Risk of premature stroke in recent immigrants (PRESARIO): population-based matched cohort study.

abstract：OBJECTIVE:To characterize brain functional connectivity in subjects with prechiasmatic visual system damage and relate functional connectivity features to extent of vision loss. METHODS:In this case-control study, resting-state, eyes-closed EEG activity was recorded in patients with partial optic nerve damage (n = 15)...

journal_title：Neurology

authors： Bola M,Gall C,Moewes C,Fedorov A,Hinrichs H,Sabel BA

更新日期：2014-08-05 00:00:00

abstract：OBJECTIVE:To examine the role of mutations in GABRB3 encoding the β3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. METHODS:We performed massive parallel sequencing of GABRB3 in 416 patient...

journal_title：Neurology

authors： Møller RS,Wuttke TV,Helbig I,Marini C,Johannesen KM,Brilstra EH,Vaher U,Borggraefe I,Talvik I,Talvik T,Kluger G,Francois LL,Lesca G,de Bellescize J,Blichfeldt S,Chatron N,Holert N,Jacobs J,Swinkels M,Betzler C,Syr

更新日期：2017-01-31 00:00:00

abstract：OBJECTIVES:To provide information on the effect of the coronavirus disease of 2019 (COVID-19) pandemic on people with epilepsy and provide consensus recommendations on how to provide the best possible care for people with epilepsy while avoiding visits to urgent care facilities and hospitalizations during the novel cor...

journal_title：Neurology

authors： French JA,Brodie MJ,Caraballo R,Devinsky O,Ding D,Jehi L,Jette N,Kanner A,Modi AC,Newton CR,Patel AA,Pennell PB,Perucca E,Sander JW,Scheffer IE,Singh G,Williams E,Wilmshurst J,Cross JH

更新日期：2020-06-09 00:00:00

abstract：:A 4-year-old girl presented to our tertiary care hospital with a complaint of lower extremity weakness and unsteady gait for 2 days. She was able to pull herself to stand, but could not stand unsupported. She had no sensory symptoms or pain. She did not complain of any weakness in her arms, trunk, face, or neck. She h...

journal_title：Neurology

authors： Chagnon SL,Naik M,Abdel-Hamid H

更新日期：2014-03-18 00:00:00

abstract：:We report a family with Machado-Joseph disease (MJD) that was previously diagnosed with dentatorubral-pallidoluysian atrophy (DRPLA), on the basis of the neuropathologic findings. Because the clinical and pathologic reevaluation strongly suggested a diagnosis of MJD, we conducted a genetic study in the family. Two pat...

journal_title：Neurology

authors： Sakai T,Antoku Y,Kawakami H,Maruyama H,Nakamura S,Tanaka K

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Virtually all adult studies of APOE genotypes and cognition have included individuals over 60. In older adults, epsilon 4 carriers may manifest greater cognitive asymmetries than non-epsilon 4 carriers even in the absence of overall mean differences. General cognitive ability may also be affected by aging an...

journal_title：Neurology

authors： Schultz MR,Lyons MJ,Franz CE,Grant MD,Boake C,Jacobson KC,Xian H,Schellenberg GD,Eisen SA,Kremen WS

更新日期：2008-05-06 00:00:00

abstract：:Alzheimer's disease is characterized by relative sparing of primary sensory and motor cortex and a lack of sensory or motor symptomatology. We report a case of presenile onset dementia accompanied by a slowly progressive hemiparesis. Autopsy examination showed severe pathologic involvement of somatosensory cortex with...

journal_title：Neurology

authors： Jagust WJ,Davies P,Tiller-Borcich JK,Reed BR

更新日期：1990-01-01 00:00:00

abstract：:A patient with a postoperative fistula of the left posterior semicircular canal is presented. Negative pressure in the external ear canal produced upbeat-torsional nystagmus, which was recorded in three dimensions using binocular scleral search coils. The nystagmus was conjugate, without skew deviation, and its trajec...

journal_title：Neurology

authors： Cremer PD,Migliaccio AA,Pohl DV,Curthoys IS,Davies L,Yavor RA,Halmagyi GM

更新日期：2000-05-23 00:00:00

abstract：OBJECTIVE:To investigate the relationship between cerebral amyloid angiopathy (CAA), dementia, and cognitive function in an autopsy sample of 211 Japanese-American men from the population-based Honolulu-Asia Aging Study. METHODS:Starting in 1991, participants were assessed with the Cognitive Abilities Screening Instru...

journal_title：Neurology

authors： Pfeifer LA,White LR,Ross GW,Petrovitch H,Launer LJ

更新日期：2002-06-11 00:00:00

abstract：OBJECTIVE:To examine the association between socioeconomic status (SES) and disability outcomes and progression in multiple sclerosis (MS). METHODS:Health administrative and MS clinical data were linked for 2 cohorts of patients with MS in British Columbia (Canada) and South East Wales (UK). SES was measured at MS sym...

journal_title：Neurology

authors： Harding KE,Wardle M,Carruthers R,Robertson N,Zhu F,Kingwell E,Tremlett H

更新日期：2019-03-26 00:00:00

abstract：:Childhood absence epilepsy (CAE) is defined by absence seizures in a normally developing child, with onset between 4 and 10 years of age.(1) Typical absence seizures consist of behavioral arrest with or without automatisms, usually last 30-60 seconds, and demonstrate a characteristic 3-Hz generalized spike-wave (GSW) ...

journal_title：Neurology

authors： Bernson-Leung ME,Mazumdar M

更新日期：2014-05-06 00:00:00

abstract：OBJECTIVES:There is currently much interest in biomarkers of disease activity in frontotemporal lobar degeneration (FTLD). We assessed MRI and behavioral measures of progression in a longitudinal FTLD cohort. METHODS:Thirty-two patients with FTLD (11 behavioral variant frontotemporal dementia [bvFTD], 11 semantic deme...

journal_title：Neurology

authors： Gordon E,Rohrer JD,Kim LG,Omar R,Rossor MN,Fox NC,Warren JD

更新日期：2010-02-23 00:00:00

abstract：OBJECTIVE:To evaluate changes from baseline in patient-reported outcomes for measures of functioning and disability among patients with migraine treated with galcanezumab or placebo. METHODS:Patients with episodic migraine (4-14 monthly migraine headache days) were treated with either galcanezumab (Evaluation of LY295...

journal_title：Neurology

authors： Ford JH,Ayer DW,Zhang Q,Carter JN,Leroux E,Skljarevski V,Aurora SK,Tockhorn-Heidenreich A,Lipton RB

更新日期：2019-07-30 00:00:00

abstract：:Eighty-five healthy elderly subjects were prospectively evaluated for 3 years to determine motor differences between those who remain cognitively intact and those who developed cognitive impairment during prospective follow-up. The 18 subjects who developed cognitive impairment had slower finger tapping and took longe...

journal_title：Neurology

authors： Camicioli R,Howieson D,Oken B,Sexton G,Kaye J

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:To model the temporal trajectory of β-amyloid accumulation using serial amyloid PET imaging. METHODS:Participants, aged 70-92 years, were enrolled in either the Mayo Clinic Study of Aging (n = 246) or the Mayo Alzheimer's Disease Research Center (n = 14). All underwent 2 or more serial amyloid PET examinatio...

journal_title：Neurology

authors： Jack CR Jr,Wiste HJ,Lesnick TG,Weigand SD,Knopman DS,Vemuri P,Pankratz VS,Senjem ML,Gunter JL,Mielke MM,Lowe VJ,Boeve BF,Petersen RC

更新日期：2013-03-05 00:00:00

abstract：:We describe 263 patients with autosomal dominant cerebellar ataxia from the Holguín province, Cuba. There is evidence of a common ancestry and the population represents the largest homogeneous group of patients yet described. Primary features include gait ataxia, dysarthria, dysmetria, adiadochokinesia, cramps, tremor...

journal_title：Neurology

authors： Orozco Diaz G,Nodarse Fleites A,Cordovés Sagaz R,Auburger G

更新日期：1990-09-01 00:00:00

abstract：:In four patients who received periocular injections of botulinum toxin for blepharospasm, abnormal neuromuscular transmission was demonstrated by single-fiber EMG in arm muscles. The time course with which the abnormalities developed and cleared, as well as the inverse relationship between the neuromuscular jitter and...

journal_title：Neurology

authors： Sanders DB,Massey EW,Buckley EG

更新日期：1986-04-01 00:00:00

abstract：OBJECTIVE:To use punch skin biopsies to evaluate the loss of intra-epidermal nerve fibers in sensory neuropathies. BACKGROUND:Previous assessments of epidermal nerve fibers have been constrained by relatively insensitive staining techniques and variability in quantification. METHODS:Punch skin biopsies were performed...

journal_title：Neurology

authors： McCarthy BG,Hsieh ST,Stocks A,Hauer P,Macko C,Cornblath DR,Griffin JW,McArthur JC

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:1) To reassess the prevalence of migraine in the United States; 2) to assess patterns of migraine treatment in the population; and 3) to contrast current patterns of preventive treatment use with recommendations for use from an expert headache panel. METHODS:A validated self-administered headache questionna...

journal_title：Neurology

authors： Lipton RB,Bigal ME,Diamond M,Freitag F,Reed ML,Stewart WF,AMPP Advisory Group.

更新日期：2007-01-30 00:00:00

abstract：:Permanent paralysis was induced in dogs by a 500 gram centimeter force injury on the spinal cord, and drug treatments were given 1 hour after injury and were continued for 3 days. Dogs were evaluated for 90 days. Isotonic saline or mannitol administration were ineffective in reversing the paralysis. In dogs receiving ...

journal_title：Neurology

authors： De La Torre JC,Johnson CM,Goode DJ,Mullan S

更新日期：1975-06-01 00:00:00

abstract：OBJECTIVE:To quantify the effects of cognitive training (CT) on cognitive and behavioral outcome measures in patients with Parkinson disease (PD). METHODS:We systematically searched 5 databases for randomized controlled trials (RCTs) of CT in patients with PD reporting cognitive or behavioral outcomes. Efficacy was me...

journal_title：Neurology

authors： Leung IH,Walton CC,Hallock H,Lewis SJ,Valenzuela M,Lampit A

更新日期：2015-11-24 00:00:00

abstract：:This study concerns the expression of Met-enkephalin (MEnk) in the striatum and the external segment of the globus pallidus proper (GPe) in normal controls, idiopathic Parkinson's disease (PD), and striatonigral degeneration (SND). For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk...

journal_title：Neurology

authors： Goto S,Hirano A,Matsumoto S

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:Carotid endarterectomy (CEA) is frequently performed based solely on noninvasive vascular imaging (NVI) results (duplex ultrasound, DU; magnetic resonance angiography, MRA; CT angiography, CTA). The authors determined how often intra-arterial contrast angiography (ANGIO) alters a CEA decision as compared to N...

journal_title：Neurology

authors： Johnston DC,Goldstein LB

更新日期：2001-04-24 00:00:00

abstract：:Using an antibody against choline acetyltransferase (ChAT), mesencephalic cholinergic cell nuclei were studied in autopsy material from 3 cases of progressive supranuclear palsy (PSP) and 4 controls. ChAT-immunoreactive neurons were quantified in sections that spanned the rostrocaudal extent of each nucleus. In PSP, t...

journal_title：Neurology

authors： Juncos JL,Hirsch EC,Malessa S,Duyckaerts C,Hersh LB,Agid Y

更新日期：1991-01-01 00:00:00

abstract：:Charcot-Marie-Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP) are inherited peripheral neuropathies. In most cases these disorders are caused by either the duplication (in CMT1A) or the deletion (in HNPP) of a 1.5-megabase DNA fragment on chromosome 17p11.2, which cont...

journal_title：Neurology

authors： Young P,Stögbauer F,Wiebusch H,Löfgren A,Timmerman V,Van Broeckhoven C,Ringelstein EB,Assmann G,Funke H

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:About 20% of patients with familial hemiplegic migraine (FHM) develop progressive cerebellar signs. Genetic studies have established an association with mutations in the CACNA1A gene. However, the mechanisms underlying cerebellar involvement are largely unknown. OBJECTIVE:To use proton MR spectroscopy (1H-M...

journal_title：Neurology

authors： Dichgans M,Herzog J,Freilinger T,Wilke M,Auer DP

更新日期：2005-02-22 00:00:00

abstract：:Acid protease activity was increased in skeletal muscle of patients with ALS. The highest levels of activity were found in individuals with the clinically and histologically most affected muscle. High levels of proteolytic activity correlated with the extent of muscle atrophy, the presence of target fibers and the ove...

journal_title：Neurology

authors： Antel JP,Chelmicka-Schorr E,Sportiello M,Stefansson K,Wollmann RL,Arnason BG

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVE:To determine whether the pathologic mechanisms of AD alter the brain networks subserving performance of a verbal recognition task. BACKGROUND:Functional imaging studies comparing task-related activation in AD patients and controls generally have not used network analysis and have not controlled for task diff...

journal_title：Neurology

authors： Stern Y,Moeller JR,Anderson KE,Luber B,Zubin NR,DiMauro AA,Park A,Campbell CE,Marder K,Bell K,Van Heertum R,Sackeim HA

更新日期：2000-11-14 00:00:00

abstract：:The visual-motor adaptation to lateral displacement of vision by prism glasses was studied in normal individuals and patients with cerebellar dysfunction, Parkinson's disease, right or left cerebral hemisphere lesions, Alzheimer's disease, or Korsakoff's syndrome. Adaptation was analyzed in two phases, the return to n...

journal_title：Neurology

authors： Weiner MJ,Hallett M,Funkenstein HH

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:Diverse autolysosomal proteins were quantified in neurally derived blood exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered neuronal autophagy. METHODS:Blood exosomes obtained once from patients with AD (n = 26) or frontotemporal dementia (n = 16), other patients with A...

journal_title：Neurology

authors： Goetzl EJ,Boxer A,Schwartz JB,Abner EL,Petersen RC,Miller BL,Kapogiannis D

更新日期：2015-07-07 00:00:00