Abstract:
OBJECTIVE:To assess whether exon deletions or duplications in CLCN1 are associated with recessive myotonia congenita (MC). METHODS:We performed detailed clinical and electrophysiologic characterization in 60 patients with phenotypes consistent with MC. DNA sequencing of CLCN1 followed by multiplex ligation-dependent probe amplification to screen for exon copy number variation was undertaken in all patients. RESULTS:Exon deletions or duplications in CLCN1 were identified in 6% of patients with MC. Half had heterozygous exonic rearrangements. The other 2 patients (50%), with severe disabling infantile onset myotonia, were identified with both a homozygous mutation, Pro744Thr, which functional electrophysiology studies suggested was nonpathogenic, and a triplication/homozygous duplication involving exons 8-14, suggesting an explanation for the severe phenotype. CONCLUSIONS:These data indicate that copy number variation in CLCN1 may be an important cause of recessive MC. Our observations suggest that it is important to check for exon deletions and duplications as part of the genetic analysis of patients with recessive MC, especially in patients in whom sequencing identifies no mutations or only a single recessive mutation. These results also indicate that additional, as yet unidentified, genetic mechanisms account for cases not currently explained by either CLCN1 point mutations or exonic deletions or duplications.
journal_name
Neurologyjournal_title
Neurologyauthors
Raja Rayan DL,Haworth A,Sud R,Matthews E,Fialho D,Burge J,Portaro S,Schorge S,Tuin K,Lunt P,McEntagart M,Toscano A,Davis MB,Hanna MGdoi
10.1212/WNL.0b013e318259e19csubject
Has Abstractpub_date
2012-06-12 00:00:00pages
1953-8issue
24eissn
0028-3878issn
1526-632Xpii
WNL.0b013e318259e19cjournal_volume
78pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::The mitochondrial genome has an underdeveloped "DNA repair repertoire" compared with the nuclear genome, making the mitochondrial DNA more susceptible to mutations by endogenous factors such as defects of the mitochondrial polymerase itself, and by exogenous factors such as radiation and UV light. Increased sensitivit...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.43.2.280
更新日期:1993-02-01 00:00:00
abstract::We carried out an open study of the effects of large doses (12 to 16 gm per day) of oral choline on medically intractable human complex partial seizures (CPS). Marked increases of plasma choline concentration (75 to 300%) in three subjects were associated with (1) shorter duration of CPS, (2) less postseizure fatigue,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.12.1334
更新日期:1980-12-01 00:00:00
abstract::A number of unresolved issues complicate the effective management of patients with Parkinson's disease (PD). Chief among these is the role of neuroprotective versus symptomatic pharmacologic interventions. Until the etiology of PD is further defined, consensus on appropriate management of this illness is unlikely. Cli...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.49.1_suppl_1.s2
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:To assess the effects of levodopa on resting-state brain metabolism in PD. BACKGROUND:In previous studies the authors used [18F] fluorodeoxyglucose (FDG) and PET to quantify regional metabolic abnormalities in PD. They found that this disease is characterized reproducibly by a specific abnormal PD-related pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.11.2083
更新日期:2001-12-11 00:00:00
abstract:OBJECTIVE:To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS:Patients with symptomatic nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic autonomic neuropathy underwent open-label droxidopa ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000000615
更新日期:2014-07-22 00:00:00
abstract:BACKGROUND:Natalizumab is an antibody directed against integrin alpha4 that reduces disease activity in patients with multiple sclerosis (MS) by blocking migration of T and B cells into the CNS. The goal of this study was to characterize the effects of natalizumab treatment on cytokine production and expression of acti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181a8266f
更新日期:2009-06-02 00:00:00
abstract:OBJECTIVE:The aim of this study was to clarify myocardial involvement and its clinical implications in subjects with spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease affecting both neuronal and nonneuronal tissues. METHODS:Two independent cardiologists evaluated ECGs from a total of 144 consecutive s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000434
更新日期:2014-05-20 00:00:00
abstract:OBJECTIVES:To investigate capacity to consent to medical treatment (competency) in cognitively impaired patients with PD. BACKGROUND:Although competency has been studied empirically in patients with cortical dementia (AD), no empirical studies have examined competency in patients with PD or other subcortical neurodege...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.1.17
更新日期:2001-01-09 00:00:00
abstract:OBJECTIVE:To evaluate published evidence of efficacy and safety of pharmacologic treatments for childhood spasticity due to cerebral palsy. METHODS:A multidisciplinary panel systematically reviewed relevant literature from 1966 to July 2008. RESULTS:For localized/segmental spasticity, botulinum toxin type A is establ...
journal_title:Neurology
pub_type: 杂志文章,实务指引,评审
doi:10.1212/WNL.0b013e3181cbcd2f
更新日期:2010-01-26 00:00:00
abstract::Plasma levels of six short-chain fatty acids (SCFA) were measured in 23 Reye's syndrome patients. In sequential measurements, only propionic acid correlated closely with neurologic severity. Although admission SCFA levels were slightly elevated, there were no significant differences between patients grouped by severit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.6.831
更新日期:1984-06-01 00:00:00
abstract:OBJECTIVE:To identify the source of delayed visual evoked potential (VEP) latencies in the fellow eyes of patients with optic neuritis (ON) and determine whether these latencies stem from clinically silent demyelination or reflect an adaptive process for synchronization with the affected eyes. METHODS:The study sample...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a1aa3e
更新日期:2013-08-20 00:00:00
abstract::We report a patient with striatonigral degeneration in whom T2-weighted MRI imaging revealed low signal and atrophy in the putamen. Neuropathologic studies confirmed putaminal atrophy and iron deposition in the MRI low signal regions. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.4.710
更新日期:1990-04-01 00:00:00
abstract::A 59-year-old woman with levodopa-responsive parkinsonism complicated by motor fluctuations and generalized levodopa dyskinesia underwent bilateral subthalamic deep brain stimulation (STN DBS) 7 years after symptom onset. DBS improved levodopa-responsive upper extremity bradykinesia but aggravated speech, swallowing, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073986.74883.36
更新日期:2003-07-22 00:00:00
abstract::Tolcapone is a potent, reversible inhibitor of catechol O-methyltransferase (COMT) intended for use as an adjunct to levodopa therapy for Parkinson's disease (PD). Findings from the first pharmacokinetics/pharmacodynamics and tolerability studies of tolcapone in volunteers are reviewed. Following linear and dose-propo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.50.5_suppl_5.s31
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare multisystem disorder associated with plasma cell dyscrasia. There is increasing evidence that high-dose chemotherapy with autologous peripheral blood stem cell transplantation (Auto-PBSCT) is an efficacious t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000323811.42080.a4
更新日期:2008-11-18 00:00:00
abstract::We performed magnetic resonance imaging (MRI), before and after the administration of gadolinium-DTPA (Gd-DTPA), in 23 patients with medically refractory partial epilepsy who subsequently had surgical treatment for their seizure disorder. In most patients, 61%, unenhanced and enhanced MRI studies were negative. In 26%...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.8.1115
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE:To improve our understanding of early β-amyloid (Aβ) accumulation processes using florbetapir-PET scan in 20- to 60-year-old individuals. METHODS:Seventy-six cognitively normal individuals aged 20 to 60 years, 57 cognitively normal older individuals (61-84 years old), and 70 patients with mild cognitive impa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004733
更新日期:2017-12-12 00:00:00
abstract::Spinocerebellar ataxia type 6 (SCA6) is a newly classified autosomal-dominant cerebellar ataxia (ADCA) associated with CAG repeat expansion. We screened 111 patients with cerebellar ataxia for the SCA6 mutation. Of these, 35 patients were found to have expanded CAG repeats in the SCA6 gene, indicating that second to S...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.5.1238
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:To examine metabolism during exercise in 2 patients with muscle phosphorylase kinase (PHK) deficiency and to further define the phenotype of this rare glycogen storage disease (GSD). METHODS:Patient 1 (39 years old) had mild exercise-induced forearm pain, and EMG showed a myopathic pattern. Patient 2 (69 yea...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824365f9
更新日期:2012-01-24 00:00:00
abstract:OBJECTIVE:To estimate rate of progression from normal cognition or mild impairment to dementia, and to identify potential risk and protective factors for incident dementia, based on age at dementia onset in a prospective study of a population-based cohort (n = 1,982) aged 65 years and older. METHODS:Following the coho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001113
更新日期:2015-01-06 00:00:00
abstract::In a double-blind, placebo-controlled, parallel-group, randomized clinical trial, we studied the efficacy of long-term (1-year) oral treatment with acetyl-L-carnitine in 130 patients with a clinical diagnosis of Alzheimer's disease. We employed 14 outcome measures to assess functional and cognitive impairment. After 1...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.41.11.1726
更新日期:1991-11-01 00:00:00
abstract::In a retrospective study of 103 corticosteroid-treated MS patients, the average rate of fracture events was 3.2% of the patients per year over 7.1 (+/- 5.7 SD) years at risk. Fractures of the ribs, pelvis, hip, or vertebrae occurred in 11 patients and became most common 5 years after starting steroids. Relatively high...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.7.1389
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:To investigate recovery of medical decision-making capacity (MDC) over the first year following traumatic brain injury (TBI). METHODS:A total of 177 participants (111 persons with TBI and 66 healthy controls) were recruited from an inpatient/outpatient TBI rehabilitation unit and outpatient neurology departm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003079
更新日期:2016-09-06 00:00:00
abstract::We studied a patient with autopsy-proven Hallervorden-Spatz syndrome (HSS) and the previously unreported finding of high-density lesions in the basal ganglia on CT. The diagnosis of HSS should be considered in a patient with dystonia and basal ganglia mineralization on CT. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.1.154
更新日期:1988-01-01 00:00:00
abstract::In multifocal motor neuropathy (MMN), little is known of the long-term effect of human immunoglobulin (HIG) infusions as a maintenance therapy. We report a patient who improved after an initial HIG infusion of 2 g/kg and continued to improve both clinically and electrophysiologically during maintenance HIG treatment c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.5.987
更新日期:1995-05-01 00:00:00
abstract::This article presents the findings relating to the European subgroup of 91 patients in an international survey of the current diagnosis and treatment of patients with amyotrophic lateral sclerosis (ALS). The mean time between first symptoms and first consultation with a physician was 4.9 months, and mean delay in seei...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment of drug-resistant partial-onset seizures. METHODS:This was a multicenter,...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0b013e3182635735
更新日期:2012-08-07 00:00:00
abstract::To test possible biochemical mechanisms by which L-tryptophan may reverse mental side effects of levodopa therapy in parkinsonism we administered levodopa, 250 mg per kilogram intraperitoneally, alone and with L-tryptophan, 500 mg per kilogram intraperitoneally, to rats pretreated with the peripheral dopa decarboxylas...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.9.861
更新日期:1975-09-01 00:00:00
abstract:OBJECTIVE:To assess the safety, tolerability, and biological activity of glial cell line-derived neurotrophic factor (GDNF) administered by an implanted intracerebroventricular (ICV) catheter and access port in advanced PD. BACKGROUND:GDNF is a peptide that promotes survival of dopamine neurons. It improved 6-OHDA- or...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.60.1.69
更新日期:2003-01-14 00:00:00
abstract::The intrathecal humoral immune response was analyzed in 83 patients with MS and 35 patients with acute CNS infections. CSF free kappa chains and CSF free lambda chains were quantified by radioimmunoassay; CSF IgG and albumin were measured by electroimmunodiffusion. The MS patients were characterized by higher levels o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.8.1334
更新日期:1987-08-01 00:00:00