Sign language aphasia due to left occipital lesion in a deaf signer.


:Localization of sign language production and comprehension in deaf people has been described as similar to that of spoken language aphasia. However, sign language employs a visuospatial modality through visual information. We present the first report of a deaf signer who showed substantial sign language aphasia with severe impairment in word production due to a left occipital lesion. This case may indicate the possibility of other localizations of plasticity.






Saito K,Otsuki M,Ueno S




Has Abstract


2007-10-02 00:00:00














  • Competitive inhibition of brain hexokinase by metrizamide.

    abstract::We compared the effect of metrizamide and its parent compound glucosamine on the kinetics of dog brain hexokinase. The Michaelis constant (Km) for glucose rose from 0.065 to 0.15 to 0.28 mM in the presence of 0, 16, and 32 mM metrizamide, respectively. For 0, 1.5, and 3.7 mM glucosamine, the Km values were 0.065, 0.4,...


    pub_type: 杂志文章


    authors: Bertoni JM,Steinman CG

    更新日期:1982-03-01 00:00:00

  • Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study.

    abstract:BACKGROUND:The major histocompatibility complex (MHC) has been consistently associated with susceptibility to MS and the course of several other human autoimmune diseases. A putative association between the course and severity of MS and the MHC remains controversial. METHODS:DR and DQ genotyping by either restriction ...


    pub_type: 杂志文章


    authors: Weinshenker BG,Santrach P,Bissonet AS,McDonnell SK,Schaid D,Moore SB,Rodriguez M

    更新日期:1998-09-01 00:00:00

  • Arm-diaphragm synkinesis: electrodiagnostic studies of aberrant regeneration of phrenic motor neurons.

    abstract::Arm-diaphragm synkinesis may occur after injury to the proximal portion of the brachial plexus or cervical nerve roots. Regenerating axons of phrenic motor neurons are misdirected to supply limb muscles. Electrodiagnostic investigations of three patients with symptoms referable to upper brachial plexus or cervical roo...


    pub_type: 杂志文章


    authors: Swift TR,Leshner RT,Gross JA

    更新日期:1980-04-01 00:00:00

  • Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages. Topiramate YD Study Group.

    abstract::We conducted a randomized double-blind comparison of three doses of the novel antiepileptic drug (AED) topiramate (200, 400, and 600 mg/day) and placebo as adjunctive therapy in patients with refractory partial onset epilepsy receiving one or two other AEDs at therapeutic concentrations. A total of 181 patients comple...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Faught E,Wilder BJ,Ramsay RE,Reife RA,Kramer LD,Pledger GW,Karim RM

    更新日期:1996-06-01 00:00:00

  • Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy.

    abstract:OBJECTIVE:To use punch skin biopsies to evaluate the loss of intra-epidermal nerve fibers in sensory neuropathies. BACKGROUND:Previous assessments of epidermal nerve fibers have been constrained by relatively insensitive staining techniques and variability in quantification. METHODS:Punch skin biopsies were performed...


    pub_type: 杂志文章


    authors: McCarthy BG,Hsieh ST,Stocks A,Hauer P,Macko C,Cornblath DR,Griffin JW,McArthur JC

    更新日期:1995-10-01 00:00:00

  • Limb-kinetic apraxia in Parkinson disease.

    abstract::To learn if limb-kinetic apraxia (LKA) is associated with Parkinson disease (PD), participants with PD (on medications) and control subjects performed finger tapping (FT), measuring movement speed, and performed coin rotation (CR), measuring precise coordinated but independent finger movements and speed. There were no...


    pub_type: 杂志文章


    authors: Quencer K,Okun MS,Crucian G,Fernandez HH,Skidmore F,Heilman KM

    更新日期:2007-01-09 00:00:00

  • A Wallerian degeneration pattern in patients at risk for MS.

    abstract:BACKGROUND:Demyelination alone may not explain the progressive disability that frequently develops in MS. An alternative explanation for irreversible disability assumes a contribution from axonal injury or loss. In theory, axonal injury may occur in the focal areas characterized by early inflammation, or can be more di...


    pub_type: 杂志文章


    authors: Simon JH,Kinkel RP,Jacobs L,Bub L,Simonian N

    更新日期:2000-03-14 00:00:00

  • Characteristics and predictors of 7- and 30-day hospital readmissions to pediatric neurology.

    abstract:OBJECTIVE:Hospital readmission is an important quality improvement measure that has not been well-studied in pediatric neurology. We examined predictors of 7-day and 30-day readmissions for pediatric patients hospitalized with a neurologic diagnosis. METHODS:This was a retrospective study of hospital readmission rates...


    pub_type: 杂志文章


    authors: Hong A,Shah Y,Singh K,Karkare S,Kothare S

    更新日期:2019-04-16 00:00:00

  • The effect of bilateral visual cortex lesions on the development of eye movements and perception.

    abstract::We studied the eye movements and visual perception in a man with extensive bilateral occipital lesions acquired at birth. He had 3/500 acuity, limited visual fields, and extrafoveal fixation attributable to an intact left superior visual cortex. Analysis of digitized electro-oculography and magnetic search coil data s...


    pub_type: 杂志文章


    authors: Rizzo M,Hurtig R

    更新日期:1989-03-01 00:00:00

  • Childhood absence epilepsy: poor attention is more than seizures.

    abstract::Dr. Masur and colleagues(1) from the Childhood Absence Epilepsy Study Group tried to answer a few important questions regarding childhood absence epilepsy (CAE) in their article "Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy." First, they wanted to know whether childr...


    pub_type: 杂志文章


    authors: Thio LL

    更新日期:2013-10-29 00:00:00

  • Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD.

    abstract::Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic...


    pub_type: 杂志文章


    authors: Eerola J,Hernandez D,Launes J,Hellström O,Hague S,Gulick C,Johnson J,Peuralinna T,Hardy J,Tienari PJ,Singleton AB

    更新日期:2003-10-14 00:00:00

  • Dementia diagnoses from clinical and neuropsychological data compared: the Cache County study.

    abstract:OBJECTIVE:To validate a neuropsychological algorithm for dementia diagnosis. METHODS:We developed a neuropsychological algorithm in a sample of 1,023 elderly residents of Cache County, UT. We compared algorithmic and clinical dementia diagnoses both based on DSM-III-R criteria. The algorithm diagnosed dementia when th...


    pub_type: 杂志文章


    authors: Tschanz JT,Welsh-Bohmer KA,Skoog I,West N,Norton MC,Wyse BW,Nickles R,Breitner JC

    更新日期:2000-03-28 00:00:00

  • FSHD1 and FSHD2 form a disease continuum.

    abstract:OBJECTIVE:To compare the clinical features of patients showing a classical phenotype of facioscapulohumeral muscular dystrophy (FSHD) with genetic and epigenetic characteristics of the FSHD1 and FSHD2 loci D4Z4 and SMCHD1. METHODS:This is a national multicenter cohort study. We measured motor strength, motor function,...


    pub_type: 杂志文章,多中心研究


    authors: Sacconi S,Briand-Suleau A,Gros M,Baudoin C,Lemmers RJLF,Rondeau S,Lagha N,Nigumann P,Cambieri C,Puma A,Chapon F,Stojkovic T,Vial C,Bouhour F,Cao M,Pegoraro E,Petiot P,Behin A,Marc B,Eymard B,Echaniz-Laguna A,Laf

    更新日期:2019-05-07 00:00:00

  • Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy.

    abstract:OBJECTIVE:To perform a double-blind, randomized study comparing efficacy and safety of daily and weekend prednisone in boys with Duchenne muscular dystrophy (DMD). METHODS:A total of 64 boys with DMD who were between 4 and 10 years of age were randomized at 1 of 12 centers of the Cooperative International Neuromuscula...


    pub_type: 杂志文章,随机对照试验


    authors: Escolar DM,Hache LP,Clemens PR,Cnaan A,McDonald CM,Viswanathan V,Kornberg AJ,Bertorini TE,Nevo Y,Lotze T,Pestronk A,Ryan MM,Monasterio E,Day JW,Zimmerman A,Arrieta A,Henricson E,Mayhew J,Florence J,Hu F,Connolly A

    更新日期:2011-08-02 00:00:00

  • Postmenopausal estrogen use and Parkinson's disease with and without dementia.

    abstract::We investigated the effects of estrogen replacement therapy (ERT) on the risk of development of dementia in 87 women with Parkinson's disease without dementia (PDND), 80 women with Parkinson's disease with dementia (PDD), and 989 nondemented healthy women from the same community. ERT was protective for the development...


    pub_type: 临床试验,杂志文章


    authors: Marder K,Tang MX,Alfaro B,Mejia H,Cote L,Jacobs D,Stern Y,Sano M,Mayeux R

    更新日期:1998-04-01 00:00:00

  • Prognosis and response to therapy of cytomegalovirus encephalitis and meningomyelitis in AIDS.

    abstract::Effective diagnosis and treatment of cytomegalovirus infection of the nervous system in AIDS patients has been limited by a lack of sensitive diagnostic measures. Retrospective series suggest a poor prognosis for cytomegalovirus encephalitis with rapid mortality. Polymerase chain reaction amplification of cytomegalovi...


    pub_type: 杂志文章


    authors: Cohen BA

    更新日期:1996-02-01 00:00:00

  • Transient global amnesia: clinical and electroencephalographic findings in 10 cases.

    abstract::We studied 10 patients with transient global amnesia (TGA). Routine electroencephalograms (EEGs) were normal in six; two showed mild temporal lobe abnormalities, one had bitemporal delta activity with rare sharp waves, and one showed bioccipital rhythmic theta activity. Nasopharyngeal (NP) recordings were obtained in ...


    pub_type: 杂志文章


    authors: Rowan AJ,Protass LM

    更新日期:1979-06-01 00:00:00

  • Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome.

    abstract:BACKGROUND:Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare multisystem disorder associated with plasma cell dyscrasia. There is increasing evidence that high-dose chemotherapy with autologous peripheral blood stem cell transplantation (Auto-PBSCT) is an efficacious t...


    pub_type: 杂志文章


    authors: Kuwabara S,Misawa S,Kanai K,Suzuki Y,Kikkawa Y,Sawai S,Hattori T,Nishimura M,Nakaseko C

    更新日期:2008-11-18 00:00:00

  • Delivery of epilepsy care to adults with intellectual and developmental disabilities.

    abstract::Epilepsy is common in people with intellectual and developmental disabilities (IDD). In adulthood, patients with IDD and epilepsy (IDD-E) have neurologic, psychiatric, medical, and social challenges compounded by fragmented and limited care. With increasing neurologic disability, there is a higher frequency of epileps...


    pub_type: 杂志文章,评审


    authors: Devinsky O,Asato M,Camfield P,Geller E,Kanner AM,Keller S,Kerr M,Kossoff EH,Lau H,Kothare S,Singh BK,Wirrell E

    更新日期:2015-10-27 00:00:00

  • Bevacizumab for recurrent ependymoma.

    abstract:BACKGROUND:Ependymoma is a rare type of glioma, representing 5% of all CNS malignancies. Radiotherapy (RT) is commonly administered, but there is no standard chemotherapy. At recurrence, ependymoma is notoriously refractory to therapy and the prognosis is poor. In recurrent glioblastoma, encouraging responses with beva...


    pub_type: 杂志文章


    authors: Green RM,Cloughesy TF,Stupp R,DeAngelis LM,Woyshner EA,Ney DE,Lassman AB

    更新日期:2009-11-17 00:00:00

  • Intermittent negative pressure ventilation in the treatment of respiratory failure in progressive neuromuscular disease.

    abstract::Five men with degenerative neuromuscular diseases (three with amyotrophic lateral sclerosis [ALS] and two with Duchenne's muscular dystrophy [DMD]) who had respiratory failure were treated with intermittent negative pressure ventilation (NPV). One patient with ALS in severe acute respiratory failure was successfully t...


    pub_type: 杂志文章


    authors: Braun SR,Sufit RL,Giovannoni R,O'Connor M,Peters H

    更新日期:1987-12-01 00:00:00

  • A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome.

    abstract:OBJECTIVES:The authors report the results of a prospective, placebo-controlled, randomized study to evaluate the effectiveness of 3,4-diaminopyridine (DAP) in patients with Lambert-Eaton myasthenic syndrome (LEMS) and to determine the acute and long-term side effects of DAP. METHODS:Twenty-six patients with LEMS compl...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sanders DB,Massey JM,Sanders LL,Edwards LJ

    更新日期:2000-02-08 00:00:00

  • Cerebral vasculitis and hemorrhage associated with phenylpropanolamine.

    abstract::A 20-year-old woman using an oral diet aid preparation containing phenylpropanolamine presented with an intracerebral hemorrhage and angiographic evidence of cerebral vasculitis. Gas chromatography demonstrated phenylpropanolamine in the urine. Even when used within recommended guidelines, phenylpropanolamine usage sh...


    pub_type: 杂志文章


    authors: Fallis RJ,Fisher M

    更新日期:1985-03-01 00:00:00

  • Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD.

    abstract:BACKGROUND:The neurodegenerative process in Alzheimer's disease (AD) and in the Lewy body variant of AD (LBV) patients is characterized by cholinergic dysfunction and deposition of amyloid beta-peptide (Abeta) 1-40 and 1-42; however, the differential effects of Abeta species on the cholinergic system are not completely...


    pub_type: 杂志文章


    authors: Masliah E,Alford M,Adame A,Rockenstein E,Galasko D,Salmon D,Hansen LA,Thal LJ

    更新日期:2003-07-22 00:00:00

  • Why acute unilateral vestibular cortex lesions mostly manifest without vertigo.

    abstract:OBJECTIVES:The aim of the current study was, first, to determine the critical causative vestibular areas that in exceptional cases manifest with transient vertigo or dizziness in acute strokes of the middle cerebral artery, and second, to try to explain why in most cases unilateral lesions of these areas manifest witho...


    pub_type: 杂志文章,meta分析


    authors: Dieterich M,Brandt T

    更新日期:2015-04-21 00:00:00

  • "Dark Victory" (prognosis negative): The beginnings of neurology on screen.

    abstract::In "Dark Victory," released in theaters in 1939, the diagnosis and management of a progressive brain tumor was a central part of the screenplay, and this film marked the beginnings of the depiction of neurologic disease in cinema. Bette Davis' cinematic portrayal of a young woman dying from a brain tumor is close to t...


    pub_type: 历史文章,杂志文章


    authors: Wijdicks EFM

    更新日期:2016-04-12 00:00:00

  • Oculomotor palsy from minor head trauma: initial sign of intracranial aneurysm.

    abstract::Minor head trauma precipitated oculomotor nerve palsies in two patients who subsequently were discovered to have ipsilateral posterior communicating artery aneurysms. A history of minor trauma should not dissuade investigation for underlying causes of oculomotor nerve palsy, including intracranial aneurysm. ...


    pub_type: 杂志文章


    authors: Walter KA,Newman NJ,Lessell S

    更新日期:1994-01-01 00:00:00

  • How transient are transient ischemic attacks?

    abstract::Information on 1,343 hospitalized patients in the Cornell Neurology Database with final diagnoses of transient ischemic attacks (TIA), reversible ischemic neurologic deficits (RIND), or ischemic stroke was examined in order to determine the duration of ischemic deficits. Episodes resolved within the first 24 hours (cl...


    pub_type: 杂志文章


    authors: Levy DE

    更新日期:1988-05-01 00:00:00

  • Brain reserve and cognitive reserve protect against cognitive decline over 4.5 years in MS.

    abstract:OBJECTIVE:Based on the theories of brain reserve and cognitive reserve, we investigated whether larger maximal lifetime brain growth (MLBG) and/or greater lifetime intellectual enrichment protect against cognitive decline over time. METHODS:Forty patients with multiple sclerosis (MS) underwent baseline and 4.5-year fo...


    pub_type: 杂志文章


    authors: Sumowski JF,Rocca MA,Leavitt VM,Dackovic J,Mesaros S,Drulovic J,DeLuca J,Filippi M

    更新日期:2014-05-20 00:00:00

  • Basilar artery embolism. Clinical syndrome and neuroradiologic patterns in patients without permanent occlusion of the basilar artery.

    abstract::The objective of this study was to clarify the clinical and radiologic features, risk factors, and prognosis of basilar embolism without permanent basilar artery occlusion. Forty-five patients (mean age, 59 years) with basilar artery embolism participated in the study. Patients with basilar artery occlusion were exclu...


    pub_type: 杂志文章


    authors: Schwarz S,Egelhof T,Schwab S,Hacke W

    更新日期:1997-11-01 00:00:00