Abstract:
OBJECTIVE:To assess dyskinesia frequency in a population-based cohort of patients with Parkinson disease (PD). Dyskinesia complicates levodopa treatment and affects quality of life. METHODS:Utilizing the 1991-2010 population-based, parkinsonism-incident cohort of Olmsted County, MN (n = 669), accessed via the Rochester Epidemiology Project, we identified patients with PD and abstracted levodopa-related dyskinesia information. RESULTS:Of 309 patients with PD (46.2% with parkinsonisms), 279 (90.3%) received levodopa. Most (230/279; 82.4%) had been treated by a Mayo Clinic neurologist. Median age of the 309 patients with PD at the time of diagnosis was 74.1 years (range 33.1-97.8 years). Median-age levodopa initiation in this cohort was 75 years (range 37-98 years), and median-duration levodopa treatment was 6 years (range 2 months to 19.8 years). Dyskinesia was documented in 84 of 279 patients (30.1%). Median time from levodopa initiation to dyskinesia onset was 4 years (range 2 months to 20 years); those with dyskinesia (65.5%; 55/84) developed it within 5 years of levodopa initiation (9 within the first year). Dyskinesia was mild in 57/84 (67.9%), moderate in 16/84 (19.1%), and severe in 9/84 (10.7%); severity was not reported in 2 cases. Dyskinesia severity led to levodopa adjustments or amantadine initiation in 60.7% (51/84 of those with dyskinesia), with improvement in 23/51 (45.1%). Thirteen patients with dyskinesia underwent deep brain stimulation, reporting marked improvement. Postmortem examination confirmed Lewy body disease in 7 autopsied cases. CONCLUSIONS:Levodopa-induced dyskinesia affected 30% of the patients with PD in our cohort. Mayo neurologists favoring levodopa dosage optimization treated most patients. Dyskinesia was severe in 3.2% of all levodopa-treated patients with PD (10.7% of all patients with dyskinesia) with marked improvement among those treated with deep brain stimulation.
journal_name
Neurologyjournal_title
Neurologyauthors
Turcano P,Mielke MM,Bower JH,Parisi JE,Cutsforth-Gregory JK,Ahlskog JE,Savica Rdoi
10.1212/WNL.0000000000006643subject
Has Abstractpub_date
2018-12-11 00:00:00pages
e2238-e2243issue
24eissn
0028-3878issn
1526-632Xpii
WNL.0000000000006643journal_volume
91pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVES:To investigate the relationship between markers of vitamin B(12) status and brain volume loss per year over a 5-year period in an elderly population. METHODS:A prospective study of 107 community-dwelling volunteers aged 61 to 87 years without cognitive impairment at enrollment. Volunteers were assessed year...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000325581.26991.f2
更新日期:2008-09-09 00:00:00
abstract:OBJECTIVE:To determine the prevalence and clinical effect of ophthalmologic symptoms in patients with Parkinson disease (PD), compared with controls, using a standardized questionnaire. METHODS:In this observational, cross-sectional, multicenter study, 848 patients with PD and 250 healthy controls completed the Visual...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000009214
更新日期:2020-04-07 00:00:00
abstract:OBJECTIVE:To clarify the clinical and neurophysiologic spectrum of myoclonus-dystonia patients with mutations of the SGCE gene. METHODS:We prospectively studied 41 consecutive patients from 22 families with documented mutations of the SGCE gene. The patients had a standardized interview, neurologic examination, and de...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000297516.98574.c0
更新日期:2008-03-25 00:00:00
abstract:OBJECTIVE:To assess frontal lobe functions of subjects with age-associated memory impairment (AAMI) and to examine whether performance on neuropsychological tests is correlated with the volume of the frontal lobes in magnetic resonance imaging. DESIGN:Cross-sectional two-group comparison. SETTING:The Memory Research ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.48.1.148
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To estimate the risk to public safety posed by drivers with epilepsy, the authors compared annual totals and disease-specific risk for fatal crashes associated with seizures and other medical conditions. They compared individual risks for fatal crashes due to seizures and other causes of mortality in patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000138590.00074.9a
更新日期:2004-09-28 00:00:00
abstract::A decade of empirical work in brain imaging, genomics, and other areas of research has yielded new knowledge about the frequency of incidental findings, investigator responsibility, and risks and benefits of disclosure. Straightforward guidance for handling such findings of possible clinical significance, however, has...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000280469.17461.94
更新日期:2008-01-29 00:00:00
abstract:BACKGROUND:On proton magnetic resonance spectroscopic imaging ((1)H MRSI), there is a decrease in cerebellar N-acetylaspartate/total creatine (NAA/tCr) in essential tremor (ET), signifying cerebellar neuronal dysfunction or degeneration. Harmane, which is present in the human diet, is a potent tremor-producing neurotox...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000266663.27398.9f
更新日期:2007-08-07 00:00:00
abstract:OBJECTIVE:To use a historical placebo control design to determine whether lithium carbonate slows progression of amyotrophic lateral sclerosis (ALS). METHODS:A phase II trial was conducted at 10 sites in the Western ALS Study Group using similar dosages (300-450 mg/day), target blood levels (0.3-0.8 mEq/L), outcome me...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31822dc7a5
更新日期:2011-09-06 00:00:00
abstract::Brainstem auditory evoked responses were recorded after acute asphyxia in 126 infants, ages birth through 18 months. Of these, 21 had markedly abnormal amplitude ratios, and all infants with abnormal amplitude ratios had severe neurologic handicaps. An abnormal amplitude ratio predicts long-term neurologic sequelae of...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.11.1429
更新日期:1981-11-01 00:00:00
abstract::Primary lateral sclerosis (PLS) is a diagnosis of exclusion in patients with progressive spinobulbar spasticity and could be part of the clinical spectrum of ALS. Unlike ALS, which is familial in 5 to 10% of the cases, PLS has been described as a sporadic disorder in adults. The authors report two patients with PLS fr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000162033.47893.F7
更新日期:2005-05-24 00:00:00
abstract::We report 2 HIV-seropositive patients with neurosyphilis whose initial CSF VDRL tests were negative. The CSF VDRL became positive after 12 days of IV penicillin treatment for syphilitic meningitis in the 1st patient. The 2nd patient developed syphilitic polyradiculopathy and a positive CSF VDRL 3 months after treatmen...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.3_part_1.541
更新日期:1990-03-01 00:00:00
abstract::X-linked spinal and bulbar muscular atrophy (SBMA) is usually associated with feminization and hypogonadism. We were unable to find androgen receptor (AR) in the scrotal skin of three patients with SBMA, and propose that AR abnormality is the cause of the disease. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.9.1724
更新日期:1992-09-01 00:00:00
abstract::Using diagnostic criteria from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, dementia was clinically diagnosed in 57 (62%) of 92 centenarians living in two northern Italian provinces. The condition was severely disabling in approximately 70% of the demented patients. Although clinica...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.2.416
更新日期:1999-07-22 00:00:00
abstract:BACKGROUND:Silas Weir Mitchell (1829 to 1914), one of the most important neurologists in American Medicine, was known for his seminal work on the phantom limb syndrome, causalgia, and nerve injuries. He was also a prolific writer of novels and short stories. The neurologic content of this fiction has not been studied. ...
journal_title:Neurology
pub_type: 传,历史文章,杂志文章
doi:10.1212/01.wnl.0000196645.96131.b2
更新日期:2006-02-14 00:00:00
abstract:BACKGROUND:Photophobia is an abnormal sensitivity to light experienced by migraineurs during attacks. The pathophysiology of photophobia is poorly understood. Nevertheless, 2 facts appear to have a link with photophobia: visual cortex hyperexcitability on the one hand and interactions between visual pathway and trigemi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182074a57
更新日期:2011-01-18 00:00:00
abstract:OBJECTIVE:To characterize a kindred with a distinctive autosomal dominant neuromuscular disorder. BACKGROUND:The authors studied a large Italian family affected by a progressive neuromyopathy. Ten individuals over three generations were affected. The disease was characterized by onset from the late teens to early 50s ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.4.830
更新日期:1999-09-11 00:00:00
abstract::Spinal cord compression by extramedullary hemopoietic tissue is a rare complication of hemolytic anemias. This is the first report of this complication in hemolytic anemia caused by pyruvate-kinase deficiency. Indium scan, computed tomography (CT) scan, and myelography were helpful in diagnosis. Surgery and radiothera...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.4.510
更新日期:1979-04-01 00:00:00
abstract::The authors describe a patient with sporadic distal myopathy associated with reduced caveolin-3 in muscle fibers in which the muscle atrophy was restricted to the small muscles of the hands and feet. Gene analysis disclosed a heterozygous 80 G-->A substitution in the caveolin-3 gene that was identical to that of repor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.2.323
更新日期:2002-01-22 00:00:00
abstract:OBJECTIVE:To determine the diagnostic value of high-resolution ultrasound (HRUS) for detection of chronic inflammatory demyelinating polyneuropathy (CIDP), Lewis-Sumner syndrome (LSS), and multifocal motor neuropathy (MMN). METHODS:Between January 2013 and January 2015, we enrolled 75 consecutive treatment-naive patie...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003483
更新日期:2017-01-10 00:00:00
abstract::Treatment of functional symptoms has a long history, and interventions were often used in soldiers returning from battle. On the 75th anniversary of the end of the Second World War, I review the portrayal of neurology in documentary film. Two documentaries were released in 1946 and 1948 (Let There Be Light and Shades ...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0000000000009593
更新日期:2020-06-09 00:00:00
abstract::The clinical and genetic findings are described for 16 patients from a large Italian family with a variant form of hereditary spastic paraplegia and congenital arachnoid cysts inherited as an autosomal dominant trait. A molecular study has revealed a novel missense mutation, T614I, in exon 17 of SPG4, which may play a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000125324.32082.d9
更新日期:2004-05-25 00:00:00
abstract:OBJECTIVE:To analyze the frequency of neurologic events during commercial airline flights and to assess whether onboard emergency medical kits are adequate for in-flight neurologic emergencies. METHODS:Collaboration of the Mayo Clinic's Departments of Emergency Medicine and Medical Transportation Service and the Divis...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.58.12.1739
更新日期:2002-06-25 00:00:00
abstract::Dementia occurs infrequently in patients with giant cell (temporal) arteritis (GCA). Three elderly women with biopsy-proven GCA showed abrupt cognitive decline during periods of clinically active GCA, 1 to 6 months after diagnostic temporal artery biopsy, during periods of corticosteroid taper. One patient had additio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.5.753
更新日期:1990-05-01 00:00:00
abstract::Long-term hypothalamic stimulation is effective in improving drug-resistant chronic cluster headache (CH). We assessed acute hypothalamic stimulation to resolve ongoing CH attacks in 16 patients implanted to prevent chronic CH, investigating 136 attacks. A pain intensity reduction of > or =50% occurred in 25 of 108 ev...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000247273.93084.49
更新日期:2006-11-28 00:00:00
abstract::In 2001, the authors described the clinical features of a genetically distinct autosomal dominant limb-girdle muscular dystrophy (LGMD; LGMD 1F). Using a genome-wide screen with more than 400 microsatellite markers, the authors identified a novel LGMD disease locus at chromosome 7q32.1-32.2. Within this chromosomal re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073984.46546.4f
更新日期:2003-08-12 00:00:00
abstract:OBJECTIVE:The aim of this prospective study was to survey our patients about their experience with our clinic's telemedicine program to better understand telemedicine's utility for families, and to improve patient satisfaction and ultimately patient care. METHODS:This was a prospective survey study of patients and the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005482
更新日期:2018-05-08 00:00:00
abstract:OBJECTIVES:To compare the degrees to which 8 domains of health are affected across types of cerebrovascular events and to identify factors associated with domain scores in different event types. METHODS:This was an observational cohort study of 2,181 patients with ischemic stroke, intracerebral hemorrhage (ICH), subar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006626
更新日期:2018-12-04 00:00:00
abstract:OBJECTIVE:To study the safety of off-label IV thrombolysis in patients with very severe stroke (NIH Stroke Scale [NIHSS] scores >25) compared with severe stroke (NIHSS scores 15-25), where treatment is within European regulations. METHODS:Data were analyzed from 57,247 patients with acute ischemic stroke receiving IV ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002199
更新日期:2015-12-15 00:00:00
abstract:OBJECTIVE:To assess safety and feasibility of real-time (RT) MRI for evaluation of dysphagia and to compare this technique to standard assessment by flexible endoscopic evaluation of swallowing (FEES) and videofluoroscopy (VF) in a cohort of patients with inclusion body myositis (IBM). METHODS:Using RT-MRI, FEES, and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003337
更新日期:2016-11-15 00:00:00
abstract::We evaluated the relationship between mesial temporal seizure focus and serum prolactin (PRL) in patients before and after they underwent anterior temporal lobectomy (ATL) for medically intractable temporal lobe epilepsy (TLE). These patients had a confirmed unilateral epileptogenic focus in mesial temporal structures...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.2.528
更新日期:1997-08-01 00:00:00