Abstract:
:This double-blind, placebo-controlled, multicenter, crossover study investigated the efficacy and tolerability of sumatriptan administered for up to three separate migraine attacks. One hundred twenty adults received sumatriptan (SC, 6 mg; three attacks) and placebo (one attack). Patients completed questionnaires assessing the impact of migraine on their lives and the performance of sumatriptan relative to their usual acute therapies. Sumatriptan statistically outperformed placebo on all efficacy measures, including pain severity; presence/absence of nausea, vomiting, phonophobia, and photophobia; rescue medication use; and clinical disability. Efficacy was consistently maintained with repeated administration. For all attacks, pain relief 90 minutes postdose occurred in 86% to 90% of sumatriptan-treated patients, compared with 9% to 38% of placebo-treated patients. Sumatriptan was well tolerated, and the frequency and severity of adverse events did not change with repeated administration. Patients' perceptions of sumatriptan were consistent with clinical data demonstrating the drug's high degree of efficacy and tolerability.
journal_name
Neurologyjournal_title
Neurologyauthors
Cady RK,Dexter J,Sargent JD,Markley H,Osterhaus JT,Webster CJdoi
10.1212/wnl.43.7.1363subject
Has Abstractpub_date
1993-07-01 00:00:00pages
1363-8issue
7eissn
0028-3878issn
1526-632Xjournal_volume
43pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
NEUROLOGY文献大全abstract::The authors investigated whether repetitive transcranial magnetic stimulation (rTMS) at 1 Hz (12 minutes; 90% of motor threshold) to the primary motor cortex (M1) leads to changes in diffusion-weighted imaging (DWI). After the rTMS train, there was a temporary small restriction in diffusion within the targeted left M1...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000058903.15205.46
更新日期:2003-05-13 00:00:00
abstract::The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.00...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000150579.54878.00
更新日期:2005-02-08 00:00:00
abstract:OBJECTIVE:To evaluate the risk of recurrent intracranial hemorrhage (ICH) in patients on vitamin K antagonists (VKAs) after a first episode of ICH. METHODS:The Cerebral Haemorrhage in patients Restarting Oral Anticoagulant Therapy (CHIRONE) Study collected data of patients eligible for the study from the database of 2...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000000245
更新日期:2014-03-25 00:00:00
abstract::Cytokines such as interleukin-1 and tumor necrosis factor are involved in the triggering of the immune response, induction of acute inflammatory events, and transition to, or persistence of, chronic inflammation. The action of proinflammatory cytokines is regulated by their receptor expression, downregulation and shed...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.45.6_suppl_6.s39
更新日期:1995-06-01 00:00:00
abstract::Prompted by the observation that a fellow medical student sneezed at about the same time in class every morning, we recorded the time of each of the 118 sneezes she made on 69 days over a 6.5-month period. Analysis of the sneeze times with the goodness-of-fit test revealed a highly nonuniform distribution (p < 0.0001)...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.3_part_1.369
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:Rebleeding of an aneurysm is a leading cause of morbidity and mortality after subarachnoid hemorrhage (SAH). Whereas numerous studies have demonstrated the risk factors associated with rebleeding, few data on complications of rebleeding, including its effect on the development of delayed cerebral ischemia (DC...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31823ed0a4
更新日期:2012-01-03 00:00:00
abstract::Ten patients with amyotrophic lateral sclerosis were given intrathecal injections of natural interferon alpha, 1 million units weekly for 7 to 24 weeks. Six patients completed the trial. Four voluntarily withdrew after 7 to 13 injections. The slopes of deterioration for 40 quantitative tests of neuromuscular function ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.36.8.1137
更新日期:1986-08-01 00:00:00
abstract::Human cytomegalovirus and herpes simplex virus DNA probes were labeled in vitro and hybridized to the DNA extracted from brains of patients with multiple sclerosis (MS) to detect the presence of genetic information related to these viruses. We were unable to detect any virus-related genetic information complementary t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.5.530
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:Recent studies have suggested modifications of serotonin cerebral metabolism and of 5-HT(1A) receptors density in Alzheimer disease (AD). This study aims at exploring hippocampus 5-HT(1A) receptor density in patients at the amnesic mild cognitive impairment (aMCI) and mild AD dementia stages. METHODS:With us...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000271377.52421.4a
更新日期:2007-09-04 00:00:00
abstract:BACKGROUND:Infection with HIV can result in a debilitating CNS disorder known as HIV dementia (HIV-D). Since the advent of highly active antiretroviral therapy (HAART), the incidence of HIV-D has declined, but the prevalence continues to increase. In this new era of HIV-D, traditional biomarkers such as CSF viral load ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000260610.79853.47
更新日期:2007-05-01 00:00:00
abstract::We performed a retrospective study on a series of 119 of our patients who have Friedreich's disease to assess the predictive value of age at onset, gender, and left ventricular hypertrophy in regard to disease progression. Outcome variables were survival, time to loss of independent gait, and time to confinement in a ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.5.1260
更新日期:1996-11-01 00:00:00
abstract::A 66-year-old woman with acute idiopathic polyneuritis (Landry-Guillain-Barré [LGB] syndrome) had normal extraocular movements, but her pupils did not react to light or accommodation. This is the first such case to be reported. Pharmacologic testing pointed to postganglionic involvement of parasympathetic and sympathe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.7.1033
更新日期:1979-07-01 00:00:00
abstract::We present an 11-year-old girl in whom high field strength MRI performed 2 1/2 years and 6 months before her death showed prominent hypointensity in the globus pallidus and substantia nigra consistent with iron deposition. This finding suggested Hallervorden-Spatz disease, which was confirmed at autopsy. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.3.440
更新日期:1989-03-01 00:00:00
abstract::Inclusion-body myositis (IBM) is an inflammatory muscle disease that has proven resistant to treatment. Tumor necrosis factor molecules have been detected in muscle biopsies from patients with IBM. Etanercept is a TNFalpha receptor fusion protein that binds and inactivates tumor necrosis factor. Nine patients were tre...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000192258.32408.54
更新日期:2006-01-24 00:00:00
abstract::We investigated the heterogeneity of serum antibodies to acetylcholine receptor (AChR) by competition with nine antihuman monoclonal antibodies in a cross-sectional study of 36 patients with myasthenia gravis (MG), and in three who showed clinical improvement associated with decrease in total anti-AChR following immun...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.5.612
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas. METHODS:This was a retrospective cohort study of US veterans ≥65 years of age with type 2 diabetes who were new users of metformin or a sulfonylurea and had no dementia. Follow-up began after 2 years of therap...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004586
更新日期:2017-10-31 00:00:00
abstract::Confusion, speech arrest, automatic behavior, and amnesia characterize the prolonged twilight states of both petit mal and psychomotor status. However, in psychomotor status two electroclinical phases were differentiated: (1) A continuous twilight state with partial responsiveness and reactive automatisms interrupted ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.3.239
更新日期:1978-03-01 00:00:00
abstract::A 20-year-old mentally retarded woman, who had a history of intractable epileptic seizures since early childhood, had prolonged episodes of confusion, decreased responsiveness and automatic behavior lasting as long as 2 days. These are believed to represent epileptic status of the complex partial (psychomotor) type be...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.2.189
更新日期:1978-02-01 00:00:00
abstract::Videotape analysis of 76 attacks in 14 epileptics showed two electro-clinical types of psychomotor attacks. The first and most common type had three clinical phases, consisting of an initial motionless stare, stereotyped movements, and reactive automatisms during impaired consciousness. The second and less common type...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.2.144
更新日期:1977-02-01 00:00:00
abstract:OBJECTIVE:To examine the lifetime prevalence and the concordance risk of cluster headache (CH) in a twin sample representative of the Swedish general population. METHODS:The authors assessed CH as defined by the second edition of the International Classification of Headache Disorders in 31,750 registered twins born fr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000233786.72356.3e
更新日期:2006-09-12 00:00:00
abstract::Effective diagnosis and treatment of cytomegalovirus infection of the nervous system in AIDS patients has been limited by a lack of sensitive diagnostic measures. Retrospective series suggest a poor prognosis for cytomegalovirus encephalitis with rapid mortality. Polymerase chain reaction amplification of cytomegalovi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.2.444
更新日期:1996-02-01 00:00:00
abstract::We studied 60 patients with idiopathic Parkinson disease with motor and neuropsychologic tests to ascertain whether the severity of motor symptoms was associated with the degree of neuropsychologic deficity. Significant correlations were found between the severity of brady kinesia and impaired performance on tests ass...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.2.133
更新日期:1982-02-01 00:00:00
abstract::Nuclear magnetic resonance (NMR) imaging was superior to CT for imaging the brain lesions of 27 patients with MS. The incidence of abnormal examinations was 78% by NMR and 63% by CT. In cases in which both studies were abnormal, NMR usually demonstrated many more lesions and more extensive involvement than CT. The app...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.1.27
更新日期:1986-01-01 00:00:00
abstract::The effects of a single oral dose of levodopa administered in a randomized, double-blind, placebo-controlled cross-over design on formation of a motor memory were studied by a training protocol in patients with chronic stroke. Levodopa enhanced the ability of motor training to encode an elementary motor memory relativ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000172340.56307.5e
更新日期:2005-08-09 00:00:00
abstract:BACKGROUND:Chronic cerebrospinal venous insufficiency (CCSVI) was proposed as the causal trigger for developing multiple sclerosis (MS). However, current data are contradictory and a gold standard for venous flow assessment is missing. OBJECTIVE:To compare structural magnetic resonance venography (MRV) and dynamic ext...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318236f0ea
更新日期:2011-11-08 00:00:00
abstract:OBJECTIVE:To describe the phenotype of adult patients with variant and classic ataxia-telangiectasia (A-T), to raise the degree of clinical suspicion for the diagnosis variant A-T, and to assess a genotype-phenotype relationship for mutations in the ATM gene. METHODS:Retrospective analysis of the clinical characterist...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181af33bd
更新日期:2009-08-11 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Posterior cortical atrophy (PCA) is a progressive neurodegenerative syndrome that presents with cortical visual dysfunction and relatively preserved memory. Although higher cortical visual syndromes are well known in PCA, visual field defects detected by computerized visual field (CVF) perimetr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31823e9f2a
更新日期:2011-12-13 00:00:00
abstract::We reviewed the clinical course of nine patients with neuro-Behçet's disease to assess difficulties in making this diagnosis. Factors delaying proper diagnosis included lack of accurate history and physical examination, lack of recognition of an underlying systemic syndrome and its relationship to the neurologic sympt...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.9.1754
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to develop an algorithm incorporating MRI metrics to classify patients with mild traumatic brain injury (mTBI) and controls. METHODS:This was an institutional review board-approved, Health Insurance Portability and Accountability Act-compliant prospective study. We recruited pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000834
更新日期:2014-09-30 00:00:00
abstract::We evaluated a new magnetic resonance (MR)-based technique for performing volumetric measurements of temporal lobe structures. The technique was designed to assist in making the clinical diagnosis of dementia of the Alzheimer type (DAT). We chose specific anatomic regions of interest because of their known involvement...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.1.183
更新日期:1992-01-01 00:00:00