Atherosclerotic carotid artery disease in patients with retinal ischemic syndromes.


:The extracranial carotid systems of 105 patients with retinal ischemia were examined using B-mode ultrasonography with integrated pulsed Doppler. Sixty-four patients had amaurosis fugax (AF), 17 central retinal artery occlusions (CRAO), and 21 branch retinal artery occlusions (BRAO). The prevalence of carotid stenosis (greater than or equal to 60%) ipsilateral to the symptomatic eye was low (16%). Eighty-six percent of AF patients had either no plaque causing less than a 60% stenosis. A significant proportion of subjects with normal duplex scans had alternative explanations for their retinal ischemia (eg, migraine, cardiac embolus). Patients with Hollenhorst plaques were more likely to have stenotic or ulcerated plaque (p = 0.04). The degree of carotid stenosis correlated significantly with the number of vascular risk factors identified in individual patients (p = 0.02). The presence of risk factors was more common in CRAO and BRAO patients compared with the AF group. Combined ultrasound-Doppler investigations of the carotid bifurcation are valuable noninvasive tools for the screening of patients with retinal ischemia.






Chawluk JB,Kushner MJ,Bank WJ,Silver FL,Jamieson DG,Bosley TM,Conway DJ,Cohen D,Savino PJ




Has Abstract


1988-06-01 00:00:00












  • Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis.

    abstract:OBJECTIVE:This study aims to evaluate protective effects of brief repetitive bilateral arm ischemic preconditioning (BAIPC) on stroke recurrence in patients with symptomatic atherosclerotic intracranial arterial stenosis (IAS). METHODS:A total of 68 consecutive cases with symptomatic IAS, diagnosed by imaging, were en...


    pub_type: 杂志文章,随机对照试验


    authors: Meng R,Asmaro K,Meng L,Liu Y,Ma C,Xi C,Li G,Ren C,Luo Y,Ling F,Jia J,Hua Y,Wang X,Ding Y,Lo EH,Ji X

    更新日期:2012-10-30 00:00:00

  • Renal cell carcinomatous meningitis: pathologic and immunohistochemical features.

    abstract::We report the clinical, radiographic, pathologic, and immunohistochemical features of a patient with widespread meningeal carcinomatosis from renal cell carcinoma. Clear and spindle tumor cell subtypes infiltrated the meninges of the cauda equina, oculomotor nerve, spinal cord, and cerebral hemispheres, forming aborti...


    pub_type: 杂志文章


    authors: Crino PB,Sater RA,Sperling M,Katsetos CD

    更新日期:1995-01-01 00:00:00

  • Prognostic significance of blood pressure variability after thrombolysis in acute stroke.

    abstract:OBJECTIVE:To evaluate the impact of early blood pressure (BP) changes on diffusion-weighted imaging (DWI) lesion evolution and clinical outcome in patients with stroke treated with IV tissue plasminogen activator (tPA). METHODS:We prospectively evaluated 80 patients with stroke with a documented middle cerebral artery...


    pub_type: 杂志文章


    authors: Delgado-Mederos R,Ribo M,Rovira A,Rubiera M,Munuera J,Santamarina E,Delgado P,Maisterra O,Alvarez-Sabin J,Molina CA

    更新日期:2008-08-19 00:00:00

  • Retinal thinning associates with nigral dopaminergic loss in de novo Parkinson disease.

    abstract:OBJECTIVE:To analyze the relationship between retinal thinning and nigral dopaminergic loss in de novo Parkinson disease (PD). METHODS:Forty-nine patients with PD and 54 age-matched controls were analyzed. Ophthalmologic examination and macula optical coherence tomography scans were performed with additional microperi...


    pub_type: 杂志文章


    authors: Ahn J,Lee JY,Kim TW,Yoon EJ,Oh S,Kim YK,Kim JM,Woo SJ,Kim KW,Jeon B

    更新日期:2018-09-11 00:00:00

  • Residual function in motor cortex contralateral to amputated hand.

    abstract:OBJECTIVE:To investigate residual function of the motor cortex corresponding to the hand of the amputated arm (MCamp). METHODS:Focal transcranial magnetic stimulation (TMS) of MCamp was performed in 10 patients 22 to 52 years after arm amputation to inhibit tonic muscle contraction in the intact hand ipsilateral to co...


    pub_type: 杂志文章


    authors: Röricht S,Meyer BU

    更新日期:2000-02-22 00:00:00

  • Striatal D2 receptors in symptomatic and asymptomatic carriers of dopa-responsive dystonia measured with [11C]-raclopride and positron-emission tomography.

    abstract::We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. We examined striatal D2-receptor binding in (1) symptomatic subjects (treated and untreated) and (2) ...


    pub_type: 杂志文章


    authors: Kishore A,Nygaard TG,de la Fuente-Fernandez R,Naini AB,Schulzer M,Mak E,Ruth TJ,Calne DB,Snow BJ,Stoessl AJ

    更新日期:1998-04-01 00:00:00

  • Polymyositis: an overdiagnosed entity.

    abstract:BACKGROUND:According to widely used criteria (Bohan and Peter criteria, 1975), dermatomyositis (DM) is differentiated from polymyositis (PM) only by skin changes. More recent criteria also include histopathologic characteristics enabling the distinction between PM and DM and the differentiation of sporadic inclusion bo...


    pub_type: 杂志文章


    authors: van der Meulen MF,Bronner IM,Hoogendijk JE,Burger H,van Venrooij WJ,Voskuyl AE,Dinant HJ,Linssen WH,Wokke JH,de Visser M

    更新日期:2003-08-12 00:00:00

  • Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease tremor.

    abstract:OBJECTIVE:To determine the efficacy and tolerability of unilateral thalamic deep brain stimulation (DBS) for patients with medically refractory essential tremor (ET) and the tremor associated with Parkinson's disease (PD). BACKGROUND:The tremor of ET and PD may produce functional disability despite optimal medical the...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ondo W,Jankovic J,Schwartz K,Almaguer M,Simpson RK

    更新日期:1998-10-01 00:00:00

  • Neuroanatomic correlates of visual hallucinations in poststroke hemianopic patients.

    abstract:OBJECTIVES:Homonymous hemianopia (HH) is the most frequent visual-field defect after a stroke. Some of these patients also have visual hallucinations, the origin and frequency of which remain largely unknown. The aims of this work were to determine the occurrence of visual hallucinations among poststroke hemianopic pat...


    pub_type: 杂志文章


    authors: Martinelli F,Perez C,Caetta F,Obadia M,Savatovsky J,Chokron S

    更新日期:2020-05-05 00:00:00

  • CSF cyclic nucleotides and somatostatin in Parkinson's disease.

    abstract::Concentrations of cyclic adenosine 3',5' monophosphate (cAMP) were significantly lower in parkinsonian patients than in controls, but concentrations of guanosine 3',5' monophosphate (cGMP) were not altered. Both cAMP and cGMP levels were lower in patients with more severe symptoms on the left side of the body. Somatos...


    pub_type: 杂志文章


    authors: Volicer L,Beal MF,Direnfeld LK,Marquis JK,Albert ML

    更新日期:1986-01-01 00:00:00

  • Cognitive decline in AD and mild cognitive impairment is associated with global brain damage.

    abstract:OBJECTIVE:To investigate the relationships between structural damage in the whole brain, the temporal lobes, and the frontal lobes and cognitive decline at old age. The authors hypothesized that widespread brain damage as quantified using magnetization transfer imaging (MTI) is related to global cognitive decline, wher...


    pub_type: 杂志文章


    authors: Van Der Flier WM,Van Den Heuvel DM,Weverling-Rijnsburger AW,Spilt A,Bollen EL,Westendorp RG,Middelkoop HA,Van Buchem MA

    更新日期:2002-09-24 00:00:00

  • Peripheral blood leukocyte NO production in MS patients with a benign vs progressive course.

    abstract:BACKGROUND:Nitric oxide (NO) may play a role in tissue destruction and axonal degeneration in multiple sclerosis (MS). OBJECTIVE:To investigate NO production by peripheral blood leukocytes (PBL) in patients with a benign and progressive course of MS. METHODS:PBL were isolated from 25 patients with a benign course of ...


    pub_type: 杂志文章


    authors: Ramsaransing GS,Teelken A,Arutjunyan AV,De Keyser J

    更新日期:2004-01-27 00:00:00

  • Retinal periphlebitis is associated with multiple sclerosis severity.

    abstract:OBJECTIVES:To assess the association of primary retinal inflammation, namely retinal periphlebitis (RP) and microcystic macular edema, with clinical, brain, and retinal imaging biomarkers of multiple sclerosis (MS) severity. METHODS:One hundred patients with MS underwent a neurologic and ophthalmic examination, MRI, a...


    pub_type: 杂志文章


    authors: Ortiz-Pérez S,Martínez-Lapiscina EH,Gabilondo I,Fraga-Pumar E,Martínez-Heras E,Saiz A,Sanchez-Dalmau B,Villoslada P

    更新日期:2013-09-03 00:00:00

  • Cytoplasmic inclusion bodies in superior rectus muscle of the eye.

    abstract::Cytoplasmic inclusion bodies are found in fibers of superior rectus muscle of the eye. They occur in middle-aged and old individuals dying with various unrelated diseases not affecting muscle and in patients with myotonic dystrophy. With light microscopy they can be observed in fibers with pathologic changes, and with...


    pub_type: 杂志文章


    authors: Culebras A,Merk FB

    更新日期:1975-05-01 00:00:00

  • Intra-blood-brain barrier synthesis of IgG: comparison of IgG synthesis formulas in a computer model and in 1,629 consecutive specimens.

    abstract::We evaluated four formulas for estimating the intra-blood-brain barrier (IBBB) synthesis of IgG in a computer model of two types of BBB damage and in 1,629 consecutively received pairs of CSF and serum. These four formulas were the IgG synthesis rate (SR), IgG(loc) (ie, local), IgG index, and IgG extended index. Resul...


    pub_type: 杂志文章


    authors: Peter JB,Bowman RL

    更新日期:1992-03-01 00:00:00

  • Microstructural white matter changes in cognitively normal individuals at risk of amnestic MCI.

    abstract:OBJECTIVE:Since Alzheimer disease (AD) is a slowly progressive disorder and its pathologic features are likely to be present for many years before symptoms become manifest, we investigated whether microstructural white matter changes similar to those identified in patients with AD can be detected in cognitively normal ...


    pub_type: 杂志文章


    authors: Zhuang L,Sachdev PS,Trollor JN,Kochan NA,Reppermund S,Brodaty H,Wen W

    更新日期:2012-08-21 00:00:00

  • Plasma exchange combined with azathioprine in multiple sclerosis using serial gadolinium-enhanced MRI to monitor disease activity: a randomized single-masked cross-over pilot study.

    abstract::We enrolled 11 patients with secondary progressive MS in a randomized single-masked cross-over study of plasma exchange (PE) in combination with azathioprine 2 mg/kg. PE was performed once a week for 4 weeks and thereafter every second week for 20 weeks (14 treatments). Eight patients completed the whole trial, and th...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sørensen PS,Wanscher B,Szpirt W,Jensen CV,Ravnborg M,Christiansen P,Schreiber K,Nordenbo A

    更新日期:1996-06-01 00:00:00

  • Presynaptic failure of neuromuscular transmission and synaptic remodeling in EA2.

    abstract:OBJECTIVE:To further investigate the basis of abnormal neuromuscular transmission in two patients with congenital myasthenic syndrome associated with episodic ataxia type 2 (EA2) using stimulated single fiber EMG (SFEMG) and in vitro microelectrode studies. METHODS:Two patients with genetically characterized EA2 previ...


    pub_type: 杂志文章


    authors: Maselli RA,Wan J,Dunne V,Graves M,Baloh RW,Wollmann RL,Jen J

    更新日期:2003-12-23 00:00:00

  • Autoimmune encephalitis: A costly condition.

    abstract:OBJECTIVE:To assess the inpatient hospitalization burden and costs of patients with autoimmune encephalitis (AE) at a tertiary care institution. METHODS:Adult inpatients with AE were identified retrospectively from July 1, 2005, to June 30, 2015. Demographic and clinical data were collected and analyzed. Billing data ...


    pub_type: 杂志文章


    authors: Cohen J,Sotoca J,Gandhi S,Yeshokumar AK,Gordon-Lipkin E,Geocadin RG,Frick KD,Probasco JC,Venkatesan A

    更新日期:2019-02-26 00:00:00

  • Spinal cord lesions in patients with clinically isolated syndrome: a powerful tool in diagnosis and prognosis.

    abstract:OBJECTIVE:Spinal cord (SC) lesions are frequently found in multiple sclerosis (MS), but are rare in healthy aging and cerebrovascular patients. Our aim was to analyze the contribution of SC involvement in clinically isolated syndrome (CIS) in diagnosing MS according the McDonald 2010 criteria and in predicting conversi...


    pub_type: 杂志文章


    authors: Sombekke MH,Wattjes MP,Balk LJ,Nielsen JM,Vrenken H,Uitdehaag BM,Polman CH,Barkhof F

    更新日期:2013-01-01 00:00:00

  • Demyelinating encephalopathy in Lyme disease.

    abstract::A 38-year-old man from southeastern Connecticut developed a diffuse encephalopathy with partial complex seizures, followed weeks later by arthritis, cryoglobulinemia, and increased serum IgM. CT showed confluent low-density lesions in the deep cerebral white matter consistent with demyelination. Neither the encephalop...


    pub_type: 杂志文章


    authors: Reik L Jr,Smith L,Khan A,Nelson W

    更新日期:1985-02-01 00:00:00

  • Copaxone's effect on MRI-monitored disease in relapsing MS is reproducible and sustained.

    abstract::All but 6% of the subjects with relapsing remitting MS who were randomly assigned to receive glatiramer acetate or placebo for the 9-month controlled phase of the European/Canadian MRI trial entered an open-label extension with quarterly clinical and MRI evaluations for another 9 months. There was a 54% reduction in t...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Wolinsky JS,Comi G,Filippi M,Ladkani D,Kadosh S,Shifroni G,European\/Canadian Glatiramer Acetate Study Group.

    更新日期:2002-10-22 00:00:00

  • The long-term clinical outcome of myasthenia gravis in patients with thymoma.

    abstract::We compared 42 myasthenia gravis (MG) patients with thymoma with 42 generalized MG patients without thymoma using a modified Osserman classification. The mean Osserman grades at diagnosis, 6 months, and 5 and 10 years post-thymectomy did not differ between groups. Our results indicate that thymoma is not a negative de...


    pub_type: 杂志文章,评审


    authors: Bril V,Kojic J,Dhanani A

    更新日期:1998-10-01 00:00:00

  • Nonadherence to antiepileptic drugs in Germany: A retrospective, population-based study.

    abstract:OBJECTIVE:To assess the effect of patient and drug characteristics on medication adherence in people with epilepsy (PWE) in a large cohort representative of the German population. METHODS:Information was obtained from the Disease Analyzer database that collects anonymous demographic and medical data from practice comp...


    pub_type: 杂志文章


    authors: Gollwitzer S,Kostev K,Hagge M,Lang J,Graf W,Hamer HM

    更新日期:2016-08-02 00:00:00

  • Recanalization after intravenous thrombolysis: does a recanalization time window exist?

    abstract:BACKGROUND:To evaluate the time course of major vessel recanalization under IV thrombolysis in relation to functional outcome in acute ischemic stroke. METHODS:A total of 99 patients with an acute anterior circulation vessel occlusion who underwent IV thrombolysis were included. All patients had a standardized admissi...


    pub_type: 杂志文章,多中心研究


    authors: Wunderlich MT,Goertler M,Postert T,Schmitt E,Seidel G,Gahn G,Samii C,Stolz E,Duplex Sonography in Acute Stroke (DIAS) Study Group.,Competence Network Stroke.

    更新日期:2007-04-24 00:00:00

  • A prion protein missense variant is integrated in kuru plaque cores in patients with Gerstmann-Sträussler syndrome.

    abstract::Kuru plaques are the pathologic hallmark in Gerstmann-Sträussler syndrome (GSS). To demonstrate that prion protein (PrP) is a component of kuru plaque cores, we fractionated and sequenced kuru plaque core derived peptides, following digestion with Achromobacter lyticus protease I. We identified 3 PrP-derived peptides ...


    pub_type: 杂志文章


    authors: Kitamoto T,Yamaguchi K,Doh-ura K,Tateishi J

    更新日期:1991-02-01 00:00:00

  • Does platelet antiaggregant therapy lessen the severity of stroke?

    abstract::Data from the Aspirin in Transient Ischemic Attack (AITIA) study, an ongoing study of two platelet antiaggregant drugs, and other published therapeutic trials were reviewed to determine whether the severity of stroke is reduced in patients taking platelet antiaggregants. Data from three of four studies suggest that st...


    pub_type: 临床试验,杂志文章,随机对照试验,评审


    authors: Grotta JC,Lemak NA,Gary H,Fields WS,Vital D

    更新日期:1985-05-01 00:00:00

  • Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype.

    abstract::Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased with age, and were higher in subjects carrying the APOE epsilo...


    pub_type: 杂志文章


    authors: Barboriak DP,Doraiswamy PM,Krishnan KR,Vidyarthi S,Sylvester J,Charles HC

    更新日期:2000-06-13 00:00:00

  • Partial epilepsy presenting as focal paroxysmal pain.

    abstract::A 3-year old, previously well child developed paroxysms of left thigh pain. Evaluation was unremarkable except for interictal and postictal EEG epileptiform activity in the right parietal and posterior temporal regions. The painful spells were controlled with anticonvulsant medication. Episodes of paroxysmal, unexplai...


    pub_type: 杂志文章


    authors: Trevathan E,Cascino GD

    更新日期:1988-02-01 00:00:00

  • Somatosensory cortical activations are suppressed in patients with tactile extinction: a PET study.

    abstract:OBJECTIVE:To investigate whether tactile extinction alters the cortical somatosensory activations induced by hand vibration. BACKGROUND:Tactile extinction occurs mainly after right-brain lesions and consists of the inability to perceive a contralesional cutaneous stimulation when a similar stimulus is applied to the m...


    pub_type: 杂志文章


    authors: Remy P,Zilbovicius M,Degos JD,Bachoud-Lévi AC,Rancurel G,Cesaro P,Samson Y

    更新日期:1999-02-01 00:00:00