Abstract:
BACKGROUND:Patients with carnitine palmitoyltransferase II (CPT II) deficiency often experience muscle pain and myoglobinuria during prolonged exercise because of impaired oxidation of long-chain fatty acids. OBJECTIVE:To investigate whether IV or oral glucose can improve exercise tolerance in CPT II deficiency. METHODS:Five patients with CPT II deficiency and healthy matched volunteers were investigated on a cycle ergometer at a constant workload of 60% of VO(2max). Perceived exertion, heart rate, and venous plasma glucose and insulin levels were monitored. The study was randomized, placebo controlled, single blind, and crossover. Glucose and placebo were administered both orally and IV in patients and IV in healthy subjects. RESULTS:In patients with CPT II, exercise duration was prolonged by 28 +/- 8% (p = 0.02), and perceived exertion (p = 0.05) and heart rate (p = 0.09) were lowered by glucose infusion. In contrast, IV glucose resulted in higher heart rate during exercise in healthy subjects. Oral glucose and placebo resulted in the same exercise duration, perceived exertion, and heart rate in patients. Plasma glucose and insulin were consistently elevated during exercise by oral and IV glucose vs placebo, but plasma glucose was higher and insulin lower in IV vs oral glucose studies in patients (p = 0.02). CONCLUSION:Exercise tolerance is markedly improved by a glucose infusion in patients with CPT II deficiency, but because of lower glucose availability and higher insulin levels that inhibit muscle glycogenolysis, the patients cannot achieve this effect themselves by oral glucose ingestion.
journal_name
Neurologyjournal_title
Neurologyauthors
Ørngreen MC,Olsen DB,Vissing Jdoi
10.1212/wnl.59.7.1046subject
Has Abstractpub_date
2002-10-08 00:00:00pages
1046-51issue
7eissn
0028-3878issn
1526-632Xjournal_volume
59pub_type
临床试验,杂志文章,随机对照试验相关文献
NEUROLOGY文献大全abstract::A 48-year-old man presented with progressive spastic paraparesis and diffuse white matter involvement on neuroimaging that suggested a primary demyelinating disease. Brain biopsy 3 years after onset of symptoms demonstrated idiopathic granulomatous angiitis. In patients with MRI features of diffuse white matter diseas...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.6.1696
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence, incidence, and predictors of epilepsy among older adults in the Cardiovascular Health Study (CHS). METHODS:We analyzed data prospectively collected in CHS and merged with data from outpatient Medicare administrative claims. We identified cases with epilepsy using self-report, ant...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003662
更新日期:2017-02-28 00:00:00
abstract:OBJECTIVE:To combine MRI-based cortical morphometry and diffusion white matter tractography to describe the anatomical correlates of repetition deficits in patients with primary progressive aphasia (PPA). METHODS:The traditional anatomical model of language identifies a network for word repetition that includes Wernic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008746
更新日期:2020-02-11 00:00:00
abstract:OBJECTIVES:Patients surviving retinopathy-positive cerebral malaria (CM) are at high risk for the development of epilepsy, developmental disabilities, and behavioral abnormalities. We aimed to establish whether retinopathy-negative CM is also a risk factor for these outcomes. METHODS:Between 2005 and 2007, survivors o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826aacd4
更新日期:2012-09-18 00:00:00
abstract:OBJECTIVE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy caused by mutations of the Notch3 gene. The disease is characterized by T2-hyperintense lesions (subcortical white matter lesions), T1-hypointense lesions (lacunar lesions), and T2...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000265221.05610.70
更新日期:2007-07-10 00:00:00
abstract:OBJECTIVE:To evaluate the effect of amyloid imaging on clinical decision making. METHODS:We conducted a retrospective analysis of 140 cognitively impaired patients (mean age 65.0 years, 46% primary β-amyloid (Aβ) diagnosis, mean Mini-Mental State Examination 22.3) who underwent amyloid (Pittsburgh compound B [PiB]) PE...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000032
更新日期:2014-01-21 00:00:00
abstract::Four patients with a clinical syndrome closely resembling amyotrophic lateral sclerosis recovered completely, without treatment, 5 to 12 months after onset. Electrodiagnostic tests revealed acute and chronic denervation, with normal motor and sensory nerve conduction studies. The CSF was normal, and tests for paraprot...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1541
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Hypothalamic hamartomas (HHs), rare developmental abnormalities of the inferior hypothalamus, often cause refractory, symptomatic, mixed epilepsy, including gelastic seizures. We present 37 patients with HH who underwent transcortical transventricular endoscopic resection. METHODS:Between October 2003 and A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000310644.40767.aa
更新日期:2008-04-22 00:00:00
abstract:OBJECTIVE:To assess longitudinal follow-up of the incidence of multiple sclerosis (MS) through five decades and estimate the prevalence rate in Hordaland County, Norway, on January 1, 2003. METHODS:All patients with MS diagnosed from 1953 to 2003 were identified in the patient records of the Department of Neurology, H...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000195549.95448.b9
更新日期:2006-01-24 00:00:00
abstract::Photoparoxysmal response (PPR) is sometimes incidentally encountered in EEGs performed for evaluation of nonepileptic symptoms. We conducted the first long-term study of a cohort of nonepileptic patients to determine their risk of having seizures subsequent to incidental recording of PPR. After 6 to 12 years (mean, 9 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.9.1719
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To determine if progressive brain atrophy could be detected over 1- and 2-year intervals in relapsing MS, based on annual MR studies from the Multiple Sclerosis Collaborative Research Group (MSCRG) trial of interferon beta-1a (Avonex). METHODS:All subjects had mild to moderate disability, with baseline expan...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.53.1.139
更新日期:1999-07-13 00:00:00
abstract::Salla disease is a lysosomal storage disorder associated with increased urinary excretion of free sialic acid. The main clinical features in 34 patients were severe psychomotor retardation of early onset, ataxia, athetosis, rigidity, spasticity, and impaired speech. Growth retardation, thick calvarium, and exotropia w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.1.57
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine the frequency of CNS infection by dengue virus (DENV) in individuals with fatal outcomes. METHODS:Samples of 150 individuals suspect of an infection disease and with fatal outcomes were investigated for evidence of the presence of DENV. The sampling was made up of 150 CSF, 120 t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824b94e9
更新日期:2012-03-06 00:00:00
abstract:OBJECTIVE:To determine the diagnostic accuracy and clinical utility of electromagnetic source imaging (EMSI) in presurgical evaluation of patients with epilepsy. METHODS:We prospectively recorded magnetoencephalography (MEG) simultaneously with EEG and performed EMSI, comprising electric source imaging, magnetic sourc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006877
更新日期:2019-02-05 00:00:00
abstract::Using a crossed-response task, monkeys with neglect induced by frontal lesions appear to have motor rather than sensory neglect. However, the crossed-response task may not reveal sensory neglect (inattention) if no perceptual discrimination is required. We therefore trained two monkeys in a perceptually complex crosse...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.6.1205
更新日期:1995-06-01 00:00:00
abstract:OBJECTIVE:Genetic variants ε2/ε4 within the APOE gene are established risk factors for lobar intracerebral hemorrhage (ICH). Published preliminary data suggest a potential role for APOE ε4 in risk of nonlobar ICH. We therefore investigated the role of APOE in recurrent nonlobar ICH, and sought to clarify whether effect...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001790
更新日期:2015-07-28 00:00:00
abstract:OBJECTIVE:To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab. METHODS:In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in c...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000277457.17420.b5
更新日期:2007-10-02 00:00:00
abstract::Mitochondrial and cytoplasmic malic isoenzymes were assayed fluorometrically in digitonin-fractionated fibroblasts from three patients with Friedreich's ataxia (FA). Normal activity was found, failing to verify an earlier report of reduced fibroblast mitochondrial malic enzyme activity in FA. The previously reported d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.6.869
更新日期:1986-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the episodic migraine (EM)-obesity association and the influence of age, race, and sex on this relationship. METHODS:We examined the EM-obesity association and the influence of age, race, and sex in 3,862 adult participants of both black and white race interviewed in the National Comorbidity Surv...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a824f7
更新日期:2013-10-08 00:00:00
abstract::Spontaneous arm levitation (SAL) is well-recognized in cortical-basal ganglionic degeneration, but not in other neurodegenerative diseases. We report six cases of progressive supranuclear palsy (PSP) with SAL. Pathologic examination in four revealed the classic features of PSP with additional areas of focal cortical d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.4.879
更新日期:1999-03-10 00:00:00
abstract:BACKGROUND:While stable xenon CT (Xe-CT) cerebral blood flow (CBF) is an accepted standard for quantitative assessment of cerebral hemodynamics, the accuracy of magnetic resonance perfusion-weighted imaging (PWI-MRI) is unclear. The Improved PWI Methodology in Acute Clinical Stroke Study compares PWI findings with Xe-C...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000345372.49233.e3
更新日期:2009-03-31 00:00:00
abstract:OBJECTIVE:To determine the incidence of first seizures, epilepsy, and seizure mimics in a geographically defined area using the updated 2014 International League Against Epilepsy (ILAE) definition, which allows an epilepsy diagnosis after a single seizure when the risk of further seizures over the next 10 years is ≈60%...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009980
更新日期:2020-08-04 00:00:00
abstract::Phenotypic heterogeneity of sporadic Creutzfeldt-Jakob disease (CJD) has been linked to biochemically distinct types of the protease-resistant form of the prion protein (type 1 and type 2 PrP(Sc)). We investigated 14 cases of sporadic CJD and found that both type 1 and type 2 PrP(Sc) coexisted in 5 subjects. The disti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.9.2173
更新日期:1999-12-10 00:00:00
abstract::We studied the cerebral effects of oxygen-derived free radicals generated from the xanthine oxidase/hypoxanthine/ADP-Fe3+ system. Xanthine oxidase/hypoxanthine/ADP-Fe3+ solution (0.1 ml) was infused into caudate putamen, and brain was frozen rapidly in situ. Brain water and sodium content increased concomitant with de...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.3.315
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:The American Academy of Neurology (AAN) ALS Practice Parameter was published in April 1999. The ALS CARE Database has been collecting data on the management of patients with ALS in North America since 1996. OBJECTIVE:To compare the management of patients with ALS in North America as recorded in the ALS CARE...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.3.500
更新日期:2001-08-14 00:00:00
abstract:OBJECTIVE:To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to the pathogenic mechanisms underlying cerebral bleeding. METHODS:We performed a case-control analysis, comparing a cohort of consecutive white patients with ICH aged 55 year...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000005814
更新日期:2018-07-17 00:00:00
abstract::The effect of bilateral frontal leukotomy on motor function was evaluated by neurologic examination, tests of praxis, and appropriate neuropsychologic tests administered to five groups of subjects. Postleukotomy schizophrenic patients were subdivided into three degrees of recovery. Two nonleukotomized groups served as...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.12.1353
更新日期:1982-12-01 00:00:00
abstract:OBJECTIVE:To investigate the risk factors of neutralizing antibody (NAB)-induced complete secondary treatment failure (cSTF) during long-term botulinum neurotoxin (BoNT) treatment in various neurologic indications. METHODS:This monocenter retrospective cohort study analyzed the data of 471 patients started on BoNT the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009444
更新日期:2020-05-19 00:00:00
abstract::We compared CT and MRI findings among 78 Alzheimer's disease (AD), 66 vascular dementia (VaD), and 41 stroke without dementia (SWD) African-American patients to identify possible neuroimaging indicators of dementia. The patients with AD and VaD were generally older and less educated than those with SWD. VaD and SWD pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.8.1456
更新日期:1995-08-01 00:00:00
abstract::Since cytomegalovirus (CMV) has been implicated in the pathogenesis of Rasmussen's syndrome, we treated four patients with ganciclovir, a potent anti-CMV drug. A 7-year-old girl with seizures escalating to 60/day over 3 months despite triple antiepileptic drug therapy became seizure-free 5 days after initiation of tre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.4.925
更新日期:1996-10-01 00:00:00