Autosomal dominant cerebellar ataxia: clinical analysis of 263 patients from a homogeneous population in Holguín, Cuba.

abstract：OBJECTIVE:This study analyzed the relationship between performance on the American Academy of Neurology Residency In-Service Training Examination (RITE) and subsequent performance on the American Board of Psychiatry and Neurology (ABPN) Certification Examination. METHODS:Pearson correlation coefficients were used to e...

journal_title：Neurology

authors： Juul D,Flynn FG,Gutmann L,Pascuzzi RM,Webb L,Massey JM,Dekosky ST,Foertsch M,Faulkner LR

更新日期：2013-01-08 00:00:00

abstract：OBJECTIVE:To determine the prognosis of asymptomatic carotid artery occlusion. BACKGROUND:As opposed to symptomatic carotid occlusion, little information is available on the prognosis of asymptomatic carotid occlusion. METHOD:Thirty never-symptomatic and 81 symptomatic patients with carotid occlusion underwent baseli...

journal_title：Neurology

authors： Powers WJ,Derdeyn CP,Fritsch SM,Carpenter DA,Yundt KD,Videen TO,Grubb RL Jr

更新日期：2000-02-22 00:00:00

abstract：OBJECTIVE:We aimed to analyze lesion patterns of lacunae-sized infarctions in the perforating arterial territory in terms of shape and to determine whether the particular pattern of conglomerated beads shape affected early neurologic deterioration. METHODS:We consecutively included acute ischemic stroke patients with ...

journal_title：Neurology

authors： Ryu DW,Shon YM,Kim BS,Cho AH

更新日期：2012-05-01 00:00:00

abstract：:The American Academy of Neurology has published a comprehensive review and guidelines for the use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) for the first time since 2002. These guidelines represent the work of MS experts, patients, and guideline experts and are based on their review of randomize...

journal_title：Neurology

authors： Corboy JR,Weinshenker BG,Wingerchuk DM

更新日期：2018-06-12 00:00:00

abstract：OBJECTIVE:To examine whether the incidence, comorbidity, and mortality of first-time ischemic stroke changed in Denmark between 1996 and 2016 overall and according to age and sex using a nationwide cohort design. METHODS:In this cohort study, 224,617 individuals ≥18 years of age admitted with first-time ischemic strok...

journal_title：Neurology

authors： Yafasova A,Fosbøl EL,Christiansen MN,Vinding NE,Andersson C,Kruuse C,Johnsen SP,Gislason GH,Torp-Pedersen C,Køber L,Butt JH

更新日期：2020-10-27 00:00:00

abstract：:We studied a patient in a minimally conscious state using PET and cognitive evoked potentials. Cerebral metabolism was below half of normal values. Auditory stimuli with emotional valence (infant cries and the patient's own name) induced a much more widespread activation than did meaningless noise; the activation patt...

journal_title：Neurology

authors： Laureys S,Perrin F,Faymonville ME,Schnakers C,Boly M,Bartsch V,Majerus S,Moonen G,Maquet P

更新日期：2004-09-14 00:00:00

abstract：OBJECTIVE:To compare nonadherence to statins in older black and white adults following an ischemic stroke. METHODS:We studied black and white adults ≥66 years of age with Medicare fee-for-service insurance coverage hospitalized for ischemic stroke from 2007 to 2012 who filled a statin prescription within 30 days follo...

journal_title：Neurology

authors： Albright KC,Zhao H,Blackburn J,Limdi NA,Beasley TM,Howard G,Bittner V,Howard VJ,Muntner P

更新日期：2017-05-09 00:00:00

abstract：:Ocular motor performance was significantly impaired in familial ataxia patients as compared with normal controls. Ataxic patients showed prolonged saccadic latencies, longer saccadic refixation times, reduced visual tracking performance, and increased hypermetria. Cutoff values were derived and applied to 15 subjects ...

journal_title：Neurology

authors： Hutton JT,Albrecht JW,Kuskowski M,Schut LJ

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVE:To assess the clinical, urodynamic, and neurophysiologic features of patients with persisting bladder, bowel, and sexual dysfunction after transverse myelitis in myelin oligodendrocyte glycoprotein antibody (MOG-Ab) disease. METHODS:Patients with a history of MOG-Ab disease-related transverse myelitis seen p...

journal_title：Neurology

authors： Li V,Malladi P,Simeoni S,Pakzad M,Everett R,Satukijchai C,Leite MI,Palace J,Panicker JN

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:To assess the temporal trend in multiple sclerosis (MS) onset during the last 50 years in Sardinia, Italy. METHODS:The authors used a cohort study to assess age at onset in 1,513 MS patients at the MS clinic in Cagliari, all born and living in Sardinia. They also assessed age at onset in 41 pairs of familia...

journal_title：Neurology

authors： Cocco E,Sardu C,Lai M,Spinicci G,Contu P,Marrosu MG

更新日期：2004-05-25 00:00:00

abstract：:Myoclonus--dystonia is a genetically heterogeneous autosomal dominant disorder caused by a mutation in the D2 dopamine receptor on chromosome 11 and a locus on chromosome 7q21-q31. The authors tested linkage to the chromosome 7q candidate region in four families with either myoclonic dystonia (n = 3) or essential myoc...

journal_title：Neurology

authors： Vidailhet M,Tassin J,Durif F,Nivelon-Chevallier A,Agid Y,Brice A,Dürr A

更新日期：2001-05-08 00:00:00

abstract：OBJECTIVES:To estimate the risk to public safety posed by drivers with epilepsy, the authors compared annual totals and disease-specific risk for fatal crashes associated with seizures and other medical conditions. They compared individual risks for fatal crashes due to seizures and other causes of mortality in patient...

journal_title：Neurology

authors： Sheth SG,Krauss G,Krumholz A,Li G

更新日期：2004-09-28 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with complicated pathogenesis that poses challenges with respect to diagnosis and monitoring of disease progression. OBJECTIVES:To identify a biomarker panel that elucidates ALS disease pathogenesis, distinguishes patients with A...

journal_title：Neurology

authors： Mitchell RM,Freeman WM,Randazzo WT,Stephens HE,Beard JL,Simmons Z,Connor JR

更新日期：2009-01-06 00:00:00

abstract：:We gave three adult rhesus monkeys seven IV injections of manganese chloride at approximately 1-week intervals. We evaluated neurologic status by serial clinical examinations and performed a levodopa test if the animal developed features of basal ganglia dysfunction. After the animals were killed, we performed neuropa...

journal_title：Neurology

authors： Olanow CW,Good PF,Shinotoh H,Hewitt KA,Vingerhoets F,Snow BJ,Beal MF,Calne DB,Perl DP

更新日期：1996-02-01 00:00:00

abstract：:Phenytoin suspension (PHY-S) is reported to settle, resulting in uneven drug distribution and variable patient dosing. We designed this study to determine the rate of settling and the amount of agitation needed to resuspend the preparation. To determine the rate of settling, we thoroughly shook three bottles of PHY-S ...

journal_title：Neurology

authors： Sarkar MA,Garnett WR,Karnes HT

更新日期：1989-02-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab. METHODS:In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in c...

journal_title：Neurology

authors： Calabresi PA,Giovannoni G,Confavreux C,Galetta SL,Havrdova E,Hutchinson M,Kappos L,Miller DH,O'Connor PW,Phillips JT,Polman CH,Radue EW,Rudick RA,Stuart WH,Lublin FD,Wajgt A,Weinstock-Guttman B,Wynn DR,Lynn F,Panzar

更新日期：2007-10-02 00:00:00

abstract：:In the coterminous United States, MS mortality rates demonstrate a north-south gradient, which is confirmed by more sophisticated--and more expensive--prevalence studies. Mortality rates from idiopathic Parkinson's disease show a similar north-south gradient, and they correlate significantly with the MS mortality and ...

journal_title：Neurology

authors： Lux WE,Kurtzke JF

更新日期：1987-03-01 00:00:00

abstract：:Patients with symptomatic > or = 60% (n = 134), asymptomatic > or = 80% (n = 143), and asymptomatic progressive > or = 60% (n = 25) internal carotid artery stenosis underwent stenting and were followed clinically and by Doppler-assisted duplex imaging for 27.1 +/- 15.6 months. Stroke and death from stroke occurred wit...

journal_title：Neurology

authors： Bibl D,Lampl C,Biberhofer I,Kerschner K,Kypta A,Bergmann J,Kaindlstorfer A,Röper C,Yazdi K,Engleder C,Hofmann R,Deibl M,Leisch F,Ransmayr G

更新日期：2005-07-12 00:00:00

abstract：:This cross-sectional mail survey evaluated the prevalence and predictors of unconventional therapy (UT) utilization among 569 community-based people with MS. One-third reported having visited a UT practitioner in the last 6 months. Utilizers tended to report at least one medical comorbidity, earn at least $50,000 a ye...

journal_title：Neurology

authors： Schwartz CE,Laitin E,Brotman S,LaRocca N

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:In multiple sclerosis (MS), the aim of therapies is to prevent the accumulation of irreversible disability. This is difficult to assess given the short time course of clinical trials. MRI markers and relapses are often used as surrogate of disability in MS studies, but their validity remains controversial. We...

journal_title：Neurology

authors： Sormani MP,Li DK,Bruzzi P,Stubinski B,Cornelisse P,Rocak S,De Stefano N

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:In acute cerebral ischemia, two variables characterize the extent of hypoperfusion: the volume of hypoperfused tissue and the intensity of hypoperfusion within these regions. We evaluated the determinants of the intensity of hypoperfusion within oligemic regions among patients who were eligible for recanaliz...

journal_title：Neurology

authors： Bang OY,Saver JL,Alger JR,Starkman S,Ovbiagele B,Liebeskind DS,UCLA Collateral Investigators.

更新日期：2008-11-25 00:00:00

abstract：:A young girl who initially presented with jaw hypomobility at age 4 years subsequently developed signs of a slowly progressive myopathy. Rods were found in all sampled muscles, and were associated with fibrous contractures in the temporomandibular joint muscles. Rods in fibers undergoing necrosis displayed a pattern o...

journal_title：Neurology

authors： Powers JM,Young GF,Bass EB Jr,Reed FE Jr

更新日期：1980-09-01 00:00:00

abstract：OBJECTIVE:To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that may block this oxidative stress. METHODS:Brain tissue from patients with HIV encephalitis and macaques with simian immune deficiency virus encephalitis was immunostained for lipid peroxidation...

journal_title：Neurology

authors： Turchan J,Pocernich CB,Gairola C,Chauhan A,Schifitto G,Butterfield DA,Buch S,Narayan O,Sinai A,Geiger J,Berger JR,Elford H,Nath A

更新日期：2003-01-28 00:00:00

abstract：OBJECTIVE:To quantify the isoprostane 8,12-iso-iPF2alpha-VI in brain tissues obtained from patients with AD, patients with frontotemporal dementia (FTD), and controls. BACKGROUND:Enhanced brain oxidative stress with secondary damage to cellular macromolecules may play a role in the pathogenesis of AD and FTD. The isop...

journal_title：Neurology

authors： Yao Y,Zhukareva V,Sung S,Clark CM,Rokach J,Lee VM,Trojanowski JQ,Praticò D

更新日期：2003-08-26 00:00:00

abstract：:We evaluated the therapeutic efficacy and toxicity of high-dose monotherapy, using carbamazepine or phenytoin, in patients with previously uncontrolled seizures. Treatment with a single drug was equal to or better than polypharmacy, but only a few patients became free of seizures. Toxicity was mild and associated with...

journal_title：Neurology

authors： Lesser RP,Pippenger CE,Lüders H,Dinner DS

更新日期：1984-06-01 00:00:00

abstract：:Immediately after a patient with myoclonus epilepsy smoked a nicotine-containing cigarette, tetraparesis and hyperreflexia with ankle clonus developed, but disappeared within several minutes. During paresis, the H-reflex size of the soleus muscle increased, EEG showed more slow waves than before smoking, and the cereb...

journal_title：Neurology

authors： Yokota T,Kagamihara Y,Hayashi H,Tsukagoshi H,Tanabe H

更新日期：1992-02-01 00:00:00

abstract：:When the WHO's Topic Advisory Group for Neurology (TAG) started work on revision of the ICD-10 diagnostic codes in June 2009, the issues were daunting. The existing classification was produced a generation ago and the need to move to the digital age was becoming imperative. Appreciating modern advances in genetics and...

journal_title：Neurology

authors： Shakir R,Bergen D

更新日期：2013-07-09 00:00:00

abstract：OBJECTIVE:To describe the phenotype and phenotype-genotype correlations in patients with amyotrophic lateral sclerosis (ALS) with TARDBP gene mutations. METHODS:French TARDBP+ patients with ALS (n = 28) were compared first to 3 cohorts: 737 sporadic ALS (SALS), 192 nonmutated familial ALS (FALS), and 58 SOD1 + FALS, a...

journal_title：Neurology

authors： Corcia P,Valdmanis P,Millecamps S,Lionnet C,Blasco H,Mouzat K,Daoud H,Belzil V,Morales R,Pageot N,Danel-Brunaud V,Vandenberghe N,Pradat PF,Couratier P,Salachas F,Lumbroso S,Rouleau GA,Meininger V,Camu W

更新日期：2012-05-08 00:00:00

abstract：:The present study sought to evaluate the validity and generality of the Mini-Mental State Examination (MMSE) and its subsection scores. We gave the MMSE and other neuropsychological tests to 51 patients with probable Alzheimer's disease. On the basis of correlational and factor analyses, overall performance on the MMS...

journal_title：Neurology

authors： Giordani B,Boivin MJ,Hall AL,Foster NL,Lehtinen SJ,Bluemlein LA,Berent S

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVE:To assess the possible abnormalities in the baroreflex modulation of both the heart and the arterial vasculature, in order to better evaluate the role of baroreflex abnormalities in the generation of the cardiovascular symptoms and complications affecting the familial dysautonomia (FD) patient. METHODS:Twent...

journal_title：Neurology

authors： Stemper B,Bernardi L,Axelrod FB,Welsch G,Passino C,Hilz MJ

更新日期：2004-10-26 00:00:00