Abstract:
:Antiepileptic drug (AED) selection in women of reproductive age should consider efficacy, tolerability, interactions with contraceptive medications, and teratogenicity. Women planning a pregnancy should be counseled regarding the need for compliance with therapy and the risk for birth defects. All women with epilepsy who are of childbearing potential should receive folate supplementation. Vitamin K supplementation is recommended during the final month of pregnancy. Withdrawal of AED therapy in seizure-free women can be considered before conception. Women who require AED therapy should receive AED monotherapy rather than polytherapy when at all possible. Medication changes post conception do not significantly reduce the risk for major fetal malformations and may compromise seizure control. Breastfeeding is generally safe for women taking AEDs. Menstrual disorders, reproductive endocrine disorders, ovulatory dysfunction, and infertility appear to be relatively common in women with epilepsy.
journal_name
Neurologyjournal_title
Neurologyauthors
Morrell MJdoi
10.1212/wnl.51.5_suppl_4.s21subject
Has Abstractpub_date
1998-11-01 00:00:00pages
S21-7issue
5 Suppl 4eissn
0028-3878issn
1526-632Xjournal_volume
51pub_type
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