Comment on 2018 American Academy of Neurology guidelines on disease-modifying therapies in MS.

abstract：OBJECTIVES:To survey US physicians involved in acute stroke care to determine the proportion of hospitals that currently meet the recommended Brain Attack Coalition (BAC) criteria for Primary Stroke Centers (PSC) and obtain opinions regarding the value of stroke centers. METHODS:A survey regarding the BAC guidelines f...

journal_title：Neurology

authors： Kidwell CS,Shephard T,Tonn S,Lawyer B,Murdock M,Koroshetz W,Alberts M,Hademenos GJ,Saver JL

更新日期：2003-05-13 00:00:00

abstract：OBJECTIVE:To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity. METHODS:We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity. RESULTS:A single session of 1 Hz rTM...

journal_title：Neurology

authors： Centonze D,Koch G,Versace V,Mori F,Rossi S,Brusa L,Grossi K,Torelli F,Prosperetti C,Cervellino A,Marfia GA,Stanzione P,Marciani MG,Boffa L,Bernardi G

更新日期：2007-03-27 00:00:00

abstract：:Evaluating rehabilitation requires rating scales that detect change. The authors examined Barthel Index (BI) data from 1,495 patients at a neurorehabilitation unit to determine whether total scale responsiveness accurately reflects item responsiveness. Total score effect sizes were moderate to large (0.47 to 1.09). It...

journal_title：Neurology

authors： O'Connor RJ,Cano SJ,Thompson AJ,Hobart JC

更新日期：2004-05-25 00:00:00

abstract：OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESUL...

journal_title：Neurology

authors： Hu G,Jousilahti P,Nissinen A,Antikainen R,Kivipelto M,Tuomilehto J

更新日期：2006-12-12 00:00:00

abstract：:We established the frequency of Horner's syndrome (HS) in 248 elective patients after coronary artery bypass surgery. Patients were evaluated neurologically pre- and post-operatively and 6 months after surgery. Nineteen patients (7.7%) developed unilateral HS postoperatively, 12 involving the left eye. The finding per...

journal_title：Neurology

authors： Barbut D,Gold JP,Heinemann MH,Hinton RB,Trifiletti RR

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer a higher lesion detection than 1.5T, but it remains unclear whether this affects the fulfilment of the diagnostic criteria for multiple sclerosis (MS). METHODS:We recruited 66 patients with CIS within 6 months...

journal_title：Neurology

authors： Hagens MHJ,Burggraaff J,Kilsdonk ID,de Vos ML,Cawley N,Sbardella E,Andelova M,Amann M,Lieb JM,Pantano P,Lissenberg-Witte BI,Killestein J,Oreja-Guevara C,Ciccarelli O,Gasperini C,Lukas C,Wattjes MP,Barkhof F,MAGNIMS St

更新日期：2018-07-17 00:00:00

abstract：:We performed a prospective study of neuroimaging studies and temporal lobe pathology in 13 patients with facial asymmetry and intractable partial epilepsy of temporal lobe origin. The 13 patients, derived from 50 consecutive patients with nonlesional medically refractory partial epilepsy, were deemed appropriate candi...

journal_title：Neurology

authors： Cascino GD,Luckstein RR,Sharbrough FW,Jack CR Jr

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer's disease (AD) using a community-dwelling cohort of women (aged 70-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). METHOD...

journal_title：Neurology

authors： Younan D,Wang X,Casanova R,Barnard R,Gaussoin SA,Saldana S,Petkus AJ,Beavers DP,Resnick SM,Manson JE,Serre ML,Vizuete W,Henderson VW,Sachs BC,Salinas JA,Gatz M,Espeland MA,Chui HC,Shumaker SA,Rapp SR,Chen JC,Wom

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) registries can provide valuable insights into the natural history of MS. Key observational findings of the registries include MS patient disability progression rate, predictors of increased disability, and changes in lifespan. MS registries have been established in Canada, the United ...

journal_title：Neurology

authors： Hurwitz BJ

更新日期：2011-01-04 00:00:00

abstract：OBJECTIVE:To identify the disease-causing gene of a family with upper limb predominant, slowly progressive amyotrophic lateral sclerosis (ALS), which was diagnosed as flail arm syndrome (FAS). METHODS:After causation of 24 known ALS genes was excluded by targeted next-generation sequencing, whole-exome sequencing was ...

journal_title：Neurology

authors： Liu Q,Shu S,Wang RR,Liu F,Cui B,Guo XN,Lu CX,Li XG,Liu MS,Peng B,Cui LY,Zhang X

更新日期：2016-10-25 00:00:00

abstract：:We studied the nature and causes of delusions after infarction of the right cerebral hemisphere. Delusions involved orientation in time and place, events in the recent past, and the identities of familiar individuals. Some were transient and disorganized, and others were more fixed. No particular site in the right hem...

journal_title：Neurology

authors： Levine DN,Grek A

更新日期：1984-05-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of optimal combination of evidence-based drug therapies including antihypertensive agents, lipid modifiers, and antithrombotic agents on risk of recurrent vascular events after stroke. METHODS:We analyzed the database of a multicenter trial involving 3,680 recent noncardioembolic st...

journal_title：Neurology

authors： Park JH,Ovbiagele B

更新日期：2015-01-06 00:00:00

abstract：:Although referrals for narcolepsy are increasing, physicians continue to confront obstacles in diagnosing and treating this condition. Patients with narcolepsy also face challenges at work, at school, and at home. One of the more disturbing problems is the lack of public awareness of the disorder and its potential the...

journal_title：Neurology

authors： Douglas NJ

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:Brain changes occurring early in HIV infection are not well characterized. The Chicago Early HIV Infection Study aimed to evaluate the presence and extent of structural brain alterations using quantitative MRI. METHODS:Forty-three HIV and 21 control subjects were enrolled. Mean length of infection was estima...

journal_title：Neurology

authors： Ragin AB,Du H,Ochs R,Wu Y,Sammet CL,Shoukry A,Epstein LG

更新日期：2012-12-11 00:00:00

abstract：:Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of ser...

journal_title：Neurology

authors： Fox NC,Scahill RI,Crum WR,Rossor MN

更新日期：1999-05-12 00:00:00

abstract：:A rare case of solitary CNS chloroma in a patient with chronic granulocytic leukemia (CGL) is described. This appears to be the first reported case of intracranial chloroma in CGL without systemic blastic crisis. ...

journal_title：Neurology

authors： Lysy J,Globus M,Okon E,Polliack A,Chowers I

更新日期：1983-08-01 00:00:00

abstract：:Four of five members of a family complained of repeated attacks of hemiplegic migraine, migraine with aura of different types, or migraine without aura. The hemiplegia always outlasted the headache and was often accompanied by altered consciousness, aphasia, and, in one patient, coma; in this latter patient, the ictal...

journal_title：Neurology

authors： Marchioni E,Galimberti CA,Soragna D,Ferrandi D,Maurelli M,Ratti MT,Bo P,Montalbetti L,Albergati A,Savoldi F

更新日期：1995-01-01 00:00:00

abstract：:Subarachnoid neurolysis using ethanol to destroy selectively the posterior roots of the spinal cord is a method for providing pain relief in patients with advanced cancer. Weakness of the extremities is a complication of the procedure that has been attributed to spread of the neurolytic agent to the anterior roots. Th...

journal_title：Neurology

authors： McGarvey ML,Ferrante FM,Patel RS,Maljian JA,Stecker M

更新日期：2000-04-11 00:00:00

abstract：BACKGROUND:There are no published MRI studies comparing interferon beta 1b (IFNbeta-1b) and glatiramer acetate (GA) for treatment of relapsing multiple sclerosis (MS). OBJECTIVE:To compare the efficacy of IFNbeta-1b and GA for suppression of MS disease activity as evidenced on frequent brain MRI. METHODS:A total of 7...

journal_title：Neurology

authors： Cadavid D,Wolansky LJ,Skurnick J,Lincoln J,Cheriyan J,Szczepanowski K,Kamin SS,Pachner AR,Halper J,Cook SD

更新日期：2009-06-09 00:00:00

abstract：:Since the first development of diagnostic criteria for multiple sclerosis (MS), there have been regular revisions of disease definitions and diagnostic thresholds aimed at improving specificity while maintaining sensitivity. The central requirements for diagnosis of MS are dissemination in space (DIS) and disseminatio...

journal_title：Neurology

authors： Selchen D,Bhan V,Blevins G,Devonshire V,Duquette P,Grand'Maison F,Kremenchutzky M,Lapierre Y,Li D,von Riedemann SJ,Freedman M

更新日期：2012-12-04 00:00:00

abstract：:We investigated levodopa intravenous infusion rates, plasma concentrations, and clinical responses in 23 parkinsonian patients with a fluctuating response to the drug. There was a linear relationship between rate of levodopa infusion and plasma concentration when carbidopa was coadministered. Minimum-therapeutically e...

journal_title：Neurology

authors： Nutt JG,Woodward WR

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between the degree of handedness and hemispheric language dominance in patients with epilepsy. METHODS:The authors examined the relationship between degree of handedness and hemispheric language dominance in 174 epilepsy surgery candidates using the intracarotid amobarbital proced...

journal_title：Neurology

authors： Isaacs KL,Barr WB,Nelson PK,Devinsky O

更新日期：2006-06-27 00:00:00

abstract：:We administered the Mini-Mental State Exam (MMSE) to 194 healthy men and women, ages 40 to 89 years. Total score was significantly associated with age (p less than 0.0001), but not vocabulary, education, Beck's Depression Inventory Score, or sex. The lowest quartile cutoff scores for the MMSE by decade were 40s - 29; ...

journal_title：Neurology

authors： Bleecker ML,Bolla-Wilson K,Kawas C,Agnew J

更新日期：1988-10-01 00:00:00

abstract：:The authors correlated neurologic features of rostral lateral pontine infarct (rLPI) with lesion location on MRI. rLPI is a motor-sensory stroke presenting as crural monoparesis or crural dominant hemiparesis and segmental superficial or deep sensory disturbances. The dorsolateral pontine base causes crural paresis wi...

journal_title：Neurology

authors： Kataoka S,Miaki M,Saiki M,Saiki S,Yamaya Y,Hori A,Hirose G

更新日期：2003-07-08 00:00:00

abstract：:We evaluated the neuroprotective effect of MK-801, a noncompetitive, selective N-methyl-D-aspartate receptor antagonist, in a neonatal hypoxic-ischemic animal model. Seven-day-old rats underwent bilateral ligation of the carotid arteries followed by exposure to an 8% oxygen atmosphere for 1 hr. We sacrificed the anima...

journal_title：Neurology

authors： Hattori H,Morin AM,Schwartz PH,Fujikawa DG,Wasterlain CG

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:Spontaneous spinal CSF leaks are an important cause of new-onset headaches. Such leaks are reported to be particularly common at the cervico-thoracic junction. The authors undertook a study to determine the significance of these cervico-thoracic CSF leaks. METHODS:The patient population consisted of a consec...

journal_title：Neurology

authors： Schievink WI,Maya MM,Chu RM,Moser FG

更新日期：2015-06-16 00:00:00

abstract：OBJECTIVES:To learn caregivers' preferences for the treatment of AD with a disease-slowing therapy, and to identify relationships between these preferences and the characteristics of caregivers and patients. METHODS:A structured interview with 40 caregivers of patients with AD. Preferences were measured for an AD-slow...

journal_title：Neurology

authors： Karlawish JH,Klocinski JL,Merz J,Clark CM,Asch DA

更新日期：2000-10-10 00:00:00

abstract：:Prostaglandins B1 and B2 were topically applied to the pial vessels of mice and arteriolar constriction was observed. This constriction could be significantly increased if serotonin was added to B1, but not when norepinephrine was added. Response to B2 was not enhanced by the simultaneous addition of either serotonin ...

journal_title：Neurology

authors： Rosenblum WI

更新日期：1975-12-01 00:00:00

abstract：OBJECTIVE:APOE ε2 and ε4 alleles have been associated with lobar intracerebral hemorrhage (ICH) in predominately white populations; we sought to evaluate whether this held true among black and Hispanic populations. METHODS:The Ethnic/Racial Variations of Intracerebral Hemorrhage study is a prospective, multicenter cas...

journal_title：Neurology

authors： Sawyer RP,Sekar P,Osborne J,Kittner SJ,Moomaw CJ,Flaherty ML,Langefeld CD,Anderson CD,Rosand J,Woo D

更新日期：2018-07-31 00:00:00

abstract：:Four toluene abusers had evidence of severe multifocal central nervous system damage. Impairment of cognitive, cerebellar, brainstem, auditory, and pyramidal tract function, as well as CT evidence of cerebral cortical, cerebellar, and brainstem atrophy, have been noted. In addition, we found opsoclonus, ocular flutter...

journal_title：Neurology

authors： Lazar RB,Ho SU,Melen O,Daghestani AN

更新日期：1983-10-01 00:00:00