Abstract:
:Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism in these two patients was shown to be pathophysiologically different than PD.
journal_name
Neurologyjournal_title
Neurologyauthors
Portman AT,Giladi N,Leenders KL,Maguire P,Veenma-van der Duin L,Swart J,Pruim J,Simon ES,Hassin-Baer S,Korczyn ADdoi
10.1212/wnl.56.12.1759subject
Has Abstractpub_date
2001-06-26 00:00:00pages
1759-62issue
12eissn
0028-3878issn
1526-632Xjournal_volume
56pub_type
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