Antiabsence drugs and inhibitory pathways.

abstract：OBJECTIVE:To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab. METHODS:In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in c...

journal_title：Neurology

authors： Calabresi PA,Giovannoni G,Confavreux C,Galetta SL,Havrdova E,Hutchinson M,Kappos L,Miller DH,O'Connor PW,Phillips JT,Polman CH,Radue EW,Rudick RA,Stuart WH,Lublin FD,Wajgt A,Weinstock-Guttman B,Wynn DR,Lynn F,Panzar

更新日期：2007-10-02 00:00:00

abstract：:Fibromyalgia (FM) and transformed migraine (TM) are common chronic pain disorders. The authors estimated the prevalence of FM in 101 patients with TM, and analyzed its relationship to depression, anxiety, and insomnia. FM was diagnosed in 35.6% of cases. Patients with FM had more insomnia, were older, and had headache...

journal_title：Neurology

authors： Peres MF,Young WB,Kaup AO,Zukerman E,Silberstein SD

更新日期：2001-10-09 00:00:00

abstract：:We studied the effects of acute ethanol intoxication on platelet function, coagulation factors, and fibrinolytic activity in 12 healthy men. During the ethanol session, 10 of the 12 developed a transient decrease in fibrinolytic activity. Ethanol ingestion increased factor VIII coagulant activity. VIII-related antigen...

journal_title：Neurology

authors： Hillbom M,Kaste M,Rasi V

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVE:Kennedy disease (KD), or spinobulbomuscular atrophy, is a slowly progressive inherited neurodegenerative disorder, marked by prominent fasciculations that typically precede the development of other symptoms. Although the genetic basis of KD relates to triplet (CAG) repeat expansion in the androgen receptor (A...

journal_title：Neurology

authors： Vucic S,Kiernan MC

更新日期：2007-11-06 00:00:00

abstract：BACKGROUND AND PURPOSE:Resistance to insulin-mediated glucose uptake by peripheral tissues is a cardinal defect in type 2 diabetes mellitus. Insulin resistance is also common among nondiabetic individuals, and may be an important risk factor for stroke in both populations. The authors review the definition, epidemiolog...

journal_title：Neurology

authors： Kernan WN,Inzucchi SE,Viscoli CM,Brass LM,Bravata DM,Horwitz RI

更新日期：2002-09-24 00:00:00

abstract：:We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a significant correlation between the change in EDS...

journal_title：Neurology

authors： Khoury SJ,Guttmann CR,Orav EJ,Hohol MJ,Ahn SS,Hsu L,Kikinis R,Mackin GA,Jolesz FA,Weiner HL

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...

journal_title：Neurology

authors： Karlawish JH,Casarett DJ,James BD,Xie SX,Kim SY

更新日期：2005-05-10 00:00:00

abstract：:We report a patient with striatonigral degeneration in whom T2-weighted MRI imaging revealed low signal and atrophy in the putamen. Neuropathologic studies confirmed putaminal atrophy and iron deposition in the MRI low signal regions. ...

journal_title：Neurology

authors： O'Brien C,Sung JH,McGeachie RE,Lee MC

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVE:To clarify the possible relation between the extent of involvement of catecholaminergic neurons and the presence of alveolar hypoventilation in patients with myotonic dystrophy (MyD). BACKGROUND:Respiratory insufficiency has been reported frequently in MyD patients. Recent data support the hypothesis that th...

journal_title：Neurology

authors： Ono S,Takahashi K,Jinnai K,Kanda F,Fukuoka Y,Kurisaki H,Mitake S,Inagaki T,Yamano T,Shimizu N,Nagao K

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:Glucocerebrosidase (GBA) gene mutations represent a strong risk factor for Parkinson disease (PD). PD penetrance in GBA mutation carriers, which represents a key issue for genetic counseling, especially for relatives of patients with Gaucher disease (GD), is unknown. Our objective was to estimate PD penetranc...

journal_title：Neurology

authors： Anheim M,Elbaz A,Lesage S,Durr A,Condroyer C,Viallet F,Pollak P,Bonaïti B,Bonaïti-Pellié C,Brice A,French Parkinson Disease Genetic Group.

更新日期：2012-02-07 00:00:00

abstract：OBJECTIVE:To describe the phenotypic spectrum and genetics of periventricular nodular heterotopia (PNH) caused by FLN1 mutations in four men. BACKGROUND:X-linked PNH caused by FLN1 mutations (MIM #300049) implies prenatal or early postnatal lethality in boys and 50% recurrence risk in daughters of affected women. MET...

journal_title：Neurology

authors： Guerrini R,Mei D,Sisodiya S,Sicca F,Harding B,Takahashi Y,Dorn T,Yoshida A,Campistol J,Krämer G,Moro F,Dobyns WB,Parrini E

更新日期：2004-07-13 00:00:00

abstract：:Parent of origin effects caused by genomic imprinting may influence the phenotypic expression of a number of heritable human disorders. To test this phenomenon in Tourette's syndrome (TS), we studied 437 first degree relatives systematically ascertained through 57 probands. We compared age at onset, age at diagnosis, ...

journal_title：Neurology

authors： Eapen V,O'Neill J,Gurling HM,Robertson MM

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:To investigate the genotype-phenotype correlation between neurofibromatosis 1 (NF1) germline mutations and imaging features of neurofibromas on whole-body MRI (WBMRI) by using radiomics image analysis techniques. MATERIALS AND METHODS:Twenty-nine patients with NF1 who had known germline mutations determined ...

journal_title：Neurology

authors： Liu Y,Jordan JT,Bredella MA,Erdin S,Walker JA,Vangel M,Harris GJ,Plotkin SR,Cai W

更新日期：2020-06-16 00:00:00

abstract：:We performed a prospective study of neuroimaging studies and temporal lobe pathology in 13 patients with facial asymmetry and intractable partial epilepsy of temporal lobe origin. The 13 patients, derived from 50 consecutive patients with nonlesional medically refractory partial epilepsy, were deemed appropriate candi...

journal_title：Neurology

authors： Cascino GD,Luckstein RR,Sharbrough FW,Jack CR Jr

更新日期：1993-04-01 00:00:00

abstract：:In four patients who received periocular injections of botulinum toxin for blepharospasm, abnormal neuromuscular transmission was demonstrated by single-fiber EMG in arm muscles. The time course with which the abnormalities developed and cleared, as well as the inverse relationship between the neuromuscular jitter and...

journal_title：Neurology

authors： Sanders DB,Massey EW,Buckley EG

更新日期：1986-04-01 00:00:00

abstract：:Glucocorticoid therapy slows the progression of Duchenne muscular dystrophy. In muscle cultures, the addition of the glucocorticoid methylprednisolone increases myogenesis in most normal mixed and clonal cultures. Conversely, in some normal clonal and most dystrophic cultures, methylprednisolone inhibits fusion. Howev...

journal_title：Neurology

authors： Hardiman O,Sklar RM,Brown RH Jr

更新日期：1993-02-01 00:00:00

abstract：:In many parkinsonian syndromes, neuromelanin (NM)-containing dopaminergic neurons of the substantia nigra (SN) are selectively targeted by the noxius pathogens. Studies of the constitutional and functional features of human NM allow the formulation of a logical hypothesis on its role in parkinsonian syndromes. In the ...

journal_title：Neurology

authors： Zecca L,Zucca FA,Albertini A,Rizzio E,Fariello RG

更新日期：2006-10-10 00:00:00

abstract：OBJECTIVE:To assess longitudinal follow-up of the incidence of multiple sclerosis (MS) through five decades and estimate the prevalence rate in Hordaland County, Norway, on January 1, 2003. METHODS:All patients with MS diagnosed from 1953 to 2003 were identified in the patient records of the Department of Neurology, H...

journal_title：Neurology

authors： Grytten N,Glad SB,Aarseth JH,Nyland H,Midgard R,Myhr KM

更新日期：2006-01-24 00:00:00

abstract：OBJECTIVES:To correlate the two types of early ischemic change on noncontrast CT (NCCT) (parenchymal hypoattenuation [PH] and isolated focal swelling [IFS]) with concurrent assessment of cerebral perfusion and to compare their rates of progression to infarction. METHODS:We assessed cortical regions on NCCT for early i...

journal_title：Neurology

authors： Parsons MW,Pepper EM,Bateman GA,Wang Y,Levi CR

更新日期：2007-03-06 00:00:00

abstract：:The extracranial carotid systems of 105 patients with retinal ischemia were examined using B-mode ultrasonography with integrated pulsed Doppler. Sixty-four patients had amaurosis fugax (AF), 17 central retinal artery occlusions (CRAO), and 21 branch retinal artery occlusions (BRAO). The prevalence of carotid stenosis...

journal_title：Neurology

authors： Chawluk JB,Kushner MJ,Bank WJ,Silver FL,Jamieson DG,Bosley TM,Conway DJ,Cohen D,Savino PJ

更新日期：1988-06-01 00:00:00

abstract：:The authors studied immunoglobulin G (IgG) Fc receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms in 62 patients with Guillain-Barré syndrome (GBS) and in 89 healthy controls. The FcgammaR genotypes and allele frequencies did not differ significantly between the patients with GBS and the controls. Patients homozygou...

journal_title：Neurology

authors： Vedeler CA,Raknes G,Myhr KM,Nyland H

更新日期：2000-09-12 00:00:00

abstract：OBJECTIVE:To determine whether the pathologic mechanisms of AD alter the brain networks subserving performance of a verbal recognition task. BACKGROUND:Functional imaging studies comparing task-related activation in AD patients and controls generally have not used network analysis and have not controlled for task diff...

journal_title：Neurology

authors： Stern Y,Moeller JR,Anderson KE,Luber B,Zubin NR,DiMauro AA,Park A,Campbell CE,Marder K,Bell K,Van Heertum R,Sackeim HA

更新日期：2000-11-14 00:00:00

abstract：OBJECTIVE:To assess dyskinesia frequency in a population-based cohort of patients with Parkinson disease (PD). Dyskinesia complicates levodopa treatment and affects quality of life. METHODS:Utilizing the 1991-2010 population-based, parkinsonism-incident cohort of Olmsted County, MN (n = 669), accessed via the Rocheste...

journal_title：Neurology

authors： Turcano P,Mielke MM,Bower JH,Parisi JE,Cutsforth-Gregory JK,Ahlskog JE,Savica R

更新日期：2018-12-11 00:00:00

abstract：OBJECTIVE:To evaluate the prospective association of long-term intake of vegetables and fruits with late-life subjective cognitive function (SCF). METHODS:Among 27,842 men with a mean age of 51 years in 1986, we used multinomial logistic regression to examine the relation of vegetable and fruit consumption to future S...

journal_title：Neurology

authors： Yuan C,Fondell E,Bhushan A,Ascherio A,Okereke OI,Grodstein F,Willett WC

更新日期：2019-01-01 00:00:00

abstract：:MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activ...

journal_title：Neurology

authors： Spranger M,Schwab S,Meinck HM,Tischendorf M,Sis J,Breitbart A,Andrassy K

更新日期：1997-01-01 00:00:00

abstract：:We administered Ro 40-7592, an inhibitor of the enzyme catechol-O-methyltransferase (COMT) that crosses the blood-brain barrier, to rats and monitored extracellular catecholamine levels in the corpus striatum before and after the intraperitoneal administration of a bolus of l-dopa. Acute administration of Ro 40-7592 i...

journal_title：Neurology

authors： Brannan T,Martínez-Tica J,Yahr MD

更新日期：1992-03-01 00:00:00

abstract：:As the substantia nigra degenerates in Parkinson's disease (PD), the nigrostriatal pathway is disrupted, reducing striatal dopamine and producing PD symptoms. Although dopamine does not readily cross the blood-brain barrier, its precursor, levodopa, does. Levodopa is absorbed in the small bowel and is rapidly cataboli...

journal_title：Neurology

authors： Koller WC,Rueda MG

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:To characterize patterns of cognitive functioning in a well-defined group of patients with MRI-identified coexisting left temporal lobe developmental malformations (TLDM) and mesial temporal sclerosis (MTS), and to examine neuropsychological outcome in this dual-pathology group following epilepsy surgery. ME...

journal_title：Neurology

authors： Martin R,Dowler R,Gilliam F,Faught E,Morawetz R,Kuzniecky R

更新日期：1999-09-11 00:00:00

abstract：OBJECTIVE:To determine the role of circulating microvesicles (MV) on long-term cardiovascular outcomes after stroke, we measured them in patients with first-ever stroke with a 3-year follow-up. METHODS:In the Prospective Cohort With Incident Stroke Berlin (PROSCIS-B), patients with first-ever ischemic stroke were foll...

journal_title：Neurology

authors： Huo S,Kränkel N,Nave AH,Sperber PS,Rohmann JL,Piper SK,Heuschmann P,Landmesser U,Endres M,Siegerink B,Liman TGG

更新日期：2020-11-12 00:00:00

abstract：OBJECTIVE:To perform a single-center pilot investigation of early hematoma removal in patients with intracerebral hemorrhage (ICH). BACKGROUND:Considerable debate remains regarding the utility of surgical clot evacuation for ICH. METHODS:This was a prospective trial of open craniotomy within 12 hours of ICH symptom o...

journal_title：Neurology

authors： Morgenstern LB,Frankowski RF,Shedden P,Pasteur W,Grotta JC

更新日期：1998-11-01 00:00:00