Abstract:
OBJECTIVE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy caused by mutations of the Notch3 gene. The disease is characterized by T2-hyperintense lesions (subcortical white matter lesions), T1-hypointense lesions (lacunar lesions), and T2*-weighted gradient-echo (GE) lesions (cerebral microhemorrhages [CMs]) visualized on clinical MRI sequences and is considered as a model of "pure" subcortical ischemic vascular dementia. Although numerous studies have investigated the impact of white matter lesions in patients with CADASIL, the clinical importance of lacunar lesions remains unknown. Our purpose was to examine the influence of the visible MRI markers in the disease, including the load of lacunar lesions on cognitive impairment and disability in CADASIL. METHODS:We collected clinical data from 147 consecutive patients enrolled in an ongoing two-center prospective cohort study. Degree of disability was assessed by modified Rankin scale and Barthel index. Degree of cognitive impairment was assessed by Mattis Dementia Rating Scale and Mini-Mental Status Examination. T1-weighted, fluid-attenuated inversion recovery, and GE images were obtained on a 1.5-T MRI. Volume and location of lacunar lesions, white matter hyperintensities (WMHs), and CMs were assessed. RESULTS:There was a significant independent association between age, volume of lacunar lesions, and global cognitive function scales when analyzed in a multivariable model. In contrast, WMHs and CMs had no independent influence on cognitive function. Disability in this cohort was associated with volume of lacunar lesions, CMs, systolic blood pressure, and age but not with WMHs. CONCLUSIONS:Among the lesions observed on conventional MRI in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the overall lacunar lesion burden seems to have the most important impact on cognitive function and disability. These findings suggest that preventive strategies to decrease the risk of lacunar lesions as observed on MRI may reduce disease-related impairment in CADASIL. These results suggest that lacunar lesions may also play a key role in disability and cognitive impairment in more common forms of small-vessel disease.
journal_name
Neurologyjournal_title
Neurologyauthors
Viswanathan A,Gschwendtner A,Guichard JP,Buffon F,Cumurciuc R,O'Sullivan M,Holtmannspötter M,Pachai C,Bousser MG,Dichgans M,Chabriat Hdoi
10.1212/01.wnl.0000265221.05610.70subject
Has Abstractpub_date
2007-07-10 00:00:00pages
172-9issue
2eissn
0028-3878issn
1526-632Xpii
69/2/172journal_volume
69pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::The frequency of recurrent cerebral ischemia and death was determined prospectively in 36 patients who presented with ischemic stroke and had atrial fibrillation. Patients were followed an average of 2.3 months (range, 3 weeks to 9 months). The recurrence rate for cerebral ischemia was 33%, and the mortality rate was ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.10.1285
更新日期:1984-10-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that physical activity modifies the association between white matter hyperintensity (WMH) burden and motor function in healthy older persons without dementia. METHODS:Total daily activity (exercise and nonexercise physical activity) was measured for up to 11 days with actigraphy (Actic...
journal_title:Neurology
pub_type: 社论
doi:10.1212/WNL.0000000000001417
更新日期:2015-03-31 00:00:00
abstract::We studied four patients with neurologic disorders of the lumbosacral plexus. Except for location of symptoms, the disorder confirmed to criteria established for the clinical diagnosis of brachial plexus neuritis. Acute onset of pain in one or both legs was followed by weakness, loss of stretch reflexes, and sometimes...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.4.470
更新日期:1981-04-01 00:00:00
abstract:OBJECTIVE:To compare the clinical features of patients with chronic daily headache (CDH) with idiopathic intracranial hypertension without papilledema (IIHWOP) to those with normal CSF pressure. METHODS:A case-control study was conducted at a tertiary headache center. Cases consisted of 25 consecutive patients (24 wom...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.1.245
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Attempts at cell-based dopamine replacement therapy in Parkinson disease (PD) have included surgical implantation of adrenal medullary, fetal mesencephalic, and cultured human mesencephalic tissue grafts. Trials involving putamenal implantation of human retinal pigment epithelial (RPE) cells in PD have also ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181bbff1c
更新日期:2009-10-06 00:00:00
abstract::Early motor manifestations are the main components of focal seizures involving the frontal lobe. We examined the relationship between the initial ictal motor manifestations and interictal abnormalities of cerebral glucose consumption (rCMRGlc) as assessed by PET in 48 consecutive patients with focal seizures of neocor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.2.341
更新日期:1997-08-01 00:00:00
abstract::An allele (263bp) of the nonamyloid component of plaques (NACP)-Repl polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD)...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.5.1195
更新日期:2000-03-14 00:00:00
abstract:BACKGROUND:In a recent study, the authors found that blinks in healthy volunteers always triggered ocular torsion quick phases during dynamic roll movements of the head. On the basis of this observation, they hypothesized that blinks in patients with a vestibular tone imbalance would also trigger torsional quick phases...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000141144.02666.8c
更新日期:2004-10-12 00:00:00
abstract:BACKGROUND:Evidence linking APOE to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggests that it may be relevant in multiple sclerosis (MS). The purpose of this study was to determine whether the epsilon4 allele of APOE is associated with cognitive deficits in patients with MS. METHOD:Using...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181e074a7
更新日期:2010-05-18 00:00:00
abstract::The P3 component of the auditory evoked potential has been shown to reflect "endogenous" processes related to cognition. This component was measured serially in seven patients who had confusional states or dementing illnesses that fluctuated in severity over time. The latency of P3 component reflected the clinical imp...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.9.1215
更新日期:1983-09-01 00:00:00
abstract::The authors describe a patient with bilateral papilledema, visual field abnormalities, poorly reactive pupils, meningeal enhancement on cranial MRI, and diffuse brain parenchymal hypervascularity. The opening pressure at the time of lumbar puncture was normal, and results of other CSF studies were normal. All abnormal...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.9.2204
更新日期:1999-12-10 00:00:00
abstract::Cisplatin, used to treat ovarian, bladder, and testicular cancers, causes a sensory dose-limiting neuropathy. Preliminary observations in humans and animals suggest that nerve damage may be prevented by ACTH analogs, particularly those belonging to the melanocortin class, and by nerve growth factor (NGF). We establish...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.3_part_1.488
更新日期:1994-03-01 00:00:00
abstract::A collector is a person who collects things on purpose, either as a hobby or business, or for personal satisfaction, e.g., stamp, coin, or art collector. In such instances, the act of collecting things represents voluntary, controlled, goal-directed, selective searching. Pathologic patterns of collecting have been obs...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.3.488
更新日期:2002-02-12 00:00:00
abstract:OBJECTIVE:To determine whether a simple small vessel disease (SVD) score, which uses information available on rapid visual assessment of clinical MRI scans, predicts risk of cognitive decline and dementia, above that provided by simple clinical measures. METHODS:Three prospective longitudinal cohort studies (SCANS [St...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009141
更新日期:2020-03-24 00:00:00
abstract::Genetic factors clearly cause Lewy-body Parkinson's disease (PD) in a subset of autosomal-dominant families. However, most cases of PD are sporadic. The two most likely models of four discussed for sporadic PD are the reduced penetrance model and the multifactorial model. Sporadic PD is likely to be caused by the comb...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.41.5_suppl_2.82
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:In the late 19th century, a man with a psychogenic movement disorder was evaluated by many of the Philadelphia neurologists associated with Silas Weir Mitchell. In 1885, prior to the development of movie cameras or projectors, the patient was photographed by pioneering photographer Eadweard Muybridge, in col...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0000000000001192
更新日期:2015-01-27 00:00:00
abstract::Antiepileptic drug (AED) selection in women of reproductive age should consider efficacy, tolerability, interactions with contraceptive medications, and teratogenicity. Women planning a pregnancy should be counseled regarding the need for compliance with therapy and the risk for birth defects. All women with epilepsy ...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章,评审
doi:10.1212/wnl.51.5_suppl_4.s21
更新日期:1998-11-01 00:00:00
abstract::E.C. Seguin was one of the early, influential 19th-century neurologists who participated in the development of neurology as a specialty in the United States. Born in France, but raised from early childhood in the United States, Seguin published widely, developed a high-profile New York City practice, and was named Cli...
journal_title:Neurology
pub_type: 传,历史文章,杂志文章
doi:10.1212/WNL.0b013e3182904f55
更新日期:2013-04-30 00:00:00
abstract:OBJECTIVE:To examine the long-term cognitive trajectories of individuals with normal cognition at baseline and distinct amyloid/tau/neurodegeneration (ATN) profiles. METHODS:Pooling data across 4 cohort studies, 814 cognitively normal participants (mean baseline age = 59.6 years) were classified into 8 ATN groups usin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007248
更新日期:2019-04-02 00:00:00
abstract::A 52-year-old woman had a fatal intracerebral hemorrhage after dental manipulation. Normotensive in the past, the initial blood pressure was high but rapidly returned to normal. Necropsy showed no vascular malformation or evidence of hypertensive vascular disease. Clinical and experimental data show that stimulation o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.3.511
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this cross-sectional study was to determine the prevalence and potential significance of stroke symptoms among end-stage renal disease (ESRD) patients without a prior diagnosis of stroke or TIA. METHODS:We enrolled 148 participants with ESRD from 5 clinics. Stroke symptoms and functional statu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826845e9
更新日期:2012-09-04 00:00:00
abstract:BACKGROUND:Although hospital-outcome relationships have been explored for a variety of procedures and interventions, little is known about the association between annual stroke admission volumes and stroke mortality. Our aim was to determine whether facility type and hospital volume was associated with stroke mortality...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000268485.93349.58
更新日期:2007-09-11 00:00:00
abstract::We studied the effects of bromocriptine on periodic limb movements in sleep (PLMS) of narcoleptic patients. Bromocriptine significantly reduced the number and index of PLMS without improving the nocturnal sleep disruption in that disorder. These results support the hypothesis that dopaminergic mechanisms are involved ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.10.2134
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:To examine the relationships between age at onset and duration of seizure disorder with severity of hippocampal sclerosis (HS) and cognitive functioning in patients with HS and unilateral temporal lobe epilepsy. METHODS:Twenty-six subjects had left temporal lobe seizure onset; 20 had right temporal onset. Me...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.2.184
更新日期:2001-07-24 00:00:00
abstract:BACKGROUND:Benefit from carotid endarterectomy is greatest when performed within 2 weeks of a presenting TIA or stroke and decreases rapidly thereafter. OBJECTIVE:To determine the delays to carotid imaging and endarterectomy in Oxfordshire, UK, and the consequences for the effectiveness of stroke prevention. METHODS:...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000170368.82460.b4
更新日期:2005-08-09 00:00:00
abstract:OBJECTIVE:To determine the risk of seizure recurrence after a first seizure due to neurocysticercosis (NC) and to evaluate risk factors for seizure recurrence, including the influence of antihelminthic treatment. METHODS:The authors prospectively followed 77 patients with a first seizure and active or transitional NC ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000036320.69823.ea
更新日期:2002-12-10 00:00:00
abstract::Hypnic headache has been described in several case reports since 1981 and is regarded as an idiopathic headache disorder. In this review of 71 cases in the literature, the clinical features, neurophysiologic including polysomnographic findings, and treatment procedures are analyzed and the pathophysiology of this cond...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000046582.21771.9c
更新日期:2003-03-25 00:00:00
abstract::Successful screening for neuropathy in patients with diabetes is available using the 10 g Semmes-Weinstein monofilament (Mid-Delta Health Systems, Inc., Belzoni, MS) (touch/pressure sensation) and the Neurothesiometer (Horwell Scientific, London, UK; vibration perception threshold). In healthy volunteers and patients ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.59.4.611
更新日期:2002-08-27 00:00:00
abstract:OBJECTIVE:To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). BACKGROUND:LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. METHOD:The authors evaluated the brains of 72 consecutive cases of pathologically conf...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.9.1675
更新日期:2001-11-13 00:00:00
abstract:OBJECTIVE:To perform a single-center pilot investigation of early hematoma removal in patients with intracerebral hemorrhage (ICH). BACKGROUND:Considerable debate remains regarding the utility of surgical clot evacuation for ICH. METHODS:This was a prospective trial of open craniotomy within 12 hours of ICH symptom o...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.51.5.1359
更新日期:1998-11-01 00:00:00