development...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.50.4.1141
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Despite convenience, accessibility, and strong correlation to severity of Alzheimer disease (AD) pathology, medial temporal lobe atrophy (MTA) has not been used as a criterion in the diagnosis of prodromal and probable AD. METHODS:Using a newly validated visual rating system, mean MTA scores of three bilate...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000336925.79704.9f
更新日期:2008-12-09 00:00:00
abstract:OBJECTIVE:To investigate the role of multiple distributed brain networks, including the default mode, fronto-temporo-parietal, and cingulo-opercular networks, which mediate domain-general and task-specific processes during speech production after aphasic stroke. METHODS:We conducted an observational functional MRI stu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002537
更新日期:2016-04-05 00:00:00
abstract:OBJECTIVE:To determine whether correlates of white matter integrity can provide general as well as specific insight into the chronic effects of head injury coupled with depression symptom expression in professional football players. METHOD:We studied 26 retired National Football League (NFL) athletes who underwent dif...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318299ccf8
更新日期:2013-07-02 00:00:00