Establishment of primary stroke centers: a survey of physician attitudes and hospital resources.

abstract：OBJECTIVE:Diverse autolysosomal proteins were quantified in neurally derived blood exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered neuronal autophagy. METHODS:Blood exosomes obtained once from patients with AD (n = 26) or frontotemporal dementia (n = 16), other patients with A...

journal_title：Neurology

authors： Goetzl EJ,Boxer A,Schwartz JB,Abner EL,Petersen RC,Miller BL,Kapogiannis D

更新日期：2015-07-07 00:00:00

abstract：BACKGROUND AND PURPOSE:Persistently elevated intracranial pressure (ICP) has been associated with poor clinical outcome after severe brain injury, such as neurotrauma, intracerebral hemorrhage, and subarachnoidal hemorrhage. Although ICP monitoring is increasingly being used in intensive care treatment of patients with...

journal_title：Neurology

authors： Schwab S,Aschoff A,Spranger M,Albert F,Hacke W

更新日期：1996-08-01 00:00:00

abstract：:The effects of a single oral dose of levodopa administered in a randomized, double-blind, placebo-controlled cross-over design on formation of a motor memory were studied by a training protocol in patients with chronic stroke. Levodopa enhanced the ability of motor training to encode an elementary motor memory relativ...

journal_title：Neurology

authors： Floel A,Hummel F,Breitenstein C,Knecht S,Cohen LG

更新日期：2005-08-09 00:00:00

abstract：:Endovascular therapy for acute ischemic stroke continues to evolve to improve both efficacy and safety. In the late 1990 s, intra-arterial chemical thrombolysis with prourokinase was shown to be effective in achieving partial recanalization and improving clinical outcome, in comparison with intra-arterial heparin admi...

journal_title：Neurology

authors： Novakovic RL,Toth G,Narayanan S,Zaidat OO

更新日期：2012-09-25 00:00:00

abstract：:The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse ev...

journal_title：Neurology

authors： Killestein J,Hoogervorst EL,Reif M,Kalkers NF,Van Loenen AC,Staats PG,Gorter RW,Uitdehaag BM,Polman CH

更新日期：2002-05-14 00:00:00

abstract：OBJECTIVE:To examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis (ALS). METHODS:We measured Nf light chain (NfL) and phosphorylated Nf heavy chain (pNfH) CSF and NfL serum levels in patients with ALS with first symptom onset...

journal_title：Neurology

authors： Feneberg E,Oeckl P,Steinacker P,Verde F,Barro C,Van Damme P,Gray E,Grosskreutz J,Jardel C,Kuhle J,Koerner S,Lamari F,Amador MDM,Mayer B,Morelli C,Muckova P,Petri S,Poesen K,Raaphorst J,Salachas F,Silani V,Stuben

更新日期：2018-01-02 00:00:00

abstract：OBJECTIVE:Development of an easy to administer, low-cost test of vestibular function. METHODS:Members of the NIH Toolbox Sensory Domain Vestibular, Vision, and Motor subdomain teams collaborated to identify 2 tests: 1) Dynamic Visual Acuity (DVA), and 2) the Balance Accelerometry Measure (BAM). Extensive work was comp...

journal_title：Neurology

authors： Rine RM,Schubert MC,Whitney SL,Roberts D,Redfern MS,Musolino MC,Roche JL,Steed DP,Corbin B,Lin CC,Marchetti GF,Beaumont J,Carey JP,Shepard NP,Jacobson GP,Wrisley DM,Hoffman HJ,Furman G,Slotkin J

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:Affective-motivational and sensory-discriminative aspects of pain were investigated in patients with mild to moderate Alzheimer disease (AD) and healthy elderly controls using the cold pressor test tolerance and repetitive stimuli of warmth and heat stimuli, evaluating the stimulus-response function. METHOD...

journal_title：Neurology

authors： Jensen-Dahm C,Werner MU,Jensen TS,Ballegaard M,Andersen BB,Høgh P,Waldemar G

更新日期：2015-04-14 00:00:00

abstract：:Conditioning stimuli to the coronal gyrus or periventricular gray matter inhibit the activity of spinal trigeminal neurons. Valproate decreased the corticofugal inhibition of the spinal trigeminal nucleus, as did ethosuximide, trimethadione, and imipramine. Valproate and ethosuximide also decreased the periventricular...

journal_title：Neurology

authors： Fromm GH,Glass JD,Chattha AS,Martinez AJ,Silverman M

更新日期：1980-02-01 00:00:00

abstract：:The "modified host protein" model of scrapie proposes that the transmissible agent is composed of the degradation-resistant protein, Sp33-37, and that clinical and pathologic signs result from neurotoxic accumulations of this protein. Sp33-37 is an abnormal, amyloidogenic isoform of the normally occurring cellular pro...

journal_title：Neurology

authors： Bendheim PE,Brown HR,Rudelli RD,Scala LJ,Goller NL,Wen GY,Kascsak RJ,Cashman NR,Bolton DC

更新日期：1992-01-01 00:00:00

abstract：:The authors describe two novel mutations of the acid alpha-glucosidase gene, P361L and R437C, which define the juvenile-onset glycogen storage disease type II (GSDII) in a 16-year-old Chinese patient. The asymptomatic 13-year-old brother of the proband is also a compound heterozygote of the two mutations. These result...

journal_title：Neurology

authors： Lam CW,Yuen YP,Chan KY,Tong SF,Lai CK,Chow TC,Lee KC,Chan YW,Martiniuk F

更新日期：2003-02-25 00:00:00

abstract：:Of 49 patients with nonconvulsive seizures studied with continuous EEG monitoring, the overall mortality was 33% (16/49). Of the 23 patients with nonconvulsive status epilepticus (NCSE), 13 died (mortality 57%). Individual variables significantly associated with mortality were age, presence of NCSE, seizure duration, ...

journal_title：Neurology

authors： Young GB,Jordan KG,Doig GS

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The best treatment for polyneuropathy associated with IgM monoclonal gammopathy (MGUS) is unknown. Oral cyclophosphamide combined with prednisone showed limited efficacy in a previous open label pilot study. We therefore performed a double-blind, randomized, placebo-controlled study of combined oral cyclopho...

journal_title：Neurology

authors： Niermeijer JM,Eurelings M,van der Linden MW,Lokhorst HM,Franssen H,Fischer K,Teunissen LL,van den Berg LH,Schobben F,Wokke JH,Notermans NC

更新日期：2007-07-03 00:00:00

abstract：:This nested case-control study assessed the putative protective effect of human herpesvirus-8 (HHV-8) against HIV-1-related dementia (dementia). The HHV-8 seropositivity of 210 male age- and HIV disease stage-matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HI...

journal_title：Neurology

authors： Polk S,Muñoz A,Sacktor NC,Jenkins FJ,Cohen B,Miller EN,Jacobson LP

更新日期：2002-09-24 00:00:00

abstract：:This double-blind, placebo-controlled, crossover study of the acute treatment of migraine investigated the efficacy and tolerability of oral sumatriptan 100 mg (Imitrex) administered for up to nine attacks compared with placebo administered for up to three attacks. Patients were randomized to receive oral sumatriptan ...

journal_title：Neurology

authors： Rederich G,Rapoport A,Cutler N,Hazelrigg R,Jamerson B

更新日期：1995-08-01 00:00:00

abstract：:Cocaine, especially in its alkaloidal or "crack" form, has been increasingly associated with cerebrovascular disease. Before the crack epidemic, cocaine hydrochloride (HCl) was also implicated as a cause of stroke. However, less is known about the differences in stroke subtypes, age at stroke onset, or presence of und...

journal_title：Neurology

authors： Levine SR,Brust JC,Futrell N,Brass LM,Blake D,Fayad P,Schultz LR,Millikan CH,Ho KL,Welch KM

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVES:To quantify the quality of physicians' emergency first response to status epilepticus (SE) and to identify risk factors for nonadherence to treatment guidelines in a standardized simulated scenario. METHODS:In this prospective trial, 58 physicians (of different background) of the University Hospital Basel, ...

journal_title：Neurology

authors： Sutter R,Tisljar K,Opić P,De Marchis GM,Bassetti S,Bingisser R,Hunziker S,Marsch S

更新日期：2019-11-05 00:00:00

abstract：OBJECTIVE:To assess the attitudes, knowledge, and practice patterns of US neurologists regarding migraine management relative to the US Headache Consortium Guidelines (the Guidelines). METHODS:Two samples of 600 neurologists each were selected from the American Academy of Neurology membership database. The first group...

journal_title：Neurology

authors： Lipton RB,Bigal ME,Rush SR,Yenkosky JP,Liberman JN,Bartleson JD,Silberstein SD

更新日期：2004-06-08 00:00:00

abstract：:We describe 263 patients with autosomal dominant cerebellar ataxia from the Holguín province, Cuba. There is evidence of a common ancestry and the population represents the largest homogeneous group of patients yet described. Primary features include gait ataxia, dysarthria, dysmetria, adiadochokinesia, cramps, tremor...

journal_title：Neurology

authors： Orozco Diaz G,Nodarse Fleites A,Cordovés Sagaz R,Auburger G

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:To determine the rate of relapse occurrence during pregnancy and postpartum. METHODS:In a cross-sectional study using the national multiple sclerosis (MS) registry, pregnant women with relapsing MS were identified. Data on demographics, clinical characteristics, and disease-modifying therapies (DMTs), includ...

journal_title：Neurology

authors： Alroughani R,Alowayesh MS,Ahmed SF,Behbehani R,Al-Hashel J

更新日期：2018-03-06 00:00:00

abstract：OBJECTIVE:To analyze the spectrum and mechanisms of cutaneous adverse events (AEs) in patients with multiple sclerosis treated with daclizumab high-yield process (DAC-HYP). METHODS:A total of 31 participants in an institutional review board-approved open-label phase I study of DAC-HYP (NCT01143441) were prospectively ...

journal_title：Neurology

authors： Cortese I,Ohayon J,Fenton K,Lee CC,Raffeld M,Cowen EW,DiGiovanna JJ,Bielekova B

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:To determine whether increased risk of acute ischemic stroke (AIS) following herpes zoster (HZ) might be modified by the status of zoster vaccine live (ZVL) vaccination and antiviral treatment following HZ. METHODS:We included 87,405 Medicare fee-for-service beneficiaries aged ≥66 years diagnosed with HZ and...

journal_title：Neurology

authors： Yang Q,George MG,Chang A,Tong X,Merritt R,Hong Y

更新日期：2020-08-11 00:00:00

abstract：OBJECTIVE:We aimed to compare survival in the multiple sclerosis (MS) population with a matched cohort from the general population, and to evaluate the association of comorbidity with survival in both populations. METHODS:Using population-based administrative data, we identified 5,797 persons with MS and 28,807 contro...

journal_title：Neurology

authors： Marrie RA,Elliott L,Marriott J,Cossoy M,Blanchard J,Leung S,Yu N

更新日期：2015-07-21 00:00:00

abstract：OBJECTIVE:To examine the association between Miller Fisher syndrome (MFS) and antecedent Haemophilus influenzae infection. BACKGROUND:Little is known about agents in prior respiratory tract infection of MFS, whereas antecedent upper respiratory symptoms are frequent. H. influenzae is a major pathogen that can cause hu...

journal_title：Neurology

authors： Koga M,Yuki N,Tai T,Hirata K

更新日期：2001-08-28 00:00:00

abstract：OBJECTIVE:To test the hypothesis that concussion-related brain alterations seen at symptomatic injury and medical clearance to return to play (RTP) will have dissipated by 1 year after RTP. METHODS:For this observational study, 24 athletes with concussion were scanned longitudinally within 1 week after injury, at RTP,...

journal_title：Neurology

authors： Churchill NW,Hutchison MG,Graham SJ,Schweizer TA

更新日期：2019-11-19 00:00:00

abstract：BACKGROUND:Ependymoma is a rare type of glioma, representing 5% of all CNS malignancies. Radiotherapy (RT) is commonly administered, but there is no standard chemotherapy. At recurrence, ependymoma is notoriously refractory to therapy and the prognosis is poor. In recurrent glioblastoma, encouraging responses with beva...

journal_title：Neurology

authors： Green RM,Cloughesy TF,Stupp R,DeAngelis LM,Woyshner EA,Ney DE,Lassman AB

更新日期：2009-11-17 00:00:00

abstract：OBJECTIVE:In addition to the main multiple sclerosis (MS) major histocompatibility complex (MHC) risk allele (HLA DRB1*1501), investigations of the MHC have implicated several class I MHC loci (HLA A, HLA B, and HLA C) as potential independent MS susceptibility loci. Here, we evaluate the role of 3 putative protective ...

journal_title：Neurology

authors： Healy BC,Liguori M,Tran D,Chitnis T,Glanz B,Wolfish C,Gauthier S,Buckle G,Houtchens M,Stazzone L,Khoury S,Hartzmann R,Fernandez-Vina M,Hafler DA,Weiner HL,Guttmann CR,De Jager PL

更新日期：2010-08-17 00:00:00

abstract：:Fifty patients underwent superficial temporal lobectomy for intractable temporal lobe epilepsy. Total cure rate was 52%, and significant improvement was achieved in 88%. Cytoarchitectural changes in gray and white tissue were analyzed under light microscopy. Neuronal dysgenesis was correlated with the duration of seiz...

journal_title：Neurology

authors： Hardiman O,Burke T,Phillips J,Murphy S,O'Moore B,Staunton H,Farrell MA

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:Causes of benign positional vertigo (BPV) are mostly unknown. The aim of this study was to elucidate an association of osteoporosis with idiopathic BPV. METHODS:Two hundred nine consecutive patients with a confirmed diagnosis of idiopathic BPV underwent bone mineral densitometry of anterior-posterior lumbar ...

journal_title：Neurology

authors： Jeong SH,Choi SH,Kim JY,Koo JW,Kim HJ,Kim JS

更新日期：2009-03-24 00:00:00

abstract：:Migraine is a frequent familial disorder that, in common with most multifactorial disorders, has an unknown etiology. The authors identified several families with multiple individuals affected by typical migraine using a single set of diagnostic criteria and studied these families for cosegregation between the disorde...

journal_title：Neurology

authors： Nyholt DR,Lea RA,Goadsby PJ,Brimage PJ,Griffiths LR

更新日期：1998-05-01 00:00:00