Gender, cognitive decline, and risk of AD in older persons.


BACKGROUND:Cross-sectional studies suggest gender differences in cognitive function and risk of AD in older persons. However, longitudinal studies comparing change in cognitive function and risk of AD in men and women have had mixed results. The authors investigated gender differences in rate of decline for different cognitive systems and for risk of developing AD. METHODS:Participants were from the Religious Orders Study, a longitudinal, clinical-pathologic study of aging and AD in older Catholic nuns, priests, and brothers. Longitudinal data were available from 577 older women and 271 older men, who completed an average of 5.8 annual evaluations with more than 95% follow-up participation in survivors. The evaluations included 21 neuropsychological tests, from which summary measures of global cognitive function and 5 functional domains were formed, and clinical classification of AD. RESULTS:Random effects models were used to analyze change in cognitive function, and proportional hazards models were used to assess risk of incident AD. On average, men and women declined in all abilities during the 8-year period but did not differ in annual rates of change in analyses that controlled for age, education, and initial level of cognitive function. Risk of incident AD did not differ between men and women. Furthermore, results were unchanged after controlling for possession of the apolipoprotein-epsilon4 allele. Duration of estrogen use was related to rate of global cognitive decline and visuospatial abilities in women but did not influence comparisons between men and women in cognitive decline. CONCLUSIONS:The results suggest that patterns of cognitive decline and incidence of AD are similar in older men and women.






Barnes LL,Wilson RS,Schneider JA,Bienias JL,Evans DA,Bennett DA




Has Abstract


2003-06-10 00:00:00












  • Reliability of the diagnosis of a first seizure.

    abstract::We studied the interrater variability among three neurologists of the diagnosis of a seizure in 100 patients evaluated for a possible "first seizure." We found that use of simple descriptive diagnostic criteria and discussion among the neurologists themselves improved the diagnostic agreement. ...


    pub_type: 杂志文章


    authors: van Donselaar CA,Geerts AT,Meulstee J,Habbema JD,Staal A

    更新日期:1989-02-01 00:00:00

  • Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging.

    abstract:OBJECTIVE:This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men. METHODS:Forty-two 40- to 60-year-old cognitively normal women ...


    pub_type: 杂志文章


    authors: Mosconi L,Berti V,Quinn C,McHugh P,Petrongolo G,Varsavsky I,Osorio RS,Pupi A,Vallabhajosula S,Isaacson RS,de Leon MJ,Brinton RD

    更新日期:2017-09-26 00:00:00

  • Assessment of hand function in a patient with chronic sensory demyelinating neuropathy.

    abstract::A 60-year-old man presented with progressive large fiber sensory loss in the right first three fingers and, to a lesser extent, in both fourth and fifth fingers. Electrophysiologic studies were characteristic of chronic sensory demyelinating polyneuropathy, a variant of chronic inflammatory demyelinating polyneuropath...


    pub_type: 杂志文章


    authors: Thonnard JL,Detrembleur C,Van den Bergh PY

    更新日期:1997-07-01 00:00:00

  • Deficiency of syntrophin, dystroglycan, and merosin in a female infant with a congenital muscular dystrophy phenotype lacking cysteine-rich and C-terminal domains of dystrophin.

    abstract::Primary deficiency of merosin is the cause of the classic form of congenital muscular dystrophy (CMD) accompanied by brain white matter abnormalities. We report a female infant with dystrophinopathy who was deficient in merosin in skeletal muscle. The patient had a phenotype of typical CMD and white matter abnormaliti...


    pub_type: 杂志文章


    authors: Tachi N,Ohya K,Chiba S,Matsuo M,Patria SY,Matsumura K

    更新日期:1997-08-01 00:00:00

  • Acetylcholine receptor antibody synthesis by thymic lymphocytes: correlation with thymic histology.

    abstract::Antiacetylcholine receptor antibody (anti-AChR) was spontaneously synthesized by cultured thymic tissue from 19 of 35 patients with myasthenia gravis. Two other thymus cultures produced antibody after stimulation by pokeweed mitogen. Antibody production correlated with histologic evidence of thymitis, long duration of...


    pub_type: 杂志文章


    authors: Scadding GK,Vincent A,Newsom-Davis J,Henry K

    更新日期:1981-08-01 00:00:00

  • Acquired channelopathies in nerve injury and MS.

    abstract::Although neurophysiologic doctrine has traditionally referred to "the" voltage-gated sodium channel, it is now clear that there are at least nine genes that encode molecularly and physiologically distinct sodium channels. Mutations of sodium channel genes provide a basis for genetic channelopathies. Dysregulated expre...


    pub_type: 杂志文章,评审


    authors: Waxman SG

    更新日期:2001-06-26 00:00:00

  • Cerebral ischemia and atrial fibrillation: prospective study.

    abstract::The frequency of recurrent cerebral ischemia and death was determined prospectively in 36 patients who presented with ischemic stroke and had atrial fibrillation. Patients were followed an average of 2.3 months (range, 3 weeks to 9 months). The recurrence rate for cerebral ischemia was 33%, and the mortality rate was ...


    pub_type: 杂志文章


    authors: Kelley RE,Berger JR,Alter M,Kovacs AG

    更新日期:1984-10-01 00:00:00

  • Faster cognitive decline in elders without dementia and decreased risk of cancer mortality: NEDICES Study.

    abstract:OBJECTIVE:To assess whether faster cognitive decline in elders without dementia is associated with decreased risk of cancer mortality. METHODS:In this population-based, prospective study of 2,627 people without dementia aged 65 years and older (Neurological Disorders in Central Spain), a 37-item version of the Mini-Me...


    pub_type: 杂志文章


    authors: Benito-León J,Romero JP,Louis ED,Bermejo-Pareja F

    更新日期:2014-04-22 00:00:00

  • Association of retinal layer measurements and adult cognitive function: A population-based study.

    abstract:OBJECTIVE:To quantify the associations of peripapillary retinal nerve fiber layer (pRNFL) thickness and macular ganglion cell layer (mGCL) volume with cognitive functioning and to investigate how demographic and vascular health factors affect these associations in a population-based sample of adults. METHODS:The sampl...


    pub_type: 杂志文章


    authors: Ward DD,Mauschitz MM,Bönniger MM,Merten N,Finger RP,Breteler MMB

    更新日期:2020-09-01 00:00:00

  • Phenytoin elimination in childhood: effect of concentration-dependent kinetics.

    abstract::The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations betw...


    pub_type: 杂志文章


    authors: Dodson WE

    更新日期:1980-02-01 00:00:00

  • Transient ischemic attacks: a prospective study of 225 patients.

    abstract::Between the years 1964 and 1973, 225 patients with transient ischemic attacks (TIAs) due primarily to atherosclerosis were evaluated and treated. They have now been followed for from 3 to 14 years (average 5.5 years). As of 1976, 82 of the 225 patients were dead, 21 from cerebral infarction, 52 from heart disease and ...


    pub_type: 杂志文章


    authors: Toole JF,Yuson CP,Janeway R,Johnston F,Davis C,Cordell AR,Howard G

    更新日期:1978-08-01 00:00:00

  • Regional pattern of white matter microstructural changes in normal aging, MCI, and AD.

    abstract:OBJECTIVE:To cross-sectionally compare the regional white matter fractional anisotropy (FA) of cognitively normal (CN) older individuals and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), separately focusing on the normal-appearing white matter (NAWM) and white matter hyperintensities (WMH), ...


    pub_type: 杂志文章


    authors: Lee DY,Fletcher E,Martinez O,Ortega M,Zozulya N,Kim J,Tran J,Buonocore M,Carmichael O,DeCarli C

    更新日期:2009-11-24 00:00:00

  • Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging.

    abstract:OBJECTIVE:We investigated the prevalence of mild cognitive impairment (MCI) in Olmsted County, MN, using in-person evaluations and published criteria. METHODS:We evaluated an age- and sex-stratified random sample of Olmsted County residents who were 70-89 years old on October 1, 2004, using the Clinical Dementia Ratin...


    pub_type: 杂志文章


    authors: Petersen RC,Roberts RO,Knopman DS,Geda YE,Cha RH,Pankratz VS,Boeve BF,Tangalos EG,Ivnik RJ,Rocca WA

    更新日期:2010-09-07 00:00:00

  • Centrotemporal spikes in families with rolandic epilepsy: linkage to chromosome 15q14.

    abstract:OBJECTIVE:To localize a gene predisposing to benign epilepsy of childhood with centrotemporal spikes (BECTS). BACKGROUND:BECTS, or rolandic epilepsy, is the most prevalent idiopathic epilepsy syndrome in childhood. Functional relevant defects in the alpha 4 subunit of the neuronal nicotinic acetylcholine receptor (ACh...


    pub_type: 杂志文章


    authors: Neubauer BA,Fiedler B,Himmelein B,Kämpfer F,Lässker U,Schwabe G,Spanier I,Tams D,Bretscher C,Moldenhauer K,Kurlemann G,Weise S,Tedroff K,Eeg-Olofsson O,Wadelius C,Stephani U

    更新日期:1998-12-01 00:00:00

  • Norming plans for the NIH Toolbox.

    abstract:OBJECTIVE:The NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox) is a comprehensive battery of brief assessment tools. The purpose of this article is to describe plans to establish normative reference values for the NIH Toolbox measures. METHODS:A large sample will be obtained from the US...


    pub_type: 杂志文章


    authors: Beaumont JL,Havlik R,Cook KF,Hays RD,Wallner-Allen K,Korper SP,Lai JS,Nord C,Zill N,Choi S,Yost KJ,Ustsinovich V,Brouwers P,Hoffman HJ,Gershon R

    更新日期:2013-03-12 00:00:00

  • Reemergence of activation with poststroke somatosensory recovery: a serial fMRI case study.

    abstract::The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory loss followed by good recovery. A return of activation in ipsilesional primary and bilateral secondary somatosensory cortic...


    pub_type: 杂志文章


    authors: Carey LM,Abbott DF,Puce A,Jackson GD,Syngeniotis A,Donnan GA

    更新日期:2002-09-10 00:00:00

  • Mitochondrial DNA in migraine with aura.

    abstract::Migraine and the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome have some clinical features in common. First, cerebral infarctions, most often in the posterior cerebral regions, which are a main symptom of MELAS, may complicate migraine. Second, migrainous headache w...


    pub_type: 杂志文章


    authors: Klopstock T,May A,Seibel P,Papagiannuli E,Diener HC,Reichmann H

    更新日期:1996-06-01 00:00:00

  • Reversible cerebral vasoconstriction syndrome and cervical artery dissection in 20 patients.

    abstract:OBJECTIVES:To describe clinical-radiologic characteristics in a prospective series of patients having both confirmed reversible cerebral vasoconstriction syndrome (RCVS) and cervical artery dissection (CeAD). METHODS:From January 2004 to December 2011, from our prospective cohorts of RCVS and CeAD, we studied patients...


    pub_type: 杂志文章


    authors: Mawet J,Boukobza M,Franc J,Sarov M,Arnold M,Bousser MG,Ducros A

    更新日期:2013-08-27 00:00:00

  • Aberrant neural circuits in malformations of cortical development and focal epilepsy.

    abstract::Malformations of cortical development (MCD) account for a high proportion of medically resistant partial seizures in children and figure prominently in pediatric surgical series. In contrast to the results of epilepsy surgery for postnatally acquired lesions, seizure freedom in patients with MCD is less certain owing ...


    pub_type: 杂志文章,评审


    authors: Duchowny M,Jayakar P,Levin B

    更新日期:2000-08-08 00:00:00

  • Migraine in pregnancy.

    abstract::Migraine does not increase the risk for complications of pregnancy for the mother or for the fetus: the incidences of toxemia, miscarriages, abnormal labour, congenital anomalies, and stillbirths are comparable to those of the general population. Several retrospective studies have shown a tendency for migraine to impr...


    pub_type: 杂志文章,评审


    authors: Aubé M

    更新日期:1999-01-01 00:00:00

  • Cerebral small-vessel disease and progression of brain atrophy: the SMART-MR study.

    abstract:OBJECTIVES:To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy. METHODS:Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 pati...


    pub_type: 杂志文章


    authors: Kloppenborg RP,Nederkoorn PJ,Grool AM,Vincken KL,Mali WP,Vermeulen M,van der Graaf Y,Geerlings MI,SMART Study Group.

    更新日期:2012-11-13 00:00:00

  • A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome.

    abstract:OBJECTIVES:The authors report the results of a prospective, placebo-controlled, randomized study to evaluate the effectiveness of 3,4-diaminopyridine (DAP) in patients with Lambert-Eaton myasthenic syndrome (LEMS) and to determine the acute and long-term side effects of DAP. METHODS:Twenty-six patients with LEMS compl...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sanders DB,Massey JM,Sanders LL,Edwards LJ

    更新日期:2000-02-08 00:00:00

  • Altered cortical excitability in obsessive-compulsive disorder.

    abstract:OBJECTIVE:To assess cortical inhibitory and excitatory mechanisms in obsessive-compulsive disorder (OCD). BACKGROUND:Transcranial magnetic stimulation (TMS) studies have found decreased neuronal inhibition and a reduced cortical silent period in the primary motor area in Tourette's syndrome, focal dystonia, and other ...


    pub_type: 杂志文章


    authors: Greenberg BD,Ziemann U,Corá-Locatelli G,Harmon A,Murphy DL,Keel JC,Wassermann EM

    更新日期:2000-01-11 00:00:00

  • Cervical dural sac and spinal cord in juvenile muscular atrophy of distal upper extremity.

    abstract:OBJECTIVE:To investigate specificity and significance of dynamic changes of the cervical dural sac and spinal cord during neck flexion in juvenile muscular atrophy of the distal upper extremity. BACKGROUND:The disorder affects young people-predominantly men-and is progressive for several years. One autopsy case showed...


    pub_type: 杂志文章


    authors: Hirayama K,Tokumaru Y

    更新日期:2000-05-23 00:00:00

  • Acoustic tumors: atypical features and recent diagnostic tests.

    abstract::About one-third of patients with acoustic tumor (AT) initially seek medical attention for nonaudiologic complaints. The nonspecific early symptoms of AT require the inclusion of AT in many neurologic differential diagnoses. Advances in electrophysiologic and radiographic tests have allowed earlier diagnosis of AT at a...


    pub_type: 杂志文章


    authors: Hart RG,Gardner DP,Howieson J

    更新日期:1983-02-01 00:00:00

  • Establishment of primary stroke centers: a survey of physician attitudes and hospital resources.

    abstract:OBJECTIVES:To survey US physicians involved in acute stroke care to determine the proportion of hospitals that currently meet the recommended Brain Attack Coalition (BAC) criteria for Primary Stroke Centers (PSC) and obtain opinions regarding the value of stroke centers. METHODS:A survey regarding the BAC guidelines f...


    pub_type: 杂志文章


    authors: Kidwell CS,Shephard T,Tonn S,Lawyer B,Murdock M,Koroshetz W,Alberts M,Hademenos GJ,Saver JL

    更新日期:2003-05-13 00:00:00

  • Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes.

    abstract:OBJECTIVE:To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes. METHODS:This is a prospective cohort study at 3 Division I National Collegiate Athletic Association athletic programs. Participants were 214 Division I ...


    pub_type: 杂志文章


    authors: McAllister TW,Flashman LA,Maerlender A,Greenwald RM,Beckwith JG,Tosteson TD,Crisco JJ,Brolinson PG,Duma SM,Duhaime AC,Grove MR,Turco JH

    更新日期:2012-05-29 00:00:00

  • Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy.

    abstract::The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hy...


    pub_type: 杂志文章


    authors: Lodi R,Pierangeli G,Tonon C,Cevoli S,Testa C,Bivona G,Magnifico F,Cortelli P,Montagna P,Barbiroli B

    更新日期:2006-04-25 00:00:00

  • Clinical and electrophysiologic correlates of elevated anti-GM1 antibody titers.

    abstract::We reviewed the clinical and electrophysiologic features of 36 patients with increased titers of IgM anti-GM1 antibodies. Mildly elevated titers of up to 3,200 were not associated with any particular clinical syndrome or disease. Clinically, 14 of 16 patients with highly elevated titers of 6,400 or higher had progress...


    pub_type: 杂志文章


    authors: Kinsella LJ,Lange DJ,Trojaborg W,Sadiq SA,Younger DS,Latov N

    更新日期:1994-07-01 00:00:00

  • Long-term benefit from prednisone therapy in Duchenne muscular dystrophy.

    abstract::Two successive, 6-month, randomized, double-blind, controlled trials of prednisone showed that 0.75 mg/kg/d was the optimal dose to improve strength in boys with Duchenne muscular dystrophy (DMD). We attempted to maintain 93 boys on that dose for an additional 2 years. During the 3 years of observation, the decline in...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fenichel GM,Florence JM,Pestronk A,Mendell JR,Moxley RT 3rd,Griggs RC,Brooke MH,Miller JP,Robison J,King W

    更新日期:1991-12-01 00:00:00